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1. 发明申请

US20220324806A1 CANNABINOID DERIVATIVES 有权
公开(公告)号：US20220324806A1
公开(公告)日：2022-10-13
申请号：US17626516
申请日：2020-07-10
申请人： CANOPY GROWTH CORPORATION
发明人： SIAWASH AHMAR , JEFFREY ALAN OMEARA , PETER MARTIN DOVE
IPC分类号： C07D213/30 , C07D307/42 , C07C39/24 , C07D239/26 , C07D333/16 , C07D231/12 , C07D333/56 , C07D261/08 , C07C255/53 , C07D257/04 , C07C43/225 , C07D295/033 , C07C43/205 , C07D271/06 , C07D271/113 , C07D249/08 , C07D207/333 , C07D277/26 , C07D209/12 , C07D235/18 , C07D473/00 , C07D305/06 , C07D303/14 , C07D203/10 , C07D263/14 , C07D309/32 , C07D241/12
摘要： The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.

2. 发明申请

US20210032198A1 COMPOUNDS FOR USE AS INHIBITORS OF ALTERNATIVE OXIDASE OR CYTOCHROME BC1 COMPLEX 有权
公开(公告)号：US20210032198A1
公开(公告)日：2021-02-04
申请号：US17060013
申请日：2020-09-30
申请人： THE UNIVERSITY OF SUSSEX
发明人： Anthony Lennox Moore , Mary Susan Albury , Luke Edward Young , Catherine Elliott
IPC分类号： C07C255/53 , A61K31/11 , C07C39/373 , C07C235/60 , C07C47/565 , C07C49/835 , A01N49/00 , C07C69/63 , C07C65/28 , C07C69/84 , C07C69/18 , C07C69/157 , C07C39/24 , A01N37/40 , A01N37/44 , C07C43/178 , A01N63/30 , A01N31/16 , A01N35/04 , A01N37/02 , A01N37/24 , A01N37/34 , A61K31/055 , A61K31/085 , A61K31/12 , A61K31/166 , A61K31/222 , A61K31/277 , C07C43/23 , C07C69/21
摘要： The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.

3. 发明授权

US10597340B2 Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination 有权
公开(公告)号：US10597340B2
公开(公告)日：2020-03-24
申请号：US14937649
申请日：2015-11-10
申请人： The Regents of the University of California
发明人： Saman Sadeghi , Qinggang He , Artem Lebedev
IPC分类号： A61K51/04 , C07B59/00 , C07C37/62 , C07C39/24
摘要： Provided herein are methods and compositions for the electrochemical selective radiofluorination of aromatic molecules. The resulting fluorine-18 labeled compounds are ideal radionuclides for use in Positron Emission Tomography (PET); they are also difficult to radiolabel efficiently and with high specific activity using existing approaches. For example, radiopharmaceuticals such as [F18]L-DOPA, which is indispensable in PET brain disease imaging, may be made electrochemically with high radiochemical yield and high specific activity using 18F-. The invention process described herein opens new possibilities and provides wider access to PET tracers such as 18F-L-Dopa, since 18F- is much more widely available than the 18F2, currently used for synthesis of electron rich substrates.

4. 发明授权

US09458174B2 Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof 有权
标题翻译：线粒体电子传递链复合物（III）的活性抑制剂及其用途
公开(公告)号：US09458174B2
公开(公告)日：2016-10-04
申请号：US14401685
申请日：2013-05-23
申请人： STEMERGIE BIOTECHNOLOGY SA
发明人： Virginie Clement-Schatlo , Thomas Fessard , Damien Barbaras , Joana Matos , Erick Carreira
IPC分类号： A61K31/41 , C07D495/10 , C07D213/81 , C07D215/28 , C07C275/42 , C07C39/30 , C07D231/56 , C07C311/08 , C07D235/26 , C07D405/12 , C07C215/50 , C07D249/06 , C07C233/25 , C07D263/32 , C07D263/34 , C07D487/10 , C07C237/38 , C07C237/42 , C07C251/48 , C07D209/42 , C07D305/06 , C07C49/825 , C07D403/12 , C07D223/28 , C07D235/18 , C07C233/33 , C07D261/08 , C07C235/60 , C07C235/62 , C07D263/57 , C07D491/107 , C07C237/40 , C07C237/44 , C07D277/56 , C07D513/10 , C07D305/08 , A01N31/08 , A01N33/10 , A01N35/04 , A01N37/24 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/50 , A01N43/20 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/46 , A01N43/52 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A01N47/30 , C07C39/24 , C07C43/178 , C07C49/245 , A61K31/137 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/397 , A61K31/421 , A61K31/44 , A61K31/47 , A61K31/55 , A61K45/06 , C07D223/24
CPC分类号： C07D495/10 , A01N31/08 , A01N33/10 , A01N35/04 , A01N37/24 , A01N37/40 , A01N37/44 , A01N37/46 , A01N37/50 , A01N43/20 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/46 , A01N43/52 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A01N47/30 , A61K31/137 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/397 , A61K31/421 , A61K31/44 , A61K31/47 , A61K31/55 , A61K45/06 , C07C39/245 , C07C39/30 , C07C43/1787 , C07C49/245 , C07C49/825 , C07C215/50 , C07C233/25 , C07C233/33 , C07C235/60 , C07C235/62 , C07C237/38 , C07C237/40 , C07C237/42 , C07C237/44 , C07C251/48 , C07C275/42 , C07C311/08 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/42 , C07D213/81 , C07D215/28 , C07D223/24 , C07D223/28 , C07D231/56 , C07D235/18 , C07D235/26 , C07D249/06 , C07D261/08 , C07D263/32 , C07D263/34 , C07D263/57 , C07D277/56 , C07D305/06 , C07D305/08 , C07D403/12 , C07D405/12 , C07D487/10 , C07D491/107 , C07D513/10
摘要： The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumor-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.
摘要翻译：本发明涉及线粒体电子传递链的复合体（III）的活性抑制剂及其在治疗和/或预防呈递肿瘤起始细胞的癌症中的用途。本发明还涉及单独或与其它药物活性剂组合含有所述抑制剂的药物组合物，以及它们作为药物或作为农药的用途，其中其作为线粒体呼吸抑制剂的性质是有益的。

