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1. 发明授权

US07067277B1 Chimeric G proteins and uses thereof 失效
标题翻译：嵌合G蛋白及其用途
公开(公告)号：US07067277B1
公开(公告)日：2006-06-27
申请号：US09471572
申请日：1999-12-23
申请人： Kenneth A. Jones , Mary W. Walker , Joseph Tamm , Theresa A. Branchek , Christophe P. G. Gerald
发明人： Kenneth A. Jones , Mary W. Walker , Joseph Tamm , Theresa A. Branchek , Christophe P. G. Gerald
IPC分类号： C12N15/12 , C12N15/63 , C12N15/00 , C07H21/04 , C07K14/00
CPC分类号： C07K14/43581 , C07K14/43545
摘要： This invention provides isolated nucleic acids encoding chimeric G proteins, vectors comprising nucleic acids encoding chimeric G proteins, cells comprising such vectors, processes of determining agonists and antagonists of mammalian G protein-coupled receptors utilizing chimeric G proteins, processes of determining compounds which bind to mammalian G protein-coupled receptors utilizing chimeric G proteins, processes for making a composition of matter which specifically binds to a mammalian G protein-coupled receptor utilizing chimeric G proteins, processes for preparing a composition which comprises admixing a carrier and a pharmaceutically effective amount of a chemical compound identified by a process of the invention utilizing chimeric G proteins, processes of identifying a ligand for a mammalian G protein-coupled receptor utilizing chimeric G proteins, and processes of screening a plurality of independent clones to identify and isolate a clone encoding a mammalian G protein-coupled receptor utilizing chimeric G proteins.
摘要翻译：本发明提供编码嵌合G蛋白的分离的核酸，包含编码嵌合G蛋白的核酸的载体，包含此类载体的细胞，利用嵌合G蛋白确定哺乳动物G蛋白偶联受体的激动剂和拮抗剂的方法，确定与使用嵌合G蛋白的哺乳动物G蛋白偶联受体，使用嵌合G蛋白特异性结合哺乳动物G蛋白偶联受体的物质组合物的方法，制备组合物的方法，该组合物包含将载体和药学上有效量的通过利用嵌合G蛋白的本发明方法鉴定的化合物，利用嵌合G蛋白鉴定哺乳动物G蛋白偶联受体的配体的方法，以及筛选多个独立克隆以识别和分离编码哺乳动物G蛋白偶联 d受体。

2. 发明授权

US07022489B2 Method of using cells expressing galanin receptor 3 (GALR3) 失效
标题翻译：使用表达甘丙肽受体3（GALR3）的细胞的方法
公开(公告)号：US07022489B2
公开(公告)日：2006-04-04
申请号：US10007132
申请日：2001-12-03
申请人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
发明人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
IPC分类号： G01N33/53
CPC分类号： C07K16/2869 , A01K2217/05 , A61K38/00 , C07K14/72 , G01N33/5088 , G01N33/74 , G01N2333/72 , G01N2500/10
摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法受体。

3. 发明授权

US06287788B1 DNA encoding galanin GALR3 receptors and uses thereof 失效
标题翻译：编码甘丙肽GALR3受体的DNA及其用途
公开(公告)号：US06287788B1
公开(公告)日：2001-09-11
申请号：US09199737
申请日：1998-11-25
申请人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
发明人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
IPC分类号： G01N3353
CPC分类号： C07K16/2869 , A01K2217/05 , A61K38/00 , C07K14/72 , G01N33/5088 , G01N33/74 , G01N2333/72 , G01N2500/10
摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法受体。

4. 发明授权

US06368812B1 Process for determining the agonist or antagonist of galanin receptor (GALR3) 失效
标题翻译：测定甘丙肽受体激动剂或拮抗剂（GALR3）的方法
公开(公告)号：US06368812B1
公开(公告)日：2002-04-09
申请号：US09058333
申请日：1998-04-09
申请人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
发明人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
IPC分类号： G01N33566
CPC分类号： C07K16/2869 , A01K2217/05 , A61K38/00 , C07K14/72 , G01N33/5088 , G01N33/74 , G01N2333/72 , G01N2500/10
摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法受体。

5. 发明授权

US06713265B1 Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 有权
标题翻译：修饰进食行为的方法，可用于这些方法的化合物和编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA
公开(公告)号：US06713265B1
公开(公告)日：2004-03-30
申请号：US09194895
申请日：1999-09-27
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： G01N33/9406 , C07K14/70571 , G01N33/566 , G01N2500/10
摘要： The invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has structure (I). In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。一种这样的化合物具有结构（I）。此外，本发明提供编码Y5受体，分离的Y5受体蛋白质的分离的核酸分子，包含编码Y5受体的分离的核酸分子的载体，包含该载体的细胞，针对Y5受体的抗体，有用的核酸探针用于检测编码Y5受体的核酸，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变Y5受体的DNA的非人转基因动物。

