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1. 发明授权

US08691970B2 Phosphoramidite compound and method for producing oligo-RNA 有权
标题翻译：亚磷酰胺化合物及其制备方法
公开(公告)号：US08691970B2
公开(公告)日：2014-04-08
申请号：US11574308
申请日：2005-08-25
申请人： Tadaaki Ohgi , Kouichi Ishiyama , Yutaka Masutomi
发明人： Tadaaki Ohgi , Kouichi Ishiyama , Yutaka Masutomi
IPC分类号： C07H19/04 , C07H21/02
CPC分类号： C07C255/13 , C07H19/067 , C07H19/167 , C07H21/02 , Y02P20/55 , Y02P20/582
摘要： An object of the present invention is to provide a useful and novel phosphoramidite compound for the synthesis of oligo-RNA.A phosphoramidite compound represented by general formula (1), wherein: BX represents a nucleobase optionally having a protecting group; and R1 is a substituent represented by general formula (2), wherein: R11, R12 and R13 are the same or different and each represents hydrogen or alkoxy; R2a and R2b are the same or different and each represents alkyl, or R2a and R2b taken together with the adjacent nitrogen atom may form a 5- to 6-membered saturated amino cyclic group, the amino cyclic group optionally having an oxygen or sulfur atom as a ring-composing member in addition to the adjacent nitrogen atom; and WG1 and WG2 are the same or different and each represents an electron-withdrawing group.
摘要翻译：本发明的目的是提供一种用于合成寡聚RNA的有用和新型的亚磷酰胺化合物。由通式（1）表示的亚磷酰胺化合物，其中：BX表示任选具有保护基的核碱基; 并且R 1是由通式（2）表示的取代基，其中：R 11，R 12和R 13相同或不同，各自表示氢或烷氧基; R2a和R2b相同或不同，各自表示烷基，或者R2a和R2b与相邻氮原子一起可以形成5-至6-元饱和的氨基环状基团，氨基环状基团任选具有氧或硫原子作为除了相邻的氮原子之外的环组成成分; WG1和WG2相同或不同，各自表示吸电子基团。

2. 发明申请

US20070282097A1 Phosphoramidite Compound And Method For Producing Oligo-Rna 有权
标题翻译：亚磷酰胺化合物及其制备方法
公开(公告)号：US20070282097A1
公开(公告)日：2007-12-06
申请号：US11574308
申请日：2005-08-25
申请人： Tadaaki Ohgi , Kouichi Ishiyama , Yutaka Masutomi
发明人： Tadaaki Ohgi , Kouichi Ishiyama , Yutaka Masutomi
IPC分类号： C07H21/02 , C07C43/12
CPC分类号： C07C255/13 , C07H19/067 , C07H19/167 , C07H21/02 , Y02P20/55 , Y02P20/582
摘要： An object of the present invention is to provide a useful and novel phosphoramidite compound for the synthesis of oligo-RNA. A phosphoramidite compound represented by general formula (1), wherein: BX represents a nucleobase optionally having a protecting group; and R1 is a substituent represented by general formula (2), wherein: R11, R12 and R13 are the same or different and each represents hydrogen or alkoxy; R2a and R2b are the same or different and each represents alkyl, or R2a and R2b taken together with the adjacent nitrogen atom may form a 5- to 6-membered saturated amino cyclic group, the amino cyclic group optionally having an oxygen or sulfur atom as a ring-composing member in addition to the adjacent nitrogen atom; and WG1 and WG2 are the same or different and each represents an electron-withdrawing group.
摘要翻译：本发明的目的是提供一种用于合成寡聚RNA的有用和新型的亚磷酰胺化合物。一种由通式（1）表示的亚磷酰胺化合物，其中：B X表示任选具有保护基团的核碱基; 和R 1是由通式（2）表示的取代基，其中：R 11，R 12和R 13， SUP>相同或不同，各自表示氢或烷氧基; R 2a和R 2b相同或不同，各自代表烷基，或R 2a取代R 2b和R 2b 与相邻的氮原子一起可以形成5至6元饱和的氨基环状基团，除了相邻的氮原子之外，氨基环状基团任选地具有作为环组成成分的氧或硫原子; 和WG ^{1和WG 2相同或不同，并且各自表示吸电子基团。}

