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1. 发明申请

US20080241840A1 Methods of detection using immuno-Q-Amp technology 审中-公开
标题翻译：使用免疫Q-Amp技术检测方法
公开(公告)号：US20080241840A1
公开(公告)日：2008-10-02
申请号：US11982198
申请日：2007-11-01
申请人： Abraham Grossman , James Moe , Sara Vasan , Phyllus Y. Mong
发明人： Abraham Grossman , James Moe , Sara Vasan , Phyllus Y. Mong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6867 , G01N33/58 , G01N33/6896 , G01N2800/2828 , C12Q2563/161
摘要： The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.
摘要翻译：本发明在某些实施方案中描述了用于检测tau蛋白的组合物，其包含具有两个末端的修饰的检测分子，能够结合tau蛋白的第一末端和包含单链DNA模板的第二末端，其中该模板是能够被RNA聚合酶复制。

2. 发明申请

US20060257904A1 Agglomeration protein cascades, compositions and methods regarding the same 审中-公开
标题翻译：聚集蛋白级联，组合物和方法相同
公开(公告)号：US20060257904A1
公开(公告)日：2006-11-16
申请号：US11400808
申请日：2006-04-07
申请人： Abraham Grossman , James Moe , Sara Vasan , Eliot Davidowitz
发明人： Abraham Grossman , James Moe , Sara Vasan , Eliot Davidowitz
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12M1/34
CPC分类号： C07K14/78 , C07K14/4711 , C07K2319/00 , C12N15/115 , C12N2310/16 , G01N2333/4709 , G01N2333/78 , G01N2800/2821
摘要： Described herein are compositions and methods for identifying cellular factors involved in protein agglomeration. One such factor is a nucleic acid component. Another factor is a cellular binding factor. The nucleic acid components, and methods of using them, to interact with agglomeration proteins are also disclosed herein. The nucleic acid compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occurring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein. Also described herein is an in vitro system (“TRIPARTITE”), which utilizes a NA and a non-NA chaperone to analyze the amyloid disease progression and test drugs potentially useful in combating such diseases. Also described are in vivo, transgenic animal models for analyzing amyloid diseases and agents potentially useful in combating those diseases.
摘要翻译：本文描述了用于鉴定涉及蛋白质聚集的细胞因子的组合物和方法。一个这样的因素是核酸组分。另一个因素是细胞结合因子。本文还公开了核酸组分及其使用方法与附聚蛋白相互作用。本文的核酸组合物包含一种或多种对至少一种附聚蛋白具有亲和力的DNA或RNA分子。核酸组分是具有二十个以上核糖核苷酸碱基的天然或非天然存在的分子。对于RNA，该RNA分子的至少一个核苷酸序列部分对结合RNA结合蛋白中存在的至少一个共有序列具有亲和力。本文公开的方法旨在使用本文所述的扩增体组合物来检测样品基质中一种或多种附聚蛋白的存在。本文还描述了一种体外系统（“TRIPARTITE”），其利用NA和非NA伴侣来分析淀粉样蛋白病进展并测试潜在地有助于抵抗此类疾病的药物。还描述了用于分析淀粉样蛋白病的体内转基因动物模型和可能用于对抗这些疾病的药剂。

3. 发明申请

US20060024736A1 Methods of detection employing immuno-Q-Amp technology 审中-公开
标题翻译：使用免疫Q-Amp技术的检测方法
公开(公告)号：US20060024736A1
公开(公告)日：2006-02-02
申请号：US11237046
申请日：2005-09-28
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C12Q1/68
CPC分类号： G01N33/58 , C12Q1/6867 , G01N33/6896 , G01N2800/2828 , C12Q2563/161
摘要： Disclosed herein are methods of detecting target molecules from a complex sample using a modified affinity ligand. In particular, the modified affinity ligand is an antibody specific for the target and has conjugated to it a nucleic acid molecule. This conjugated nucleic acid molecule serves as a template for a replicase that can replicate the template a billion-fold in an matter of minutes. The replication products then serve to facilitate a detectable signal indicating the presence of the target in the sample.
摘要翻译：本文公开了使用修饰的亲和配体从复合物样品检测靶分子的方法。特别地，修饰的亲和配体是对靶标具有特异性的抗体，并与其缀合核酸分子。该缀合的核酸分子用作复制酶的模板，其可以在几分钟内复制模板十亿倍。然后复制产物用于促进指示样品中目标物的存在的可检测信号。

