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81. 发明申请

US20040096986A1 Pharmaceutical combi-chem purification factory system 审中-公开
标题翻译：药用组合净化厂系统
公开(公告)号：US20040096986A1
公开(公告)日：2004-05-20
申请号：US10705940
申请日：2003-11-13
发明人： Kenneth J. Klein , Kimber D. Fogelman , Vincent L. Worley , Terry A. Berger
IPC分类号： G01N033/558 , C02F001/28 , B01D015/08
CPC分类号： B01L3/5085 , B01D15/247 , B01D15/40 , B01L9/06 , B01L2200/026 , B01L2200/0678 , B01L2300/022 , B01L2300/0829 , G01N1/18 , G01N30/02 , G01N30/80 , G01N30/82 , G01N2035/00217 , G01N2035/00861 , G01N2035/0405
摘要： The invention relates to a system for sample fi-action collection in chromatography, and more specifically for using an extended vessel assembly that increases the total collectible volume of a liquid sample fraction in a single collection vessel in an automated system for collection, purification, and storage of purified sample fractions. The system uses an extended vessel assembly to provide collection of substantially large volumes of liquid fractions from chromatography system, such as a preparatory scale supercritical fluid chromatography (Prep Scale SFC) or preparatory scale liquid chromatography (Prep Scale LC), into a single collection vessel. The invention improves productivity while reducing the need for sample transfer between vessels and reducing the risk of human error. The collected liquid solvent is removed after purification using one of several types of evaporation devices or techniques, such as evaporation at moderate temperature under a vacuum with liquid agitation. Collection vessels are labeled and grouped into labeled racks for tracking, efficient movement between system modules, and storage.
摘要翻译：本发明涉及一种用于色谱法中样品取样操作的系统，更具体地说，涉及使用扩展容器组件，其在用于收集，纯化的自动化系统中增加单个收集容器中的液体样品馏分的总可收集体积储存纯化的样品级分。该系统使用扩展的容器组件来从色谱系统（例如预备量表超临界流体色谱法（Prep Scale SFC）或准备比例液相色谱法（Prep Scale LC））中收集基本上大量的液体馏分到单个收集容器。本发明提高生产效率，同时减少对容器之间的样品转移的需要并降低人为错误的风险。使用几种蒸发装置或技术之一，在纯化后除去收集的液体溶剂，例如在中等温度下在真空下用液体搅拌蒸发。收集容器被标记并分组成标签机架，用于跟踪，系统模块之间的有效移动和存储。

82. 发明申请

US20040048388A1 Microfluidic chip for biomolecule crystallization 失效
标题翻译：用于生物分子结晶的微流控芯片
公开(公告)号：US20040048388A1
公开(公告)日：2004-03-11
申请号：US10328931
申请日：2002-12-23
申请人： Teragenics, Inc.
发明人： John Gilbert , Jaishree Trikha
IPC分类号： G01N001/18 , G01N033/00
CPC分类号： C30B7/00 , B01L3/0248 , B01L3/06 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/0678 , B01L2300/0681 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , C30B29/58 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
摘要翻译：用于结晶蛋白质和其他生物分子的系统包括用于输送含有待结晶的生物分子的溶液的流动通道和与沿流动通道形成的结晶过程相关的一个或多个变电站。该系统通过使生物分子溶液流过流动通道，然后在微量级上进行透析以设定结晶条件来操作。透析后，通过从生物分子溶液中除去水或溶剂来改变生物分子溶液的浓度，以促进在流动通道的段中形成晶体。可以从流动通道观察并收获形成的晶体。

83. 发明授权

US09962706B2 Sample tube adapters and methods of use thereof 有权
公开(公告)号：US09962706B2
公开(公告)日：2018-05-08
申请号：US15028132
申请日：2014-10-07
申请人： University Of Utah Research Foundation
发明人： Frederick G. Strathmann
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： B01L3/563 , B01L3/50853 , B01L2200/02 , B01L2200/0678 , B01L2200/141 , B01L2300/048 , B01L2300/0829 , B01L2300/0832 , G01N2035/00287
摘要： Sample tube adapters dimensioned to fit into one or more sample tubes in order to prevent carryover or contamination between sample tubes that are adjacent to one another during one or more stages of sample preparation. Methods for use of such sample tube adapters and methods for preventing carryover or contamination between sample tubes that are prepared adjacent to one another are also described. The apparatus described herein was developed to mitigate or eliminate cross-well contamination identified in high-throughput assays, e.g., 96-well based assays. In one embodiment, the apparatus is designed to fit onto the top of a standard 96-well plate and is kept in place during one or more stages of sample preparation, e.g., the entire forced-air drydown portion of sample preparation.

