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1. 发明授权

US08603076B2 Microfabricated nanopore device for sustained release of therapeutic agent 有权
公开(公告)号：US08603076B2
公开(公告)日：2013-12-10
申请号：US13098067
申请日：2011-04-29
申请人： Francis J. Martin , Anthony A. Boiarski
发明人： Francis J. Martin , Anthony A. Boiarski
IPC分类号： A61K9/22
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0097 , A61K9/1694 , A61K9/4808 , A61K31/7004 , A61K38/02 , A61K38/19 , A61K38/27 , A61K38/38 , A61K38/47 , A61M5/14276 , A61M5/16804 , A61M31/002 , A61M2207/00 , C12Y302/01017
摘要： A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.

2. 发明授权

US07955614B2 Microfabricated nanopore device for sustained release of therapeutic agent 有权
标题翻译：用于缓释治疗剂的微制纳米孔装置
公开(公告)号：US07955614B2
公开(公告)日：2011-06-07
申请号：US11530729
申请日：2006-09-11
申请人： Francis J. Martin , Anthony A. Boiarski
发明人： Francis J. Martin , Anthony A. Boiarski
IPC分类号： A61F2/02
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0097 , A61K9/1694 , A61K9/4808 , A61K31/7004 , A61K38/02 , A61K38/19 , A61K38/27 , A61K38/38 , A61K38/47 , A61M5/14276 , A61M5/16804 , A61M31/002 , A61M2207/00 , C12Y302/01017
摘要： A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.
摘要翻译：一种药物输送装置，其包括用于植入体内的胶囊; 胶囊还包括用于容纳诸如治疗剂的物质的储存器，用于允许物质从储存器扩散或以其他方式排出的至少一个端口，以及与出口处或附近的胶囊连通的纳米孔膜，用于控制物质从出口口的扩散速率。该装置还包括用于为纳米孔膜提供结构稳定性和用于保持纳米孔膜的孔隙的可选屏幕。药物递送装置的一个实施方案包括用于产生流过装置的流体的装置内部的渗透发动机。

3. 发明申请

US20090114289A1 RELIEF VALVE INCLUDING A CHECK VALVE IN A DAMPING CHAMBER 有权
标题翻译：减压阀包括在阻尼室中的检查阀
公开(公告)号：US20090114289A1
公开(公告)日：2009-05-07
申请号：US11934876
申请日：2007-11-05
申请人： Francis J. Martin
发明人： Francis J. Martin
IPC分类号： F16K17/10
CPC分类号： F16K17/10 , Y10T137/2642 , Y10T137/7852 , Y10T137/7853 , Y10T137/7925
摘要： A relief valve includes a body, a damping chamber in the body, a poppet in the body, wherein the poppet includes an end in the damping chamber, and a check valve in the damping chamber. The damping chamber is located adjacent an inlet side of the relief valve, and the check valve includes a sealing member to prevent fluid flow into the damping chamber at the inlet side. The sealing member is unseated during opening of the poppet to permit fluid to flow into the damping chamber at the inlet side.
摘要翻译：安全阀包括主体，主体中的阻尼室，主体中的提升阀，其中提升阀包括阻尼室中的端部和阻尼室中的止回阀。阻尼室位于安全阀的入口侧附近，止回阀包括密封构件，以防止流体在入口侧流入阻尼室。在打开提升阀的过程中，密封件是脱开的，以允许流体在入口侧流入阻尼室。

4. 发明授权

US06043094A Therapeutic liposome composition and method 失效
公开(公告)号：US06043094A
公开(公告)日：2000-03-28
申请号：US949039
申请日：1997-10-10
申请人： Francis J. Martin , Samuel Zalipsky , Shi Kun Huang
发明人： Francis J. Martin , Samuel Zalipsky , Shi Kun Huang
IPC分类号： A61K9/127 , A61K31/715 , A61K38/00 , A61K47/30 , A61P29/00 , A61P35/00 , C12N5/02 , C12N15/64
CPC分类号： A61K9/1273 , A61K9/1271
摘要： A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface. The hydrophilic polymer coating is made up of polymer chains covalently linked to surface lipid components in the liposomes through releasable linkages. After a desired liposome biodistribution is achieved, a releasing agent is administered to cause cleaving of a substantial portion of the releasable linkages in the liposomes, to expose the affinity agent to the target surface.

