专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09283338B2 Dose counter for a metered-dose inhaler 有权
标题翻译：计量吸入器的剂量计数器
公开(公告)号：US09283338B2
公开(公告)日：2016-03-15
申请号：US13387535
申请日：2010-07-28
申请人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
发明人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
IPC分类号： A61M11/04 , A61M15/00 , G06M1/04 , G06M1/24
CPC分类号： A61M15/0078 , A61M15/0073 , A61M15/0075 , A61M15/009 , A61M2202/064 , G06M1/04 , G06M1/041 , G06M1/24
摘要： A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.
摘要翻译：用于计量由计量剂量吸入器分配或保留的药物剂量的剂量计数器。剂量计数器包括具有棘轮齿的可旋转地安装的第一齿轮和耦合到第一齿轮的显示器，显示器具有响应于第一齿轮的旋转运动可转位的剂量计数标记的可见阵列。剂量计数器还包括致动器机构，其具有第一棘轮驱动爪，用于响应于药物剂量的分配而啮合第一齿轮的棘齿;以及第二棘轮驱动爪，用于接合齿轮的棘轮齿，到展示。在使用中，第一齿轮的第一棘轮齿由第一棘爪旋转地驱动，然后连接到显示器的齿轮的第二棘齿由第二棘爪转动。

2. 发明授权

US08978966B2 Dose counters for inhalers, inhalers and methods of assembly thereof 有权
公开(公告)号：US08978966B2
公开(公告)日：2015-03-17
申请号：US13110532
申请日：2011-05-18
申请人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Dan Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
发明人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Dan Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
IPC分类号： G06M1/06 , A61M11/00 , A61M15/00 , G06M1/24
CPC分类号： A61M15/0078 , A61M11/00 , A61M15/0025 , A61M15/0026 , A61M15/0065 , A61M15/007 , A61M15/0071 , A61M15/009 , A61M2202/064 , A61M2205/6063 , A61M2207/00 , A61M2207/10 , G06M1/246 , Y10T29/49 , Y10T29/49764 , Y10T29/49826
摘要： A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

3. 发明申请

US20120241526A1 DOSE COUNTER FOR A METERED-DOSE INHALER 有权
标题翻译：剂量计数器用于计量吸入器
公开(公告)号：US20120241526A1
公开(公告)日：2012-09-27
申请号：US13387508
申请日：2010-07-28
申请人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
发明人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
IPC分类号： G06C11/02
CPC分类号： A61M15/0078 , A61M15/0073 , A61M15/0075 , A61M15/009 , A61M2202/064 , G06M1/04 , G06M1/041 , G06M1/24
摘要： A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.
摘要翻译：用于计量由计量剂量吸入器分配或保留的药物剂量的剂量计数器。剂量计数器包括：可旋转地安装的齿轮，其具有棘轮齿的圆形布置; 耦合到所述齿轮的显示器，所述显示器具有响应于所述齿轮的旋转运动可转位的剂量计数标记的可见阵列; 以及致动器机构，其具有用于响应于药物剂量的分配而可旋转地驱动齿轮的驱动器，所述驱动器布置成接合齿轮的棘轮齿。致动器机构包括具有输入部分的可枢转地安装的杠杆。杆被布置成放大输入部分处的线性行程，使得驾驶员的线性行程超过线性输入行程。通过放大行程，可能会降低由于行程长度不足引起的欠计数风险。

4. 发明授权

US5228456A Contraceptive diaphragm with molded plastic rim 失效
标题翻译：避孕膜与模塑塑料边缘
公开(公告)号：US5228456A
公开(公告)日：1993-07-20
申请号：US762380
申请日：1991-09-19
申请人： Jeffrey A. Karg , Robert J. Staab
发明人： Jeffrey A. Karg , Robert J. Staab
IPC分类号： A61F6/08
CPC分类号： A61F6/08
摘要： A contraceptive diaphragm has a cup-shaped body molded from a thermoplastic or thermosetting material, and a rim formed with the diaphragm body having a thickness and an inner core structure sufficient to provide a desired bending resilience for use of the diaphragm without any metal spring therein. The thermoplastic or thermosetting material is preferably a silicone rubber. In one embodiment, the rim is molded with a solid inner core structure with a circular cross-section of between 0.060 to 0.375 inch outer diameter. In another embodiment, the rim is formed by an outer layer molded around an inner core in the form of a plastic, injection- or compression-molded ring. The molded plastic ring is preferably made of an acetal plastic material with an outer diameter of between 0.040 to 0.250 inch. The plastic ring may have two or more cutout portions formed spaced apart along its circumference for defining flexing points on the diaphragm rim.
摘要翻译：避孕隔膜具有由热塑性或热固性材料模制的杯状体，并且形成有膜片本体的边缘具有厚度和内芯结构，足以提供使用隔膜的期望的弯曲弹性，而没有任何金属弹簧。热塑性或热固性材料优选为硅橡胶。在一个实施例中，轮辋用具有0.060至0.375英寸外径的圆形横截面的实心内芯结构模制。在另一个实施例中，边缘由塑料，注射或压缩模制环形式的围绕内芯模制的外层形成。模塑塑料环优选由外径在0.040至0.250英寸之间的缩醛塑料材料制成。塑料环可以具有沿其圆周形成间隔开的两个或更多个切口部分，用于限定隔膜轮辋上的弯曲点。

