专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US4960936A Process for the preparation of halogenated aromatic primary amines 失效
标题翻译：卤代芳族伯胺的制备方法
公开(公告)号：US4960936A
公开(公告)日：1990-10-02
申请号：US286102
申请日：1988-12-19
申请人： Peter Baumeister , Wilfried Scherrer
发明人： Peter Baumeister , Wilfried Scherrer
IPC分类号： C07C211/36 , C07C67/00 , C07C209/00 , C07C209/36 , C07C211/52
CPC分类号： C07C209/365
摘要： The catalytic hydrogenation of halogenated nitro aromatics using Raney nickel in the presence of a formamidine salt as dehalogenation inhibitor affords halogenated aromatic primary amines in high yields and high chemical purity within short reaction times even at elevated temperatures.
摘要翻译：在甲脒盐作为脱卤抑制剂存在下，使用阮内镍的卤代硝基芳族化合物的催化氢化，即使在升高的温度下也能在较短的反应时间内以高产率和高化学纯度提供卤代芳族伯胺。

82. 发明授权

US4769483A Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation 失效
标题翻译：环烷基取代的4-氨基苯基衍生物及其制备方法
公开(公告)号：US4769483A
公开(公告)日：1988-09-06
申请号：US902873
申请日：1986-09-02
申请人： Paolo Lombardi , Angelo Crugnola , Enrico di Salle
发明人： Paolo Lombardi , Angelo Crugnola , Enrico di Salle
IPC分类号： C12N9/99 , A61K31/135 , A61K31/165 , A61K31/215 , A61P13/02 , A61P15/00 , A61P35/00 , A61P43/00 , C07C67/00 , C07C201/00 , C07C205/06 , C07C205/42 , C07C205/56 , C07C205/57 , C07C209/00 , C07C209/36 , C07C209/50 , C07C211/45 , C07C213/00 , C07C217/76 , C07C227/00 , C07C227/04 , C07C227/18 , C07C229/42 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C233/62 , C07C237/20 , C07C101/00
CPC分类号： C07C205/56 , C07C205/42 , C07C205/45
摘要： The invention relates to cycloalkyl substituted 4-aminophenyl derivatives of formula (I) ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl:n is an integer of 1 to 5; and either(a) A is ##STR2## and B is --O--, --NH-- or --CH.sub.2 --; or (b) A is --CH.sub.2 -- and B is --O--, --NH--, --CH.sub.2 -- or ##STR3## or (c) A is --O-- and B is ##STR4## or --CH.sub.2 --; or (d) A is --NH-- and B is ##STR5## or --CH.sub.2 -- and their pharmaceutically acceptable salts.The scope of the invention includes also a process for preparing the said compounds of formula (I) and pharmaceutical compositions containing same.The compounds of the invention show aromatase inhibiting activity and can be useful, e.g., in treating hormone-dependent tumors and prostatic hypertrophy or hyperplasia.
摘要翻译：本发明涉及式（I）的环烷基取代的4-氨基苯基衍生物其中R是C 1 -C 4烷基：n是1至5的整数; 和（a）A是＆lt; IMAGE＆gt;而B是-O - ， - NH-或-CH 2 - ; 或（b）A是-CH 2 - ，B是-O - ， - NH - ， - CH 2 - 或者（c）A是-O-并且B是<或> 或（d）A是-NH-，B是或者-CH 2 - 及其药学上可接受的盐。本发明的范围还包括制备所述式（I）化合物和含有其的药物组合物的方法。本发明的化合物显示芳香酶抑制活性，并且可用于例如治疗激素依赖性肿瘤和前列腺肥大或增生。