5. 发明授权

US5972379A Liposome composition and method for administering a quinolone 失效
标题翻译：脂质体组合物和用于施用喹诺酮的方法
公开(公告)号：US5972379A
公开(公告)日：1999-10-26
申请号：US054857
申请日：1998-04-02
申请人： Luke S. S. Guo , Josh Gittelman , Samuel Zalipsky , Francis J. Martin
发明人： Luke S. S. Guo , Josh Gittelman , Samuel Zalipsky , Francis J. Martin
IPC分类号： A61K9/00 , A61K9/127 , A61K31/47 , A61K31/495 , A61K31/496 , A61K41/00 , A61K47/48 , A61P31/04
CPC分类号： A61K9/1278 , A61K41/0038 , A61K47/48038 , A61K47/48046 , A61K9/1271
摘要： A liposome composition for treating a bacterial infection is described. The composition includes liposomes having a surface coating of hydrophilic polymer chains and an entrapped drug-conjugate composed of ciprofloxacin conjugated to an amino acid.
摘要翻译：描述了用于治疗细菌感染的脂质体组合物。该组合物包括具有亲水性聚合物链的表面包被的脂质体和与氨基酸缀合的环丙沙星组成的截留的药物缀合物。

6. 发明授权

US5064655A Liposome gel composition and method 失效
标题翻译： LIPOSOME凝胶组合物和方法
公开(公告)号：US5064655A
公开(公告)日：1991-11-12
申请号：US356262
申请日：1989-05-23
申请人： Paul S. Uster , Jacqueline K. Morano , Francis J. Martin
发明人： Paul S. Uster , Jacqueline K. Morano , Francis J. Martin
IPC分类号： A61K8/14 , A61K9/127 , A61K38/18 , A61K47/18 , A61Q19/00 , A61K37/22
CPC分类号： A61K8/042 , A61K38/1808 , A61K47/183 , A61K8/14 , A61K9/0014 , A61K9/127 , A61Q19/00 , A61Q17/04 , A61Q19/007 , A61Q19/08 , Y10T428/2984
摘要： A liposome gel composition and method of preparing the same. The composition is composed of charged liposomes, at a relatively low lipid concentration, in a low-conductivity medium. The composition preferably contains a zwitterionic compound at its isoelectric point. The liposomes can be designed for cosmetic use, transdermal drug delivery, or enhanced retention on mucosal tissues, such as for ophthalmic use.
摘要翻译：一种脂质体凝胶组合物及其制备方法。该组合物由低电导率培养基中以相对低的脂质浓度的带电脂质体组成。组合物优选在其等电点含有两性离子化合物。脂质体可以设计用于化妆品用途，透皮药物递送或增强对粘膜组织的保留，例如用于眼科用途。

7. 发明授权

US4737323A Liposome extrusion method 失效
标题翻译：脂质体挤出法
公开(公告)号：US4737323A
公开(公告)日：1988-04-12
申请号：US829710
申请日：1986-02-13
申请人： Francis J. Martin , Jacqueline K. Morano
发明人： Francis J. Martin , Jacqueline K. Morano
IPC分类号： A61K9/00 , A61K9/127 , B01J13/02 , C04B38/00 , A61K9/52
CPC分类号： C04B38/0051 , A61K9/1277 , C04B2111/00793 , Y10S436/829 , Y10T428/2984
摘要： A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed liposomes have a selected average size of about 0.4 microns or less, depending on the number of filter cycles, and a narrow distribution.
摘要翻译：尺寸主要大于约1微米的脂质体的悬浮液通过其内表面孔径为约1微米的不对称陶瓷过滤器。经处理的脂质体具有约0.4微米或更小的选择的平均尺寸，这取决于过滤器循环的数量和窄的分布。

