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61. 发明申请

US20140134110A1 OPTICAL IMAGING PROBES 有权
标题翻译：光学成像探测器
公开(公告)号：US20140134110A1
公开(公告)日：2014-05-15
申请号：US14110616
申请日：2012-04-05
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61K49/00
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0054 , A61K49/0056 , A61K49/006 , G01N21/6428 , G01N21/6458 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
摘要翻译：本发明涉及可视化细胞的方法，特别是尽管不仅仅在体内使用染料，例如由细胞内化的树枝状大分子染料分子或多分支染料分子，从而允许通过共聚焦荧光内显微镜或其它光学检测器随后观察。还提供用于可视化细胞的内部淬灭的探针，特别是虽然不是通过共聚焦荧光内显微镜而不是专门在体内，并且使用内部淬灭的探针与共聚焦荧光内显微镜组合，用于通过探针的内在化和去猝灭来可视化细胞细胞。在特定实施方案中，细胞是活化的嗜中性粒细胞，例如在受试者的肺内。

62. 发明申请

US20140127679A1 Chemical probe compounds that become fluorescent upon reduction, and methods for their use 有权
标题翻译：在还原时变成荧光的化学探针化合物及其使用方法
公开(公告)号：US20140127679A1
公开(公告)日：2014-05-08
申请号：US13975675
申请日：2013-08-26
申请人： Life Technologies Corporation
发明人： Ching-Ying CHEUNG , Diane Gray , Stephen Yue
IPC分类号： G01N33/58 , C12Q1/18
CPC分类号： G01N33/1806 , C07D211/62 , C07D295/112 , C07D401/14 , C07D417/06 , C07D417/14 , C09B23/04 , C12Q1/04 , C12Q1/18 , G01N21/643 , G01N33/52 , G01N33/582 , G01N2021/6432
摘要： Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
摘要翻译：公开了含有荧光团和可还原淬火单元的化学染料化合物。可还原淬火单元在处于氧化状态时淬灭荧光团。在还原时，淬火单元的淬火特性减弱或消除。化合物可用于各种应用，包括检测细菌细胞，监测细菌细胞的电子传递链功能，监测非生物系统的氧化状态，以及测定抗菌剂或抗菌剂的有效性。

63. 发明授权

US08691500B2 Device and method for detecting biomolecule 有权
标题翻译：用于检测生物分子的装置和方法
公开(公告)号：US08691500B2
公开(公告)日：2014-04-08
申请号：US13560285
申请日：2012-07-27
申请人： Sang Kyung Kim , Kyoungja Woo , Yu Ri Choi
发明人： Sang Kyung Kim , Kyoungja Woo , Yu Ri Choi
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34 , G01N21/64
CPC分类号： G01N21/6428 , G01N2021/6432
摘要： Disclosed are a method for detecting a biomolecule including: immobilizing a nucleic acid aptamer capable of specifically binding to a biomolecule to be detected on the surface of a bead on which fluorophores are arranged; hybridizing the nucleic acid aptamer with a guard nucleic acid (g-nucleic acid) labeled with a quencher to quench fluorescence; and reacting a sample including the biomolecule to be detected with the nucleic acid aptamer and detecting a fluorescence signal emitted as the biomolecule binds with the nucleic acid aptamer and the g-nucleic acid labeled with the quencher is separated, and a device for detecting a biomolecule for conducting the detection method. The present disclosure allows for effective, convenient and fast detection of the biomolecule to be detected, enables quantitative analysis, and enables detection of even a trace amount of sample.
摘要翻译：本发明公开了一种检测生物分子的方法，包括：将能够特异性结合待检测的生物分子的核酸适配体固定在配置有荧光体的珠粒的表面上; 将核酸适体与用猝灭剂标记的保护核酸（g-核酸）杂交以淬灭荧光; 并且使包含待检测的生物分子的样品与核酸适配体反应并检测作为生物分子发射的荧光信号与核酸适配体结合，并用猝灭剂标记的g-核酸被分离，并且用于检测生物分子的装置用于进行检测方法。本公开允许有效，方便和快速地检测待检测的生物分子，使得能够进行定量分析，并且甚至能够检测痕量的样品。