83. 发明授权

US4764498A Silica-containing shaped articles and a process for their preparation 失效
标题翻译：二氧化硅成型制品及其制备方法
公开(公告)号：US4764498A
公开(公告)日：1988-08-16
申请号：US791890
申请日：1985-10-28
申请人： Adolf Wissner , Josef Haydn , Udo Birkenstock
发明人： Adolf Wissner , Josef Haydn , Udo Birkenstock
IPC分类号： C07C67/05 , B01J21/08 , B01J23/22 , B01J23/44 , B01J23/46 , B01J23/72 , B01J37/02 , C01B33/12 , C07B31/00 , C07B35/04 , C07B35/06 , C07B43/06 , C07B61/00 , C07C45/00 , C07C45/34 , C07C45/35 , C07C45/38 , C07C45/41 , C07C45/62 , C07C46/04 , C07C67/00 , C07C67/055 , C07C69/15 , C07C209/00 , C07C209/36 , C07D307/89 , B01J20/10 , B01J21/14
CPC分类号： C07C46/04 , B01J21/08 , B01J37/02 , B01J37/0242 , C07C209/36 , C07C45/002 , C07C45/006 , C07C45/34 , C07C45/35 , C07C45/38 , C07C45/41 , C07C45/62 , C07C67/055
摘要： In the new shaped articles a hollow space or a lumpy inorganic base material is surrounded by a porous silica-containing layer. They can be prepared by applying silica sol or a mixture containing water, silica sol and/or waterglass and, if appropriate, finely pulverulent water-insoluble silica and/or porosity producing agents to a lumpy base material, and, if use is made of organic base materials, then removing these organic base materials by heating. The new shaped articles can be used as support material for catalysts or, if the layer containing the porous silica contains catalytically active substances, as catalysts.
摘要翻译：在新型成型制品中，中空空间或块状无机基材被多孔含二氧化硅的层包围。它们可以通过将硅溶胶或含有水，二氧化硅溶胶和/或水玻璃的混合物和（如果合适的话）将微粉碎的水不溶性二氧化硅和/或孔隙率产生剂施加到块状基材上制备，并且如果使用有机基材，然后通过加热除去这些有机基材。新型成型制品可用作催化剂的载体材料，或者如果含有多孔二氧化硅的层含有催化活性物质，则可用作催化剂。

84. 发明授权

US4551264A Polyhalogenoaromatic compounds for liquid crystal compositions 失效
标题翻译：用于液晶组合物的多卤代芳族化合物
公开(公告)号：US4551264A
公开(公告)日：1985-11-05
申请号：US474862
申请日：1983-03-14
申请人： Rudolf Eidenschink , Michael Romer , Georg Weber
发明人： Rudolf Eidenschink , Michael Romer , Georg Weber
IPC分类号： G02F1/13 , C07C17/00 , C07C17/26 , C07C25/18 , C07C27/00 , C07C39/24 , C07C39/27 , C07C39/42 , C07C41/00 , C07C43/192 , C07C43/196 , C07C43/225 , C07C43/23 , C07C45/00 , C07C49/813 , C07C49/83 , C07C67/00 , C07C69/02 , C07C69/157 , C07C69/63 , C07C69/75 , C07C69/76 , C07C69/773 , C07C69/94 , C07C201/00 , C07C205/06 , C07C205/12 , C07C209/00 , C07C209/36 , C07C211/45 , C07C213/00 , C07C215/74 , C07C217/74 , C07C217/80 , C07C227/00 , C07C227/02 , C07C227/04 , C07C229/46 , C07C229/52 , C07C253/00 , C07C253/30 , C07C255/46 , C07C255/47 , C07C255/50 , C07C255/51 , C07C255/53 , C07C255/54 , C07D319/06 , C09K19/00 , C09K19/12 , C09K19/20 , C09K19/30 , C09K19/32 , C09K19/34 , C09K19/54 , G09F9/00 , C07C79/12 , C07C87/60 , C07C121/75
CPC分类号： C07C205/12 , C07C17/35 , C07C25/18 , C07C255/00 , C07C43/225 , C07C45/004 , C07D319/06 , C09K19/12 , C09K19/3003 , C09K19/321 , C09K19/3402 , C09K2019/3422
摘要： New polyhalogenoaromatic compounds of Formula I ##STR1## wherein Y and Z are each independently alkyl, alkoxy or alkanoyl each of 1 to 12 C atoms, --COOR.sup.1, --O--CO--R.sup.1, CN, NO.sub.2, NH.sub.2 or OH;Q is one or two identical or different radicals selected from Ph, Cy, 1,4-bicyclo[2,2,2]octylene or 1,3-dioxane-2,5-diyl;X.sup.1 to X.sup.4 are each independently H, F, Cl or Br;R.sup.1 is alkyl of 1 to 4 C atoms, Ph--R.sup.2 or Cy--R.sup.2 ;R.sup.2 is alkyl or alkoxy each of 1-12 C atoms or CN;Ph is 1,4-phenylene; and Cy is 1,4-cyclohexylene,can be used as components of liquid-crystal dielectrics.
摘要翻译：式I的新型多卤代芳族化合物其中Y和Z各自独立地为1至12个C原子的烷基，烷氧基或烷酰基，-COOR 1，-O-CO-R 1，CN，NO 2，NH 2或OH; Q是选自Ph，Cy，1,4-双环[2,2,2]亚辛基或1,3-二恶烷-2,5-二基中的一个或两个相同或不同的基团; X1至X4各自独立地为H，F，Cl或Br; R1是1-4个C原子的烷基，Ph-R2或Cy-R2; R2是1-12个碳原子或CN的烷基或烷氧基; Ph为1,4-亚苯基; Cy为1,4-亚环己基，可用作液晶电介质的成分。