6. 发明授权

US06316203B1 Methods of screening and preparing a composition using DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 有权
标题翻译：使用编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA筛选和制备组合物的方法
公开(公告)号：US06316203B1
公开(公告)日：2001-11-13
申请号：US09200673
申请日：1998-11-25
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： G01N33/9406 , A01K2217/05 , A61K31/137 , A61K38/00 , C07K14/70571 , C12Q1/6883 , G01N2500/02
摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds are selective agonists or antagonists or the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用化合物是选择性激动剂或拮抗剂或Y5受体。一种这样的化合物具有以下结构：此外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含用于检测核酸的所述酸性探针的细胞酸编码Y5受体，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。

7. 发明授权

US06818445B2 Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
标题翻译：修饰进食行为的方法，可用于这些方法的化合物和编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA
公开(公告)号：US06818445B2
公开(公告)日：2004-11-16
申请号：US09962646
申请日：2001-09-24
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： C07H2100
CPC分类号： G01N33/9406 , A01K2217/05 , A61K31/137 , A61K38/00 , C07K14/70571 , C12Q1/6883 , G01N2500/02
摘要： This invention provides isolated nucleic acid molecules encoding a neuropeptide Y (NPY) Y5 receptor which hybridizes under high stringency conditions to a nucleic acid molecule of SEQ ID NO:3, vectors comprising such isolated nucleic acid molecules, and cells comprising such vectors.
摘要翻译：本发明提供编码神经肽Y（NPY）Y5受体的分离的核酸分子，其在高严格条件下与SEQ ID NO：3的核酸分子，包含这种分离的核酸分子的载体和包含该载体的细胞杂交。

8. 发明授权

US06645774B1 Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
标题翻译：用于人类下丘脑非典型神经肽Y /肽YY受体（Y5）的化合物改变进食行为的方法
公开(公告)号：US06645774B1
公开(公告)日：2003-11-11
申请号：US09447907
申请日：1999-11-23
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： A61K31/137 , A01K2217/05 , A61K38/00 , C07K14/70571 , C12Q1/6883
摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。一种这样的化合物具有以下结构：另外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含这种载体的细胞，针对 Y5受体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变型Y5受体的DNA的非人类转基因动物。

9. 发明授权

US5602024A DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof 失效
标题翻译：编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA及其用途
公开(公告)号：US5602024A
公开(公告)日：1997-02-11
申请号：US349025
申请日：1994-12-02
申请人： Christophe P. G. Gerald , Mary W. Walker , Theresa Branchek , Richard L. Weinshank
发明人： Christophe P. G. Gerald , Mary W. Walker , Theresa Branchek , Richard L. Weinshank
IPC分类号： A01K67/027 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/12 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P5/24 , A61P5/50 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P29/00 , A61P43/00 , C07H21/00 , C07K14/705 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： G01N33/9406 , A61K31/137 , C07K14/70571 , C12Q1/6883 , A01K2217/05 , A61K38/00 , G01N2500/02
摘要： This invention provides an isolated nucleic acid molecule encoding a human Y5 receptor, an isolated protein which is a human Y5 receptor, vectors comprising an isolated nucleic acid molecule encoding a human Y5 receptor, mammalian cells comprising such vectors, antibodies directed to the human Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding human Y5 receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human Y5 receptor, pharmaceutical compounds related to human Y5 receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human Y5 receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human Y5 receptor.
摘要翻译：本发明提供了编码人Y5受体的分离的核酸分子，分离的人Y5受体的蛋白质，包含编码人Y5受体的分离的核酸分子的载体，包含该载体的哺乳动物细胞，针对人Y5受体的抗体可用于检测编码人Y5受体的核酸的核酸探针，与编码人Y5受体的核酸分子的任何序列互补的反义寡核苷酸，与人Y5受体相关的药物化合物，以及表达DNA正常的非人类转基因动物突变体人Y5受体。本发明还提供了用于测定配体结合，检测表达，药物筛选和涉及人Y5受体的治疗的方法。

10. 发明授权

US5968819A DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
标题翻译：编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA
公开(公告)号：US5968819A
公开(公告)日：1999-10-19
申请号：US566096
申请日：1995-12-01
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： A01K67/027 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/12 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P5/24 , A61P5/50 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P29/00 , A61P43/00 , C07H21/00 , C07K14/705 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： G01N33/9406 , A61K31/137 , C07K14/70571 , C12Q1/6883 , A01K2217/05 , A61K38/00 , G01N2500/02
摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds are selective agonists or antagonists or the Y5 receptor. One such compound has the structure: ##STR1## In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用化合物是选择性激动剂或拮抗剂或Y5受体。一种这样的化合物具有以下结构：另外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含这种载体的细胞，针对 Y5受体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达正常或突变型Y5受体的非人类转基因动物。

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