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1. 发明授权

US08445262B2 Method for evaluating analyte 有权
标题翻译：评估分析物的方法
公开(公告)号：US08445262B2
公开(公告)日：2013-05-21
申请号：US12239987
申请日：2008-09-29
申请人： Kenji Arinaga , Ulrich Rant , Simon Scherer , Erika Pringsheim
发明人： Kenji Arinaga , Ulrich Rant , Simon Scherer , Erika Pringsheim
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , G01N33/5438 , G01N2021/6432 , Y10T436/143333
摘要： In an analyte evaluation method for evaluating an analyte, AC voltage is applied between a substrate electrode on a substrate and a counter electrode, and signals obtained from a marker provided on an analyte bound to the substrate electrode are observed, wherein the frequency of the AC voltage is changed and the behavior of the average value of the marker signals is observed. A novel, highly-selective, low-noise method of evaluating a object of evaluation is thus achieved.
摘要翻译：在用于评价分析物的分析物评价方法中，在基板上的基板电极和对置电极之间施加AC电压，并且观察到从与基板电极结合的分析物上提供的标记获得的信号，其中AC的频率电压被改变，并且观察到标记信号的平均值的行为。从而实现了评价评价对象的新颖，高选择性，低噪声的方法。

2. 发明申请

US20100133121A1 METHOD FOR EVALUATING TARGET MOLECULES 有权
标题翻译：评估目标分子的方法
公开(公告)号：US20100133121A1
公开(公告)日：2010-06-03
申请号：US12626729
申请日：2009-11-27
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
IPC分类号： G01N27/26
CPC分类号： B82Y15/00 , G01N21/6428 , G01N27/3275 , G01N33/5438 , G01N2021/6432
摘要： A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.
摘要翻译：用于评价与设置有标记的探针分子结合的靶分子的方法包括：在设置在基板上的工作电极和对电极之间施加交流电压; 并且当交流电压的频率发生变化时，使用从标记获得的信号在与工作电极结合的探针分子上，或者信号的平均值，以确定目标的斯托克斯半径或分子量中的至少一个分子，探针分子和靶分子之间的结合速率，它们之间的结合速率常数，它们之间的解离速率和它们之间的解离速率常数。

3. 发明申请

US20080003666A1 Method and apparatus for producing a molecular film with an adjusted density 有权
标题翻译：用于生产具有调节密度的分子膜的方法和设备
公开(公告)号：US20080003666A1
公开(公告)日：2008-01-03
申请号：US11700264
申请日：2007-01-31
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
IPC分类号： C12M1/00
CPC分类号： G01N33/54353
摘要： An object of the present invention is to provide a technique that can adjust a molecular density of the film of functional molecules (e.g. DNA molecules), which is utilized for biochips such as DNA chip, to a desired degree efficiently and easily. The method for producing a molecular film with an adjusted density according to the present invention includes forming a molecular film and adjusting a molecular density. In the forming a molecular film, a molecular film composed of molecules is formed on a conductive substrate, wherein the molecule includes a region capable of binding to the conductive substrate at least in a portion thereof. In the density adjusting, a molecular density of the molecular film is adjusted by desorbing a part of the molecules which make up the molecular film from the conductive substrate.
摘要翻译：本发明的一个目的是提供一种可以有效且容易地调整用于生物芯片如DNA芯片的功能分子（例如DNA分子）的膜的分子密度达到期望的程度的技术。根据本发明的具有调节密度的分子膜的制备方法包括形成分子膜并调节分子密度。在形成分子膜时，在导电性基板上形成由分子构成的分子膜，其中，所述分子具有能够至少部分地与导电性基板结合的区域。在密度调节中，分子膜的分子密度通过从导电性基材上解吸构成分子膜的一部分分子来调节。

4. 发明授权

US08568966B2 Method and apparatus for producing a molecular film with an adjusted density 有权
标题翻译：用于生产具有调节密度的分子膜的方法和设备
公开(公告)号：US08568966B2
公开(公告)日：2013-10-29
申请号：US11700264
申请日：2007-01-31
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
IPC分类号： C12Q1/00
CPC分类号： G01N33/54353
摘要： An object of the present invention is to provide a technique that can adjust a molecular density of the film of functional molecules (e.g. DNA molecules), which is utilized for biochips such as DNA chip, to a desired degree efficiently and easily. The method for producing a molecular film with an adjusted density according to the present invention includes forming a molecular film and adjusting a molecular density. In the forming a molecular film, a molecular film composed of molecules is formed on a conductive substrate, wherein the molecule includes a region capable of binding to the conductive substrate at least in a portion thereof. In the density adjusting, a molecular density of the molecular film is adjusted by desorbing a part of the molecules which make up the molecular film from the conductive substrate.
摘要翻译：本发明的一个目的是提供一种可以有效且容易地调整用于生物芯片如DNA芯片的功能分子（例如DNA分子）的膜的分子密度达到期望的程度的技术。根据本发明的具有调节密度的分子膜的制备方法包括形成分子膜并调节分子密度。在形成分子膜时，在导电性基板上形成由分子构成的分子膜，其中，所述分子具有能够至少部分地与导电性基板结合的区域。在密度调节中，分子膜的分子密度通过从导电性基材上解吸构成分子膜的一部分分子来调节。

