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1. 发明申请

US20190099696A1 Cannabinoid extraction process using brine 审中-公开
公开(公告)号：US20190099696A1
公开(公告)日：2019-04-04
申请号：US16112033
申请日：2018-08-24
申请人： NextLeaf Solutions Ltd.
发明人： Ryan Delmoral Ko , Brock Hughes , Krupal Pal , Alexzander Samuelsson
IPC分类号： B01D11/02 , B01D15/00 , B01D3/08 , C07D311/80 , C07C37/00 , C07C37/86 , B01D3/40 , C07C39/19
CPC分类号： B01D11/0288 , B01D3/085 , B01D3/40 , B01D11/0292 , B01D15/00 , C07C37/004 , C07C37/50 , C07C37/74 , C07C37/86 , C07C39/19 , C07C2601/16 , C07D311/80 , C07C39/23
摘要： Raw cannabis plant material is mixed with ethanol and spun-dry to extract cannabinoids. The ethanol may be chilled before adding it to the raw cannabis plant material, and a non-polar solvent stage may be used to increase the yield of the extraction. The resulting crude oil and ethanol with the dissolved cannabinoids is separated from the raw cannabis plant material and filtered to remove particulates, waxes, lipids, fats and dissolved impurities. The ethanol is then evaporated from the resulting mixture of oil and ethanol, and the remaining oil then undergoes brine-washing, decarboxylation and distillation to obtain the cannabinoids and other desirable volatile phytochemicals.

2. 发明授权

US10053406B2 Synthesis of honokiol 有权
公开(公告)号：US10053406B2
公开(公告)日：2018-08-21
申请号：US15331640
申请日：2016-10-21
申请人： Colgate-Palmolive Company , The Trustees of the University of Pennsylvania
发明人： Stanislav Jaracz , Marisa Kozlowski , Young Eun Lee , Sun Min Kim
IPC分类号： C07C37/055 , C07C37/14 , C07C41/24 , C07C41/09 , C07C41/22 , C07C39/21 , C07C37/50
CPC分类号： C07C37/0555 , C07C37/11 , C07C37/14 , C07C37/50 , C07C39/15 , C07C39/21 , C07C41/09 , C07C41/16 , C07C41/22 , C07C41/24 , C07C41/30 , C07C43/2055 , C07C43/225 , C07C43/215
摘要： Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.

3. 发明申请

US20180155271A1 SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES 审中-公开
公开(公告)号：US20180155271A1
公开(公告)日：2018-06-07
申请号：US15889295
申请日：2018-02-06
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： ROBERT H. GRUBBS , ALEXEY FEDOROV , ANTON TOUTOV , NICHOLAS A. SWISHER
IPC分类号： C07C209/28 , C07F7/08 , C07C321/26 , C07C319/06 , C07C211/48 , C07C209/62 , C07C39/15 , C07C37/50 , C07C37/055 , C07C15/24 , C07C15/18 , C07C15/16 , C07C15/14 , C07C15/06 , C07C15/04 , C07C15/02 , C07C1/22
CPC分类号： C07C209/28 , C07B2200/05 , C07C1/22 , C07C37/055 , C07C37/50 , C07C209/62 , C07C319/06 , C07F7/081 , C07F7/0814 , C07C39/15 , C07C15/06 , C07C15/16 , C07C15/18 , C07C15/14 , C07C15/04 , C07C15/02 , C07C15/24 , C07C211/48 , C07C321/26
摘要： The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

4. 发明授权

US09845279B2 Chemical intermediates by catalytic fast pyrolysis process 有权
公开(公告)号：US09845279B2
公开(公告)日：2017-12-19
申请号：US14685757
申请日：2015-04-14
申请人： Anellotech, Inc.
发明人： Terry Mazanec , Eugene Schmelzer , Fred Pesa , Dennis McCullough , Ruozhi Song , Yu-Ting Cheng
IPC分类号： C07C51/31 , C07C37/58 , C07C51/42 , C07C1/22 , C07C2/66 , C07C5/10 , C07C5/333 , C07C7/00 , C07C29/15 , C07C29/20 , C07C37/50 , C07C37/68 , C08G63/183 , C08F212/08 , C08F212/10 , C08G63/80 , C10G1/02 , C10G9/00 , B29C43/00 , B29C49/00 , C10G1/00 , C08F12/08 , C10G29/20 , C10G57/00 , C10G3/00 , C10G45/44 , C10G50/00 , C07C2/86 , C07C45/00 , C07C45/28 , C07C45/78 , B29K67/00
CPC分类号： C07C51/31 , B29C43/003 , B29C49/0005 , B29K2067/003 , C07C1/22 , C07C2/66 , C07C2/864 , C07C5/10 , C07C5/333 , C07C7/00 , C07C29/15 , C07C29/20 , C07C37/50 , C07C37/58 , C07C37/68 , C07C45/006 , C07C45/28 , C07C45/78 , C07C51/42 , C08F12/08 , C08F212/08 , C08F212/10 , C08G63/183 , C08G63/80 , C10G1/002 , C10G1/02 , C10G3/40 , C10G3/42 , C10G9/00 , C10G29/205 , C10G45/44 , C10G50/00 , C10G57/005 , C10G2400/20 , C10G2400/22 , C10G2400/30 , Y02E50/32 , Y02E50/343
摘要： In this invention, a portion of the products from a pyrolysis reactor are reacted in a process to form one or more chemical intermediates.