4. 发明申请

US20060141467A1 Methods and kits for making double stranded ribonucleic acids 审中-公开
标题翻译：制备双链核糖核酸的方法和试剂盒
公开(公告)号：US20060141467A1
公开(公告)日：2006-06-29
申请号：US10539850
申请日：2003-12-18
申请人： Brian Zeiler
发明人： Brian Zeiler
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12P19/34
摘要： Embodiments of the present invention are directed to methods and kits for the generation of double stranded RNA by RNA dependent RNA polymerases. The methods and kits feature exponential generation of such RNAs through simple steps/ The RNA is suitable for interference with expression in cells.
摘要翻译：本发明的实施方案涉及通过RNA依赖性RNA聚合酶产生双链RNA的方法和试剂盒。这些方法和试剂盒通过简单的步骤来表征这些RNA的指数生成.RNA适合干扰细胞中的表达。

5. 发明申请

US20050214805A1 Methods of detection employing immuno-Q-Amp technology 审中-公开
标题翻译：使用免疫Q-Amp技术的检测方法
公开(公告)号：US20050214805A1
公开(公告)日：2005-09-29
申请号：US10985183
申请日：2004-11-09
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/58 , G01N33/68
CPC分类号： G01N33/58 , C12Q1/6867 , G01N33/6896 , G01N2800/2828 , C12Q2563/161
摘要： Disclosed herein are methods of detecting target molecules from a complex sample using a modified affinity ligand. In particular, the modified affinity ligand is an antibody specific for the target and has conjugated to it a nucleic acid molecule. This conjugated nucleic acid molecule serves as a template for a replicase that can replicate the template a billion-fold in an matter of minutes. The replication products then serve to facilitate a detectable signal indicating the presence of the target in the sample.
摘要翻译：本文公开了使用修饰的亲和配体从复合物样品检测靶分子的方法。特别地，修饰的亲和配体是对靶标具有特异性的抗体，并与其缀合核酸分子。该缀合的核酸分子用作复制酶的模板，其可以在几分钟内复制模板十亿倍。然后复制产物用于促进指示样品中目标物的存在的可检测信号。

6. 发明申请

US20060199194A1 Methods of detection using immuno-Q-Amp technology 审中-公开
标题翻译：使用免疫Q-Amp技术检测方法
公开(公告)号：US20060199194A1
公开(公告)日：2006-09-07
申请号：US11237057
申请日：2005-09-28
申请人： Abraham Grossman , James Moe , Sara Vasan , Phyllus Mong
发明人： Abraham Grossman , James Moe , Sara Vasan , Phyllus Mong
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6867 , G01N33/58 , G01N33/6896 , G01N2800/2828 , C12Q2563/161
摘要： The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.
摘要翻译：本发明在某些实施方案中描述了用于检测tau蛋白的组合物，其包含具有两个末端的修饰的检测分子，能够结合tau蛋白的第一末端和包含单链DNA模板的第二末端，其中该模板是能够被RNA聚合酶复制。

7. 发明申请

US20050272081A1 Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule 审中-公开
标题翻译：用于制备对靶分子具有选择亲和性的核酸分子的方法，组合物和装置
公开(公告)号：US20050272081A1
公开(公告)日：2005-12-08
申请号：US11135673
申请日：2005-05-24
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C12M1/34 , C12N15/10 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1058
摘要： The present invention is directed to methods, compositions, kits and devices for making a nucleic acid having selected affinity to a target molecule. One embodiment of the present invention is a method of making a replicatable nucleic acid template having a selected affinity to a target. The method comprises the step of applying a selection to a first generation comprising at least one replicatable nucleic acid template as the replicatable nucleic acid template is replicated by a nucleic acid polymerase to form at least one subsequent generation comprising a replicatable nucleic acid template. The selection is based on the affinity of the replicatable nucleic template of different generations to the target. The nucleic acid polymerase introduces genetic variability between generations of the replicatable nucleic acid template to produce replicatable nucleic acid templates having different affinities to the target. The replicatable nucleic acid templates are separated on the basis of the affinity of the replicatable nucleic acid template to the target.
摘要翻译：本发明涉及用于制备对靶分子具有选择亲和性的核酸的方法，组合物，试剂盒和装置。本发明的一个实施方案是制备具有对靶的亲和力的可复制核酸模板的方法。该方法包括将选择应用于包含至少一个可复制核酸模板的第一代，因为可复制核酸模板由核酸聚合酶复制以形成至少一个包含可复制核酸模板的后续生物。该选择基于不同世代的可复制核酸模板对靶标的亲和力。核酸聚合酶在可复制的核酸模板的世代之间引入遗传变异性以产生与靶具有不同亲和力的可复制的核酸模板。可复制的核酸模板基于可重复核酸模板与靶标的亲和力而分离。

