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1. 发明授权

US06225058B1 Compositions, methods, kits and apparatus for determining the presence or absence of target molecules 失效
标题翻译：用于确定靶分子存在或不存在的组合物，方法，试剂盒和装置
公开(公告)号：US06225058B1
公开(公告)日：2001-05-01
申请号：US09229287
申请日：1999-01-13
申请人： Alexander Munishkin , Abraham Grossman
发明人： Alexander Munishkin , Abraham Grossman
IPC分类号： C12Q168
CPC分类号： C12Q1/6811 , C12Q2531/149
摘要： The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.
摘要翻译：本发明涉及用于鉴定和检测目标分析物的存在或不存在的方法，组合物，试剂盒和装置。本发明的实施例在标本和样品中的各种化学化合物的医学诊断和分析中具有实用性，以及用于实施这些方法的测试试剂盒和设备的设计。

2. 发明授权

US06916613B2 Compositions, methods, kits and apparatus for determining the presence or absence of target molecules 失效
标题翻译：用于确定靶分子存在或不存在的组合物，方法，试剂盒和装置
公开(公告)号：US06916613B2
公开(公告)日：2005-07-12
申请号：US09844935
申请日：2001-04-27
申请人： Alexander Munishkin , Abraham Grossman
发明人： Alexander Munishkin , Abraham Grossman
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/20 , C12N15/00 , C12N15/63
CPC分类号： C12Q1/6811 , C12Q2531/149
摘要： The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.
摘要翻译：本发明涉及用于鉴定和检测目标分析物的存在或不存在的方法，组合物，试剂盒和装置。本发明的实施例在标本和样品中的各种化学化合物的医学诊断和分析中具有实用性，以及用于实施这些方法的测试试剂盒和设备的设计。

3. 发明申请

US20060024736A1 Methods of detection employing immuno-Q-Amp technology 审中-公开
标题翻译：使用免疫Q-Amp技术的检测方法
公开(公告)号：US20060024736A1
公开(公告)日：2006-02-02
申请号：US11237046
申请日：2005-09-28
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C12Q1/68
CPC分类号： G01N33/58 , C12Q1/6867 , G01N33/6896 , G01N2800/2828 , C12Q2563/161
摘要： Disclosed herein are methods of detecting target molecules from a complex sample using a modified affinity ligand. In particular, the modified affinity ligand is an antibody specific for the target and has conjugated to it a nucleic acid molecule. This conjugated nucleic acid molecule serves as a template for a replicase that can replicate the template a billion-fold in an matter of minutes. The replication products then serve to facilitate a detectable signal indicating the presence of the target in the sample.
摘要翻译：本文公开了使用修饰的亲和配体从复合物样品检测靶分子的方法。特别地，修饰的亲和配体是对靶标具有特异性的抗体，并与其缀合核酸分子。该缀合的核酸分子用作复制酶的模板，其可以在几分钟内复制模板十亿倍。然后复制产物用于促进指示样品中目标物的存在的可检测信号。

4. 发明授权

US06207388B1 Compositions, methods, kits and apparatus for determining the presence or absence of target molecules 失效
公开(公告)号：US06207388B1
公开(公告)日：2001-03-27
申请号：US09437034
申请日：1999-11-09
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C12Q168
CPC分类号： C12Q1/6862 , C12Q1/6867 , C12Q2531/149 , C12Q2531/137
摘要： The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.