5. 发明申请

US20170349529A1 Method to Prepare Phenolics from Biomass 审中-公开
公开(公告)号：US20170349529A1
公开(公告)日：2017-12-07
申请号：US15544172
申请日：2016-01-18
申请人： Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO
发明人： Marc CROCKATT , Jan Harm URBANUS , Paul Mathijs KONST , Martijn Constantijn DE KONING
IPC分类号： C07C67/347 , C07C51/367 , C07C51/09 , C07C231/02 , C07C37/00
CPC分类号： C07C67/347 , C07C37/002 , C07C37/20 , C07C37/50 , C07C37/62 , C07C51/09 , C07C51/367 , C07C67/08 , C07C67/31 , C07C67/317 , C07C213/02 , C07C231/02 , C07C69/84 , C07C65/03 , C07C39/07 , C07C235/60 , C07C235/46 , C07C69/78 , C07C63/06 , C07C215/76 , C07C39/04 , C07C69/157 , C07C39/11 , C07C39/20 , C07C39/24 , C07C65/10
摘要： The present invention is directed to a method for preparing a final phenolic product from biomass comprising the steps of providing a furanic compound obtainable from biomass; reacting the furanic compound with a dienophile to obtain a phenolic compound; reacting the phenolic compound further to obtain the final phenolic product.

6. 发明申请

US20170044121A1 TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMAECUTICAL USE 审中-公开
标题翻译： TETRA-O-取代的丁烷修饰的NDGA衍生物，其合成和药物使用
公开(公告)号：US20170044121A1
公开(公告)日：2017-02-16
申请号：US15339822
申请日：2016-10-31
申请人： Jonathan Daniel Heller , Qingqi Chen , Rocio Alejandra Lopez , Amanda Jean Morris
发明人： Jonathan Daniel Heller , Qingqi Chen , Rocio Alejandra Lopez , Amanda Jean Morris
IPC分类号： C07D295/088 , C07D277/24 , C07C217/54 , C07C43/205
CPC分类号： C07D295/088 , C07C37/50 , C07C39/21 , C07C39/367 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C47/27 , C07C47/273 , C07C217/20 , C07C217/54 , C07C255/33 , C07D277/24 , C07C39/16
摘要： The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
摘要翻译：本发明涉及去甲二氢愈创木酸衍生物化合物，即丁烷桥改性的二氢愈创木酸（NDGA）化合物和丁烷桥改性的四-O-取代的NDGA化合物，含有它们的药物组合物，制备它们的方法及其使用方法和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HPV感染或HSV感染引起的或与病毒感染相关的疾病，诸如各种类型的关节炎和炎症性肠病的炎性疾病，代谢疾病，如糖尿病和高血压，或增殖性疾病，如各种类型的癌症。

7. 发明授权

US09517987B1 Renewable bisphenols and resins from salicylic acid 有权
标题翻译：水杨酸可再生双酚和树脂
公开(公告)号：US09517987B1
公开(公告)日：2016-12-13
申请号：US14692362
申请日：2015-04-21
申请人： The United States of America as represented by the Secretary of the Navy
发明人： Benjamin G. Harvey , Heather A. Meylemans , Michael E. Wright , Andrew Chafin
IPC分类号： C08G64/20 , C08G64/24 , C08G64/28 , C07C37/20 , C07C37/00 , C08G64/30 , C08G73/00 , C08L69/00 , C08K7/14 , C08K7/06 , C07C39/16 , C08L79/00 , C08G64/06
CPC分类号： C07C37/20 , C07C37/002 , C07C37/50 , C07C51/353 , C08G8/10 , C08G8/12 , C08G64/06 , C08G64/24 , C08G64/28 , C08G64/307 , C08L69/00 , C07C65/105 , C07C39/16 , C07C39/04
摘要： A method for the selective synthesis of bisphenols, thermosetting resins, and thermoplastics from salicylic acid, the major component of wintergreen oil, and a viable target for engineered biosynthesis. Condensation of salicylic acid, structural analogs of salicylic acid, and derivatives of salicylic acid with short chain aldehydes or ketones and subsequent decarboxylation has the potential to produce bisphenols that are direct replacements for conventional resins, while the steric and electronic effects of salicylic acid improve the efficiency and selectivity of the conversion process. The utilization of renewable polyphenols as precursors to epoxies, poly carbonates, and high temperature thermosets including cyanate esters, provides an opportunity to develop full-performance resins while reducing the use of petroleum based feedstocks. This approach will then diminish the overall environmental impact of resin production while allowing for a sustainable source of phenols.
摘要翻译：一种从水杨酸，冬青油的主要组分选择性合成双酚，热固性树脂和热塑性塑料的方法，以及工程生物合成的可行目标。水杨酸的缩合，水杨酸的结构类似物和水杨酸的衍生物与短链醛或酮和随后的脱羧有可能生产直接替代常规树脂的双酚，而水杨酸的空间和电子效应改善了转换过程的效率和选择性。可再生多酚作为环氧树脂，聚碳酸酯和高温热固性物质（包括氰酸酯）的前体的利用提供了开发全性能树脂同时减少使用石油基原料的机会。然后，这种方法将减少树脂生产的总体环境影响，同时允许可持续的酚类来源。