5. 发明授权

US08288590B2 N-substituted monomers and polymers 有权
标题翻译： N-取代的单体和聚合物
公开(公告)号：US08288590B2
公开(公告)日：2012-10-16
申请号：US13183051
申请日：2011-07-14
申请人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
发明人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
IPC分类号： C07C233/00 , C07C215/00 , C07C39/24 , C08G65/32 , C08G75/00 , A61K49/04 , A61K47/30
CPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , B33Y70/00 , B33Y80/00 , C08G63/6856 , C08G64/045 , C08G64/12 , C08G64/183 , C08G64/186 , C08G79/04 , C08L85/02 , C08L69/00
摘要： Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
摘要翻译：包含多个含有酰胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中所述酰胺基团是N-取代的，N-取代基和N-取代度对降低熔体粘度，溶液粘度或两者均有效，与没有N-取代的相同聚合物相比。

6. 发明授权

US08008528B2 N-substituted monomers and polymers 有权
标题翻译： N-取代的单体和聚合物
公开(公告)号：US08008528B2
公开(公告)日：2011-08-30
申请号：US11873979
申请日：2007-10-17
申请人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
发明人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
IPC分类号： C07C235/00 , C07C239/00 , C07C39/24 , C07C39/34
CPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , B33Y70/00 , B33Y80/00 , C08G63/6856 , C08G64/045 , C08G64/12 , C08G64/183 , C08G64/186 , C08G79/04 , C08L85/02 , C08L69/00
摘要： Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
摘要翻译：包含多个含有酰胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中所述酰胺基团是N-取代的，N-取代基和N-取代度对降低熔体粘度，溶液粘度或两者均有效，与没有N-取代的相同聚合物相比。

7. 发明申请

US20100234456A1 APOPTOSIS PROMOTERS 有权
标题翻译： APOPTOSIS促销者
公开(公告)号：US20100234456A1
公开(公告)日：2010-09-16
申请号：US12787140
申请日：2010-05-25
申请人： Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
发明人： Michael D. Wendt , Hong Ding , Sheela A. Thomas , Steven W. Elmore , Wang Shen , Daniel A. Dickman , David Augeri
IPC分类号： A61K31/255 , C07C39/24 , A61K31/055 , C07C39/04 , A61K31/05 , C07C305/22 , C07C47/52 , A61K31/11 , C07C63/00 , A61K31/192 , C07C211/44 , A61K31/135 , A61P35/00
CPC分类号： C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
摘要翻译：公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。

8. 发明授权

US07166337B2 Liquid-crystal composition, methods of adjusting the resistance, and substituted phenols 有权
标题翻译：液晶组合物，调节电阻的方法和取代的酚类
公开(公告)号：US07166337B2
公开(公告)日：2007-01-23
申请号：US09907654
申请日：2001-07-19
申请人： Michael Darius , Volker Reiffenrath , Kazuaki Tarumi , Bernhard Rieger , Michael Heckmeier , Marcus Reuter , Peer Kirsch
发明人： Michael Darius , Volker Reiffenrath , Kazuaki Tarumi , Bernhard Rieger , Michael Heckmeier , Marcus Reuter , Peer Kirsch
IPC分类号： C09K19/52 , C09K19/54 , C07C33/20 , C07C33/34 , C07C39/24 , C07C39/27 , C07C205/21
CPC分类号： C07C39/17 , C07C255/53 , C07C2601/14 , C09K19/02 , C09K19/12 , C09K19/3001 , C09K19/3003 , C09K19/44 , C09K19/54 , C09K2019/3021 , Y10T428/10
摘要： The present invention relates to liquid-crystal mixtures having specific resistance values, comprising acidic compounds. The present invention furthermore relates to liquid-crystal displays containing these liquid-crystal mixtures. The invention furthermore relates to compounds of the formula I, in which the parameters are as defined in the text, to their preparation, and to their use for achieving certain specific resistance values in liquid-crystal mixtures. The application also relates to a method of adjusting the specific resistance of liquid-crystal mixtures using acidic compounds.
摘要翻译：本发明涉及具有电阻值的液晶混合物，其含有酸性化合物。本发明还涉及含有这些液晶混合物的液晶显示器。本发明还涉及式I化合物，其中参数如本文所定义，其制备及其在液晶混合物中达到某些比电阻值的用途。本申请还涉及使用酸性化合物调节液晶混合物的电阻率的方法。

