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1. 发明公开

US20240269074A1 LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS 审中-公开
公开(公告)号：US20240269074A1
公开(公告)日：2024-08-15
申请号：US18617058
申请日：2024-03-26
申请人： SUZHOU ABOGEN BIOSCIENCES CO., LTD.
发明人： Bo YING , Xiulian WANG
IPC分类号： A61K9/16 , C07C217/28 , C07C219/06 , C07C229/16 , C07C229/22 , C07C235/06 , C07D207/24 , C07D295/13
CPC分类号： A61K9/1617 , C07C217/28 , C07C219/06 , C07C229/16 , C07C229/22 , C07C235/06 , C07D207/24 , C07D295/13 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

2. 发明公开

US20240238212A1 LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS 审中-公开
公开(公告)号：US20240238212A1
公开(公告)日：2024-07-18
申请号：US18558353
申请日：2023-01-18
申请人： SUZHOU ABOGEN BIOSCIENCES CO., LTD.
发明人： XiuLian WANG , Bo YING
IPC分类号： A61K9/51 , A61K39/00 , C07C217/28 , C07C217/40 , C07C219/06
CPC分类号： A61K9/5123 , A61K39/0011 , C07C217/28 , C07C217/40 , C07C219/06
摘要： Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

3. 发明申请

US20180044280A1 Y-TYPE DISCRETE POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREOF 审中-公开
公开(公告)号：US20180044280A1
公开(公告)日：2018-02-15
申请号：US15791405
申请日：2017-10-23
申请人： JENKEM TECHNOLOGY CO., LTD. (BEIJING)
发明人： Hui ZHU , Meina LIN , Xiaomeng CHEN , Zhen'gang ZHU , Xuan ZHAO
IPC分类号： C07C217/28 , C08G65/26 , C07C213/06
CPC分类号： C07C217/28 , C07C213/02 , C07C213/06 , C07C217/08 , C08G65/2618 , C08G65/33306 , C08G65/33396 , C08G65/3344 , C08G2650/30 , C08G2650/50
摘要： The present invention discloses a Y-type discrete polyethylene glycol derivative and a preparation method thereof, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative, meanwhile the preparation method has simple steps, mild conditions, without need for strictly anhydrous environment or performing protection and deprotection steps. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.

4. 发明申请

US20160324781A1 NOVEL LIPIDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS 有权
公开(公告)号：US20160324781A1
公开(公告)日：2016-11-10
申请号：US15219602
申请日：2016-07-26
申请人： AXOLABS GMBH
发明人： Rainer CONSTIEN , Anke GEICK , Philipp HADWIGER , Torsten HANEKE , Ludger ICKENSTEIN , Carla Alexandra HERNANDEZ PRATA , Andrea SCHUSTER , Timo WEIDE
IPC分类号： A61K9/14 , C07D241/04 , A61K31/713 , C07D295/13
CPC分类号： A61K9/145 , A61K9/1271 , A61K31/575 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K38/02 , A61K39/00 , A61K47/18 , A61K47/22 , B82Y5/00 , C07C211/11 , C07C211/13 , C07C211/14 , C07C211/22 , C07C217/08 , C07C217/28 , C07C217/42 , C07D241/04 , C07D295/13 , C07D295/30
摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

5. 发明授权

US09441168B2 Low interfacial tension surfactants for petroleum applications 有权
公开(公告)号：US09441168B2
公开(公告)日：2016-09-13
申请号：US14258364
申请日：2014-04-22
申请人： SOANE ENERGY, LLC
发明人： David S. Soane , Rosa Casado Portilla , John H. Dise , Robert P. Mahoney
IPC分类号： C10G21/20 , C09K8/524 , C09K8/60 , C10G1/04 , C10G31/08 , C09K8/584 , C10G21/16
CPC分类号： C10G1/045 , C07C69/593 , C07C69/612 , C07C217/28 , C07C235/76 , C07C235/84 , C09K8/524 , C09K8/584 , C09K8/604 , C10G1/047 , C10G21/16 , C10G21/20 , C10G31/08 , C10G2300/206
摘要： The invention relates to a class of novel surfactants that have utility in the recovery and/or extraction of oil.

6. 发明授权

US09433681B2 Lipids and compositions for intracellular delivery of biologically active compounds 有权
公开(公告)号：US09433681B2
公开(公告)日：2016-09-06
申请号：US14178538
申请日：2014-02-12
申请人： AXOLABS GMBH
发明人： Rainer Constien , Anke Geick , Philipp Hadwiger , Torsten Haneke , Ludger Markus Ickenstein , Carla Alexandra Hernandez Prata , Andrea Schuster , Timo Weide
IPC分类号： C07C211/22 , C07D295/30 , C07D241/04 , A61K31/713 , A61K31/7088 , C07C211/11 , C07C211/13 , A61K47/18 , A61K31/575 , A61K31/70 , B82Y5/00 , C07C217/42 , C07C211/14 , C07C217/08 , C07C217/28 , A61K9/127 , A61K9/14 , A61K38/02 , A61K47/22 , A61K39/00
CPC分类号： A61K9/145 , A61K9/1271 , A61K31/575 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K38/02 , A61K39/00 , A61K47/18 , A61K47/22 , B82Y5/00 , C07C211/11 , C07C211/13 , C07C211/14 , C07C211/22 , C07C217/08 , C07C217/28 , C07C217/42 , C07D241/04 , C07D295/13 , C07D295/30
摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