5. 发明申请

US20060212947A1 Non-naturally occurring animal that expresses an untranslated non-coding RNA 审中-公开
标题翻译：表达非翻译非编码RNA的非天然存在的动物
公开(公告)号：US20060212947A1
公开(公告)日：2006-09-21
申请号：US11328882
申请日：2006-01-10
申请人： Abraham Grossman , Michael Evgenev
发明人： Abraham Grossman , Michael Evgenev
IPC分类号： A01K67/027
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , A01K2267/0318 , C12N15/8509 , C12N2800/90 , C12N2830/002 , C12N2830/42
摘要： Embodiments of the present invention feature compositions and methods for making an animal and an animal exhibiting characteristics of an agglomeration disease. The method comprises the steps of providing an animal cell and placing a vector in said cell having a non-coding RNA under the control of a promoter and controlling the expression of said non-coding RNA with said promoter.
摘要翻译：本发明的实施方案的特征在于制备具有附聚疾病特征的动物和动物的组合物和方法。该方法包括以下步骤：提供动物细胞并将载体置于具有启动子控制下的非编码RNA的所述细胞中，并用所述启动子控制所述非编码RNA的表达。

6. 发明申请

US20050266401A1 Compositions and methods for binding agglomeration proteins 审中-公开
标题翻译：用于结合聚集蛋白的组合物和方法
公开(公告)号：US20050266401A1
公开(公告)日：2005-12-01
申请号：US11112929
申请日：2005-04-22
申请人： Abraham Grossman , Valentine Kryukov , Brian Zeiler
发明人： Abraham Grossman , Valentine Kryukov , Brian Zeiler
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C12Q1/68 , C12Q1/70 , G01N33/68
CPC分类号： C07H21/04 , C12Q1/6834 , C12Q1/702 , G01N33/6803 , Y10S977/704 , C12Q2565/113 , C12Q2525/161 , C12Q2525/101
摘要： Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one agglomeration protein. The nucleic acid component is a naturally or non-naturally occuring molecule with twenty or more ribonucleotide bases. For RNA, at least one nucleotide sequence portion of this RNA molecule has affinity to at least one consensus sequence present in the agglomeration RNA-binding protein. The portion of nucleotide sequence of RNA having affinity for agglomeration proteins is a sequence that is derived from either and RNA virus, and RNA agglomeration proteins is a sequence that is derived from either and RNA virus, an RNA phage, a messenger RNA (“mRNA”), a ribosomal RNA (“rRNA), a transfer RNA (“tRNA”), a sequence that is received as a template by one or more RNA dependent RNA polymerases, or a combination thereof. Methods disclosed herein are directed towards detecting the presence of one or more agglomeration proteins in a sample matrix using the amplibody compositions described herein.
摘要翻译：本文公开了用于与附聚蛋白相互作用的放大抗体组合物和方法。本文的组合物包含对至少一种附聚蛋白具有亲和力的一种或多种DNA或RNA分子。核酸组分是具有二十个以上核糖核苷酸碱基的天然或非天然存在的分子。对于RNA，该RNA分子的至少一个核苷酸序列部分对结合RNA结合蛋白中存在的至少一个共有序列具有亲和力。对聚集蛋白具有亲和性的RNA的核苷酸序列部分是衍生自RNA病毒和RNA病毒的序列，RNA附聚蛋白是衍生自RNA病毒，RNA噬菌体，信使RNA（“mRNA”）的序列 “），核糖体RNA（”rRNA“），转移RNA（”tRNA“），通过一种或多种RNA依赖性RNA聚合酶作为模板接受的序列或其组合。本文公开的方法旨在检测使用本文所述的扩增体组合物在样品基质中存在一种或多种附聚蛋白。

7. 发明授权

US6001570A Compositions, methods, kits and apparatus for determining the presence or absence of target molecules 失效
标题翻译：用于确定靶分子存在或不存在的组合物，方法，试剂盒和装置
公开(公告)号：US6001570A
公开(公告)日：1999-12-14
申请号：US801154
申请日：1997-02-18
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6862 , C12Q1/6867
摘要： The present invention is directed to methods, compositions, kits and apparatus; to identify and detect the presence or absence of target analytes. The embodiments of the present invention have utility in medical diagnosis and analysis of various chemical compounds in specimens and samples, as well as the design of test kits and apparatus for implementing such methods.
摘要翻译：本发明涉及方法，组合物，试剂盒和装置; 识别和检测目标分析物的存在或不存在。本发明的实施例在标本和样品中的各种化学化合物的医学诊断和分析中具有实用性，以及用于实施这些方法的测试试剂盒和设备的设计。