3. 发明授权

US07163921B1 Peptide derivatives and medicinal compositions 有权
标题翻译：肽衍生物和药物组合物
公开(公告)号：US07163921B1
公开(公告)日：2007-01-16
申请号：US10257238
申请日：2001-04-16
申请人： Kouichi Ishiyama , Tomohiro Terada , Tatsuya Oyama , Tadaaki Ohgi
发明人： Kouichi Ishiyama , Tomohiro Terada , Tatsuya Oyama , Tadaaki Ohgi
IPC分类号： A61K38/07 , A61K38/05 , A61K38/06 , C07K5/08 , C07K7/04
CPC分类号： C07K5/1016 , A61K38/00 , C07K5/0812 , C07K5/1027 , C07K7/56
摘要： The present invention to novel nociceptin receptor agonists which are peptide derivatives represented by the following general formula (1): (in which A is alkylene, —CH2)nCO— or a group expressed by the following formula (2) or (3): wherein n represents an integer of 1 to 8; X and Y are same or different and each represents —CONH— or —CH2NH—; R1, R2 and R3 are same or different and each represents alkyl, aryl or heteroaryl; Z represents —CON(R4)R5 or —CH2N(R4)R5; R4 and R5 are same or different and each represents hydrogen, alkyl, aryl or heteroaryl) or a pharmaceutically acceptable salt thereof. A pharmaceutical composition according to the present invention is useful as a nociceptin receptor agonist.
摘要翻译：本发明涉及由以下通式（1）表示的肽衍生物的新的伤害感受激素受体激动剂：（其中A为亚烷基，-CH 2 O 2）n CO- 或由下式（2）或（3）表示的基团：其中n表示1至8的整数; X和Y相同或不同，各自表示-CONH-或-CH 2 NH-; R 1，R 2和R 3相同或不同，各自表示烷基，芳基或杂芳基; Z表示-CON（R 4）R 5或-CH 2 N（R 4）R SUP > 5 ; R 4和R 5相同或不同，各自表示氢，烷基，芳基或杂芳基）或其药学上可接受的盐。根据本发明的药物组合物可用作伤害感受肽受体激动剂。

4. 发明授权

US06780429B1 Chain-shortened polynucleotide and method for preparation thereof 失效
标题翻译：链缩短的多核苷酸及其制备方法
公开(公告)号：US06780429B1
公开(公告)日：2004-08-24
申请号：US09913521
申请日：2001-08-13
申请人： Shinji Matsuyama , Kouichi Ishiyama , Junzo Seki , Tadaaki Ohgi
发明人： Shinji Matsuyama , Kouichi Ishiyama , Junzo Seki , Tadaaki Ohgi
IPC分类号： A61K9127
CPC分类号： A61K31/7125 , A61K9/1272 , A61K31/7088 , A61K31/713
摘要： The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2′-5′ phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a pharmaceutical composition containing the same, and a method for producing the same.
摘要翻译：本发明提供了一种链缩短的多核苷酸，其中基于整个磷酸二酯键的2'-5'磷酸二酯键的比例高达3％或其盐和含有它们的药物组合物，以及制备相同。

