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    • 83. 发明授权
    • Phosphoramidite compound and method for producing oligo-RNA
    • 亚磷酰胺化合物及其制备方法
    • US08691970B2
    • 2014-04-08
    • US11574308
    • 2005-08-25
    • Tadaaki OhgiKouichi IshiyamaYutaka Masutomi
    • Tadaaki OhgiKouichi IshiyamaYutaka Masutomi
    • C07H19/04C07H21/02
    • C07C255/13C07H19/067C07H19/167C07H21/02Y02P20/55Y02P20/582
    • An object of the present invention is to provide a useful and novel phosphoramidite compound for the synthesis of oligo-RNA.A phosphoramidite compound represented by general formula (1), wherein: BX represents a nucleobase optionally having a protecting group; and R1 is a substituent represented by general formula (2), wherein: R11, R12 and R13 are the same or different and each represents hydrogen or alkoxy; R2a and R2b are the same or different and each represents alkyl, or R2a and R2b taken together with the adjacent nitrogen atom may form a 5- to 6-membered saturated amino cyclic group, the amino cyclic group optionally having an oxygen or sulfur atom as a ring-composing member in addition to the adjacent nitrogen atom; and WG1 and WG2 are the same or different and each represents an electron-withdrawing group.
    • 本发明的目的是提供一种用于合成寡聚RNA的有用和新型的亚磷酰胺化合物。 由通式(1)表示的亚磷酰胺化合物,其中:BX表示任选具有保护基的核碱基; 并且R 1是由通式(2)表示的取代基,其中:R 11,R 12和R 13相同或不同,各自表示氢或烷氧基; R2a和R2b相同或不同,各自表示烷基,或者R2a和R2b与相邻氮原子一起可以形成5-至6-元饱和的氨基环状基团,氨基环状基团任选具有氧或硫原子作为 除了相邻的氮原子之外的环组成成分; WG1和WG2相同或不同,各自表示吸电子基团。