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1. 发明授权

US07917216B1 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US07917216B1
公开(公告)日：2011-03-29
申请号：US11458649
申请日：2006-07-19
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

2. 发明授权

US08750993B2 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US08750993B2
公开(公告)日：2014-06-10
申请号：US13029048
申请日：2011-02-16
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

3. 发明申请

US20110137364A1 MULTI-SITE PACING FOR ATRIAL TACHYARRHYTHMIAS 有权
标题翻译：多功能TACHYARRHYTHMIA的多地点
公开(公告)号：US20110137364A1
公开(公告)日：2011-06-09
申请号：US13029048
申请日：2011-02-16
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多部位电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组

4. 发明授权

US07917214B1 Methods and systems for identifying a preferred pacing configuration for a multi-electrode implantable cardiac electrotherapy device 有权
标题翻译：用于识别多电极可植入心脏电疗装置的优选起搏配置的方法和系统
公开(公告)号：US07917214B1
公开(公告)日：2011-03-29
申请号：US11851240
申请日：2007-09-06
申请人： Jong Gill , Annapurna Karicherla , Kyungmoo Ryu , Gene A. Bornzin
发明人： Jong Gill , Annapurna Karicherla , Kyungmoo Ryu , Gene A. Bornzin
IPC分类号： A61N1/362
CPC分类号： A61N1/372 , A61N1/3686
摘要： Methods and systems of identifying an electrode or combination of electrodes of a multi-electrode device for pacing include selecting a first electrode or electrode combination as a first candidate; delivering a pacing pulse through the first candidate and determining a measurement based on sensed cardiac electrical activity resulting from the first candidate pacing; selecting a second candidate; delivering a pacing pulse through the second candidate and determining a measurement based on sensed cardiac electrical activity resulting from the second candidate pacing; comparing the measurement for the first and second candidates; and identifying the first or second candidate for pacing based on the comparison. The measurement may be one or more of activation time ΔTact, activation recovery interval (ARI), a fractioned electrogram width, and a standard deviation of a fractioned electrogram feature.
摘要翻译：识别用于起搏的多电极装置的电极或电极组合的方法和系统包括选择第一电极或电极组合作为第一候选; 通过所述第一候选者发送起搏脉冲，并且基于由所述第一候选起搏产生的感测的心脏电活动来确定测量; 选择第二候选人; 通过所述第二候选者递送起搏脉冲，并且基于由所述第二候选起搏产生的感测到的心脏电活动来确定测量; 比较第一和第二候选人的测量; 以及基于所述比较来识别用于起搏的第一或第二候选者。测量可以是一个或多个激活时间＆Dgr; Tact，激活恢复间隔（ARI），分数的电描记图宽度和分数的电描记图特征的标准偏差。

5. 发明授权

US07632235B1 System and method for measuring cardiac output via thermal dilution using an implantable medical device with an external ultrasound power delivery system 有权
标题翻译：使用具有外部超声功率输送系统的可植入医疗装置通过热稀释测量心输出量的系统和方法
公开(公告)号：US07632235B1
公开(公告)日：2009-12-15
申请号：US11099888
申请日：2005-04-05
申请人： Annapurna Karicherla , Xiaoyi Min , Peter Boileau , Jong Gill , Gene A. Bornzin
发明人： Annapurna Karicherla , Xiaoyi Min , Peter Boileau , Jong Gill , Gene A. Bornzin
IPC分类号： A61B5/029 , A61B5/028 , A61B8/06
CPC分类号： A61B5/028 , A61B5/029 , A61B2560/0209 , A61B2560/0214 , A61N1/3627 , A61N1/3655
摘要： The implantable device is capable of performing thermal dilution analysis of the cardiac output of a patient using power delivered from an external source. By using power from an external source, the implantable device conserves its power resources for other purposes, such as for pacing or defibrillation therapy. In one example, an external programmer or bedside monitor provides power through a hand-held power delivery wand via electromagnetic induction, with the power routed from a subcutaneous coil to a heating element implanted in the right atrium, which heats blood as it passes through the right atrium. In another example, the heating element is formed of a material that generates heat in response to a beam of ultrasound provided by the wand. In either case, a downstream blood temperature profile is detected using a thermistor implanted in the pulmonary artery and cardiac output is then estimated by analyzing the temperature profile.
摘要翻译：可植入装置能够使用从外部源传递的功率来对患者的心输出量进行热稀释分析。通过使用来自外部来源的电力，可植入装置为其他目的节省其功率资源，例如用于起搏或除颤疗法。在一个示例中，外部编程器或床边监视器通过电磁感应通过手持式电力输送棒提供电力，电力从皮下线圈路由到植入右心房的加热元件，该加热元件在通过右心房。在另一个实例中，加热元件由响应于由魔杖提供的超声波束产生热量的材料形成。在任一情况下，使用植入肺动脉中的热敏电阻检测下游血液温度分布，然后通过分析温度分布来估计心输出量。

6. 发明授权

US07627366B1 Analysis of polarization information 有权
标题翻译：极化信息分析
公开(公告)号：US07627366B1
公开(公告)日：2009-12-01
申请号：US11123300
申请日：2005-05-06
申请人： Annapurna Karicherla , Xiaoyi Min , Xiaozheng Zhang , Jong Gill
发明人： Annapurna Karicherla , Xiaoyi Min , Xiaozheng Zhang , Jong Gill
IPC分类号： A61N1/37
CPC分类号： A61N1/36507
摘要： An exemplary method includes providing a first value indicative of electrode polarization, delivering a cardiac stimulus and determining a second value indicative of electrode polarization associated with the cardiac stimulus, comparing the second value to the first value to determine whether a change in cardiac condition has occurred and, based at least in part on the comparing, deciding whether to adjust a cardiac stimulation therapy.
摘要翻译：示例性方法包括提供指示电极极化的第一值，递送心脏刺激并确定指示与心脏刺激相关联的电极极化的第二值，将第二值与第一值进行比较，以确定心脏状态的变化是否已发生并且至少部分地基于比较，决定是否调整心脏刺激疗法。

