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1. 发明授权

US09549997B2 Optical imaging probes 有权
标题翻译：光学成像探头
公开(公告)号：US09549997B2
公开(公告)日：2017-01-24
申请号：US14110616
申请日：2012-04-05
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , A61K49/00 , G01N21/64
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0054 , A61K49/0056 , A61K49/006 , G01N21/6428 , G01N21/6458 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to methods of visualizing cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalized by the cells and thus permits subsequent visualization by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualizing cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualizing cells by virtue of internalization and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
摘要翻译：本发明涉及可视化细胞的方法，特别是尽管不仅仅在体内使用染料，例如由细胞内化的树枝状大分子染料分子或多分支染料分子，从而允许通过共聚焦荧光内显微镜或其它光学检测器随后观察。还提供用于可视化细胞的内部淬灭的探针，特别是虽然不是通过共聚焦荧光内显微镜而不是专门在体内使用内部淬灭的探针与共聚焦荧光内显微镜组合，用于通过探针的内化和去猝灭来可视化细胞细胞。在特定实施方案中，细胞是活化的嗜中性粒细胞，例如在受试者的肺内。

2. 发明授权

US10434191B2 Optical imaging probes 有权
公开(公告)号：US10434191B2
公开(公告)日：2019-10-08
申请号：US15413139
申请日：2017-01-23
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , A61K49/00 , G01N21/64
摘要： The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.

3. 发明申请

US20140134110A1 OPTICAL IMAGING PROBES 有权
标题翻译：光学成像探测器
公开(公告)号：US20140134110A1
公开(公告)日：2014-05-15
申请号：US14110616
申请日：2012-04-05
申请人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
发明人： Tashfeen Walton , Mark Bradley , Kev Dhaliwal , Nikolaos Avlonitis , Chris Haslett , Neil McDonald , Manuelle Debunne
IPC分类号： A61K49/00
CPC分类号： A61K49/0043 , A61K49/0041 , A61K49/0054 , A61K49/0056 , A61K49/006 , G01N21/6428 , G01N21/6458 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
摘要翻译：本发明涉及可视化细胞的方法，特别是尽管不仅仅在体内使用染料，例如由细胞内化的树枝状大分子染料分子或多分支染料分子，从而允许通过共聚焦荧光内显微镜或其它光学检测器随后观察。还提供用于可视化细胞的内部淬灭的探针，特别是虽然不是通过共聚焦荧光内显微镜而不是专门在体内，并且使用内部淬灭的探针与共聚焦荧光内显微镜组合，用于通过探针的内在化和去猝灭来可视化细胞细胞。在特定实施方案中，细胞是活化的嗜中性粒细胞，例如在受试者的肺内。

4. 发明申请

US20070169844A1 Inverted bottle fluid dispensing system 审中-公开
标题翻译：倒瓶流体分配系统
公开(公告)号：US20070169844A1
公开(公告)日：2007-07-26
申请号：US11318918
申请日：2005-12-27
申请人： Fangzhen Zheng , Neil McDonald , Mark Copelli
发明人： Fangzhen Zheng , Neil McDonald , Mark Copelli
IPC分类号： B65B1/04
CPC分类号： B67D3/0029
摘要： An inverted-bottle fluid dispensing system providing efficient fluid dispensation. Various aspects of the present invention provide a stem comprising an outer surface and an inner surface defining an inner fluid flow cavity. A slot may, for example, provide a flow path between the outer surface and the inner cavity. The slot may, for example, be substantially longitudinally aligned on the stem. The stem may, for example, include a cylindrically shaped portion and a flat portion, at least a portion of which may be longitudinally coextensive with the cylindrically shaped portion. Further for example, the stem may include a plurality of faces culminating in a vertex at a tip, where at least one of the faces may comprise an aperture extending between the outer surface and the inner cavity. Also for example, the stem may comprise a base portion, where the base portion includes at least one aperture extending therethrough.
摘要翻译：提供有效的流体分配的倒瓶流体分配系统。本发明的各个方面提供了一种杆，其包括限定内部流体流动腔的外表面和内表面。例如，槽可以在外表面和内腔之间提供流动路径。槽可以例如在杆上基本上纵向对准。杆可以例如包括圆柱形部分和平坦部分，其至少一部分可以与圆柱形部分纵向共同延伸。此外，例如，杆可以包括多个顶点，其顶端处于顶点，其中至少一个面可以包括在外表面和内腔之间延伸的孔。还例如，杆可以包括基部，其中基部包括延伸穿过其中的至少一个孔。