5. 发明授权

US08309365B2 Method for evaluating target molecules 有权
标题翻译：靶分子评估方法
公开(公告)号：US08309365B2
公开(公告)日：2012-11-13
申请号：US12626729
申请日：2009-11-27
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
IPC分类号： G01N21/76 , G12Q1/00
CPC分类号： B82Y15/00 , G01N21/6428 , G01N27/3275 , G01N33/5438 , G01N2021/6432
摘要： A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.
摘要翻译：用于评价与设置有标记的探针分子结合的靶分子的方法包括：在设置在基板上的工作电极和对电极之间施加交流电压; 并且当交流电压的频率发生变化时，使用从标记获得的信号在与工作电极结合的探针分子上，或者信号的平均值，以确定目标的斯托克斯半径或分子量中的至少一个分子，探针分子和靶分子之间的结合速率，它们之间的结合速率常数，它们之间的解离速率和它们之间的解离速率常数。

6. 发明申请

US20060040378A1 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 有权
公开(公告)号：US20060040378A1
公开(公告)日：2006-02-23
申请号：US11036367
申请日：2005-01-18
申请人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
发明人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.

7. 发明授权

US08945944B2 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 有权
标题翻译：用于定量测定分析物的装置和方法，确定分子的有效尺寸的方法，将分子附着于基底的方法以及用于检测分子的装置
公开(公告)号：US08945944B2
公开(公告)日：2015-02-03
申请号：US12923588
申请日：2010-09-29
申请人： Kenji Arinaga , Ulrich Rant
发明人： Kenji Arinaga , Ulrich Rant
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.
摘要翻译：提供了一种用于定量测定分析物的装置，以显着提高定量测定的性能。该装置配备有流路，用于捕获和检测分析物的分析物检测单元和用于定量测定分析物的定量测量单元，其中当分析物检测单元检测到分析物时产生的信号被分成多个在定量测量单元处的流动通道中的流动方向上的部件进行处理。还提供了包括用于控制附着在固体表面上的分子的密度的技术。在这些技术中，当分子连接到基底上时，通过在含有分子的溶液中也存在电解质来调节附着分子的密度，以调节电解质的筛选效果，并考虑到有效尺寸一个分子

8. 发明申请

US20070048760A1 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 审中-公开
标题翻译：用于定量测定分析物的装置和方法，确定分子的有效尺寸的方法，将分子附着于基底的方法以及用于检测分子的装置
公开(公告)号：US20070048760A1
公开(公告)日：2007-03-01
申请号：US11430045
申请日：2006-05-09
申请人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
发明人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.
摘要翻译：提供了一种用于定量测定分析物的装置，以显着提高定量测定的性能。该装置配备有流路，用于捕获和检测分析物的分析物检测单元和用于定量测定分析物的定量测量单元，其中当分析物检测单元检测到分析物时产生的信号被分成多个在定量测量单元处的流动通道中的流动方向上的部件进行处理。还提供了包括用于控制附着在固体表面上的分子的密度的技术。在这些技术中，当分子连接到基底上时，通过在含有分子的溶液中也存在电解质来调节附着分子的密度，以调节电解质的筛选效果，并考虑到有效尺寸一个分子

9. 发明申请

US20110100822A1 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 有权
标题翻译：用于定量测定分析物的装置和方法，确定分子的有效尺寸的方法，将分子附着于基底的方法以及用于检测分子的装置
公开(公告)号：US20110100822A1
公开(公告)日：2011-05-05
申请号：US12923588
申请日：2010-09-29
申请人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
发明人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
IPC分类号： G01N27/447 , C12Q1/37
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.
摘要翻译：提供了一种用于定量测定分析物的装置，以显着提高定量测定的性能。该装置配备有流路，用于捕获和检测分析物的分析物检测单元和用于定量测定分析物的定量测量单元，其中当分析物检测单元检测到分析物时产生的信号被分成多个在定量测量单元处的流动通道中的流动方向上的部件进行处理。还提供了包括用于控制附着在固体表面上的分子的密度的技术。在这些技术中，当分子连接到基底上时，通过在含有分子的溶液中也存在电解质来调节附着分子的密度，以调节电解质的筛选效果，并考虑到有效尺寸一个分子

10. 发明授权

US07169617B2 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 有权
公开(公告)号：US07169617B2
公开(公告)日：2007-01-30
申请号：US11036367
申请日：2005-01-18
申请人： Kenji Arinaga , Ulrich Rant
发明人： Kenji Arinaga , Ulrich Rant
IPC分类号： G01N33/543 , G01N33/551 , G01N33/553 , G01N15/06 , G06F19/00
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.

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