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1. 发明授权

US09549997B2 Optical imaging probes 有权
标题翻译：光学成像探头
公开(公告)号：US09549997B2
公开(公告)日：2017-01-24
申请号：US14110616
申请日：2012-04-05
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , A61K49/00 , G01N21/64
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0054 , A61K49/0056 , A61K49/006 , G01N21/6428 , G01N21/6458 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to methods of visualizing cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalized by the cells and thus permits subsequent visualization by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualizing cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualizing cells by virtue of internalization and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
摘要翻译：本发明涉及可视化细胞的方法，特别是尽管不仅仅在体内使用染料，例如由细胞内化的树枝状大分子染料分子或多分支染料分子，从而允许通过共聚焦荧光内显微镜或其它光学检测器随后观察。还提供用于可视化细胞的内部淬灭的探针，特别是虽然不是通过共聚焦荧光内显微镜而不是专门在体内使用内部淬灭的探针与共聚焦荧光内显微镜组合，用于通过探针的内化和去猝灭来可视化细胞细胞。在特定实施方案中，细胞是活化的嗜中性粒细胞，例如在受试者的肺内。

2. 发明授权

US10434191B2 Optical imaging probes 有权
公开(公告)号：US10434191B2
公开(公告)日：2019-10-08
申请号：US15413139
申请日：2017-01-23
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , A61K49/00 , G01N21/64
摘要： The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.

3. 发明申请

US20140134110A1 OPTICAL IMAGING PROBES 有权
标题翻译：光学成像探测器
公开(公告)号：US20140134110A1
公开(公告)日：2014-05-15
申请号：US14110616
申请日：2012-04-05
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61K49/00
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0054 , A61K49/0056 , A61K49/006 , G01N21/6428 , G01N21/6458 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
摘要翻译：本发明涉及可视化细胞的方法，特别是尽管不仅仅在体内使用染料，例如由细胞内化的树枝状大分子染料分子或多分支染料分子，从而允许通过共聚焦荧光内显微镜或其它光学检测器随后观察。还提供用于可视化细胞的内部淬灭的探针，特别是虽然不是通过共聚焦荧光内显微镜而不是专门在体内，并且使用内部淬灭的探针与共聚焦荧光内显微镜组合，用于通过探针的内在化和去猝灭来可视化细胞细胞。在特定实施方案中，细胞是活化的嗜中性粒细胞，例如在受试者的肺内。

4. 发明申请

US20190106460A1 BINDING INHIBITORS OF THE BETA. TRANSDUCIN REPEAT-CONTAINING PROTEIN 审中-公开
公开(公告)号：US20190106460A1
公开(公告)日：2019-04-11
申请号：US16129700
申请日：2018-09-12
申请人： Mark Bradley , Jeffrey George Andrew Walton , Sunay Vijaykumar Chankeshwara , Mazen Sleiman , George S. Baillie , Lucien Gibson
发明人： Mark Bradley , Jeffrey George Andrew Walton , Sunay Vijaykumar Chankeshwara , Mazen Sleiman , George S. Baillie , Lucien Gibson
IPC分类号： C07K14/00 , C07K7/08 , C07K7/06 , C07K7/64 , A61K38/08 , C12N9/00
摘要： The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (βTrCP), and modulate the activity of βTrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.

5. 发明申请

US20140315784A1 Binding Inhibitors of the Beta. Transducin Repeat-Containing Protein 审中-公开
标题翻译：结合抑制剂的Beta。转导蛋白重复蛋白
公开(公告)号：US20140315784A1
公开(公告)日：2014-10-23
申请号：US14127430
申请日：2012-06-27
申请人： Mark Bradley , Jeffrey George Andrew Walton , Sunay Vijaykumar Chankeshwara , Mazen Sleiman , George S. Baillie , Lucien Gibson
发明人： Mark Bradley , Jeffrey George Andrew Walton , Sunay Vijaykumar Chankeshwara , Mazen Sleiman , George S. Baillie , Lucien Gibson
IPC分类号： C07K14/00 , C07K7/08 , C07K7/64 , C07K7/06
CPC分类号： C07K14/00 , A61K38/00 , A61K38/08 , C07K7/06 , C07K7/08 , C07K7/64 , C12N9/93 , C12Y603/02019 , G01N2333/9015 , G01N2500/04
摘要： The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (PTrCP), and modulate the activity of 13TrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.
摘要翻译：本发明涉及结合含β反式-Ducin重复蛋白（PTrCP）的化合物，并调节13TrCP的活性。特别地，本发明涉及证明优化的结合PTrCP的化合物。本发明还涉及包含这些化合物的药物组合物以及这些化合物作为药物的用途，特别是用于治疗与异常蛋白质降解相关的疾病例如癌症。优选的结合抑制剂是衍生自动力学DSGXXS的肽，例如。 DEGFWE，DDGFWD和琥珀酰-EGFWE。

