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1. 发明授权

US08043865B2 Metering doses of sample liquids 有权
公开(公告)号：US08043865B2
公开(公告)日：2011-10-25
申请号：US12873625
申请日：2010-09-01
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： G01N1/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.

2. 发明授权

US08080218B2 Metering doses of sample liquids 有权
标题翻译：样品液体的计量剂量
公开(公告)号：US08080218B2
公开(公告)日：2011-12-20
申请号：US12563439
申请日：2009-09-21
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

3. 发明申请

US20110027906A1 METERING DOSES OF SAMPLE LIQUIDS 有权
标题翻译：计量液体样品量
公开(公告)号：US20110027906A1
公开(公告)日：2011-02-03
申请号：US12873625
申请日：2010-09-01
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： G01N1/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

4. 发明授权

US07592185B2 Metering doses of sample liquids 有权
标题翻译：样品液体的计量剂量
公开(公告)号：US07592185B2
公开(公告)日：2009-09-22
申请号：US10911845
申请日：2004-08-05
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： G01N1/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

5. 发明授权

US06706538B1 Microvolume liquid dispensing array 失效
标题翻译：微量液体分配阵列
公开(公告)号：US06706538B1
公开(公告)日：2004-03-16
申请号：US09591807
申请日：2000-06-12
申请人： Jeffrey A. Karg , Douglas W. Kroncke , Michael J. Jobin
发明人： Jeffrey A. Karg , Douglas W. Kroncke , Michael J. Jobin
IPC分类号： G01N110
CPC分类号： B01L3/0293 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00364 , B01L3/0265 , B01L2200/0605 , C40B60/14 , G01N35/1002 , G01N35/1074 , Y10T436/2575
摘要： Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters. Integrated arrays of reservoir/tap units are suitable for use in automated, multiwell formats such as those commonly used for high-throughput screening.
摘要翻译：公开了用于集成包装，运输，储存和精确分配极小体积液体的装置和方法，例如溶解在有机溶剂中的水溶液和化合物。本发明的装置包括具有集成计量分接头的密封容器。水龙头包括计量管，其可在储存器内部的填充位置与储存器外部的排出位置之间平移。计量管包括：（1）管的下部中的管端封闭，（2）管端封闭件上方的端口，以及（3）管的上部的活塞。活塞可以在密封侧端口的下降位置和端口上方的上方位置之间移动。活塞从向上位置移动到向下位置可以从10纳升至20微升，例如从20纳升升至2微升，或50纳升至500纳升。储存器/分接头单元的集成阵列适用于自动化，多孔格式，例如通常用于高通量筛选的那些。

6. 发明申请

US20100008827A1 METERING DOSES OF SAMPLE LIQUIDS 有权
标题翻译：计量液体样品量
公开(公告)号：US20100008827A1
公开(公告)日：2010-01-14
申请号：US12563439
申请日：2009-09-21
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

7. 发明授权

US07459128B2 Microfluidic mixing and dispensing 失效
标题翻译：微流控混合和分配
公开(公告)号：US07459128B2
公开(公告)日：2008-12-02
申请号：US10778776
申请日：2004-02-13
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： G01N35/1074 , B01F11/0071 , B01F13/0059 , B01F15/0266 , B01F15/028 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00369 , B01J2219/00418 , B01L3/021 , B01L2200/0605 , B01L2300/0829 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , G01N35/028 , G01N35/1072 , G01N2035/1039 , Y10T436/2575
摘要： A microfluidic dispensing tap, such as for use in screening assays, includes a dispensing tube translatable within a sealed reservoir housing. The tube has an outer surface and defines an inner cavity open at a lower end of the tube, and a metering aperture extending through a side wall of the tube between the inner cavity and the outer surface to define a known volume. The tube is movable against a seal at a lower end of the reservoir housing between a first position, in which the metering aperture is disposed below the seal, and a second position, in which the metering aperture is disposed above the seal and exposed to the reservoir for entraining a discrete dose of a sample liquid within the aperture. An injector is configured to inject a known quantity of a diluent into the inner cavity of the tube and into fluidic contact with the dose of sample liquid in the aperture, such that the dose of sample liquid diffuses into the diluent to form a discrete mixture for dispensing from an open end of the tube.
摘要翻译：诸如用于筛选测定的微流体分配龙头包括可在密封的储存器壳体内平移的分配管。管具有外表面并且限定在管的下端开口的内腔，以及在内腔和外表面之间延伸穿过管的侧壁的计量孔，以限定已知体积。所述管可在所述储存器壳体的下端处抵靠所述密封件的第一位置和所述第二位置之间移动，所述第一位置在所述第一位置和所述第二位置之间，所述计量孔设置在所述密封件的上方并暴露于所述第二位置用于在孔内夹带离散剂量的样品液体的储存器。注射器构造成将已知量的稀释剂注射到管的内腔中并与孔中的样品液体的剂量流体接触，使得样品液体的剂量扩散到稀释剂中以形成离散的混合物从管的开放端分出。

