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1. 发明申请

US20180080927A1 SYSTEMS INCLUDING JANUS DROPLETS 审中-公开
公开(公告)号：US20180080927A1
公开(公告)日：2018-03-22
申请号：US15269543
申请日：2016-09-19
申请人： Massachusetts Institute of Technology
发明人： Timothy M. Swager , Qifan Zhang , Suchol Savagatrup
IPC分类号： G01N33/543 , G01N21/77 , C12Q1/68
CPC分类号： G01N33/5432 , C12Q1/6834 , G01N21/59 , G01N21/77 , G01N33/54366 , G01N2021/7783 , C12Q2563/161
摘要： Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications. For example, the systems and methods described herein may be used for determining the presence of a contaminant such as bacteria (e.g., detecting pathogenic bacteria in food and water samples which helps to prevent widespread infection, illness, and even death). Advantageously, the systems and methods described herein may not have the drawbacks in current detection technologies including, for example, relatively high costs, long enrichment steps and analysis times, and/or the need for extensive user training. Another advantageous feature provided by the systems and methods described herein includes fabrication in a relatively large scale. In some embodiments, the systems and methods may be used in conjunction with a detector including handheld detectors incorporated with, for example, smartphones (e.g., for the on-site detection of analytes such as pathogenic bacteria).

2. 发明授权

US09655848B2 Liposomes for in-vivo delivery 有权
公开(公告)号：US09655848B2
公开(公告)日：2017-05-23
申请号：US14440834
申请日：2013-11-19
申请人： Technion Research and Development Foundation Limited
发明人： Nahum Allon , Moshe Gavish
IPC分类号： A61K9/127 , A61K47/42 , A61K31/365 , C07K1/107 , C07K7/00 , C12N15/88
CPC分类号： A61K9/1272 , A61K9/1277 , A61K31/365 , A61K47/42 , C07K1/1077 , C07K7/00 , C12N15/88 , C12N2320/32 , C12N2320/53 , C12N2500/36 , C12Q2563/161
摘要： The present invention provides a liposome based composition wherein the liposome includes a peptide conjugated thereto via a peptide bond, wherein the peptide includes a spacer amino acid and a short Apolipoprotein E recognition sequence or a short Amyloid beta recognition sequence. This invention further provides a process for making the liposome and methods of utilizing the liposome based composition for therapeutic and diagnostic purposes.

3. 发明申请

US20160002736A1 USE OF MICROVESICLES IN ANALYZING NUCLEIC ACID PROFILES 审中-公开
标题翻译：微分子在分析核酸分布中的应用
公开(公告)号：US20160002736A1
公开(公告)日：2016-01-07
申请号：US14792212
申请日：2015-07-06
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Mikkel NOERHOLM , Johan Karl Olov SKOG , Xandra O. BREAKEFIELD , Bob CARTER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/158 , G01N33/57407 , C12Q2563/161
摘要： The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for disease in a subject.
摘要翻译：本发明涉及从微泡获得的基因特征以及应用这些基因签名帮助确定生物学条件的方法。生物学条件的确定可能有助于例如对象中疾病的诊断，预后和治疗治疗选择。

4. 发明申请

US20150337297A1 NUCLEIC ACID ARRAYS 有权
标题翻译：核酸阵列
公开(公告)号：US20150337297A1
公开(公告)日：2015-11-26
申请号：US14732316
申请日：2015-06-05
申请人： ILLUMINA CAMBRIDGE LIMITED
发明人： Roberto Rigatti , Geoffrey Paul Smith , Jonathan Mark Boutell
IPC分类号： C12N15/10
CPC分类号： C12N15/1068 , B01J19/0046 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2565/537 , C12Q2563/149 , C12Q2563/161
摘要： The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface. Nucleic acid content can be transferred using a method including the steps of (a) providing a surface having one or more primer oligonucleotides attached to the surface; (b) providing a pool of beads, wherein beads in the pool have a plurality of templates attached thereto, the plurality comprising multiple copies of a single nucleic acid template sequence; (c) arraying the beads onto the surface by hybridizing the templates to the primer oligonucleotides; and (d) extending the primers to produce copies of the templates attached to the surface.
摘要翻译：本发明提供了基于从多个珠粒转移到表面的内容来在表面上创建特征阵列的方法。可以使用包括以下步骤的方法转移核酸含量：（a）提供具有附着于所述表面的一种或多种引物寡核苷酸的表面; （b）提供珠池，其中所述池中的珠子具有连接到其上的多个模板，所述多个模板包含单个核酸模板序列的多个拷贝; （c）通过将模板与引物寡核苷酸杂交将珠子排列在表面上; 和（d）扩展引物以产生附着在表面上的模板的拷贝。

