会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明授权
    • Thiophene derivatives and methods for producing the same
    • 噻吩衍生物及其制备方法
    • US4792612A
    • 1988-12-20
    • US171388
    • 1988-03-21
    • Hiroshi GodaMasao KawamuraKunioki KatoMakoto Sato
    • Hiroshi GodaMasao KawamuraKunioki KatoMakoto Sato
    • C07D333/22C07D333/28C07D333/34C07D333/38C07D333/44
    • C07D333/44C07D333/22C07D333/28C07D333/34C07D333/38
    • Novel compounds, 2-(.alpha.-alkoxyimino)ethylthiophenes are susceptible to electrophilic substitution reactions, and the acetylation, nitration, sulfonation and halogenation of the compounds provide 5-acetyl-2-(.alpha.-alkoxyimino)ethylthiophenes, 5-nitro-2-(.alpha.-alkoxyimino)ethylthiophenes, 5-(.alpha.-alkoxyimino)ethyl-2-thiophenesulfonic acid and 5-halo-2-(.alpha.-alkoxyimino)ethylthiophenes, respectively.The hydrolysis of 5-acetyl-2-(.alpha.-alkoxyimino)ethylthiophenes readily provides a known compound, 2,5-diacetylthiophene which is an important intermediate for the production of medicines, whereas the haloform reaction provides novel compounds, 5-(.alpha.-alkoxyimino)ethyl-2-thiophenecarboxylic acids, the hydrolysis of which compounds readily provides a known compound, 5-acetyl-2-thiophenecarboxylic acids, an important intermediate for the production of medicines.The hydrolysis of 5-(.alpha.-alkoxyimino)ethyl-2-thiophenesulfonic acids and their salts provide novel 5-acetyl-2-thiophenesulfonic acid and its salts, respectively.Novel compounds, 2-(.alpha.-alkoxyimino)ethylthiophenes are obtained either by 0-alkylation of 2-acetylthiophene oxime or by directly reacting 2-acetylthiophene with an 0-alkylhydroxylamine.
    • 新化合物2-(α-烷氧基亚氨基)乙基噻吩对亲电取代反应敏感,化合物的乙酰化,硝化,磺化和卤化提供5-乙酰基-2-(α-烷氧基亚氨基)乙基噻吩,5-硝基-2- (α-烷氧基亚氨基)乙基噻吩,5-(α-烷氧基亚氨基)乙基-2-噻吩磺酸和5-卤代-2-(α-烷氧基亚氨基)乙基噻吩。 5-乙酰基-2-(α-烷氧基亚氨基)乙基噻吩的水解容易提供已知的化合物,2,5-二乙酰基噻吩,其是制备药物的重要中间体,而卤代反应提供新化合物5-(α- 烷氧基亚氨基)乙基-2-噻吩羧酸,其中哪些化合物的水解容易提供已知化合物5-乙酰基-2-噻吩羧酸,这是生产药物的重要中间体。 5-(α-烷氧基亚氨基)乙基-2-噻吩磺酸及其盐的水解分别提供新的5-乙酰基-2-噻吩磺酸及其盐。 通过2-乙酰基噻吩肟的O-烷基化或通过使2-乙酰基噻吩与O-烷基羟胺直接反应得到2-(α-烷氧基亚氨基)乙基噻吩的新型化合物。
    • 2. 发明授权
    • Novel thiophene derivatives and methods for producing the same
    • 新型噻吩衍生物及其制备方法
    • US5101049A
    • 1992-03-31
    • US569540
    • 1990-08-20
    • Hiroshi GodaMasao KawamuraKunioki KatoMakoto Sato
    • Hiroshi GodaMasao KawamuraKunioki KatoMakoto Sato
    • C07D333/22C07D333/28C07D333/34C07D333/38C07D333/44
    • C07D333/38C07D333/22C07D333/28C07D333/34C07D333/44
    • Novel compounds, 2-(.alpha.-alkoxyimino)ethylthiophenes are susceptible to electrophilic substitution reactions, and the acetylation, nitration, sulfonation and halogenation of the compounds provide 5-acetyl-2-(.alpha.-alkoxyimino)ethylthiophenes, 5-nitro-2-(.alpha.-alkoxyimino)ethylthiophenes, 5-(.alpha.-alkoxyimino)ethyl-2-thiophenesulfonic acid and 5-halo-2-(.alpha.-alkoxyimino)ethylthiophenes, respectively.The hydrolysis of 5-acetyl-2-(.alpha.-alkoxyimino)ethylthiophenes readily provides a known compound, 2,5-diacetylthiophene which is an important intermediate for the production of medicines, whereas the haloform reaction provides novel compounds, 5-(.alpha.-alkoxyimino)ethyl-2-thiophenecarboxylic acids, the hydrolysis of which compounds readily provides a known compound, 5-acetyl-2-thiophenecarboxylic acids, an important intermediate for the production of medicines.The hydrolysis of 5-(.alpha.-alkoxyimino)ethyl-2-thiophenesulfonic acids and their salts provide novel 5-acetyl-2-thiophenesulfonic acid and its salts, respectively.Novel compounds, 2-(.alpha.-alkoxyimino)ethylithiophenes are obtained either by 0-alkylation of 2-acetylthiophene oxime or by directly reacting 2-acetylthiophene with an 0-alkylhydroxylamine.