8. 发明授权

US06224903B1 Polymer-lipid conjugate for fusion of target membranes 有权
标题翻译：用于融合靶膜的聚合物 - 脂质缀合物
公开(公告)号：US06224903B1
公开(公告)日：2001-05-01
申请号：US09208684
申请日：1998-12-10
申请人： Francis J. Martin , Samuel Zalipsky
发明人： Francis J. Martin , Samuel Zalipsky
IPC分类号： A61K9127
CPC分类号： A61K9/1272 , A61K9/1271
摘要： A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposome outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed is a polymer-lipid conjugate for use in promoting fusion between target membranes. The conjugate is composed of a first segment composed of a hydrophilic polymer and a second hydrophobic polymer segment. The second segment is joined to the first segment by a bond effective to release the first segment in response to an existing or an induced physiologic condition. Attached to the second segment is a vesicle-forming lipid member.
摘要翻译：描述了用于将脂质体包埋的化合物递送到靶细胞的细胞质中的融合脂质体组合物。脂质体具有化学上可释放的亲水性聚合物链的外表面涂层，其在脂质体外表面上屏蔽疏水性聚合物。亲水性聚合物链的释放使疏水性聚合物暴露于与靶细胞的外细胞膜相互作用，以促进脂质体与靶细胞的融合。还公开了用于促进靶膜之间的融合的聚合物 - 脂质缀合物。缀合物由由亲水性聚合物和第二疏水性聚合物链段构成的第一链段组成。第二段通过有效释放第一段的键与第一段连接，以响应于现有或诱导的生理状况。附着于第二段是形成囊泡的脂质成分。

9. 发明授权

US06180134B2 Enhanced ciruclation effector composition and method 失效
标题翻译：增强的ciruclation效应物组成和方法
公开(公告)号：US06180134B2
公开(公告)日：2001-01-30
申请号：US08480332
申请日：1995-06-07
申请人： Samuel Zalipsky , Martin C. Woodle , Francis J. Martin , Yechezkel Barenholz
发明人： Samuel Zalipsky , Martin C. Woodle , Francis J. Martin , Yechezkel Barenholz
IPC分类号： A61K9127
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/00 , A61K38/12 , A61K38/1774 , A61K47/61 , A61K47/62 , A61K47/6911 , Y10S424/812 , A61K2300/00
摘要： A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.
摘要翻译：公开了包含小的表面结合效应分子的脂质体组合物。脂质体具有亲水性聚合物链的表面层，用于增强血流中的循环时间。效应分子连接到聚合物链的末端。在一个实施方案中，效应物是多粘菌素B，用于治疗败血性休克。

10. 发明授权

US5891468A Fusogenic liposome compositions and method 失效
标题翻译：融合脂质体组成及方法
公开(公告)号：US5891468A
公开(公告)日：1999-04-06
申请号：US949046
申请日：1997-10-10
申请人： Francis J. Martin , Samuel Zalipsky
发明人： Francis J. Martin , Samuel Zalipsky
IPC分类号： A61K9/127 , A61K47/30 , A61K48/00 , A61P35/00
CPC分类号： A61K9/1272 , A61K9/1271 , Y10S436/829
摘要： A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polymers on the liposome outer surface. Release of the hydrophilic polymer chains exposes the hydrophobic polymers for interaction with outer cell membranes of the target cells to promote fusion of the liposome with the target cells. Also disclosed is a method for using the composition to deliver a compound to target cells, and a method for selecting suitable hydrophobic polymers for use in the composition.
摘要翻译：描述了用于将脂质体包埋的化合物递送到靶细胞的细胞质中的融合脂质体组合物。脂质体具有化学上可释放的亲水性聚合物链的外表面涂层，其在脂质体外表面上屏蔽疏水性聚合物。亲水性聚合物链的释放使疏水性聚合物暴露于与靶细胞的外细胞膜相互作用，以促进脂质体与靶细胞的融合。还公开了使用该组合物将化合物递送至靶细胞的方法，以及选择用于组合物中的合适的疏水性聚合物的方法。

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