7. 发明申请

US20120197141A1 IMPLANTABLE ECHO DOPPLER FLOW SENSOR FOR MONITORING OF HEMODYNAMICS 审中-公开
标题翻译：用于监测血液动力学的可植入式ECHO多普勒流量传感器
公开(公告)号：US20120197141A1
公开(公告)日：2012-08-02
申请号：US13016101
申请日：2011-01-28
申请人： Guy Vanney , Thao Ngo , Scott Sjoquist , Dorab N. Sethna , Annapurna Karicherla , George K. Lewis , Dan E. Gutfinger , Gene A. Bornzin
发明人： Guy Vanney , Thao Ngo , Scott Sjoquist , Dorab N. Sethna , Annapurna Karicherla , George K. Lewis , Dan E. Gutfinger , Gene A. Bornzin
IPC分类号： A61B5/026
CPC分类号： A61B5/026 , A61B5/02158 , A61B5/6846 , A61B5/6856 , A61B5/6858 , A61B5/686 , A61B5/6862 , A61B5/6869 , A61B5/6882 , A61B8/06 , A61B8/065 , A61B8/12 , A61B8/445
摘要： Systems, devices and methods of monitoring blood flow velocity are disclosed herein. For example, one method of monitoring blood flow velocity includes: locating a blood flow velocity sensor near the ostium in the coronary sinus; and sensing towards a portion of the aorta. A second example method includes: locating a blood flow velocity sensor in a vein; and sensing towards an adjacent artery. A third example method includes: locating a blood flow velocity sensor near the tricuspid valve; and sensing towards a tricuspid valve annulus. A fourth example method includes: locating a blood flow velocity sensor right ventricular outflow tract; and sensing towards a portion of the aorta. A fifth example method includes: locating a blood flow velocity sensor in the great cardiac vein; and sensing towards a left anterior descending artery. A sixth example method includes: locating a blood flow velocity sensor in the right atrial appendage; and sensing towards a portion of the aorta.
摘要翻译：本文公开了监测血流速度的系统，装置和方法。例如，监测血流速度的一种方法包括：将血流速度传感器定位在冠状窦口附近; 并且朝向主动脉的一部分进行感测。第二示例性方法包括：将血流速度传感器定位在静脉中; 并向相邻动脉进行感测。第三示例性方法包括：在三尖瓣附近定位血流速度传感器; 并向三尖瓣环进行感测。第四示例性方法包括：定位血流速度传感器右心室流出道; 并且朝向主动脉的一部分进行感测。第五示例方法包括：在大心脏静脉中定位血流速度传感器; 并向左前降支动脉进行感测。第六示例性方法包括：在右心耳中定位血流速度传感器; 并且朝向主动脉的一部分进行感测。

8. 发明授权

US07389134B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07389134B1
公开(公告)日：2008-06-17
申请号：US11053374
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

9. 发明申请

US20130238085A1 SILVER NANOPARTICLE ANTIMICROBIAL COATING FOR LONG-TERM AND SHORT-TERM INFECTION RESISTANCE 有权
标题翻译：用于长期和短期感染电阻的银纳米抗微生物涂层
公开(公告)号：US20130238085A1
公开(公告)日：2013-09-12
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61F2/02 , A61N1/05 , A61F2/82 , B05D1/00 , A61N1/375
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

10. 发明申请

US20130012824A1 CORONARY VENOUS SYSTEM PRESSURE SENSING 审中-公开
标题翻译：冠状静脉系统压力感测
公开(公告)号：US20130012824A1
公开(公告)日：2013-01-10
申请号：US13614620
申请日：2012-09-13
申请人： Guy Vanney , Scott Salys , Thao Ngo , Elizabeth Nee , Annapurna Karicherla , Ravisankar Gurusamy , Gene A. Bornzin
发明人： Guy Vanney , Scott Salys , Thao Ngo , Elizabeth Nee , Annapurna Karicherla , Ravisankar Gurusamy , Gene A. Bornzin
IPC分类号： A61B5/0215
CPC分类号： A61B5/02158 , A61N1/3627 , A61N1/36564 , A61N1/395 , A61N2001/0585
摘要： Disclose herein is a method of measuring pressures in a coronary sinus. In one embodiment, the method includes: introducing a distal portion of a lead or tool into the coronary sinus, wherein the distal portion includes first and second pressure sensors and at least one selectably expandable member; expanding the at least one expandable member such that the first and second sensors are isolated from each other within the coronary sinus; and taking pressure measurements with the first and second sensors when isolated from each other.
摘要翻译：这里公开的是测量冠状窦压力的方法。在一个实施例中，该方法包括：将引导件或工具的远端部分引入冠状窦，其中远端部分包括第一和第二压力传感器和至少一个可选择地可扩张的构件; 膨胀所述至少一个可膨胀构件，使得所述第一和第二传感器在所述冠状窦内彼此隔离; 并且当彼此隔离时，利用第一和第二传感器进行压力测量。

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