    • 新化合物2-(α-烷氧基亚氨基)乙基噻吩对亲电取代反应敏感,化合物的乙酰化,硝化,磺化和卤化提供5-乙酰基-2-(α-烷氧基亚氨基)乙基噻吩,5-硝基-2- (α-烷氧基亚氨基)乙基噻吩,5-(α-烷氧基亚氨基)乙基-2-噻吩磺酸和5-卤代-2-(α-烷氧基亚氨基)乙基噻吩。 5-乙酰基-2-(α-烷氧基亚氨基)乙基噻吩的水解容易提供已知的化合物,2,5-二乙酰基噻吩,其是制备药物的重要中间体,而卤代反应提供新化合物5-(α- 烷氧基亚氨基)乙基-2-噻吩羧酸,其中哪些化合物的水解容易提供已知化合物5-乙酰基-2-噻吩羧酸,这是生产药物的重要中间体。 5-(α-烷氧基亚氨基)乙基-2-噻吩磺酸及其盐的水解分别提供新的5-乙酰基-2-噻吩磺酸及其盐。 通过2-乙酰基噻吩肟的O-烷基化或通过使2-乙酰基噻吩与O-烷基羟胺直接反应,得到2-(α-烷氧基亚氨基)乙基噻吩类化合物。
    • 9. 发明授权
    • 2,5-dichlorophenylthioglycolic acid derivative and method for its
production
    • 2,5-二氯苯硫基乙酸衍生物及其制备方法
    • US5352821A
    • 1994-10-04
    • US19906
    • 1993-02-19
    • Hiroshi GodaNario KimuraNaohiro YoshikawaKatsuhiko Yoshida
    • Hiroshi GodaNario KimuraNaohiro YoshikawaKatsuhiko Yoshida
    • C07C323/66C07C323/62
    • C07C323/66
    • The present invention is directed to novel 2,5-dichlorophenylthioglycolic acid derivative, a process for their production and a process for producing the desired product 2,5-dichlorophenylthioglycolic acid derived from said novel compounds. 2,5-dichlorophenylthioglycolic acid derivative of the present invention can be obtained by reacting 2,4,5-trichlorobenzensulfonates and thioglycolic acid in the presence of base, and said desired product can be obtained by desulfonating said compound in an aqueous solution of mineral acid. Novel 4-carboxymethylthio-2,5-dichlorobenzenesulfonates of the present invention can be used advantageously as an intermediate for the production of 2,5-dichlorophenylthioglycolic acid. The use of said intermediate makes it possible to obtain the desired product in a decreased process steps with high yield. In addition, it poses no problem of environmental pollution as pointed out with conventional methods because it uses no heavy metals.
    • 本发明涉及新的2,5-二氯苯基硫代乙醇酸衍生物,其制备方法和由所述新化合物衍生的所需产物2,5-二氯苯基乙氧基乙酸的制备方法。 本发明的2,5-二氯苯硫代乙酸衍生物可以通过使2,4,5-三氯苯磺酸盐和巯基乙酸在碱存在下反应而获得,所需要的产物可通过将无机酸水溶液中的所述化合物脱磺酸 。 本发明的新型4-羧甲基硫代-2,5-二氯苯磺酸盐可以有利地用作生产2,5-二氯苯乙硫醇的中间体。 使用所述中间体使得可以以降低的工艺步骤以高产率获得所需产物。 另外,由于不使用重金属,因此常规方法指出了环境污染问题。