5. 发明授权

US08511181B2 Variable torque rate test joint 有权
标题翻译：可变转矩试验接头
公开(公告)号：US08511181B2
公开(公告)日：2013-08-20
申请号：US13510462
申请日：2010-11-17
申请人： Adrian James Duffin , John Edward Burton , Peter William Everitt , Neil McDonald , Andrew Wilkins
发明人： Adrian James Duffin , John Edward Burton , Peter William Everitt , Neil McDonald , Andrew Wilkins
IPC分类号： B25B23/14
CPC分类号： G01L3/1464 , G01L3/1457 , G01L5/0042 , G01L5/24 , G01L25/003
摘要： In a variable torque rate test joint, screw-threaded first and second elements are rotated relative to one another by a tool under test. At least one spring beam is cantilevered over a pivot point to exert an axial force between the first and second elements and the torque rate of the test joint can be varied by moving the pivot point to change the axial force. The first element may be a shaft that is fixed during testing and the second element is a nut rotatably mounted on the shaft, whereby the element rotated by the tool has a minimal moment of inertia. Whichever of the first and second elements is held stationary during the test may be mounted in a hub that is locked during the test but can be rotated at the end of the test to reset the test joint. Measurements may be made of the torque and the rotation angle to derive an actual torque rate of the joint, which allows correction of errors by moving the pivot point.
摘要翻译：在可变转矩测试接头中，螺纹的第一和第二元件通过被测工具相对于彼此旋转。至少一个弹簧梁悬挂在枢轴点上以在第一和第二元件之间施加轴向力，并且可以通过移动枢轴点来改变测试接头的扭矩来改变轴向力。第一元件可以是在测试期间被固定的轴，并且第二元件是可旋转地安装在轴上的螺母，由此由工具旋转的元件具有最小的惯性矩。第一和第二元件中的任何一个在测试期间保持固定可以安装在在测试期间被锁定的毂中，但是可以在测试结束时旋转以复位测试接头。可以测量扭矩和旋转角度以导出接头的实际扭矩率，这允许通过移动枢转点来校正误差。

6. 发明申请

US20130125666A1 VARIABLE TORQUE RATE TEST JOINT 有权
标题翻译：可变扭矩率测试接头
公开(公告)号：US20130125666A1
公开(公告)日：2013-05-23
申请号：US13510462
申请日：2010-11-17
申请人： Adrian James Duffin , John Edward Burton , Peter William Everitt , Neil McDonald , Andrew Wilkins
发明人： Adrian James Duffin , John Edward Burton , Peter William Everitt , Neil McDonald , Andrew Wilkins
IPC分类号： G01L3/14
CPC分类号： G01L3/1464 , G01L3/1457 , G01L5/0042 , G01L5/24 , G01L25/003
摘要： In a variable torque rate test joint, screw-threaded first and second elements are rotated relative to one another by a tool under test. At least one spring beam is cantilevered over a pivot point to exert an axial force between the first and second elements and the torque rate of the test joint can be varied by moving the pivot point to change the axial force. The first element may be a shaft that is fixed during testing and the second element is a nut rotatably mounted on the shaft, whereby the element rotated by the tool has a minimal moment of inertia. Whichever of the first and second elements is held stationary during the test may be mounted in a hub that is locked during the test but can be rotated at the end of the test to reset the test joint. Measurements may be made of the torque and the rotation angle to derive an actual torque rate of the joint, which allows correction of errors by moving the pivot point.
摘要翻译：在可变转矩测试接头中，螺纹的第一和第二元件通过被测工具相对于彼此旋转。至少一个弹簧梁悬挂在枢轴点上以在第一和第二元件之间施加轴向力，并且可以通过移动枢轴点来改变测试接头的扭矩来改变轴向力。第一元件可以是在测试期间被固定的轴，并且第二元件是可旋转地安装在轴上的螺母，由此由工具旋转的元件具有最小的惯性矩。第一和第二元件中的任何一个在测试期间保持固定可以安装在在测试期间被锁定的毂中，但是可以在测试结束时旋转以复位测试接头。可以测量扭矩和旋转角度以导出接头的实际扭矩率，这允许通过移动枢转点来校正误差。