5. 发明申请

US20120240925A1 DOSE COUNTER FOR A METERED-DOSE INHALER 审中-公开
标题翻译：剂量计数器用于计量吸入器
公开(公告)号：US20120240925A1
公开(公告)日：2012-09-27
申请号：US13387532
申请日：2010-07-28
申请人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
发明人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
IPC分类号： A61M15/00 , G06M1/00
CPC分类号： A61M15/0078 , A61M15/0073 , A61M15/0075 , A61M15/009 , A61M2202/064 , G06M1/04 , G06M1/041 , G06M1/24
摘要： A dose counter for counting does of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted gear wheel having a circular arrangement of ratchet teeth defining a root circle and a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel. The dose counter further includes an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes an actuator shaft mounted for linear movement in response to the dispensing of a dose of medicament. In use, the travel of the driver along the root circle of the gear wheel exceeds the corresponding linear movement of the actuator shaft.
摘要翻译：用于计数的剂量计数器是由计量剂量吸入器分配或留在计量吸入器中的药物。剂量计数器包括可旋转地安装的齿轮，其具有限定根圆的棘轮的圆形布置和耦合到齿轮的显示器，显示器具有响应于齿轮的旋转运动可转位的剂量计数标记的可见阵列。剂量计数器还包括具有驱动器的致动器机构，所述驱动器响应于药物剂量的分配而可旋转地驱动齿轮，所述驱动器被布置成接合齿轮的棘轮齿。致动器机构包括致动器轴，其被安装成响应于剂量的药物的分配而线性运动。在使用中，驾驶员沿齿轮根圆的移动超过致动器轴的相应线性运动。

6. 发明申请

US20110283997A1 DOSE COUNTERS FOR INHALERS, INHALERS AND METHODS OF ASSEMBLY THEREOF 有权
标题翻译：吸入剂，吸入剂及其组合方法的剂量计数器
公开(公告)号：US20110283997A1
公开(公告)日：2011-11-24
申请号：US13110532
申请日：2011-05-18
申请人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Dan Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
发明人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Dan Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
IPC分类号： A61M11/00 , B23P17/04 , G06F17/50 , B67D7/22
CPC分类号： A61M15/0078 , A61M11/00 , A61M15/0025 , A61M15/0026 , A61M15/0065 , A61M15/007 , A61M15/0071 , A61M15/009 , A61M2202/064 , A61M2205/6063 , A61M2207/00 , A61M2207/10 , G06M1/246 , Y10T29/49 , Y10T29/49764 , Y10T29/49826
摘要： A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.
摘要翻译：手动计量剂量吸入器包括剂量计数器室，其包括由棘轮驱动的剂量显示带，所述剂量显示带依次由通过罐的移动致动的致动器棘爪驱动，在吸入器的使用过程中磁带从存货筒管退绕，旋转调节器被设置用于股票筒管并且包括具有凹陷的波纹接合表面，所述凹槽与分裂销的弹性叉上的凸起形式的突起形式接合，从而允许库存筒管的增量展开，但是如果吸入器是掉在硬表面上。

7. 发明申请

US20100008827A1 METERING DOSES OF SAMPLE LIQUIDS 有权
标题翻译：计量液体样品量
公开(公告)号：US20100008827A1
公开(公告)日：2010-01-14
申请号：US12563439
申请日：2009-09-21
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