64. 发明申请

US20140084181A1 IRREGULAR EXCITATION OF OPTICAL SENSORS 有权
标题翻译：光传感器的不正当激励
公开(公告)号：US20140084181A1
公开(公告)日：2014-03-27
申请号：US14118303
申请日：2012-05-18
申请人： Samuel Walker Inman , Ian W. Hunter
发明人： Samuel Walker Inman , Ian W. Hunter
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , G01J3/0218 , G01J3/4406 , G01N21/6408 , G01N21/7703 , G01N2021/6432 , G01N2021/6484 , G01N2021/772 , G01N2021/7786 , G01N2201/0691
摘要： A material is excited with light whose intensity is modulated according to a modulation signal. The modulation signal includes multiple transitions between at least two intensity levels, with times of at least a first contiguous sequence of the transitions being selected according to an irregular pattern. A response of the material to the excitation is detected.
摘要翻译：材料被激发，其光强度根据调制信号被调制。所述调制信号包括至少两个强度级之间的多个转换，根据不规则图案选择所述转换的至少第一连续序列的时间。检测材料对激发的响应。

65. 发明授权

US08663922B2 Systems and methods for detecting multiple optical signals 有权
标题翻译：用于检测多个光信号的系统和方法
公开(公告)号：US08663922B2
公开(公告)日：2014-03-04
申请号：US12791390
申请日：2010-06-01
申请人： Matthew J. Hayes , Byron J. Knight , Haitao Li , Robert F. Scalese
发明人： Matthew J. Hayes , Byron J. Knight , Haitao Li , Robert F. Scalese
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： To minimize cross talk in systems and methods for detecting two or more different optical signals emitted from each of a plurality of reaction receptacles, an excitation signal associated with each of the optical signals has a known excitation frequency, and any detected signal having a frequency that is inconsistent with the excitation frequency is discarded. The receptacles are moved relative to optical sensors configured to detect each unique optical signal from an associated receptacle, and to further minimize cross talk, the optical sensors are arranged so that only one reaction receptacle at a time is in a signal detecting position with respect to one of its associated optical sensors, and the optical sensors are grouped by the optical signal they are configured to detect so that a first optical signal is detected from each of the reaction receptacles before a second optical signal is detected from the reaction receptacles.
摘要翻译：为了最小化用于检测从多个反应容器中的每一个发射的两个或多个不同光信号的系统和方法中的串扰，与每个光信号相关联的激励信号具有已知的激励频率，并且任何检测信号的频率为与激励频率不一致被丢弃。插座相对于被配置为从相关联的容器检测每个唯一的光信号的光学传感器移动，并且进一步最小化串扰，光学传感器被布置成使得一次只有一个反应容器处于信号检测位置其相关联的光学传感器之一，并且光学传感器被配置为被检测的光信号分组，使得在从反应容器检测到第二光信号之前，从每个反应容器检测第一光信号。

66. 发明授权

US08637436B2 Integrated semiconductor bioarray 有权
标题翻译：集成半导体生物芯片
公开(公告)号：US08637436B2
公开(公告)日：2014-01-28
申请号：US11844996
申请日：2007-08-24
申请人： Arjang Hassibi
发明人： Arjang Hassibi
IPC分类号： C40B50/18 , C40B30/04
CPC分类号： C12Q1/6837 , C40B30/04 , G01N21/6428 , G01N21/6454 , G01N33/54373 , G01N2021/6432 , H01L27/1446
摘要： A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
摘要翻译：用于基于亲和力的测定的生物传感器阵列，系统和方法，其能够同时获得多个分析物的结合特征的高质量测量，并且能够确定溶液中的那些分析物的量。本发明还提供用于检测基于亲和力的测定的实时特性的完全整合的生物阵列。

67. 发明申请

US20130344619A1 GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器
公开(公告)号：US20130344619A1
公开(公告)日：2013-12-26
申请号：US13686760
申请日：2012-11-27
申请人： LIGHTSHIP MEDICAL LIMITED
发明人： Barry Colin Crane , William Paterson , Nicholas Paul Barwell , Peter Edgley
IPC分类号： G01N33/66 , A61B5/1459 , A61B5/1473 , A61B5/145
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/1473 , G01N21/6408 , G01N21/6428 , G01N21/7703 , G01N27/3271 , G01N2021/6432 , G01N2021/6434 , G01N2021/6441 , G01N2021/6484 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N2021/7793
摘要： A method of quantifying the amount of glucose in a sample is provided herein that may further comprise an interferent such as mannitol. At least two measurements are obtained using measurement methods that differ in their sensitivity to the amount of interferent in the sample, thus enabling the results to be compared to determine whether any interferent is present in the sample. A glucose sensor for carrying out a method described herein is also provided
摘要翻译：本文提供了定量样品中葡萄糖量的方法，其可以进一步包含诸如甘露醇之类的干扰物。使用测量方法获得至少两个测量值，这些测量方法的灵敏度与样品中干扰物的数量不同，从而使结果能够比较，以确定样品中是否存在任何干扰物。还提供了用于执行本文所述的方法的葡萄糖传感器