6. 发明授权

US08716457B2 Nucleobase characterisation 有权
标题翻译：核碱基表征
公开(公告)号：US08716457B2
公开(公告)日：2014-05-06
申请号：US12679221
申请日：2008-09-19
申请人： Mark Bradley , Juan J. Diaz-Mochon
发明人： Mark Bradley , Juan J. Diaz-Mochon
IPC分类号： C12Q1/68 , C07G3/00 , C07H21/00
CPC分类号： C07D239/36 , C07D239/47 , C07D239/54 , C07D405/12 , C07D473/18 , C07D473/34 , C07D498/10 , Y10T436/143333
摘要： The present invention provides modified nucleobase compounds, modified nucleic acid mimetic compounds and various uses thereof. In addition, the invention provides methods for nucleobase characterisation, SNP characterisation and nucleic acid sequencing.
摘要翻译：本发明提供了修饰的核碱基化合物，修饰的核酸模拟化合物及其各种用途。此外，本发明提供了核碱基表征，SNP表征和核酸测序的方法。

7. 发明授权

US06797699B1 Neuroprotective agents 失效
标题翻译：神经保护剂
公开(公告)号：US06797699B1
公开(公告)日：2004-09-28
申请号：US09581397
申请日：2000-10-02
申请人： Lars Eric Sundstrom , Fausto Iannotti , Mark Bradley , Ashley Ker Pringle
发明人： Lars Eric Sundstrom , Fausto Iannotti , Mark Bradley , Ashley Ker Pringle
IPC分类号： C07K506
CPC分类号： C07C279/14 , C07C237/10 , C07D209/20
摘要： Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of carbon atoms in said straight chains of Rb and Rc being 7); R2 and R3 each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1 represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.
摘要翻译：式（I）化合物其中：Q表示脒基，氰基或式XYN-基团（其中X和Y为氢或各种基团）; R“>代表亚烷基; R b和R c各自表示亚烷基，R 3和R c的所述直链中的总碳原子数为7）; R 2和R 3各自表示氢或式R，RCO-，ROCO-或RNHCO-的基团，其中R表示烷基或芳基; 由星号表示的手性碳原子为L构型; Z是芳香族氨基酸残基; n为0或1; R 1表示氢，烷基或芳基; W表示氢，烷基或芳基; 及其药学上可接受的盐具有保护免受由缺血事件引起的神经元损伤的能力。

8. 发明授权

US06572837B1 Fuel processing system 失效
公开(公告)号：US06572837B1
公开(公告)日：2003-06-03
申请号：US09619204
申请日：2000-07-19
申请人： Robert Holland , Gary Schubak , Mark Bradley , Kevin O'Connor , Brant Peppley
发明人： Robert Holland , Gary Schubak , Mark Bradley , Kevin O'Connor , Brant Peppley
IPC分类号： C01B302
CPC分类号： C01B3/501 , C01B3/16 , C01B3/382 , C01B2203/0233 , C01B2203/0244 , C01B2203/0261 , C01B2203/0283 , C01B2203/0288 , C01B2203/0405 , C01B2203/047 , C01B2203/1205 , C01B2203/142 , C01B2203/143 , C01B2203/146
摘要： A method and apparatus for processing a hydrocarbon fuel comprises: a primary fuel processing reactor for converting a feed stream to a first reformate stream comprising hydrogen; a first hydrogen separator located downstream of the primary fuel processing reactor and fluidly connected thereto for receiving the first reformate stream, the first separator comprising a first membrane for separating the first reformate stream into a first hydrogen-rich stream and a first retentate stream; and a secondary fuel processing reactor fluidly connected to the first separator for receiving and converting the first retentate stream to a second reformate stream comprising hydrogen. A fuel cell power generation system includes the present apparatus and a fuel cell stack fluidly connected thereto for receiving hydrogen-rich streams therefrom.