85. 发明授权

US4535162A Process for catalytically reducing nitroaromatic compounds 失效
标题翻译：催化还原硝基芳族化合物的方法
公开(公告)号：US4535162A
公开(公告)日：1985-08-13
申请号：US504748
申请日：1983-06-16
申请人： Giovanni Mestroni , Grazia Zassinovich , Enzo Alessio
发明人： Giovanni Mestroni , Grazia Zassinovich , Enzo Alessio
IPC分类号： C07D213/18 , B01J31/00 , C07B61/00 , C07C67/00 , C07C209/00 , C07C209/36 , C07C211/46 , C07C211/47 , C07C211/51 , C07C211/52 , C07D213/22 , C07D471/04 , C07D215/38 , C07D211/72 , C07D239/02
CPC分类号： C07C209/36
摘要： A process is herein described for catalytically reducing nitroaromatic compounds by displacement of hydrogen from carbon monoxide and water or from synthesis gas to nitroaromatic compounds, the catalytic reduction being catalyzed by complexes of rhodium, iridium, ruthenium and osmium; said process is characterized in that the CO+H.sub.2 O system or the (CO+H.sub.2)+H.sub.2 O system is caused to react with a nitroaromatic compound of formula:Ar--(NO.sub.2).sub.x (I)wherein Ar is an aryl or hetero-aryl group, also substituted by inert groups; x is an integer from 1 to 3, in the presence of a complex catalyst of formula:[MChel(L).sub.2 ].sup.+ X.sup.- (II)or of a catalyst composed by carbonyl compounds and chelants of formula:Mz(CO).sub.y +nChel (III)wherein M=Rh, Ir, Ru, Os; "Chel" is a bidentate or tridentate aromatic nitrogen chelating compound; "L" is a molecule of carbon monoxide or of an olefin or half a molecule of a diolefin; X.sup.- is an anion selected from Cl.sup.-, Br.sup.-, I.sup.-, PF.sub.6.sup.-, BF.sub.4.sup.-, B(C.sub.6 H.sub.5).sub.4.sup.-, CO.sub.3.sup.-- and HCO.sub.3.sup.- ; z, y are integers with n being an integer or a fractional number, at temperatures ranging from about 25.degree. C. to 250.degree. C., at a carbon monoxide pressure between 1 and 150 atmospheres.The products obtained from the hydrogenation of the starting nitroaromatic compounds consist of arylamines in general and are utilized as intermediates for the organic syntheses in the field of fine chemicals.
摘要翻译：本文描述了通过将氢从一氧化碳和水或从合成气置换为硝基芳族化合物来催化还原硝基芳族化合物的方法，催化还原由铑，铱，钌和锇的络合物催化; 所述方法的特征在于使CO + H 2 O体系或（CO + H 2）+ H 2 O体系与式Ar-（NO 2）x（I）的硝基芳族化合物反应，其中Ar是芳基或杂芳基组，也被惰性基团取代; 在具有下式的复合催化剂存在下，x是1至3的整数：[MChel（L）2] + X-（II）或由羰基化合物和下式的螯合剂组成的催化剂：Mz（CO）y + nChel（III）其中M = Rh，Ir，Ru，Os; “Chel”是二齿或三齿芳族氮螯合化合物; “L”是一氧化碳或烯烃或半分子二烯烃的分子; X-是选自Cl-，Br-，I-，PF6-，BF4-，B（C6H5）4-，CO3-和HCO3-的阴离子; z，y是在约25℃至250℃的温度范围内，在1至150个大气压的一氧化碳压力下，n为整数或分数的整数。从起始硝基芳族化合物的氢化获得的产物通常由芳基胺组成，并用作精细化学品领域的有机合成的中间体。