8. 发明申请

US20030180725A1 Compositions, methods, kits and apparatus for determining the presence or absence of target molecules 失效
标题翻译：用于确定靶分子存在或不存在的组合物，方法，试剂盒和装置
公开(公告)号：US20030180725A1
公开(公告)日：2003-09-25
申请号：US09844935
申请日：2001-04-27
申请人： Q-RNA, INC.
发明人： Alexander Munishkin , Abraham Grossman
IPC分类号： C12Q001/68 , C07H021/02 , C12P019/34
CPC分类号： C12Q1/6811 , C12Q2531/149
摘要： The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.
摘要翻译：本发明涉及用于鉴定和检测目标分析物的存在或不存在的方法，组合物，试剂盒和装置。本发明的实施例在标本和样品中的各种化学化合物的医学诊断和分析中具有实用性，以及用于实施这些方法的测试试剂盒和设备的设计。

9. 发明申请

US20030087233A1 Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule 审中-公开
标题翻译：用于制备对靶分子具有选择亲和性的核酸分子的方法，组合物和装置
公开(公告)号：US20030087233A1
公开(公告)日：2003-05-08
申请号：US09752231
申请日：2000-12-29
申请人： Q-RNA, Inc.
发明人： Abraham Grossman
IPC分类号： C12Q001/68 , C12P019/34 , C12M001/34
CPC分类号： C12N15/1058
摘要： The present invention is directed to methods, compositions, kits and devices for making a nucleic acid having selected affinity to a target molecule. One embodiment of the present invention is a method of making a replicatable nucleic acid template having a selected affinity to a target. The method comprises the step of applying a selection to a first generation comprising at least one replicatable nucleic acid template as the replicatable nucleic acid template is replicated by a nucleic acid polymerase to form at least one subsequent generation comprising a replicatable nucleic acid template. The selection is based on the affinity of the replicatable nucleic template of different generations to the target. The nucleic acid polymerase introduces genetic variability between generations of the replicatable nucleic acid template to produce replicatable nucleic acid templates having different affinities to the target. The replicatable nucleic acid templates are separated on the basis of the affinity of the replicatable nucleic acid template to the target.
摘要翻译：本发明涉及用于制备对靶分子具有选择亲和性的核酸的方法，组合物，试剂盒和装置。本发明的一个实施方案是制备具有对靶的亲和力的可复制核酸模板的方法。该方法包括将选择应用于包含至少一个可复制核酸模板的第一代，因为可复制核酸模板由核酸聚合酶复制以形成包含可复制核酸模板的至少一个随后的一代。该选择基于不同世代的可复制核酸模板对靶标的亲和力。核酸聚合酶在可复制的核酸模板的世代之间引入遗传变异性以产生与靶具有不同亲和力的可复制的核酸模板。可复制的核酸模板基于可重复核酸模板与靶标的亲和力而分离。

10. 发明申请

US20060212947A1 Non-naturally occurring animal that expresses an untranslated non-coding RNA 审中-公开
标题翻译：表达非翻译非编码RNA的非天然存在的动物
公开(公告)号：US20060212947A1
公开(公告)日：2006-09-21
申请号：US11328882
申请日：2006-01-10
申请人： Abraham Grossman , Michael Evgenev
发明人： Abraham Grossman , Michael Evgenev
IPC分类号： A01K67/027
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , A01K2267/0318 , C12N15/8509 , C12N2800/90 , C12N2830/002 , C12N2830/42
摘要： Embodiments of the present invention feature compositions and methods for making an animal and an animal exhibiting characteristics of an agglomeration disease. The method comprises the steps of providing an animal cell and placing a vector in said cell having a non-coding RNA under the control of a promoter and controlling the expression of said non-coding RNA with said promoter.
摘要翻译：本发明的实施方案的特征在于制备具有附聚疾病特征的动物和动物的组合物和方法。该方法包括以下步骤：提供动物细胞并将载体置于具有启动子控制下的非编码RNA的所述细胞中，并用所述启动子控制所述非编码RNA的表达。

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