5. 发明授权

US07223857B2 Chain-shortened polynucleotide and method for preparation thereof 失效
标题翻译：链缩短的多核苷酸及其制备方法
公开(公告)号：US07223857B2
公开(公告)日：2007-05-29
申请号：US10873797
申请日：2004-06-22
申请人： Shinji Matsuyama , Kouichi Ishiyama , Junzo Seki , Tadaaki Ohgi
发明人： Shinji Matsuyama , Kouichi Ishiyama , Junzo Seki , Tadaaki Ohgi
IPC分类号： C07H21/00 , C07H21/04 , C12Q1/68
CPC分类号： A61K31/7125 , A61K9/1272 , A61K31/7088 , A61K31/713
摘要： The present invention provides a chain-shortened polynucleotide wherein the proportion of a 2′-5′ phosphodiester bond is up to 3% based on the whole phosphodiester bonds or a salt thereof and a pharmaceutical composition containing the same, and a method for producing the same.
摘要翻译：本发明提供了一种链缩短的多核苷酸，其中基于整个磷酸二酯键的2'-5'磷酸二酯键的比例高达3％或其盐和含有它们的药物组合物，以及制备相同。

6. 发明授权

US06285284B1 Theft preventive tag and method for attaching the same 失效
标题翻译：防盗标签及其附着方法
公开(公告)号：US06285284B1
公开(公告)日：2001-09-04
申请号：US09424588
申请日：1999-11-24
申请人： Takeshi Soe , Masami Miyake , Minoru Nakazato , Kouichi Ishiyama
发明人： Takeshi Soe , Masami Miyake , Minoru Nakazato , Kouichi Ishiyama
IPC分类号： G08B1314
CPC分类号： G08B13/2414 , G08B13/2431 , G08B13/2437 , G08B13/2442 , G08B13/246
摘要： The resonance frequency of a resonant circuit section does not change even if the surface of an article whose theft is monitored is formed of any material. An antitheft tag mounted on the article (11) whose theft is monitored includes a resonant circuit section resonating with the radio wave having a particular frequency and transmitted from a transmitting antenna. An electromagnetic shield layer formed of an insulating material is interposed between the mounting surface of the article and the resonant circuit section. The electromagnetic shield layer may be formed of ferrite powder or soft magnetic powder which has a particle size of 10 &mgr;m or less and plastic or rubber or may be formed by laminating a first layer composed of a composite material and a second layer composed of plastic or rubber. Preferably, the soft magnetic powder is any of amorphous alloy, Permalloy, soft magnetic iron, silicon steel, Sendust alloy and Fe—Al alloy.
摘要翻译：即使被监视的物品的表面由任何材料形成，共振电路部分的谐振频率也不会改变。安装在被监测的物品（11）上的防盗标签包括与具有特定频率的无线电波谐振的谐振电路部分，并从发射天线发射。由绝缘材料形成的电磁屏蔽层介于物品的安装表面和谐振电路部分之间。电磁屏蔽层可以由粒径为10μm以下的铁氧体粉末或软磁性粉末形成，也可以是塑料或橡胶，也可以通过将由复合材料构成的第一层和由塑料构成的第二层橡胶。优选地，软磁性粉末是非晶合金，坡莫合金，软磁铁，硅钢，Sendust合金和Fe-Al合金中的任何一种。