86. 发明授权

US4422954A Method to restore the metal content of a noble metal hydrogenation catalyst 失效
标题翻译：恢复贵金属氢化催化剂金属含量的方法
公开(公告)号：US4422954A
公开(公告)日：1983-12-27
申请号：US364109
申请日：1982-03-31
申请人： Jan F. Van Peppen
发明人： Jan F. Van Peppen
IPC分类号： B01J23/96 , C07C51/36 , C07C209/36 , B01J23/38 , C07C29/20 , C07C45/00
CPC分类号： C07C209/36 , B01J23/96 , C07C51/36 , Y02P20/584
摘要： This invention is a method to restore the metal content of a supported noble metal hydrogenation catalyst comprising adding the appropriate amount of a noble metal salt of a weak acid to a fluid feed passing across the catalyst.
摘要翻译：本发明是一种还原负载的贵金属氢化催化剂的金属含量的方法，包括将适量的弱酸贵金属盐加入到通过催化剂的流体进料中。

87. 发明授权

US4361500A Process for the preparation of supported metal catalysts 失效
标题翻译：负载金属催化剂的制备方法
公开(公告)号：US4361500A
公开(公告)日：1982-11-30
申请号：US264802
申请日：1981-05-18
申请人： Tibor Mathe , Antal Tungler , Jozsef Petro
发明人： Tibor Mathe , Antal Tungler , Jozsef Petro
IPC分类号： C07B31/00 , B01J23/06 , B01J23/14 , B01J23/18 , B01J23/36 , B01J23/38 , B01J23/40 , B01J23/54 , B01J23/60 , B01J23/62 , B01J23/64 , B01J23/644 , B01J23/70 , B01J23/76 , B01J23/89 , B01J27/24 , B01J37/02 , B01J37/04 , C07C1/22 , C07C5/10 , C07C5/41 , C07C29/141 , C07C29/145 , C07C29/17 , C07C37/00 , C07C45/00 , C07C45/41 , C07C67/00 , C07C209/36 , C07C209/48 , C07D209/08 , B01J31/28 , B01J21/18 , B01J31/26
CPC分类号： C07D209/08 , B01J23/06 , B01J23/14 , B01J23/18 , B01J23/36 , B01J23/54 , B01J23/76 , B01J27/24 , B01J37/0203 , C07C1/22 , C07C209/36 , C07C209/48 , C07C29/141 , C07C29/145 , C07C29/172 , C07C29/175 , C07C37/003 , C07C45/002 , C07C45/006 , C07C45/41 , C07C5/10 , C07C5/417 , C07C2102/10 , C07C2521/04 , C07C2521/08 , C07C2521/18 , C07C2523/42 , C07C2523/44 , C07C2523/656 , C07C2523/755 , Y02P20/52