68. 发明申请

US20130256515A1 ADJUSTMENT OF MEASUREMENT SYSTEM COMPONENTS 有权
标题翻译：测量系统组件的调整
公开(公告)号：US20130256515A1
公开(公告)日：2013-10-03
申请号：US13432939
申请日：2012-03-28
申请人： David T. Crook , Areef A. Moin
发明人： David T. Crook , Areef A. Moin
IPC分类号： G01J1/42
CPC分类号： G01N21/645 , G01D3/022 , G01N21/643 , G01N2021/6432 , G01N2201/12723
摘要： One aspect provides a system including a sensor adjustment component comprising: a memory device having adjustment information stored therein; signal source capable of producing a signal detectable by a sensor to be adjusted; and one or more processors; wherein the one or more processors are configured to execute program instructions to operate the signal source to produce a predetermined signal pattern detectable by a measurement component of the sensor to be adjusted; and wherein the predetermined signal pattern comprises the adjustment information. Other aspects are disclosed.
摘要翻译：一个方面提供一种包括传感器调节部件的系统，包括：具有存储在其中的调节信息的存储器装置; 信号源能够产生可由传感器检测的信号进行调节; 和一个或多个处理器; 其中所述一个或多个处理器被配置为执行程序指令以操作所述信号源以产生可由待调整的所述传感器的测量部件检测的预定信号图案; 并且其中所述预定信号图案包括所述调整信息。公开其他方面。

69. 发明授权

US08454895B2 Online contaminant detection and removal system 有权
标题翻译：在线污染物检测和清除系统
公开(公告)号：US08454895B2
公开(公告)日：2013-06-04
申请号：US12598627
申请日：2008-05-02
申请人： Karina Yew-Hoong Gin , Trevor R. Garrett
发明人： Karina Yew-Hoong Gin , Trevor R. Garrett
IPC分类号： G01N33/53 , G01N33/533
CPC分类号： G01N21/05 , C02F1/32 , C02F2209/008 , C02F2209/02 , C02F2209/06 , C02F2209/08 , C02F2303/04 , G01N21/6428 , G01N21/645 , G01N33/569 , G01N2021/0325 , G01N2021/6432
摘要： This invention refers to continuous flow devices for detecting and/or removal of contaminants from a liquid stream. The device comprises a cartridge with an inlet and outlet for the liquid stream, a radiation incident and emerging wall portion and optically transparent support material packed in the cartridge such that a liquid stream can pass between voids or spaces formed within the optically transparent material, as well as a radiation source and detector. The support material comprises molecules for capturing at least one contaminant on the surface of the support material and each of the capture molecules comprises at least one reporter group which emits a signal upon binding of the contaminant. Another form of the invention refers to a rotatable support within the liquid stream.
摘要翻译：本发明涉及用于从液体流中检测和/或去除污染物的连续流动装置。该装置包括具有用于液体流的入口和出口的筒，辐射入射和出现的壁部分和填充在筒中的光学透明支撑材料，使得液体流可以在形成在光学透明材料内的空隙或空间之间通过，如以及作为辐射源和检测器。载体材料包括用于捕获载体材料表面上的至少一种污染物的分子，并且每个捕获分子包含至少一个在污染物结合时发出信号的报道基团。本发明的另一种形式是指液体流内的可旋转支撑件。

70. 发明授权

US08445262B2 Method for evaluating analyte 有权
标题翻译：评估分析物的方法
公开(公告)号：US08445262B2
公开(公告)日：2013-05-21
申请号：US12239987
申请日：2008-09-29
申请人： Kenji Arinaga , Ulrich Rant , Simon Scherer , Erika Pringsheim
发明人： Kenji Arinaga , Ulrich Rant , Simon Scherer , Erika Pringsheim
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , G01N33/5438 , G01N2021/6432 , Y10T436/143333
摘要： In an analyte evaluation method for evaluating an analyte, AC voltage is applied between a substrate electrode on a substrate and a counter electrode, and signals obtained from a marker provided on an analyte bound to the substrate electrode are observed, wherein the frequency of the AC voltage is changed and the behavior of the average value of the marker signals is observed. A novel, highly-selective, low-noise method of evaluating a object of evaluation is thus achieved.
摘要翻译：在用于评价分析物的分析物评价方法中，在基板上的基板电极和对置电极之间施加AC电压，并且观察到从与基板电极结合的分析物上提供的标记获得的信号，其中AC的频率电压被改变，并且观察到标记信号的平均值的行为。从而实现了评价评价对象的新颖，高选择性，低噪声的方法。

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