7. 发明授权

US5543070A Magnetic recording powder having low curie temperature and high saturation magnetization 失效
标题翻译：具有低居里温度和高饱和磁化强度的磁记录粉末
公开(公告)号：US5543070A
公开(公告)日：1996-08-06
申请号：US352137
申请日：1994-12-01
申请人： Kouichi Ishiyama , Kazunori Igarashi , Norikazu Komada , Takuo Takeshita , Kiyoyuki Ookubo
发明人： Kouichi Ishiyama , Kazunori Igarashi , Norikazu Komada , Takuo Takeshita , Kiyoyuki Ookubo
IPC分类号： C01G49/00 , C09D5/23 , C09D7/12 , G11B5/706 , C04B35/26
CPC分类号： G11B5/70678 , C01G49/009 , C01P2002/52 , C01P2002/76 , C01P2006/42 , C01P2006/80
摘要： This invention relates to a magnetic recording powder having a low Curie temperature and a high saturation magnetization (.sigma.s). The magnetic recording powder of this invention is of a composite oxide having a hexagonal ferrite type crystal structure comprises: (a) between 14 and 20 atomic % of at least one of strontium oxide and barium oxide, (b) between 15 and 40 atomic % of chromium oxide, (c) between 2 and 15 atomic % of at least one member of the group consisting of zinc oxide, magnesium oxide and copper oxide, (d) between 2 and 15 atomic % of at least one member of the group consisting of titanium oxide, zirconium oxide and tin oxide, with substantial remainder being iron oxide and unavoidable impurities. Further, the magnetic recording powder of this invention is of a composite oxide having saturation magnetization (.sigma.s) of 15 emu/g or higher, and a Curie temperature (Tc) of 155.degree. C. or lower.
摘要翻译：本发明涉及具有低居里温度和高饱和磁化强度（sigma s）的磁记录粉末。本发明的磁记录粉末是具有六方晶系铁氧体晶体结构的复合氧化物，包括：（a）14至20原子％的氧化锶和氧化钡中的至少一种，（b）15至40原子％的氧化铬，（c）2至15原子％的至少一种由氧化锌，氧化镁和氧化铜组成的组中的至少一种，（d）2至15原子％的至少一种组为的氧化钛，氧化锆和氧化锡，其余部分为氧化铁和不可避免的杂质。此外，本发明的磁记录粉末是饱和磁化强度（sigma）为15emu / g以上且居里温度（Tc）为155℃以下的复合氧化物。

8. 发明授权

US5211770A Magnetic recording powder having a high coercive force at room temperatures and a low curie point 失效
标题翻译：在室温下具有高矫顽力和低居里点的磁记录粉末
公开(公告)号：US5211770A
公开(公告)日：1993-05-18
申请号：US921843
申请日：1992-07-29
申请人： Ginya Ishiguro , Kouichi Ishiyama , Yoshinari Ishii , Takuo Takeshita , Hachiro Saito , Yasuaki Yoshioka
发明人： Ginya Ishiguro , Kouichi Ishiyama , Yoshinari Ishii , Takuo Takeshita , Hachiro Saito , Yasuaki Yoshioka
IPC分类号： G03G5/16 , G11B5/706 , H01F1/057
CPC分类号： G03G5/16 , G11B5/70615 , H01F1/0571
摘要： A magnetic recording powder for use as a material for magnetic recording media including magnetic tapes and magnetic cards, the powder having a high coercive force at room temperatures and a low Curie point, consists of at least one element selected from the group consisting of Y and rare-earth elements (R): 5-20 atomic %, B: 5-20 atomic %, Mn: 4-20 atomic %; and Fe and inevitable impurities: the balance. If required, the powder may further contain Al: 1-10 atomic %, and/or Cr: 1-10 atomic %. The powder has a mean particle size of 0.5-2 .mu.m and a mean crystal grain size of 0.1-0.4 .mu.m.
摘要翻译：一种用作磁记录介质的材料的磁记录粉末，包括磁带和磁卡，在室温和低居里点具有高矫顽力的粉末由至少一种选自Y和稀土元素（R）：5-20原子％，B：5-20原子％，Mn：4-20原子％; 和Fe和不可避免的杂质：平衡。如果需要，粉末可以进一步含有Al：1-10原子％和/或Cr：1-10原子％。粉末的平均粒径为0.5〜20μm，平均结晶粒径为0.1-0.4μm。

