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1. 发明授权

US08397748B2 Check valve having two seats 有权
标题翻译：止回阀有两个座位
公开(公告)号：US08397748B2
公开(公告)日：2013-03-19
申请号：US11938428
申请日：2007-11-12
申请人： Kenneth Bram , Francis J. Martin
发明人： Kenneth Bram , Francis J. Martin
IPC分类号： F16K31/12
CPC分类号： F16K11/105 , Y10T137/7781 , Y10T137/7866 , Y10T137/7925
摘要： A valve includes a body, a cavity in the body, and a check valve formed in the cavity. The check valve includes a poppet having a first end and a second end, and a first seat and a second seat, wherein the first seat is formed at the first end, the second seat is formed at the second end, and a diameter of the second seat is greater than a diameter of the first seat.
摘要翻译：阀包括主体，主体中的空腔和形成在空腔中的止回阀。止回阀包括具有第一端和第二端的提升阀，以及第一座和第二座，其中第一座形成在第一端，第二座形成在第二端，并且直径第二座椅大于第一座椅的直径。

2. 发明授权

US07913715B2 Relief valve including a check valve in a damping chamber 有权
标题翻译：泄压阀包括阻尼室中的止回阀
公开(公告)号：US07913715B2
公开(公告)日：2011-03-29
申请号：US11934876
申请日：2007-11-05
申请人： Francis J. Martin
发明人： Francis J. Martin
IPC分类号： F16K21/10
CPC分类号： F16K17/10 , Y10T137/2642 , Y10T137/7852 , Y10T137/7853 , Y10T137/7925
摘要： A relief valve includes a body, a damping chamber in the body, a poppet in the body, wherein the poppet includes an end in the damping chamber, and a check valve in the damping chamber. The damping chamber is located adjacent an inlet side of the relief valve, and the check valve includes a sealing member to prevent fluid flow into the damping chamber at the inlet side. The sealing member is unseated during opening of the poppet to permit fluid to flow into the damping chamber at the inlet side.
摘要翻译：安全阀包括主体，主体中的阻尼室，主体中的提升阀，其中提升阀包括阻尼室中的端部和阻尼室中的止回阀。阻尼室位于安全阀的入口侧附近，止回阀包括密封构件，以防止流体在入口侧流入阻尼室。在打开提升阀的过程中，密封件是脱开的，以允许流体在入口侧流入阻尼室。

3. 发明申请

US20100209348A1 METHODS FOR DETERMINING LIPOSOME BIOEQUIVALENCE 审中-公开
标题翻译：用于测定脂质体生物等效性的方法
公开(公告)号：US20100209348A1
公开(公告)日：2010-08-19
申请号：US12487039
申请日：2009-06-18
申请人： Francis J. Martin
发明人： Francis J. Martin
IPC分类号： A61B10/00 , G01N33/15 , A61K49/00
CPC分类号： A61K49/0004 , Y10T436/142222
摘要： This invention provides methods for determining liposome bioequivalence between a generic drug product and a reference brand-name product. Specific methods for determining bioequivalence between doxorubicin hydrochloric acid (HCl) liposome injection product (Doxil®) and a generic pegylated liposome doxorubicin product are disclosed herein.
摘要翻译：本发明提供了测定仿制药与参考品牌产品之间脂质体生物等效性的方法。本文公开了用于确定多柔比星盐酸（HCl）脂质体注射产物（Doxil？）和普通聚乙二醇化脂质体多柔比星产物之间的生物等效性的具体方法。

4. 发明授权

US06955670B2 Nanopump system 失效
标题翻译：纳米泵系统
公开(公告)号：US06955670B2
公开(公告)日：2005-10-18
申请号：US10170774
申请日：2002-06-13
申请人： Francis J. Martin , Robbie J. Walczak
发明人： Francis J. Martin , Robbie J. Walczak
IPC分类号： B01D57/02 , B01D61/56 , B01L3/00 , F04B17/00 , F04B19/00 , A61K9/22
CPC分类号： B82Y15/00 , B01D57/02 , B01D61/56 , B01L3/50273 , B01L3/502753 , B01L2300/0681 , B01L2300/0896 , B01L2400/0415 , B01L2400/0418 , B82Y30/00 , F04B17/00 , F04B19/006 , F05B2250/84
摘要： A self-contained delivery device for delivery a selected volume of stored electrolyte solution at selected time intervals is disclosed. The device includes a housing having a delivery port, a chamber containing an upstream supply reservoir for holding a quantity of electrolyte solution, a downstream delivery reservoir for receiving electrolyte solution from the supply reservoir and, disposed between the two reservoirs, a membrane having a plurality of flow-through channels extending between the two reservoirs. A pair of electrodes placed in the chamber on either side of the membrane and controlled by a controller contained within the housing for pumping selected quantities of the electrolyte solution at selected time intervals. The device includes a chamber, and a membrane disposed in said chamber and having a channel extending between an upstream chamber region, where the said channel has a selected minimum cross-sectional dimension in the range between 2 and 100 nm.
摘要翻译：公开了一种用于以选定的时间间隔递送选定体积的储存电解质溶液的独立输送装置。该装置包括具有输送口的壳体，容纳用于保持一定数量的电解质溶液的上游供应储存器的室，用于从供应储存器接收电解质溶液的下游输送储存器，以及设置在两个储存器之间的膜，的两个储存器之间延伸的流通通道。一对电极放置在膜的两侧的腔室中，并由包含在壳体内的控制器控制，用于以选定的时间间隔泵送选定量的电解质溶液。该装置包括一个室和一个设置在所述室中并具有在上游室区域之间延伸的通道的膜，其中所述通道具有在2和100nm之间范围内的选定的最小横截面尺寸。

