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    • 2. 发明授权
    • Personalized prognosis modeling in medical treatment planning
    • 医疗策划中的个性化预后建模
    • US08579784B2
    • 2013-11-12
    • US12944288
    • 2010-11-11
    • Sriram KrishnanR. Bharat RaoChristopher Jude Amies
    • Sriram KrishnanR. Bharat RaoChristopher Jude Amies
    • A61N5/00
    • A61N5/103A61N2005/1041G06F19/00G06F19/3481G16H50/30G16H50/50
    • Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.
    • 提供自动化治疗计划,具体考虑。 一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。 通过确定多个剂量的存活率,从特定患者确定作为剂量的函数的存活率所表示的生物学模型。 类似地,确定并发症或副作用的机会。 生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。 选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。 选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。