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1. 发明申请

US20190112257A1 Etheramine Compounds 审中-公开
公开(公告)号：US20190112257A1
公开(公告)日：2019-04-18
申请号：US16211284
申请日：2018-12-06
申请人： Huntsman Petrochemical LLC
发明人： Donald H Champion
IPC分类号： C07C217/08 , C07C253/30 , C07C255/13 , C07C213/02
CPC分类号： C07C217/08 , C07C213/02 , C07C253/30 , C07C255/13 , C07C2601/14
摘要： Embodiments described herein provide a compound that may be used in a variety of applications such as corrosion inhibition, additives for metalworking, mining reagents, epoxy curatives, emulsifiers, fuel or lubricant additives, surfactant manufacture, acid scavengers and asphalt additives. The compound has the following structure: where R1 is a methoxy group, R2, R3, R4 and R5 are independently a hydrogen atom or an alkyl group, and R6 is an aminomethyl group.

2. 发明授权

US09394242B2 Method for preparing dinitrile compound 有权
标题翻译：二腈化合物的制备方法
公开(公告)号：US09394242B2
公开(公告)日：2016-07-19
申请号：US14026233
申请日：2013-09-13
申请人： LG CHEM, LTD.
发明人： Byoung-Bae Lee , Jae-Seung Oh , You-Jin Shim , Yeon-Suk Hong
IPC分类号： C07C253/30 , B01J31/02 , C07C255/13
CPC分类号： C07C253/30 , B01J31/0212 , B01J2231/32 , C07C255/13
摘要： Disclosed is a method for preparing a dinitrile compound. The method includes reacting an alcohol compound with a nitrile compound having a terminal carbon-carbon unsaturated bond under anhydrous conditions. A potassium alkoxide having 1 to 5 carbon atoms is used as a catalyst in the course of the reaction. According to the method, a high-purity dinitrile compound can be prepared in a simple manner within a short reaction time indicating high productivity.
摘要翻译：公开了二腈化合物的制备方法。该方法包括在无水条件下使醇化合物与具有末端碳 - 碳不饱和键的腈化合物反应。在反应过程中使用具有1至5个碳原子的醇盐作为催化剂。根据该方法，可以在短的反应时间内以简单的方式制备高纯度二腈化合物，表明生产率高。

3. 发明授权

US08633245B2 PAI-1 inhibitor 有权
标题翻译： PAI-1抑制剂
公开(公告)号：US08633245B2
公开(公告)日：2014-01-21
申请号：US12422099
申请日：2009-04-10
申请人： Youichi Yamaguchi , Takeshi Yanase , Susumu Muto , Akiko Itai
发明人： Youichi Yamaguchi , Takeshi Yanase , Susumu Muto , Akiko Itai
IPC分类号： A61K31/19 , C07C51/00
CPC分类号： C07C59/90 , C07C39/27 , C07C47/277 , C07C47/55 , C07C47/565 , C07C47/575 , C07C49/84 , C07C69/712 , C07C205/06 , C07C205/35 , C07C205/37 , C07C205/38 , C07C205/44 , C07C205/56 , C07C211/52 , C07C217/80 , C07C217/86 , C07C217/90 , C07C229/18 , C07C233/15 , C07C233/56 , C07C233/60 , C07C237/40 , C07C251/24 , C07C255/13 , C07C255/37 , C07C255/54 , C07C311/08 , C07C311/29 , C07C317/22 , C07C323/20 , C07C323/41 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D211/76 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/205 , C07D317/18 , C07D317/28 , C07F7/1804
摘要： The compound represented by the following formula (I) and the like have PAI-1 inhibition activity;wherein: R1 represents a C6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 or 1; when m is 0, G represents —N—C(═O)—CO2H or the like; when m is 1, G represents an oxygen atom or the like; R2 represents a C6-10 aryl group which may be substituted or the like; E represents the following formula (II) wherein one of R31, R32, R33 and R34 represents the formula R1-T-, each of the other three independently represents a hydrogen atom or the like, and R35 represents the formula —X—Y′, a hydrogen atom or the like; X represents —CH2— or the like; Y′ represents a carboxy group or the like; M represents a single bond or the like.
摘要翻译：由下式（I）等表示的化合物具有PAI-1抑制活性; 其中：R1表示可以被取代的C6-10芳基等; T表示单键等; m表示0或1; 当m为0时，G表示-N-C（= O）-CO 2 H等; 当m为1时，G表示氧原子等; R2表示可以被取代的C6-10芳基等; E表示式（II）中，R 31，R 32，R 33和R 34之一表示式R 1〜T，其余3个独立地表示氢原子等，R 35表示式-X-Y' ，氢原子等; X表示-CH 2 - 等; Y'表示羧基等; M表示单键等。