5. 发明授权

US06586002B2 Enhanced circulation effector composition and method 失效
标题翻译：增强循环效应器组成和方法
公开(公告)号：US06586002B2
公开(公告)日：2003-07-01
申请号：US09877978
申请日：2001-06-08
申请人： Samuel Zalipsky , Martin C. Woodle , Francis J. Martin , Yechezkel Barenholz , Herve Bercovier
发明人： Samuel Zalipsky , Martin C. Woodle , Francis J. Martin , Yechezkel Barenholz , Herve Bercovier
IPC分类号： A61K9127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
摘要翻译：公开了包含小的表面结合效应分子的脂质体组合物。脂质体具有亲水性聚合物链的表面层，用于增强血流中的循环时间。效应分子连接到聚合物链的末端。在一个实施方案中，效应物是多粘菌素B，用于治疗败血性休克。

6. 发明授权

US06355270B1 Particles for oral delivery of peptides and proteins 有权
标题翻译：用于口服肽和蛋白质的颗粒
公开(公告)号：US06355270B1
公开(公告)日：2002-03-12
申请号：US09479389
申请日：2000-01-06
申请人： Mauro Ferrari , Peter J. Dehlinger , Francis J. Martin , Carl F. Grove , David R. Friend
发明人： Mauro Ferrari , Peter J. Dehlinger , Francis J. Martin , Carl F. Grove , David R. Friend
IPC分类号： A61K914
CPC分类号： G03F7/00 , A61K9/0097 , A61K9/1676 , A61K9/1694 , A61K9/4891
摘要： Microfabricated, asymmetrical, reservoir-containing particles for use in the oral delivery of biopolymer therapeutic agents such as peptides, proteins and oligonucleotides are disclosed. The particles are encapsulated in enteric-coated capsules or tablets to provide passage through the stomach and release of a suspension of the particles in the intestinal lumen. The particles have a selected shape, and uniform dimensions preferably in the 100 &mgr;m to 1 mm range. The reservoirs open to the face of the particle and are filled with a therapeutic agent and selected excipients. The excipients are selected to delay the dissolution/release of the agent from the particle reservoirs for 5-60 minutes after the particle is released in the intestinal lumen. Alternatively, the pore is plugged with an erodable material. The face of the particle is grafted with a layer of muco-adhesive ligands designed to quickly bind the particle to the intestinal mucosa for several minutes to several hours after release of the particles from the enteric-coated carrier.
摘要翻译：公开了用于生物聚合物治疗剂例如肽，蛋白质和寡核苷酸的口服递送的微制造的，不对称的，含储层的颗粒。将颗粒包封在肠溶衣胶囊或片剂中以提供穿过胃的通道并释放颗粒在肠腔中的悬浮液。颗粒具有选定的形状，并且尺寸均匀，优选在100μm至1mm范围内。储存器对颗粒的表面开放并填充有治疗剂和选定的赋形剂。选择赋形剂以在颗粒在肠腔中释放后延迟药剂从颗粒储存器中溶解/释放5-60分钟。或者，孔被可侵蚀的材料堵塞。该颗粒的表面用一层粘膜 - 粘合剂配体接枝，其设计用于在从肠溶衣载体上释放颗粒之后将颗粒快速结合至肠粘膜数分钟至数小时。

7. 发明授权

US5534259A Polymer compound and coated particle composition 失效
标题翻译：高分子化合物和涂层颗粒组成
公开(公告)号：US5534259A
公开(公告)日：1996-07-09
申请号：US89086
申请日：1993-07-08
申请人： Samuel Zalipsky , Francis J. Martin
发明人： Samuel Zalipsky , Francis J. Martin
IPC分类号： A61K9/127 , A01N25/26 , A01N25/28
CPC分类号： A61K9/1271 , A61K9/1273
摘要： A composition of polymer-coated particles, and a polymer compound used in forming the particles are disclosed. The polymer compound is composed of a hydrophilic polymer attached to a lipophilic moiety through a linking segment which contains chemical groups through which the compound can be crosslinked to other such compounds. The particles in the composition are prepared by forming lipid structures containing ordered arrays of the polymer compounds, and crosslinking the compounds through their chemical groups. The particles are used for parenteral administration of a pharmaceutical compound which is entrapped in the particles.
摘要翻译：公开了聚合物涂覆颗粒的组合物和用于形成颗粒的聚合物化合物。高分子化合物由亲水性部分组成，该亲水性聚合物通过连接部分连接，该连接部分含有化学基团，通过该化学基团，化合物可以与其他这样的化合物交联。组合物中的颗粒通过形成含有聚合物化合物的有序阵列的脂质结构并通过化学基团交联化合物来制备。颗粒用于胃肠外给药被包埋在颗粒中的药物化合物。