5. 发明申请

US20150010913A1 MONOCLONAL ANTIBODY FOR DETECTING EXOSOMES 有权
标题翻译：用于检测EXOSOMES的单克隆抗体
公开(公告)号：US20150010913A1
公开(公告)日：2015-01-08
申请号：US14368706
申请日：2012-12-26
申请人： SHIONOGI & CO., LTD.
发明人： Hideki Ohta , Chihiro Okada , Tomi Murakami , Hiroyuki Okamoto , Hikaru Sonoda
IPC分类号： G01N33/574 , C12Q1/68 , C07K16/28
CPC分类号： G01N33/574 , C07K16/18 , C07K16/2896 , C12Q1/6804 , C12Q1/6886 , G01N33/577 , G01N2333/70596 , G01N2500/04 , C12Q2563/161
摘要： A monoclonal antibody for detecting or capturing an exosome, selected from the group consisting of a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 195 of the amino acid sequence as shown in SEQ ID NO: 1, a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 104 to 202 of the amino acid sequence as shown in SEQ ID NO: 2, a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 36 to 54 of the amino acid sequence as shown in SEQ ID NO: 3, and a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 201 of the amino acid sequence as shown in SEQ ID NO: 3, each capable of detecting or capturing an exosome. The monoclonal antibody for detecting an exosome of the present invention is capable of detecting CD9, CD63 or CD81 on the exosome in a living body with an excellent sensitivity and specificity.
摘要翻译：用于检测或捕获外来体的单克隆抗体，其选自SEQ ID NO：1所示的氨基酸序列的氨基酸编号113〜195的单克隆抗体或其抗体片段，单克隆抗体或抗体如SEQ ID NO：2所示的识别氨基酸序列的氨基酸编号104至202的其片段，识别SEQ ID NO所示的氨基酸序列的36至54位氨基酸的单克隆抗体或其抗体片段 3，以及识别SEQ ID NO：3所示氨基酸序列的氨基酸编号113〜201的单克隆抗体或其抗体片段，其各自能够检测或捕获外来体。用于检测本发明的外来体的单克隆抗体能够以极好的灵敏度和特异性检测活体中的外来体上的CD9，CD63或CD81。

6. 发明申请

US20140057863A1 MODIFIED NUCLEOSIDES FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION 审中-公开
标题翻译：用于治疗病毒感染和异常细胞增殖的改良核苷酸
公开(公告)号：US20140057863A1
公开(公告)日：2014-02-27
申请号：US13908098
申请日：2013-06-03
申请人： GILEAD SCIENCES, INC.
发明人： Lieven Stuyver , Kyoichi Watanabe
IPC分类号： C07H19/16 , C07H19/06
CPC分类号： C07H19/16 , A61K31/7064 , A61K31/7076 , C07H19/048 , C07H19/06 , C07H19/10 , C07H19/20 , C07H21/04 , C12Q1/6809 , C12Q1/689 , C12Q1/6895 , Y02A50/393 , C12Q2563/161
摘要： The disclosed invention is a composition for and a method of treating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug.This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction (“RT-PCR”). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.
摘要翻译：所公开的发明是在宿主中治疗黄病毒科（包括BVDV和HCV），正粘病毒科（包括甲型和乙型）或副粘病毒（包括RSV）感染或与异常细胞增殖有关的病症的组合物和方法，包括动物，特别是人，使用通式（I） - （XXIII）的核苷或其药学上可接受的盐或前药。本发明还提供了使用实时聚合酶链反应（“RT-PCR”）在宿主中定量病毒载量，特别是BVDV，HCV或西尼罗河病毒载量的有效方法。另外，本发明公开了可以与存在于样品中的病毒量成比例发荧光的探针分子。