7. 发明申请

US20120104031A1 WATER DISPENSER AND METHOD OF OPERATING IT 有权
标题翻译：水分配器及其操作方法
公开(公告)号：US20120104031A1
公开(公告)日：2012-05-03
申请号：US12916658
申请日：2010-11-01
申请人： Neil McDonald , Daniel Capelle , Daniel Brosnan
发明人： Neil McDonald , Daniel Capelle , Daniel Brosnan
IPC分类号： B67D7/00 , B67D7/06 , B67D7/08
CPC分类号： B67D1/0014 , B67D1/0888 , B67D2001/0088 , B67D2210/0001 , B67D2210/00149
摘要： A water dispenser is fluidly connectable to a water source. The water dispenser includes a water tank; a faucet fluidly connected to the water tank and configured to generate an activation signal after being activated; a valve fluidly connectable to the water source and fluidly connected to the water tank; a first float switch movably disposed in the water tank and configured to generate an open signal after moving away from a predetermined position; and a controller operatively connected to the faucet and the first float switch. The controller is configured to open the valve to refill the water tank with water from the water source after the controller receives both the activation signal from the faucet and the open signal from the first float switch. A method of operating the water dispenser is also disclosed.
摘要翻译：水分配器可流体地连接到水源。饮水机包括一个水箱; 水龙头，其流体地连接到所述水箱并且被配置为在被激活之后产生激活信号; 阀可流体连接到水源并且流体连接到水箱; 第一浮动开关，其可移动地设置在所述水箱中，并且构造成在远离预定位置移动之后产生打开信号; 以及可操作地连接到水龙头和第一浮子开关的控制器。控制器被配置为在控制器接收到来自水龙头的启动信号和来自第一浮子开关的打开信号之后，打开阀以从水源向水箱补充水。还公开了一种操作饮水机的方法。

8. 发明授权

US4514036A Cable having a laminated plastic insulating sheath 失效
标题翻译：电缆具有层压塑料绝缘护套
公开(公告)号：US4514036A
公开(公告)日：1985-04-30
申请号：US518328
申请日：1983-08-01
申请人： Neil McDonald
发明人： Neil McDonald
IPC分类号： H01B7/02 , B32B27/00 , B32B27/08 , B32B27/32 , G02B6/44 , H01B3/44 , H01B7/18 , H01B11/18 , G02B5/16 , H01B7/00
CPC分类号： G02B6/4438 , B32B27/08 , H01B3/44 , H01B7/18 , H01B7/188 , Y10T428/2947 , Y10T428/2958
摘要： Considerable problems are experienced with cables when inserting them in conduit. Only a limited length can be inserted in the conduit so that there must be frequent joints in the cable and the outer sheath is often damaged. The present invention provides a laminate which is particularly applicable as the outer sheath on a cable and which includes a first inner layer of plastics and an outer layer of different harder plastics and incompatible with the first layer and bonded to the inner layer by a bonding layer which is a mixture of the plastics of the two layers. The laminate has applications in addition to cable sheaths.
摘要翻译：将电缆插入管道时，电缆会遇到相当大的问题。导管中只能插入有限的长度，使得电缆中必须有频繁的接头，外护套常常损坏。本发明提供了一种特别适用于电缆上的外护套的层压材料，其包括塑料的第一内层和不同硬质塑料的外层，并且与第一层不相容并通过粘合层结合到内层它是两层塑料的混合物。除了电缆护套之外，该层压板还具有应用。