8. 发明申请

US20160355471A1 PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES 审中-公开
公开(公告)号：US20160355471A1
公开(公告)日：2016-12-08
申请号：US15238665
申请日：2016-08-16
申请人： THERACOS SUB, LLC
发明人： Jacques ROBERGE , Carine VAXELAIRE , Baohu LIU , Ge XU , Jian ZHANG , Xinxing TANG , Baihua XU
IPC分类号： C07C309/73 , C07C41/24 , C07C303/28
CPC分类号： C07C309/73 , C07B2200/05 , C07B2200/13 , C07C37/055 , C07C37/50 , C07C41/09 , C07C41/16 , C07C41/24 , C07C41/26 , C07C41/40 , C07C303/28 , C07C309/75 , C07C2601/02 , C07C39/367 , C07C43/225 , C07C43/196
摘要： Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.

9. 发明授权

US09382178B2 Process for producing phenol 有权
标题翻译：苯酚生产工艺
公开(公告)号：US09382178B2
公开(公告)日：2016-07-05
申请号：US14787862
申请日：2014-04-09
申请人： ExxonMobil Chemical Patents Inc.
发明人： Bryan A. Patel , John S. Coleman
IPC分类号： C07C45/53 , C07C37/08 , C07C2/66 , C07C37/50 , C07C2/74 , C07C407/00 , C07C409/14
CPC分类号： C07C37/50 , C07C2/74 , C07C37/08 , C07C45/53 , C07C407/00 , C07C409/14 , C07C2529/70 , C07C2601/14 , C07C39/04 , C07C49/403 , C07C13/28
摘要： In a process for producing phenol and cyclohexanone, reaction components comprising cyclohexylbenzene hydroperoxide and an acid catalyst are supplied to a cleavage reaction zone, mixed under mixing conditions effective to combine the reaction components into a reaction mixture and at least part of the cyclohexylbenzene hydroperoxide in the reaction mixture is converted under cleavage conditions to into phenol and cyclohexanone; and a cleavage effluent is recovered from the cleavage reaction zone. The cleavage and mixing conditions are controlled such that the ratio tR/tM is at least 10, where tR is the half-life of cyclohexylbenzene hydroperoxide under the cleavage conditions and tM is the time required after injection of a tracer material into the reaction mixture under the mixing conditions for at least 95% by volume of the entire reaction mixture to attain at least 95% of the volume-averaged tracer material concentration.
摘要翻译：在生产酚和环己酮的方法中，将包含环己基苯氢过氧化物和酸催化剂的反应组分供应至裂解反应区，在有效将反应组分混合成反应混合物和至少部分环己基苯氢过氧化物的混合条件下混合，在裂解条件下将反应混合物转化成苯酚和环己酮; 并从裂解反应区回收裂解流出物。控制裂解和混合条件使得tR / tM的比例至少为10，其中t R是在切割条件下环己基苯氢过氧化物的半衰期，tM是将示踪材料注入反应混合物中所需的时间整个反应混合物的至少95体积％的混合条件达到体积平均示踪剂材料浓度的至少95％。

10. 发明授权

US09340475B2 Process for generating hemp oil with a high cannabidiol (CBD) content 有权
标题翻译：生产大麻油（CBD）含量高的麻油的方法
公开(公告)号：US09340475B2
公开(公告)日：2016-05-17
申请号：US14791184
申请日：2015-07-02
申请人： CANNAVEST CORP.
发明人： Michael J. Mona, III , Joshua A. Hartsel , Greg Waterbury
IPC分类号： C07C37/50 , C07C37/70 , B65D75/36 , B65D73/00
CPC分类号： C07C37/50 , B01D3/106 , B01D3/148 , B65D73/0092 , B65D75/367 , C07C37/70 , C07C37/74 , C07C2601/16 , C07D311/80 , C11B3/00 , C11B3/001 , C11B3/12
摘要： A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.
摘要翻译：一种生产大麻油的方法，包括大麻油中CBDA的脱羧作用; CBD从脱羧大麻油短路蒸发生产CBD油; 对脱羧大麻油进行选择性THC至CBN转化。

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