7. 发明授权

US08399192B2 Using populations of beads for the fabrication of arrays on surfaces 有权
标题翻译：使用珠子的种群在表面上制造阵列
公开(公告)号：US08399192B2
公开(公告)日：2013-03-19
申请号：US13365562
申请日：2012-02-03
申请人： Roberto Rigatti , Geoffrey Paul Smith , Jonathan Mark Boutell
发明人： Roberto Rigatti , Geoffrey Paul Smith , Jonathan Mark Boutell
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1068 , B01J19/0046 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2565/537 , C12Q2563/149 , C12Q2563/161
摘要： The present invention provides a method of creating an array of features. The method can include steps of (a) providing a plurality of beads, wherein each bead in the plurality of beads includes probe content; (b) contacting the plurality of beads with a surface to produce a layer of beads on the surface; and (c) transferring the probe content from the beads to the surface to create an array of spatially discrete features on the surface, wherein each spatially discrete feature includes probe content from a bead in the plurality of beads.
摘要翻译：本发明提供了一种创建特征阵列的方法。该方法可以包括以下步骤：（a）提供多个珠，其中多个珠中的每个珠包括探针含量; （b）使多个珠粒与表面接触以在表面上产生一层珠粒; 和（c）将探针含量从珠粒转移到表面以在表面上产生空间上离散的特征的阵列，其中每个空间上离散的特征包括来自多个珠粒中的珠粒的探针含量。

8. 发明申请

US20130040833A1 USE OF MICROVESICLES IN ANALYZING NUCLEIC ACID PROFILES 审中-公开
标题翻译：微分子在分析核酸分布中的应用
公开(公告)号：US20130040833A1
公开(公告)日：2013-02-14
申请号：US13395284
申请日：2010-09-09
申请人： Mikkel Noerholm , Johan Karl Olov Skog , Xandra O. Breakefield , Bob Carter
发明人： Mikkel Noerholm , Johan Karl Olov Skog , Xandra O. Breakefield , Bob Carter
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12Q1/6806 , C12Q2563/161
摘要： The invention concerns gene signatures obtained from microvesicles and a method of applying these gene signatures in helping to determine a biological condition. The determination of a biological condition may aid, for example, the diagnosis, prognosis, and therapy treatment selection for a disease in a subject.
摘要翻译：本发明涉及从微泡获得的基因特征以及应用这些基因签名帮助确定生物学条件的方法。生物学条件的测定可以帮助例如对受试者的疾病的诊断，预后和治疗治疗选择。

9. 发明申请

US20120172259A1 USING POPULATIONS OF BEADS FOR THE FABRICATION OF ARRAYS ON SURFACES 有权
标题翻译：使用人造丝来制作表面阵列
公开(公告)号：US20120172259A1
公开(公告)日：2012-07-05
申请号：US13365562
申请日：2012-02-03
申请人： Roberto Rigatti , Geoffrey Paul Smith , Jonathan Mark Boutell
发明人： Roberto Rigatti , Geoffrey Paul Smith , Jonathan Mark Boutell
IPC分类号： C40B50/18 , C40B50/06
CPC分类号： C12N15/1068 , B01J19/0046 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2565/537 , C12Q2563/149 , C12Q2563/161
摘要： The present invention provides a method of creating an array of features. The method can include steps of (a) providing a plurality of beads, wherein each bead in the plurality of beads includes probe content; (b) contacting the plurality of beads with a surface to produce a layer of beads on the surface; and (c) transferring the probe content from the beads to the surface to create an array of spatially discrete features on the surface, wherein each spatially discrete feature includes probe content from a bead in the plurality of beads.
摘要翻译：本发明提供了一种创建特征阵列的方法。该方法可以包括以下步骤：（a）提供多个珠，其中多个珠中的每个珠包括探针含量; （b）使多个珠粒与表面接触以在表面上产生一层珠粒; 和（c）将探针含量从珠粒转移到表面以在表面上产生空间上离散的特征的阵列，其中每个空间上离散的特征包括来自多个珠粒中的珠粒的探针含量。

10. 发明授权

US08206917B2 Combinatorial decoding of random nucleic acid arrays 有权
标题翻译：随机核酸阵列的组合解码
公开(公告)号：US08206917B2
公开(公告)日：2012-06-26
申请号：US13159302
申请日：2011-06-13
申请人： Mark S. Chee , David R. Walt
发明人： Mark S. Chee , David R. Walt
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6874 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B20/04 , C40B40/06 , C40B70/00 , C12Q2563/161 , C12Q2563/185 , C12Q2525/179 , C12Q2563/155 , C12Q2565/514
摘要： Methods disclosed herein relate to identification of nucleotides in a nucleotide sequence.
摘要翻译：本文公开的方法涉及鉴定核苷酸序列中的核苷酸。

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