84. 发明授权

US09855557B2 Microplates and methods for protein crystallization and biotechnology 有权
公开(公告)号：US09855557B2
公开(公告)日：2018-01-02
申请号：US14385573
申请日：2013-03-28
申请人： MITEGEN, LLC
发明人： Robert E. Thorne , Benjamin Apker , Robert Newman
IPC分类号： B01L3/00 , C30B35/00 , C12M1/32
CPC分类号： B01L3/5085 , B01L2200/0678 , B01L2300/0829 , B01L2300/0858 , B01L2300/0893 , C12M23/12 , C30B35/002
摘要： Devices and methods for manual and high-throughput protein crystal growth and growth of other biological and organic crystals. A microplate includes a plurality of cells and a frame that defines the cells in the microplate. In each cell there is at least one well open at top. Each well in a cell may be enclosed at bottom, or it may be open at bottom, in which case the well bottom may be sealed by a separate part, which may be, e.g., a separate film or plate (e.g., of plastic, glass or metal) or a molded part.

85. 发明申请

US20170071520A1 METHOD AND APPARATUS FOR ACQUIRING BLOOD FOR TESTING 审中-公开
标题翻译：用于测试血液的方法和装置
公开(公告)号：US20170071520A1
公开(公告)日：2017-03-16
申请号：US15288842
申请日：2016-10-07
申请人： Neoteryx, LLC.
发明人： James Rudge , Emmet Welch , Yibo Guo , Allen A. Bischofberger , Stuart A. Kushon , Peter Rahn
IPC分类号： A61B5/15 , B01L3/00
CPC分类号： A61B5/150358 , A61B5/150022 , A61B5/150213 , A61B5/150305 , A61B5/150343 , A61B5/150351 , A61B5/150755 , B01L3/0275 , B01L3/50 , B01L3/5023 , B01L3/5085 , B01L9/543 , B01L2200/0678 , B01L2300/069 , B01L2300/105 , G01N2001/4027
摘要： A blood sampling device is provided having holder with a manipulating end and an absorbent probe on the opposing end. The probe is of hydrophilic polymer sized to directly absorb a predetermined volume of up to about 30 microliters of blood. Ribs on the holder position the probe within a compartment of a container to prevent contact with the container. The ribs also position the probe within extraction wells.
摘要翻译：提供了一种采血装置，其具有在相对端具有操纵端和吸收探针的保持器。该探针是亲水聚合物，其大小适于直接吸收高达约30微升血液的预定体积。支架上的肋将探头放置在容器的隔室内，以防止与容器接触。肋也将探针放置在提取孔内。

86. 发明授权

US09384942B2 Specimen preparation for transmission electron microscopy 有权
标题翻译：透射电子显微镜样品制备
公开(公告)号：US09384942B2
公开(公告)日：2016-07-05
申请号：US14412653
申请日：2013-07-08
申请人： NATIONAL HEALTH RESEARCH INSTITUTES , MATERIALS ANALYSIS TECHNOLOGY (US) CORP
发明人： Yong-fen Hsieh , Chih-hsun Chu , Pradeep Sharma , Yu-feng Ko , Chung-shi Yang , Lin-ai Tai , Yu-ching Chen , Hsiao-chun Ting
IPC分类号： H01J37/00 , H01J37/26 , B01L3/00 , G01N1/40 , G01N23/02 , G01N1/28 , H01J37/16 , H01J37/22 , H01J37/20
CPC分类号： H01J37/261 , B01L3/508 , B01L2200/0678 , B01L2300/0822 , G01N1/28 , G01N1/4022 , G01N23/02 , G01N2001/4027 , H01J37/16 , H01J37/20 , H01J37/222 , H01J37/3178 , H01J2237/2007 , H01J2237/2602 , H01J2237/2802
摘要： A TEM specimen kit is disclosed, which comprises: (a) a top substrate and a bottom substrate, the top and the bottom substrates being transparent and substantially parallel to each other; (b) a first spacer and a second spacer, located beneath the top substrate and sitting on the bottom substrate, the second spacer being opposite to and spaced apart from the first spacer at a distance of d; and (c) a chamber formed between the top and bottom substrate and between the first and second spacer, the chamber having two ends open to the atmosphere and characterized by having a height defined by the thickness h of the spacer, wherein the height being smaller than the diameter of a red blood cell. Also enclosed are methods for preparing a dry specimen for TEM nanoparticle characterization, and methods for analyzing TEM images of nanoparticles in a liquid sample.
摘要翻译：公开了TEM样本试剂盒，其包括：（a）顶部基底和底部基底，所述顶部和底部基底是透明的并且基本上彼此平行; （b）第一间隔件和第二间隔件，位于顶部基板下方并且位于底部基板上，第二间隔件与第一间隔件相对并间隔开距离d; 和（c）在顶部和底部基底之间以及在第一和第二间隔物之间形成的腔室，该腔室具有通向大气的两个端部，其特征在于具有由间隔物的厚度h限定的高度，其中高度较小比红细胞的直径。还包括用于制备用于TEM纳米颗粒表征的干试样的方法，以及用于分析液体样品中纳米颗粒的TEM图像的方法。