9. 发明授权

US07022886B2 Selective catalytic oxybromination of hydroxyaromatic compounds 有权
标题翻译：羟基芳族化合物的选择性催化氧溴化
公开(公告)号：US07022886B2
公开(公告)日：2006-04-04
申请号：US10650567
申请日：2003-08-28
申请人： Grigorii Lev Soloveichik
发明人： Grigorii Lev Soloveichik
IPC分类号： C07C39/24
CPC分类号： C07B39/00 , C07C37/62 , C07C39/27
摘要： A method for selectively brominating hydroxyaromatic compounds is disclosed. Hydroxyaromatic compounds are contacted with oxygen and a bromine source, in an acidic medium, in the presence of a catalyst selected from the group of compounds and mixtures of compounds of Group IV–VIII transition metals of the Periodic Table of Elements. The selectivity of mono-brominated products produced, predominantly in the para-position, from the method using transition metal compounds as catalysts is significantly higher than that of known methods using other catalysts. Thus, there is a significant reduction in the production of undesirable dibrominated and more highly brominated by-products.
摘要翻译：公开了选择性溴化羟基芳族化合物的方法。羟基芳族化合物在酸性介质中，在选自元素周期表第IV-VIII族过渡金属化合物和混合物的催化剂存在下，与氧和溴源接触。从使用过渡金属化合物作为催化剂的方法中主要在对位产生的单溴化产物的选择性显着高于使用其它催化剂的已知方法的选择性。因此，不希望的二溴和更高溴化的副产物的生产显着减少。

10. 发明申请

US20050261469A1 High performance polymer electrolyte with improved thermal and chemical characteristics 审中-公开
标题翻译：具有改善的热和化学特性的高性能聚合物电解质
公开(公告)号：US20050261469A1
公开(公告)日：2005-11-24
申请号：US10851414
申请日：2004-05-21
申请人： Gangadhar Panambur , Rameshkumar Chellappan
发明人： Gangadhar Panambur , Rameshkumar Chellappan
IPC分类号： C07C39/16 , C07C39/24 , C07C39/367 , C08G65/34 , H01M8/04 , H01M8/10
CPC分类号： C07C39/367 , C07C39/16 , C07C39/24 , C08G65/40 , C08G65/4018 , C08G75/23 , H01M8/1007 , H01M8/1025 , H01M8/1027 , H01M8/1032 , H01M8/1039
摘要： A novel monomer composition and a process of synthesizing the novel monomer is described. Generally, such novel monomers have an aliphatic spacer unit between two phenyl rings. In one embodiment the inventive monomer has a general structure of: wherein X and X′ independently include a functional group selected from the group consisting of hydroxy, halogen, nitro, carboxylic acid, trimethylsiloxy and amines; G and G′ independently include one selected from the group consisting of hydrogen, sulfonic acid, phosphoric acid, carboxylic acid, sulfonamide, and imidazole; “m” and “o” being integers and each independently having a value in the range from 0 to 15. The aliphatic spacer unit in alternative described embodiments of the inventive monomer does not contain the fluorinated methylene unit. Novel processes of synthesizing such monomers are also described. Based on these inventive monomer compositions, inventive polymer structures and processes of synthesizing them are also described.
摘要翻译：描述了新型单体组合物和合成新单体的方法。通常，这些新型单体在两个苯环之间具有脂肪族间隔单元。在一个实施方案中，本发明的单体具有以下通式结构：其中X和X'独立地包括选自羟基，卤素，硝基，羧酸，三甲基甲硅烷氧基和胺的官能团; G和G'独立地包括选自氢，磺酸，磷酸，羧酸，磺酰胺和咪唑的一种; “m”和“o”为整数，并且各自独立地具有在0至15的范围内。本发明单体的另外描述的实施方案中的脂肪族间隔体单元不含有氟化亚甲基单元。还描述了合成这些单体的新方法。基于这些本发明的单体组合物，还描述了本发明的聚合物结构及其合成方法。

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