9. 发明申请

US20130306471A1 SPUTTERING TARGET FOR FORMING MAGNETIC RECORDING MEDIUM FILM AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：用于形成磁记录介质膜的溅射目标及其生产方法
公开(公告)号：US20130306471A1
公开(公告)日：2013-11-21
申请号：US13982443
申请日：2012-01-27
申请人： Kouichi Ishiyama , Sohei Nonaka , Masanori Yosuke , Hideharu Matsuzaki
发明人： Kouichi Ishiyama , Sohei Nonaka , Masanori Yosuke , Hideharu Matsuzaki
IPC分类号： C23C14/34
CPC分类号： C23C14/3414 , B22F3/14 , B22F2998/10 , C22C1/02 , C22C1/0466 , C22C5/04 , C22C32/0084 , C22C38/002 , C22C38/16 , C23C14/3407 , G11B5/851 , H01F10/123 , H01F41/183 , B22F3/24 , B22F9/08
摘要： Provided are a sputtering target for forming a magnetic recording medium film, on which a film having a low ordering temperature can be formed and which can suppress generation of particles, and a method for producing the same. The sputtering target for forming a magnetic recording medium film consists of a sintered body having a composition represented by the general formula: {(FexPt100-x)(100-y)Agy}(100-z)Cz, wherein x, y, and z are represented by atomic percent as 30≦x≦80, 1≦y≦30, and 3≦z≦63. Also, the method for producing the sputtering target has a step of hot pressing a mixed powder of AgPt alloy powder, FePt alloy powder, Pt powder, and graphite powder or carbon black powder in a vacuum or an inert gas atmosphere.
摘要翻译：提供一种用于形成磁记录介质膜的溅射靶，其上可以形成具有低有序温度的膜并且可以抑制颗粒的产生及其制造方法。用于形成磁记录介质膜的溅射靶由具有由以下通式表示的组成的烧结体构成：{（FexPt100-x）（100-y）Agy}（100-z）Cz，其中x，y和 z由原子百分数表示为30 @ x @ 80，1 @ y @ 30和3 @ z @ 63。此外，溅射靶的制造方法具有在真空或惰性气体气氛中热压AgPt合金粉末，FePt合金粉末，Pt粉末，石墨粉末或炭黑粉末的混合粉末的工序。

10. 发明授权

US06304182B1 Apparatus for detecting theft by a radio wave 失效
标题翻译：用于通过无线电波检测盗窃的装置
公开(公告)号：US06304182B1
公开(公告)日：2001-10-16
申请号：US09220443
申请日：1998-12-24
申请人： Tomohiro Mori , Takanori Endo , Kouichi Ishiyama , Tadashi Yonezawa , Masami Miyake , Shigeyuki Osawa , Seiro Yahata
发明人： Tomohiro Mori , Takanori Endo , Kouichi Ishiyama , Tadashi Yonezawa , Masami Miyake , Shigeyuki Osawa , Seiro Yahata
IPC分类号： G08B1314
CPC分类号： G08B13/2414 , G08B13/2477 , G08B13/248
摘要： A burglar detection apparatus has a tag 11 that includes a resonance circuit. The tag is preferably contained with an object 15 whose theft is desired to be detected. The tagged object may be placed in a drawer 14 which is contained in a box 13. A tag detection sensor 16 is installed in the box and detects whether the tag 11 is present in the drawer 14. Also, a drawer sensor 17 detects whether the drawer is opened. Based on respective detection outputs of the tag detection sensor 16 and the drawer sensor 17, a control circuit 19 controls an alarm 18. Advantageously, the apparatus can be installed in a comparatively small space, does not malfunction even if subjected to large amounts of electrical noise, and reliably detects the presence or absence of a tag even if the tag is located near a metal object.
摘要翻译：防盗检测装置具有包括谐振电路的标签11。该标签优选地包含有希望检测其盗窃的物体15。被标签的物体可以放置在包含在盒子13中的抽屉14中。标签检测传感器16安装在盒中并检测标签11是否存在于抽屉14中。而且，抽屉传感器17检测是否抽屉打开。基于标签检测传感器16和抽屉传感器17的各自的检测输出，控制电路19控制报警器18.有利的是，该设备可以安装在相对较小的空间中，即使经受大量电气也不会发生故障噪声，并且即使标签位于金属物体附近，也可靠地检测标签的存在或不存在。

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