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1. 发明授权

US08043865B2 Metering doses of sample liquids 有权
公开(公告)号：US08043865B2
公开(公告)日：2011-10-25
申请号：US12873625
申请日：2010-09-01
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： G01N1/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.

2. 发明授权

US08080218B2 Metering doses of sample liquids 有权
标题翻译：样品液体的计量剂量
公开(公告)号：US08080218B2
公开(公告)日：2011-12-20
申请号：US12563439
申请日：2009-09-21
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

3. 发明申请

US20110027906A1 METERING DOSES OF SAMPLE LIQUIDS 有权
标题翻译：计量液体样品量
公开(公告)号：US20110027906A1
公开(公告)日：2011-02-03
申请号：US12873625
申请日：2010-09-01
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： G01N1/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

4. 发明授权

US07592185B2 Metering doses of sample liquids 有权
标题翻译：样品液体的计量剂量
公开(公告)号：US07592185B2
公开(公告)日：2009-09-22
申请号：US10911845
申请日：2004-08-05
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： G01N1/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

5. 发明授权

US06706538B1 Microvolume liquid dispensing array 失效
标题翻译：微量液体分配阵列
公开(公告)号：US06706538B1
公开(公告)日：2004-03-16
申请号：US09591807
申请日：2000-06-12
申请人： Jeffrey A. Karg , Douglas W. Kroncke , Michael J. Jobin
发明人： Jeffrey A. Karg , Douglas W. Kroncke , Michael J. Jobin
IPC分类号： G01N110
CPC分类号： B01L3/0293 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00364 , B01L3/0265 , B01L2200/0605 , C40B60/14 , G01N35/1002 , G01N35/1074 , Y10T436/2575
摘要： Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters. Integrated arrays of reservoir/tap units are suitable for use in automated, multiwell formats such as those commonly used for high-throughput screening.
摘要翻译：公开了用于集成包装，运输，储存和精确分配极小体积液体的装置和方法，例如溶解在有机溶剂中的水溶液和化合物。本发明的装置包括具有集成计量分接头的密封容器。水龙头包括计量管，其可在储存器内部的填充位置与储存器外部的排出位置之间平移。计量管包括：（1）管的下部中的管端封闭，（2）管端封闭件上方的端口，以及（3）管的上部的活塞。活塞可以在密封侧端口的下降位置和端口上方的上方位置之间移动。活塞从向上位置移动到向下位置可以从10纳升至20微升，例如从20纳升升至2微升，或50纳升至500纳升。储存器/分接头单元的集成阵列适用于自动化，多孔格式，例如通常用于高通量筛选的那些。

6. 发明申请

US20100008827A1 METERING DOSES OF SAMPLE LIQUIDS 有权
标题翻译：计量液体样品量
公开(公告)号：US20100008827A1
公开(公告)日：2010-01-14
申请号：US12563439
申请日：2009-09-21
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的装置和方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

7. 发明授权

US07459128B2 Microfluidic mixing and dispensing 失效
标题翻译：微流控混合和分配
公开(公告)号：US07459128B2
公开(公告)日：2008-12-02
申请号：US10778776
申请日：2004-02-13
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L3/02
CPC分类号： G01N35/1074 , B01F11/0071 , B01F13/0059 , B01F15/0266 , B01F15/028 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00369 , B01J2219/00418 , B01L3/021 , B01L2200/0605 , B01L2300/0829 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , G01N35/028 , G01N35/1072 , G01N2035/1039 , Y10T436/2575
摘要： A microfluidic dispensing tap, such as for use in screening assays, includes a dispensing tube translatable within a sealed reservoir housing. The tube has an outer surface and defines an inner cavity open at a lower end of the tube, and a metering aperture extending through a side wall of the tube between the inner cavity and the outer surface to define a known volume. The tube is movable against a seal at a lower end of the reservoir housing between a first position, in which the metering aperture is disposed below the seal, and a second position, in which the metering aperture is disposed above the seal and exposed to the reservoir for entraining a discrete dose of a sample liquid within the aperture. An injector is configured to inject a known quantity of a diluent into the inner cavity of the tube and into fluidic contact with the dose of sample liquid in the aperture, such that the dose of sample liquid diffuses into the diluent to form a discrete mixture for dispensing from an open end of the tube.
摘要翻译：诸如用于筛选测定的微流体分配龙头包括可在密封的储存器壳体内平移的分配管。管具有外表面并且限定在管的下端开口的内腔，以及在内腔和外表面之间延伸穿过管的侧壁的计量孔，以限定已知体积。所述管可在所述储存器壳体的下端处抵靠所述密封件的第一位置和所述第二位置之间移动，所述第一位置在所述第一位置和所述第二位置之间，所述计量孔设置在所述密封件的上方并暴露于所述第二位置用于在孔内夹带离散剂量的样品液体的储存器。注射器构造成将已知量的稀释剂注射到管的内腔中并与孔中的样品液体的剂量流体接触，使得样品液体的剂量扩散到稀释剂中以形成离散的混合物从管的开放端分出。