8. 发明授权

US06620383B1 Microvolume liquid dispensing device 失效
标题翻译：微量体液分配装置
公开(公告)号：US06620383B1
公开(公告)日：2003-09-16
申请号：US09591803
申请日：2000-06-12
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L302
CPC分类号： B01L3/0265 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00364 , B01L3/0293 , B01L2200/0605 , C40B60/14 , G01N35/1002 , G01N35/1074 , Y10T436/2575
摘要： Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters. Integrated arrays of reservoir/tap units are suitable for use in automated, multiwell formats such as those commonly used for high-throughput screening.
摘要翻译：公开了用于集成包装，运输，储存和精确分配极小体积液体的装置和方法，例如溶解在有机溶剂中的水溶液和化合物。本发明的装置包括具有集成计量分接头的密封容器。水龙头包括计量管，其可在储存器内部的填充位置与储存器外部的排出位置之间平移。计量管包括：（1）管的下部中的管端封闭，（2）管端封闭件上方的端口，以及（3）管的上部的活塞。活塞可以在密封侧端口的下降位置和端口上方的上方位置之间移动。活塞从向上位置移动到向下位置可以从10纳升至20微升，例如从20纳升升至2微升，或50纳升至500纳升。储存器/分接头单元的集成阵列适用于自动化，多孔格式，例如通常用于高通量筛选的那些。

9. 发明授权

US09283338B2 Dose counter for a metered-dose inhaler 有权
标题翻译：计量吸入器的剂量计数器
公开(公告)号：US09283338B2
公开(公告)日：2016-03-15
申请号：US13387535
申请日：2010-07-28
申请人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
发明人： Simon G. Kaar , Jeffrey A. Karg , Timothy Norman Johnson , Robert Charles Uschold
IPC分类号： A61M11/04 , A61M15/00 , G06M1/04 , G06M1/24
CPC分类号： A61M15/0078 , A61M15/0073 , A61M15/0075 , A61M15/009 , A61M2202/064 , G06M1/04 , G06M1/041 , G06M1/24
摘要： A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.
摘要翻译：用于计量由计量剂量吸入器分配或保留的药物剂量的剂量计数器。剂量计数器包括具有棘轮齿的可旋转地安装的第一齿轮和耦合到第一齿轮的显示器，显示器具有响应于第一齿轮的旋转运动可转位的剂量计数标记的可见阵列。剂量计数器还包括致动器机构，其具有第一棘轮驱动爪，用于响应于药物剂量的分配而啮合第一齿轮的棘齿;以及第二棘轮驱动爪，用于接合齿轮的棘轮齿，到展示。在使用中，第一齿轮的第一棘轮齿由第一棘爪旋转地驱动，然后连接到显示器的齿轮的第二棘齿由第二棘爪转动。

10. 发明授权

US08978966B2 Dose counters for inhalers, inhalers and methods of assembly thereof 有权
公开(公告)号：US08978966B2
公开(公告)日：2015-03-17
申请号：US13110532
申请日：2011-05-18
申请人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Dan Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
发明人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Dan Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
IPC分类号： G06M1/06 , A61M11/00 , A61M15/00 , G06M1/24
CPC分类号： A61M15/0078 , A61M11/00 , A61M15/0025 , A61M15/0026 , A61M15/0065 , A61M15/007 , A61M15/0071 , A61M15/009 , A61M2202/064 , A61M2205/6063 , A61M2207/00 , A61M2207/10 , G06M1/246 , Y10T29/49 , Y10T29/49764 , Y10T29/49826
摘要： A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.

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