87. 发明授权

US08749777B2 Concentrator and locator device of a solute and method for concentrating and locating a solute 失效
标题翻译：溶质的浓缩器和定位装置以及浓缩和定位溶质的方法
公开(公告)号：US08749777B2
公开(公告)日：2014-06-10
申请号：US13061457
申请日：2009-08-28
申请人： Enzo Mario Di Fabrizio , Giovanni Cuda , Federico Mecarini , Francesco De Angelis , Francesco Gentile
发明人： Enzo Mario Di Fabrizio , Giovanni Cuda , Federico Mecarini , Francesco De Angelis , Francesco Gentile
IPC分类号： G01J3/44
CPC分类号： B01L3/502746 , B01L3/502707 , B01L3/5088 , B01L2200/0678 , B01L2300/089 , B01L2300/0896 , B01L2300/166 , B01L2400/086 , B82Y30/00 , G01N21/554
摘要： Concentrator and locator device (1) of a solute comprising a substrate (2) and a plurality of prismatic lithographic micro-structures (4) orthogonally emerging from the substrate (2). The microstructures (4) are spaced from one another in a periodical manner so as to make such a substrate (2) super-hydrophobic.
摘要翻译：包括基板（2）和从基板（2）正交地出射的多个棱镜光刻微结构（4）的溶质的集中器和定位装置（1）。微结构（4）以周期性方式彼此间隔开，以使这种基底（2）超疏水。

88. 发明申请

US20140154736A1 METHODS FOR SAMPLE STORAGE AND DEVICE THEREOF 有权
标题翻译：用于样品储存的方法及其装置
公开(公告)号：US20140154736A1
公开(公告)日：2014-06-05
申请号：US13690801
申请日：2012-11-30
申请人： GENERAL ELECTRIC COMPANY
发明人： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk
IPC分类号： G01N1/30 , G01N1/31
CPC分类号： G01N1/30 , A01N1/0242 , A01N1/0284 , B01L3/5023 , B01L3/5088 , B01L7/00 , B01L2200/0678 , B01L2300/0825 , B01L2300/126 , B01L2300/1877 , G01N2001/4027 , Y10T436/2525
摘要： A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.
摘要翻译：提供了一种干燥设置在基板上的生物样品的方法。该方法包括提供包括样品加载区域和热源的基底; 激活热源产生热量; 将衬底加热至少高于65℃; 并干燥生物样品。还提供了用于存储样品的装置，其中所述装置包括用于生物样品储存的基底; 以及产生热量以保持至少高于65℃的温度的加热组分。加热组分可以含有一种或多种试剂，其中试剂产生热量以保持至少高于65℃的温度。

89. 发明申请

US20140106462A1 MICROFLUIDIC SYSTEM FOR HIGH-THROUGHPUT, DROPLET-BASED SINGLE MOLECULE ANALYSIS WITH LOW REAGENT CONSUMPTION 有权
标题翻译：微量流动系统，用于高渗透，基于滴液的单分子分析，低试剂消耗
公开(公告)号：US20140106462A1
公开(公告)日：2014-04-17
申请号：US14136671
申请日：2013-12-20
申请人： The Johns Hopkins University
发明人： Jeff T. Wang , Kelvin J. Liu , Christopher M. Puleo , Tushar D. Rane
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , B01L3/502753 , B01L3/502769 , B01L7/52 , B01L2200/0678 , B01L2200/10 , B01L2300/088 , B01L2400/0481 , B01L2400/0655 , G01N1/38 , G01N15/1484 , G01N21/6458 , G01N2001/4027 , G01N2015/0038 , G01N2015/1493 , G01N2021/6419 , G01N2021/6421 , Y10T436/143333
摘要： A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region.
摘要翻译：用于共焦荧光检测系统的微流体装置具有由微流体装置的主体限定的输入通道，由微流体装置的主体限定并与输入通道流体连接的样品浓度部分，由身体限定的混合部分的微流体装置，并且与浓缩部分流体连接;以及检测区域，其对于共聚焦荧光检测系统的照明光至少部分透明，并且当从作为样品的观察样品发射时对荧光至少部分透明流过检测区域。

90. 发明申请

US20140011289A1 ARRANGEMENT FOR PRESERVATION OF BIOLOGICAL SAMPLES 有权
标题翻译：保存生物样本的安排
公开(公告)号：US20140011289A1
公开(公告)日：2014-01-09
申请号：US14005909
申请日：2012-03-15
申请人： Michael John Smith , Stevan Paul Tortorella
发明人： Michael John Smith , Stevan Paul Tortorella
IPC分类号： G01N1/31
CPC分类号： G01N1/312 , B01L3/5029 , B01L3/5055 , B01L7/00 , B01L2200/0678 , B01L2300/0822 , G01N1/2813 , G01N1/44 , G01N2001/2826 , G01N2001/4027 , Y10T436/2525
摘要： The invention relates to an arrangement for drying of biological samples on a sample storage substrate, comprising at least one sample storage substrate holder and at least one chemical heat pad.
摘要翻译：本发明涉及用于干燥样品存储基底上的生物样品的装置，其包括至少一个样品存储基底保持器和至少一个化学加热垫。

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