4. 发明授权

US08507493B2 Amide and amidine derivatives and uses thereof 有权
标题翻译：酰胺和脒衍生物及其用途
公开(公告)号：US08507493B2
公开(公告)日：2013-08-13
申请号：US12763808
申请日：2010-04-20
申请人： Sridhar Peddi , Meena V. Patel , Jeffrey J. Rohde
发明人： Sridhar Peddi , Meena V. Patel , Jeffrey J. Rohde
IPC分类号： A61K31/496 , A61K31/155 , A61K31/277 , A61K31/165 , C07D401/02 , C07D401/04 , C07D213/84 , C07C255/00 , C07C327/38 , C07C257/10
CPC分类号： C07C261/04 , C07C229/50 , C07C235/14 , C07C255/13 , C07C257/06 , C07C257/14 , C07C271/24 , C07C311/29 , C07C311/36 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/40 , C07C317/44 , C07C317/50 , C07C323/41 , C07C323/60 , C07C327/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2602/44 , C07C2603/66 , C07C2603/74 , C07D205/04 , C07D207/10 , C07D207/26 , C07D209/08 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/38 , C07D211/46 , C07D211/96 , C07D211/98 , C07D213/30 , C07D213/64 , C07D213/74 , C07D213/85 , C07D215/14 , C07D223/16 , C07D239/42 , C07D265/30 , C07D277/82 , C07D295/125 , C07D307/66 , C07D317/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/08 , C07D487/04 , C07D491/056
摘要： The present invention relates to inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译：本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖，脂质障碍，代谢综合征，中枢神经系统疾病和疾病和病症中的用途这与过量的糖皮质激素有关。

5. 发明申请

US20120061325A1 CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS 有权
标题翻译：化学化合物和固定化的螯合剂
公开(公告)号：US20120061325A1
公开(公告)日：2012-03-15
申请号：US13278498
申请日：2011-10-21
申请人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Robert Joseph Kuhn , Surendra Dawadi
发明人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Robert Joseph Kuhn , Surendra Dawadi
IPC分类号： B01D15/08 , C08F112/08 , C08F212/36 , C07C311/19 , C07C275/24
CPC分类号： C02F1/683 , B01D15/3828 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J45/00 , C02F2101/20 , C07C217/28 , C07C255/13 , C07C259/06 , C07C311/17
摘要： Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.
摘要翻译：提出了可用作螯合剂的新型化合物，其制备中间体和从溶液中除去三价和四价金属离子的方法。

6. 发明申请

US20110245520A1 METHOD OF MAKING FLUORINATED ALKOXY CARBOXYLIC ACIDS AND PRECURSORS THEREOF 有权
标题翻译：制备氟化烷氧基羧酸及其前体的方法
公开(公告)号：US20110245520A1
公开(公告)日：2011-10-06
申请号：US13133734
申请日：2009-11-24
申请人： Tilman Zipplies , Klaus Hintzer , Oleg Shyshkov
发明人： Tilman Zipplies , Klaus Hintzer , Oleg Shyshkov
IPC分类号： C07C247/04 , C07C51/08
CPC分类号： C07C255/13 , C07C51/08 , C07C59/135 , C07C67/08 , C07C69/708 , C07C247/04 , C07C253/14
摘要： A method for preparing saturated partially fluorinated alkoxy carboxylic acids or salts thereof by treating a compound: (II), where Rf represents a fluorinated, linear or branched alkyl residue interruptible by one or more oxygen atoms, n is 0 or 1, with a Z-anion in a reaction medium comprising water and an organic solvent, where the Z-anion is selected from CN—, SCN— and OCN— or combinations thereof. A method of making partially fluorinated ethers of the general formula (I) wherein Rf is defined as above, n is 0 or 1, and Z is nitrile (—CN), azide (—N3), thiocyanate (—SCN) or cyanate (—OCN) group, said method comprising treating a fluorinated olefin of the general formula (II) wherein the Z-anion is CN—, OCN—, SCN— or N3−. A compound of the general formula (I) as previously described where Z is selected from SCN, OCN and N3.
摘要翻译：通过处理化合物（II）制备饱和部分氟化的烷氧基羧酸或其盐的方法，其中Rf表示可被一个或多个氧原子中断的氟化的直链或支链烷基，n为0或1，Z为阴离子在包含水和有机溶剂的反应介质中，其中Z-阴离子选自CN-，SCN-和OCN-或其组合。制备通式（I）的部分氟化醚的方法，其中Rf定义如上，n为0或1，Z为腈（-CN），叠氮化物（-N 3），硫氰酸酯（-SCN）或氰酸酯 -OCN）基团，所述方法包括处理通式（II）的氟化烯烃，其中Z-阴离子是CN-，OCN-，SCN-或N 3 - 。其中Z选自SCN，OCN和N 3，如前所述的通式（I）的化合物。