9. 发明授权

US08540118B2 Water dispenser and method of operating it 有权
标题翻译：饮水机及其操作方法
公开(公告)号：US08540118B2
公开(公告)日：2013-09-24
申请号：US12916658
申请日：2010-11-01
申请人： Neil McDonald , Daniel Capelle , Daniel Brosnan
发明人： Neil McDonald , Daniel Capelle , Daniel Brosnan
IPC分类号： B67D1/00
CPC分类号： B67D1/0014 , B67D1/0888 , B67D2001/0088 , B67D2210/0001 , B67D2210/00149
摘要： A water dispenser is fluidly connectable to a water source. The water dispenser includes a water tank; a faucet fluidly connected to the water tank and configured to generate an activation signal after being activated; a valve fluidly connectable to the water source and fluidly connected to the water tank; a first float switch movably disposed in the water tank and configured to generate an open signal after moving away from a predetermined position; and a controller operatively connected to the faucet and the first float switch. The controller is configured to open the valve to refill the water tank with water from the water source after the controller receives both the activation signal from the faucet and the open signal from the first float switch. A method of operating the water dispenser is also disclosed.
摘要翻译：水分配器可流体地连接到水源。饮水机包括一个水箱; 水龙头，其流体地连接到所述水箱并且被配置为在被激活之后产生激活信号; 阀可流体连接到水源并且流体连接到水箱; 第一浮动开关，其可移动地设置在所述水箱中，并且构造成在远离预定位置移动之后产生打开信号; 以及可操作地连接到水龙头和第一浮子开关的控制器。控制器被配置为在控制器接收到来自水龙头的启动信号和来自第一浮子开关的打开信号之后，打开阀以从水源向水箱补充水。还公开了一种操作饮水机的方法。

10. 发明申请

US20050176060A1 Crystal structure 审中-公开
标题翻译：水晶结构
公开(公告)号：US20050176060A1
公开(公告)日：2005-08-11
申请号：US10362026
申请日：2001-08-17
申请人： Neil McDonald , Judith Murray-Rust , James Leiper , Mark McAlister , Patrick John Vallance
发明人： Neil McDonald , Judith Murray-Rust , James Leiper , Mark McAlister , Patrick John Vallance
IPC分类号： G01N23/20 , A61K38/46 , A61K45/00 , A61P3/06 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/06 , A61P25/18 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C12N9/78 , C12N15/55 , C12Q1/34 , G01N33/48 , G01N33/483 , G01N33/68 , G01N33/53 , G01N33/50 , G06F19/00
CPC分类号： C12N9/78 , C07K2299/00 , C12Q1/34 , G01N33/6803
摘要： Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an argininc deliminase (DI) or a fragment thercof to X-ray diffraction measurements and deducing the structural coordinales from the diffraction measurements arc used to identify, screen, characteristic, design or modify a chemical entity. The chemical entities so generated may be used in methods of Therapy or to identify the presence or absence of a DDAH or DI substrate.
摘要翻译：通过使包含二甲基精氨酸二甲基氨基水解酶（DDAH）或其片段的晶体或精氨酸分离酶（DI）或片段抗体的晶体进行X射线衍射测量并从衍射测量中推导结构配位体获得的结构坐标用于鉴定筛选，特征，设计或修改化学实体。如此产生的化学物质可用于治疗方法或鉴定DDAH或DI底物的存在或不存在。

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