8. 发明授权

US4003363A Solar panel construction 失效
标题翻译：太阳能电池板结构
公开(公告)号：US4003363A
公开(公告)日：1977-01-18
申请号：US477811
申请日：1974-06-10
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： F24S10/75 , F24J3/02
CPC分类号： F24J2/268 , F24J2/42 , F24J2/4618 , F24J2/465 , F24J2002/502 , Y02E10/44 , Y10S126/908 , Y10T29/49355
摘要： A solar panel construction including an elongated, sealed, flat, polygonal case or receptacle within which is supported a metal solar energy collector panel on rigid permeable insulation material and also relatively soft yieldable permeable insulation material and a radiant energy transmitting means is spaced above the collector panel, the construction being hermetically sealed and dehumidified and particularly arranged to yield under conditions of temperature extremes without loss of hermetic sealing and loss of efficiency. A method of preconditioning such a solar panel construction to obtain optimum effectiveness between temperature ranges to which the panel construction will be subjected.
摘要翻译：一种太阳能电池板结构，其包括细长的，密封的，平坦的多边形外壳或插座，其内部支撑有刚性可渗透绝缘材料上的金属太阳能收集器面板，以及相对柔软的可屈服的可渗透绝缘材料，辐射能传递装置在收集器之上该结构被密封和除湿，并且特别地布置成在极端温度条件下屈服，而不会损失气密性和效率损失。一种预处理这种太阳能电池板结构以在板结构将经受的温度范围之间获得最佳效果的方法。

9. 发明申请

US20060199194A1 Methods of detection using immuno-Q-Amp technology 审中-公开
标题翻译：使用免疫Q-Amp技术检测方法
公开(公告)号：US20060199194A1
公开(公告)日：2006-09-07
申请号：US11237057
申请日：2005-09-28
申请人： Abraham Grossman , James Moe , Sara Vasan , Phyllus Mong
发明人： Abraham Grossman , James Moe , Sara Vasan , Phyllus Mong
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6867 , G01N33/58 , G01N33/6896 , G01N2800/2828 , C12Q2563/161
摘要： The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an RNA polymerase.
摘要翻译：本发明在某些实施方案中描述了用于检测tau蛋白的组合物，其包含具有两个末端的修饰的检测分子，能够结合tau蛋白的第一末端和包含单链DNA模板的第二末端，其中该模板是能够被RNA聚合酶复制。

10. 发明申请

US20060051760A1 Compositions and methods used for identifying factors required for the agglomeration of proteins 审中-公开
标题翻译：用于鉴定蛋白质聚集所需的因子的组合物和方法
公开(公告)号：US20060051760A1
公开(公告)日：2006-03-09
申请号：US10524681
申请日：2003-08-13
申请人： Abraham Grossman
发明人： Abraham Grossman
IPC分类号： C40B40/08 , C12Q1/68
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： Described herein are compositions and methods for identifying cellular factors involved in protein agglomeration. One such factor is a nucleic acid component. Another factor is a cellular macromolecular co-binding component. The presence of certain NAs and co-binding factors facilitate the agglomeration of certain proteins. The compositions and methods described herein are employed to identify this factors involved in the protein agglomeration process. Moreover, methods for assessing the efficacy of a pharmaceutical agent in protecting prion proteins is also described herein.
摘要翻译：本文描述了用于鉴定涉及蛋白质聚集的细胞因子的组合物和方法。一个这样的因素是核酸组分。另一个因素是细胞大分子共结合组分。某些NAs和共结合因子的存在有助于某些蛋白质的聚集。本文描述的组合物和方法用于鉴定参与蛋白质聚集过程的这些因素。此外，本文还描述了用于评估药剂在保护朊病毒蛋白中的功效的方法。

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