7. 发明申请

US20100267795A1 NITROSUBSTITUTED ARYLOXYALKYLIMIDAZOLINES FOR USE AS PESTICIDES 审中-公开
标题翻译：用作杀虫剂的硝基苯甲酰胺基咪唑啉
公开(公告)号：US20100267795A1
公开(公告)日：2010-10-21
申请号：US12741741
申请日：2008-10-24
申请人： Christoph Luethy , Anthony Cornelius O'Sullivan , Thomas Pitterna , Jurgen Harry Schaetzer
发明人： Christoph Luethy , Anthony Cornelius O'Sullivan , Thomas Pitterna , Jurgen Harry Schaetzer
IPC分类号： A01N43/50 , C07D233/22 , C07C255/16 , A01P7/02 , A01P7/04
CPC分类号： C07D233/22 , A01N43/50 , C07C255/13
摘要： The present invention relates to imidazoline derivatives and their use as insecticidal and acaricidal agents. The invention also extends to insecticidal and acaricidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect and acarine pests. In particular the present invention relates to phenoxy-imidazoline derivatives wherein the phenoxy moiety is substituted with a nitro group. A method of combating and/or controlling an insect or acarid pest, which comprises applying to said pest, or to the locus of said pest, or to a plant susceptible to attack by said pest, a compound of formula (I): or salt or N-oxide thereof.
摘要翻译：本发明涉及咪唑啉衍生物及其作为杀虫剂和杀螨剂的用途。本发明还延伸到包含这种咪唑啉衍生物的杀虫和杀螨组合物，以及使用这些衍生物和/或组合物来对抗和控制昆虫和螨类害虫的方法。特别地，本发明涉及苯氧基 - 咪唑啉衍生物，其中苯氧基部分被硝基取代。一种防治昆虫或螨类害虫的方法，其包括向所述有害生物或所述有害生物所在地或向所述有害生物易受攻击的植物施用式（I）化合物或盐或N-氧化物。

8. 发明申请

US20100267738A1 NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF 有权
标题翻译：新型酰胺和氨基衍生物及其用途
公开(公告)号：US20100267738A1
公开(公告)日：2010-10-21
申请号：US12763808
申请日：2010-04-20
申请人： Sridhar Peddi , Meena V. Patel , Jeffrey J. Rohde
发明人： Sridhar Peddi , Meena V. Patel , Jeffrey J. Rohde
IPC分类号： A61K31/155 , C07C255/00 , C07D213/84 , C07C327/38 , C07D401/04 , C07C257/10 , C07D401/02 , A61K31/496 , A61K31/277 , A61K31/165 , A61P3/00 , A61P9/12 , A61P19/10 , A61P27/02 , A61P19/02 , A61P25/28 , A61P25/22 , A61P25/24 , A61P3/04 , A61P25/18
CPC分类号： C07C261/04 , C07C229/50 , C07C235/14 , C07C255/13 , C07C257/06 , C07C257/14 , C07C271/24 , C07C311/29 , C07C311/36 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/40 , C07C317/44 , C07C317/50 , C07C323/41 , C07C323/60 , C07C327/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2602/44 , C07C2603/66 , C07C2603/74 , C07D205/04 , C07D207/10 , C07D207/26 , C07D209/08 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/38 , C07D211/46 , C07D211/96 , C07D211/98 , C07D213/30 , C07D213/64 , C07D213/74 , C07D213/85 , C07D215/14 , C07D223/16 , C07D239/42 , C07D265/30 , C07D277/82 , C07D295/125 , C07D307/66 , C07D317/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/08 , C07D487/04 , C07D491/056
摘要： The present invention relates to inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译：本发明涉及11-＆bgr-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病中的用途，以及与过量糖皮质激素有关的病症。

9. 发明授权

US07169817B2 Bis-aromatic alkanols 有权
标题翻译：双芳族链烷醇
公开(公告)号：US07169817B2
公开(公告)日：2007-01-30
申请号：US10445967
申请日：2003-05-27
申请人： Shifeng Pan , Nathanael S. Gray , Wenqui Gao , Klaus Hinterding , Sophie Lefebvre , Yuan Mi , Peter Nussbaumer , Wei Wang , Federic Zecri , Fan Yi , Lawrence Blas Perez , Kenneth Richad la Montagne , Peter Ettmayer
发明人： Shifeng Pan , Nathanael S. Gray , Wenqui Gao , Klaus Hinterding , Sophie Lefebvre , Yuan Mi , Peter Nussbaumer , Wei Wang , Federic Zecri , Fan Yi , Lawrence Blas Perez , Kenneth Richad la Montagne , Peter Ettmayer
IPC分类号： C07C211/03 , C07C251/32 , A61K31/15 , A61K31/137
CPC分类号： C07D263/57 , C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D261/08 , C07D317/58 , C07D333/20 , C07F9/094
摘要： The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: wherein the substituents have the values mentioned herein.
摘要翻译：本发明涉及联苯衍生物，其制备方法及其用途和含有它们的药物组合物。根据本发明的化合物基于以下化学式：其中取代基具有本文提及的值。

10. 发明授权

US07034165B2 Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production 失效
公开(公告)号：US07034165B2
公开(公告)日：2006-04-25
申请号：US10211236
申请日：2002-08-05
申请人： Jurgen Westermann , Johannes Platzek , Orlin Petrov
发明人： Jurgen Westermann , Johannes Platzek , Orlin Petrov
IPC分类号： C07D319/06 , C07F7/10 , C07C255/03
CPC分类号： C12P13/004 , C07C253/30 , C07C255/12 , C07C255/13 , C07C255/20 , C07D319/06 , C07F7/1804 , C12P41/004 , Y02P20/55
摘要： The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

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