摘要： The invention relates to a new process for the preparation of a supported metal catalyst containing at least one metal belonging to Group A and optionally at least one metal belonging to Group B, wherein Group A encompasses the metals palladium, rhodium, ruthenium, platinum, iridium, osmium, silver, gold and cadmium and Group B encompasses the metals zinc, mercury, germanium, tin, antimony and lead. According to the invention, the metal(s) is (are) applied onto the support in the presence of at least one compound of the general formula (I), ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each stands for a straight-chained or branched C.sub.1-20 alkyl group, a C.sub.1-4 hydroxyalkyl group or a phenyl-(C.sub.1-4 alkyl) group optionally having additional substituents, preferably C.sub.1-4 alkyl groups, on the phenyl ring, andX is hydroxy group or the residue of an organic or mineral acid.According to the invention, highly active catalysts can be prepared by an easy and economical process.
摘要翻译：本发明涉及一种制备载体金属催化剂的新方法，该催化剂含有属于A组的至少一种金属和任选的至少一种属于B组的金属，其中A组包括金属钯，铑，钌，铂，铱，镉，银，金，镉和B族包括金属锌，汞，锗，锡，锑和铅。根据本发明，在至少一种通式（I）的化合物，其中R 1，R 2，R 3和R 4各自独立地存在的情况下，将金属（s）施加到载体上对于直链或支链C 1-20烷基，在苯环上任选具有另外的取代基，优选C 1-4烷基的C 1-4羟基烷基或苯基 - （C 1-4烷基），X是羟基或有机或无机酸的残基。根据本发明，可以通过简单和经济的方法制备高活性催化剂。

88. 发明授权

US4348335A Process for the partial reduction of polynitrated diaryl compounds 失效
标题翻译：部分还原多价二芳基化合物的方法
公开(公告)号：US4348335A
公开(公告)日：1982-09-07
申请号：US139952
申请日：1980-04-14
申请人： Karl Linhart , Dieter Pawellek , Harald Gleinig
发明人： Karl Linhart , Dieter Pawellek , Harald Gleinig
IPC分类号： C07C319/20 , C07C67/00 , C07C209/00 , C07C209/36 , C07C211/56 , C07C213/00 , C07C213/02 , C07C215/82 , C07C217/90 , C07C313/00 , C07C323/09 , C07C143/29
CPC分类号： C07C215/82
摘要： Polynitrated diaryl compounds of the formula given in the description are reduced with 1-2 mols of sulphides, or compounds which donate sulphide ions, per mol of nitro group in the presence of 0.5-10 mols of ammonia per mol of starting compound at 30.degree.-110.degree. C. to give nitroamino-diaryl compounds, for example 4,4'-dinitro-dibenzyl-2,2'-disulphonic acid is reduced to 4-nitro-4'-amino-stilbene-2,2'-disulphonic acid.
摘要翻译：在描述中给出的通式给出的多硝基二芳基化合物在每10摩尔起始化合物在0.5-10摩尔氨存在下，每1-2摩尔硫化物或者硫化物离子的化合物还原， -110℃，得到硝基氨基 - 二芳基化合物，例如将4,4'-二硝基 - 二苄基-2,2'-二磺酸还原成4-硝基-4'-氨基 - 茋-2,2'-二磺酸酸。