8. 发明授权

US07459128B2 Microfluidic mixing and dispensing 失效
标题翻译：微流控混合和分配
公开(公告)号：US07459128B2
公开(公告)日：2008-12-02
申请号：US10778776
申请日：2004-02-13
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： G01N35/1074 , B01F11/0071 , B01F13/0059 , B01F15/0266 , B01F15/028 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00369 , B01J2219/00418 , B01L3/021 , B01L2200/0605 , B01L2300/0829 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , G01N35/028 , G01N35/1072 , G01N2035/1039 , Y10T436/2575
摘要： A microfluidic dispensing tap, such as for use in screening assays, includes a dispensing tube translatable within a sealed reservoir housing. The tube has an outer surface and defines an inner cavity open at a lower end of the tube, and a metering aperture extending through a side wall of the tube between the inner cavity and the outer surface to define a known volume. The tube is movable against a seal at a lower end of the reservoir housing between a first position, in which the metering aperture is disposed below the seal, and a second position, in which the metering aperture is disposed above the seal and exposed to the reservoir for entraining a discrete dose of a sample liquid within the aperture. An injector is configured to inject a known quantity of a diluent into the inner cavity of the tube and into fluidic contact with the dose of sample liquid in the aperture, such that the dose of sample liquid diffuses into the diluent to form a discrete mixture for dispensing from an open end of the tube.
摘要翻译：诸如用于筛选测定的微流体分配龙头包括可在密封的储存器壳体内平移的分配管。管具有外表面并且限定在管的下端开口的内腔，以及在内腔和外表面之间延伸穿过管的侧壁的计量孔，以限定已知体积。所述管可在所述储存器壳体的下端处抵靠所述密封件的第一位置和所述第二位置之间移动，所述第一位置在所述第一位置和所述第二位置之间，所述计量孔设置在所述密封件的上方并暴露于所述第二位置用于在孔内夹带离散剂量的样品液体的储存器。注射器构造成将已知量的稀释剂注射到管的内腔中并与孔中的样品液体的剂量流体接触，使得样品液体的剂量扩散到稀释剂中以形成离散的混合物从管的开放端分出。

9. 发明授权

US06620383B1 Microvolume liquid dispensing device 失效
标题翻译：微量体液分配装置
公开(公告)号：US06620383B1
公开(公告)日：2003-09-16
申请号：US09591803
申请日：2000-06-12
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L302
CPC分类号： B01L3/0265 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00364 , B01L3/0293 , B01L2200/0605 , C40B60/14 , G01N35/1002 , G01N35/1074 , Y10T436/2575
摘要： Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters. Integrated arrays of reservoir/tap units are suitable for use in automated, multiwell formats such as those commonly used for high-throughput screening.
摘要翻译：公开了用于集成包装，运输，储存和精确分配极小体积液体的装置和方法，例如溶解在有机溶剂中的水溶液和化合物。本发明的装置包括具有集成计量分接头的密封容器。水龙头包括计量管，其可在储存器内部的填充位置与储存器外部的排出位置之间平移。计量管包括：（1）管的下部中的管端封闭，（2）管端封闭件上方的端口，以及（3）管的上部的活塞。活塞可以在密封侧端口的下降位置和端口上方的上方位置之间移动。活塞从向上位置移动到向下位置可以从10纳升至20微升，例如从20纳升升至2微升，或50纳升至500纳升。储存器/分接头单元的集成阵列适用于自动化，多孔格式，例如通常用于高通量筛选的那些。

10. 发明授权

US06135337A Electric stapler 失效
标题翻译：电动订书机
公开(公告)号：US06135337A
公开(公告)日：2000-10-24
申请号：US232111
申请日：1999-01-15
申请人： James M. Harris , Gerald P. Fregeolle , Jeffrey A. Karg , David F. Tyndell
发明人： James M. Harris , Gerald P. Fregeolle , Jeffrey A. Karg , David F. Tyndell
IPC分类号： B25C5/02 , B27F7/00
CPC分类号： B25C5/0228
摘要： An electrically powered stapler is disclosed having a sliding blade for driving staples which is reciprocated by a lever and crank mechanism driven by an electric motor through a torque increasing gear train. Jamming of the stapler is prevented by mounting the lever's fulcrum on a plunger which is releasably retained to a fixed support by a flexible collar. The plunger has an enlarged head, and the collar has a plurality of flexible fingers which grip the plunger behind the head to retain the plunger to the collar. The plunger can be disengaged from the collar by the application of a predetermined force directed away from the plunger, such as occurs on the fulcrum during a jammed condition when the blade cannot drive a staple and is stalled. The pivot point of the lever then shifts to the blade end of the lever and the plunger is reciprocated by the lever instead of the blade, allowing the motor and other components to cycle through their full range of motion without stalling. The plunger is reengaged into the collar automatically as the plunger is reciprocated and the stapler is again ready to staple.
摘要翻译：公开了一种电动订书机，其具有用于驱动订书钉的滑动叶片，所述滑动叶片由杠杆和由电动机驱动的曲柄机构通过扭矩增加齿轮系往复运动。通过将杠杆的支点安装在通过柔性套环可释放地保持到固定支撑件的柱塞上来防止订书机的卡住。柱塞具有扩大的头部，并且套环具有多个柔性指状物，其将柱塞夹在头部后面以将柱塞保持在套环上。柱塞可以通过施加远离柱塞的预定力而与套环分离，例如当卡盘不能驱动订书钉并停滞时在卡住状态下发生在支点上。然后，杠杆的枢转点移动到杠杆的刀片端部，并且柱塞通过杠杆而不是刀片往复运动，允许电动机和其它部件循环通过其全部运动范围而不停滞。当柱塞往复运动时，柱塞自动重新接合到轴环中，并且订书机再次准备好订书钉。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式