8. 发明授权

US5527528A Solid-tumor treatment method 失效
标题翻译：固体肿瘤治疗方法
公开(公告)号：US5527528A
公开(公告)日：1996-06-18
申请号：US40544
申请日：1993-03-31
申请人： Theresa M. Allen , Francis J. Martin
发明人： Theresa M. Allen , Francis J. Martin
IPC分类号： A61K9/127 , A61K47/48 , C07F9/553 , A61K51/12 , A61K39/44
CPC分类号： C07F9/5537 , A61K47/48815 , A61K47/48823 , A61K9/1271 , Y10S424/812
摘要： A method of administering an anti-tumor compound to a subject is disclosed. The method includes administering to a subject liposomes having sizes predominantly in the range 0.05 to 0.12 microns, and containing an anti-tumor compound in liposome-entrapped form, a surface coating of polyethylene glycol chains, at a surface concentration thereof sufficient to extend the blood circulation time of the liposomes severalfold over that of liposomes in the absence of such coating, and surface-attached antibody molecules effective to bind specifically to tumor-associated antigens present at the tumor site. One liposome composition includes doxorubicin in entrapped form, and, on the liposome surface, a monoclonal antibody against highly proliferating cells in a lung squamous cell carcinoma.
摘要翻译：公开了向受试者施用抗肿瘤化合物的方法。该方法包括向主体脂质体施用主要在0.05至0.12微米范围内的脂质体，并且含有脂质体包埋形式的抗肿瘤化合物，其表面浓度足以延长血液的聚乙二醇链的表面包衣在不存在这种涂层的情况下脂质体的循环时间比脂质体的循环时间多几倍，以及有效结合肿瘤位点处的肿瘤相关抗原的表面附着的抗体分子。一种脂质体组合物包括夹心形式的多柔比星，和在脂质体表面上的抗肺鳞状细胞癌中高增殖细胞的单克隆抗体。

9. 发明授权

US5395619A Lipid-polymer conjugates and liposomes 失效
标题翻译：脂质 - 聚合物共轭物和脂质体
公开(公告)号：US5395619A
公开(公告)日：1995-03-07
申请号：US25602
申请日：1993-03-03
申请人： Samuel Zalipsky , Martin C. Woodle , Danilo D. Lasic , Francis J. Martin
发明人： Samuel Zalipsky , Martin C. Woodle , Danilo D. Lasic , Francis J. Martin
IPC分类号： A61K9/127 , A61K47/32 , A61K47/34 , A61K47/48 , C08F289/00 , C08G69/10 , C08G69/48 , C08G73/02 , C08G73/10 , C08G81/02
CPC分类号： A61K9/1271 , Y10T428/2984
摘要： A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropyl methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxazoline, polyethyloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.
摘要翻译：公开了用于形成长循环脂质体的脂质 - 聚合物缀合物。缀合物包括与其极性头基共价连接的囊泡形成脂质，聚合物之一：聚乙烯吡咯烷酮，聚乙烯基甲基醚，聚羟基丙基甲基丙烯酸酯，聚羟基丙基甲基丙烯酰胺，聚羟基乙基丙烯酸酯，聚甲基丙烯酰胺，聚二甲基丙烯酰胺，聚甲基恶唑啉，聚乙基恶唑啉，聚羟乙基唑啉，聚羟基丙基恶唑啉或聚天冬酰胺。还公开了一种制备含有脂质 - 聚合物缀合物的脂质体的方法。

10. 发明授权

US5356633A Method of treatment of inflamed tissues 失效
标题翻译：治疗发炎组织的方法
公开(公告)号：US5356633A
公开(公告)日：1994-10-18
申请号：US958100
申请日：1992-10-07
申请人： Martin C. Woodle , Francis J. Martin , Shi K. Huang
发明人： Martin C. Woodle , Francis J. Martin , Shi K. Huang
IPC分类号： A61K9/127 , A61K47/48 , C07F9/553 , A61K37/22
CPC分类号： A61K9/1271 , C07F9/5537 , Y10S514/863 , Y10S514/886
摘要： A method of and composition for concentrating a therapeutic agent in an inflamed dermal region are disclosed. The composition, which is also used in the method, is a liposomal composition. The liposomes contain the therapeutic agent in entrapped form and are composed of vesicle-forming lipids including a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer. After intravenous administration, the liposomes are taken up by the inflamed region within 24-48 hours, for site-specific release of entrapped compound into the inflamed region.
摘要翻译：公开了一种用于浓缩治疗剂在发炎真皮区域中的方法和组合物。也用于该方法的组合物是脂质体组合物。脂质体含有截留形式的治疗剂，并且由囊泡形成脂质组成，其包括用亲水生物相容性聚合物衍生的囊泡形成脂质。静脉内给药后，脂质体在24-48小时内由发炎区域吸收，以将捕获的化合物的位点特异性释放到发炎区域。

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