89. 发明授权

US4224249A Toluene diamine from non-washed dinitrotoluene 失效
标题翻译：来自未洗涤二硝基甲苯的甲苯二胺
公开(公告)号：US4224249A
公开(公告)日：1980-09-23
申请号：US38976
申请日：1979-05-14
申请人： Nance D. Kunz , Thomas A. Johnson , Barton Milligan
发明人： Nance D. Kunz , Thomas A. Johnson , Barton Milligan
IPC分类号： C07B61/00 , B01J29/00 , C07C67/00 , C07C209/00 , C07C209/36 , C07C211/51 , C07C85/11 , C07C85/26
CPC分类号： C07C209/36
摘要： This invention relates to an improvement in a process for preparing toluene diamine. The improvement resides in a process which is capable of permitting reduction of dinitrotoluene to toluene diamine without prior alkaline treatment for removal of nitrocresols in the dinitrotoluene. In carrying out the improvement the feed dinitrotoluene is water washed to remove HNO.sub.3 to a level below 6000 ppm, and the catalytic conversion of dinitrotoluene to toluene diamine is done continuously. Dinitrotoluene is charged to a reaction vessel containing a liquid carrier and reduced with hydrogen at constant pressure, the dinitrotoluene being added at a rate to maintain a concentration of dinitrotoluene of 0.0001 to 25% by weight of the total reactor contents while the hydrogenation catalyst is maintained at a level from about 0.1 to 3% based on the weight of reactor contents.
摘要翻译：本发明涉及一种制备甲苯二胺的方法的改进。改进之处在于能够允许将二硝基甲苯还原成甲苯二胺而不经过碱性处理除去二硝基甲苯中的硝基甲酚。在进行改进时，将进料二硝基甲苯进行水洗以除去HNO 3至低于6000ppm的水平，并连续进行二硝基甲苯向甲苯二胺的催化转化。将二硝基甲苯加入到含有液体载体的反应容器中并在恒定压力下用氢气还原，二硝基甲苯的加入速率使二硝基甲苯的浓度保持在总反应器内容物的0.0001至25重量％，同时保持氢化催化剂基于反应器内容物的重量为约0.1至3％的水平。

90. 发明授权

US4185036A Hydrogenation of mixed aromatic nitrobodies 失效
标题翻译：混合芳族硝基的氢化
公开(公告)号：US4185036A
公开(公告)日：1980-01-22
申请号：US837633
申请日：1977-09-28
申请人： Karl F. Cossaboon
发明人： Karl F. Cossaboon
IPC分类号： B01J23/40 , B01J23/64 , B01J23/652 , B01J23/89 , C07C209/36 , C07C85/11
CPC分类号： C07C209/36 , B01J23/40 , B01J23/64 , B01J23/6522 , B01J23/89
摘要： Process, batch or continuous, for hydrogenating a mixture of an aromatic mononitro-non-amino compound and an aromatic dinitro and/or an aromatic mononitromonoamino compound, which process comprises reacting hydrogen and a homogeneous or heterogeneous liquid mixture of at least 25 weight % of an aromatic mononitro-non-amino compound and at least 25 weight % of at least one compound selected from aromatic dinitro compounds and aromatic mononitromonoamino compounds, for example, a 25:75 weight % mixture of p-nitroaniline and o-nitrotoluene, with vigorous mixing, in the presence of 0.05-1.0 weight % of an hydrogenation catalyst derived from a metal of Group VIII of the Periodic Chart of the Elements, at a temperature of 75.degree.-225.degree. C. and a pressure of 50-800 p.s.i.g.
摘要翻译：用于氢化芳族单硝基非氨基化合物和芳族二硝基和/或芳香族单硝基氨基化合物的混合物的方法，分批或连续方法，该方法包括使氢和均相或非均相液体混合物与至少25重量％芳族单硝基非氨基化合物和至少25重量％的至少一种选自芳族二硝基化合物和芳族单硝基氨基化合物的化合物，例如，对硝基苯胺和邻硝基甲苯的25:75重量％混合物，具有剧烈的在0.05〜1.0重量％的衍生自元素周期表第Ⅷ族金属的氢化催化剂的存在下，在75〜-225℃的温度和50-800psig的压力下，

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式