7. 发明授权

US09371271B2 Method for manufacturing tertiary amino group-containing lipid 有权
标题翻译：制备含叔氨基脂质的方法
公开(公告)号：US09371271B2
公开(公告)日：2016-06-21
申请号：US14412546
申请日：2013-06-21
申请人： NOF CORPORATION
发明人： Kazuhiro Kubo , Kota Tange , Masaki Ohta
IPC分类号： C07C213/06 , C07D295/08
CPC分类号： C07C213/06 , C07D295/08 , C07C217/28
摘要： In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from a cis form to a trans form is suppressed.A compound represented by the following formula (I): R1—X (I) (in Formula, R1 represents a hydrocarbon group having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule and having the carbon number of 8 to 24 and X represents a releasing group) is reacted with (B) a compound having at least one of each of tertiary amino group and hydroxyl group in the molecule in a saturated hydrocarbon solvent having the carbon number of 5 to 10 in the presence of an alkali catalyst.
摘要翻译：在分子中具有夹在相邻的两个顺式形式双键之间的至少一个亚甲基的阳离子脂质的生产中，抑制了从顺式形式到反式形式的异构化。由下式（I）表示的化合物：R1-X（I）（式中，R1表示分子中相邻的两个顺式双键之间具有至少一个亚甲基的碳原子数为8的烃基至24，X表示脱模基团）与（B）在分子中具有碳数为5〜10的饱和烃溶剂中的叔氨基和羟基中的至少一个的化合物在存在下反应碱催化剂。

8. 发明申请

US20150320786A1 COMPOUNDS SUITED AS NANOCARRIERS FOR ACTIVE AGENTS AND THEIR USE 有权
标题翻译：化合物作为活性剂的纳米颗粒及其使用
公开(公告)号：US20150320786A1
公开(公告)日：2015-11-12
申请号：US14803155
申请日：2015-07-20
申请人： Ramot at Tel-Aviv University Ltd. , Freie Universitaet Berlin
发明人： Rainer HAAG , Wiebke FISCHER , Abdul Mohiuddin QUADIR , Ronit SATCHI-FAINARO , Paula OFEK
IPC分类号： A61K31/713 , C07C229/22 , A61K45/06 , C12N15/113 , C07C271/20
CPC分类号： A61K31/713 , A61K45/06 , C07C217/28 , C07C229/22 , C07C271/20 , C12N15/1135
摘要： The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.
摘要翻译：本发明涉及一种适合作为实体载体的化合物，具有通式（I），其中X为本文进一步定义的含胺残基。本发明还涉及这样的化合物，纳米载体系统，包含这些化合物的试剂盒和用于基因沉默和抗癌治疗的方法的用途。

9. 发明申请

US20150299100A1 SULFIDE SCAVENGERS, METHODS FOR MAKING AND METHODS FOR USING 有权
标题翻译： SULFIDE SCAVENGERS，制造方法和使用方法
公开(公告)号：US20150299100A1
公开(公告)日：2015-10-22
申请号：US14755269
申请日：2015-06-30
申请人： General Electric Company
发明人： Gregory Kaplan
IPC分类号： C07C213/00 , C02F1/68 , C10L3/10 , C10G29/20 , C07C217/42 , C07C217/28
CPC分类号： C07C213/00 , C02F1/68 , C02F2101/101 , C02F2305/00 , C07C217/28 , C07C217/42 , C10G29/20 , C10G29/24 , C10G2300/207 , C10L3/103 , C10L2290/545
摘要： Methods for making sulfide scavenging compositions are provided. The method comprises reacting at least one secondary amine with at least one aldehyde and solvent in the presence of a catalyst to form a reaction composition, wherein a reaction temperature is less than or equal to 90° C. Sulfide scavengers using the above method are also disclosed. Methods for removing sulfides from fluid streams are also provided. The methods include adding the above sulfide scavengers to fluid streams.
摘要翻译：提供了制备硫化物清除组合物的方法。该方法包括在催化剂存在下使至少一种仲胺与至少一种醛和溶剂反应以形成反应组合物，其中反应温度小于或等于90℃。使用上述方法的硫化物清除剂也是披露还提供了从流体流中除去硫化物的方法。所述方法包括将上述硫化物清除剂加入到流体流中。

10. 发明授权

US09139456B2 Chelating compounds and immobilized tethered chelators 有权
标题翻译：螯合化合物和固定的束缚螯合剂
公开(公告)号：US09139456B2
公开(公告)日：2015-09-22
申请号：US13278498
申请日：2011-10-21
申请人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Robert Joseph Kuhn , Surendra Dawadi
发明人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Robert Joseph Kuhn , Surendra Dawadi
IPC分类号： C02F1/68 , B01J20/32 , B01J45/00 , C07C217/28 , C07C255/13 , C07C259/06 , C07C311/17 , C02F101/20 , B01D15/38
CPC分类号： C02F1/683 , B01D15/3828 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J45/00 , C02F2101/20 , C07C217/28 , C07C255/13 , C07C259/06 , C07C311/17
摘要： Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.
摘要翻译：提出了可用作螯合剂的新型化合物，其制备中间体和从溶液中除去三价和四价金属离子的方法。

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