9. 发明授权

US08092078B2 Measurement of melting points of multiple samples 失效
标题翻译：测量多个样品的熔点
公开(公告)号：US08092078B2
公开(公告)日：2012-01-10
申请号：US10575061
申请日：2004-10-11
申请人： Mark Bradley , Jean-Francois Thaburet
发明人： Mark Bradley , Jean-Francois Thaburet
IPC分类号： G01N25/04 , G01K11/06
CPC分类号： G01N25/04
摘要： In a method of measuring a temperature value associated with melting, softening or decomposition of sample substances, an array of samples is deposited onto a support tray. The support tray is placed onto a heating device provided with temperature sensing means, the support tray is illuminated, and the array of samples is observed by a imaging device. WNle varying the temperature of the heating device, the image data from the imaging device is fed to an image recording device and temperature values associated with each feed of image data are also recorded. The image data is reviewed to detect changes in the image, such as image intensity, at each or selected sample locations, and the temperature of the heating device at an image change associated with a change in state of a sample is logged. Image processing software may be used to detect changes in the image, for example in the intensity of the image, at each sample location. The method may be used as a means for rapidly obtaining a melting point value for comparison of the physical characteristics of the members of a library of samples, especially polymer samples.
摘要翻译：在测量与样品物质的熔化，软化或分解相关的温度值的方法中，将样品阵列沉积在支撑盘上。支撑托盘被放置在具有温度检测装置的加热装置上，支撑托盘被照亮，并且通过成像装置观察样品阵列。通过改变加热装置的温度，将来自成像装置的图像数据馈送到图像记录装置，并且还记录与图像数据的每个进给相关联的温度值。检查图像数据以检测图像中的变化，例如在每个或所选样品位置处的图像强度，并记录与样品状态变化相关联的图像变化时加热装置的温度。图像处理软件可用于检测图像的变化，例如在每个采样位置处的图像强度。该方法可以用作快速获得熔点值的手段，用于比较样品库，特别是聚合物样品的成员的物理特性。

10. 发明申请

US20100129550A1 MODIFIED PIGMENTS 审中-公开
标题翻译：改性颜料
公开(公告)号：US20100129550A1
公开(公告)日：2010-05-27
申请号：US11815498
申请日：2005-12-22
申请人： John D. Goddard , Alan R. Pitt , Elizabeth A. Simister , Mark Bradley , Anais F. Ronot
发明人： John D. Goddard , Alan R. Pitt , Elizabeth A. Simister , Mark Bradley , Anais F. Ronot
IPC分类号： B05D5/00 , C08F2/46 , C08F20/56 , C08F120/06 , C08F120/10 , C09D11/10
CPC分类号： C09C3/048 , C01P2004/84 , C01P2006/12 , C01P2006/22 , C01P2006/90 , C09C1/565 , C09C3/04 , C09D11/322 , C09D11/324
摘要： Pigments for inkjet inks are controllably functionalised to improve water-dispersibility, ozone resistance, etc., by irradiation of the pigment particle with high energy radiation, such as gamma radiation in air or by plasma activation, to form a stable functionalisable intermediate pigment particle, then activating the stable functionalisable intermediate, e.g. by heating, in the presence of a functionalising precursor (e.g. a polymer or polymerisable monomer) to form a modified pigment particle having one or more functionalising group grafted onto the pigment particle.
摘要翻译：通过用空气中的γ射线或等离子体激活等高能量辐射照射颜料颗粒，可以可控地使用喷墨油墨的颜料来改善水分散性，耐臭氧性等，以形成稳定的可官能的中间颜料颗粒，然后激活稳定的可功能中间体，例如通过在官能化前体（例如聚合物或可聚合单体）的存在下加热以形成具有接枝到颜料颗粒上的一个或多个官能化基团的改性颜料颗粒。

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