8. 发明授权

US06840011B2 Window panel balance apparatus and method 有权
标题翻译：窗户平衡装置和方法
公开(公告)号：US06840011B2
公开(公告)日：2005-01-11
申请号：US10149181
申请日：2000-12-13
申请人： Roy A. Thompson , Douglas W. Kroncke , John C. Costello , David P. Chastain , Jack D. Gundlach , Timothy J. Kelley , Larry Versteeg , Thomas Hansel , Arthur R. King, IV , James R. Harger , Michael L. Doll , James L. Peterson , Dennis A. Galowitz , Richard M. Fischer
发明人： Roy A. Thompson , Douglas W. Kroncke , John C. Costello , David P. Chastain , Jack D. Gundlach , Timothy J. Kelley , Larry Versteeg , Thomas Hansel , Arthur R. King, IV , James R. Harger , Michael L. Doll , James L. Peterson , Dennis A. Galowitz , Richard M. Fischer
IPC分类号： E05C17/64 , E05D15/22
CPC分类号： E05D13/08 , E05D13/1207 , E05D15/22 , E05Y2201/67 , E05Y2900/148
摘要： A window having a window panel that slides in a frame and at least one balancer that is secured to the window panel is disclosed. The window is of the tiltable hung type having a vertical operating position in which the balancer slides with the window panel in the frame and a tilted position in which the balancer remains secured to the window panel. The balancer includes an extensible member having a first end operatively coupled to the balancer and a second end operatively coupled to a frame so that the balancer can exert a force on the window panel to assist against the force of gravity when the window panel is in the vertical operating position. A method of constructing a tiltable hung window with a balancer secured to the window panel is also disclosed.
摘要翻译：公开了一种具有在框架中滑动的窗口面板和至少一个固定到窗户面板的平衡器的窗口。窗口是具有垂直操作位置的倾斜悬挂型，其中平衡器与窗框在框架中滑动，并且平衡器保持固定在窗板上的倾斜位置。平衡器包括可伸展构件，其具有可操作地联接到平衡器的第一端和可操作地联接到框架的第二端，使得平衡器可以在窗面板上施加力以帮助抵抗重力，当窗面板处于垂直操作位置。还公开了一种用固定于窗板的平衡器构成可倾斜悬挂窗的方法。

9. 发明授权

US06620383B1 Microvolume liquid dispensing device 失效
标题翻译：微量体液分配装置
公开(公告)号：US06620383B1
公开(公告)日：2003-09-16
申请号：US09591803
申请日：2000-06-12
申请人： Jeffrey A. Karg , Douglas W. Kroncke
发明人： Jeffrey A. Karg , Douglas W. Kroncke
IPC分类号： B01L302
CPC分类号： B01L3/0265 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00353 , B01J2219/00364 , B01L3/0293 , B01L2200/0605 , C40B60/14 , G01N35/1002 , G01N35/1074 , Y10T436/2575
摘要： Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters. Integrated arrays of reservoir/tap units are suitable for use in automated, multiwell formats such as those commonly used for high-throughput screening.
摘要翻译：公开了用于集成包装，运输，储存和精确分配极小体积液体的装置和方法，例如溶解在有机溶剂中的水溶液和化合物。本发明的装置包括具有集成计量分接头的密封容器。水龙头包括计量管，其可在储存器内部的填充位置与储存器外部的排出位置之间平移。计量管包括：（1）管的下部中的管端封闭，（2）管端封闭件上方的端口，以及（3）管的上部的活塞。活塞可以在密封侧端口的下降位置和端口上方的上方位置之间移动。活塞从向上位置移动到向下位置可以从10纳升至20微升，例如从20纳升升至2微升，或50纳升至500纳升。储存器/分接头单元的集成阵列适用于自动化，多孔格式，例如通常用于高通量筛选的那些。

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