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61. 发明申请

US20140163461A1 Method and Apparatus for Mitigating Acute Reoxygenation Injury During Percutaneous Coronary Intervention 有权
标题翻译：经皮冠状动脉介入治疗急性再氧合损伤的方法与装置
公开(公告)号：US20140163461A1
公开(公告)日：2014-06-12
申请号：US14039673
申请日：2013-09-27
申请人： Neil J. Thomas , Gintaras A. Vaisnys
发明人： Neil J. Thomas , Gintaras A. Vaisnys
IPC分类号： A61M1/36 , A61M5/172
CPC分类号： A61M1/3613 , A61M1/1698 , A61M1/32 , A61M1/36 , A61M1/3664 , A61M1/3666 , A61M5/1723 , A61M25/10 , A61M25/104 , A61M2025/1095 , A61M2202/0439 , A61M2205/3306 , A61M2205/3375 , A61M2230/005 , A61M2230/205
摘要： A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.
摘要翻译：描述了用于改善急性冠状动脉综合征期间缺血性心脏组织的管理的系统和方法。该系统结合了基于导管的子系统，其允许在经皮冠状动脉介入期间同时气囊扩张冠状动脉和输注精心控制的灌注液。该系统允许在经皮干预时调节氧气的水平。此外，提供导管和系统用于在干预期间施用具有改进的氧含量的流体，其包括上游流动控制构件以区分目标冠状动脉和心脏的其余部分的灌注。

62. 发明授权

US08685320B2 Oxygenator 有权
标题翻译：氧气机
公开(公告)号：US08685320B2
公开(公告)日：2014-04-01
申请号：US12783889
申请日：2010-05-20
申请人： Mitsuaki Ogihara , Hidetaka Nakayama , Kazuhiro Mizoguchi
发明人： Mitsuaki Ogihara , Hidetaka Nakayama , Kazuhiro Mizoguchi
IPC分类号： A61M1/16 , A61M1/18 , A61M1/34 , A61M1/36 , A61M1/38 , B01D69/08
CPC分类号： A61M1/1698 , A61M1/3627 , A61M1/3633 , A61M2205/366 , A61M2205/7527
摘要： An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.
摘要翻译：有助于避免血液中的气泡通过氧合器的血液出口排出的氧合器包括壳体，壳体中的中空纤维膜束，并由用于气体交换，气体入口的多个中空纤维膜形成，与中空纤维膜的气体通道连通的气体出口，以及血液入口和出血口。过滤构件设置在靠近中空纤维膜束的血液出口侧的一侧，用于捕捉血液中的气泡。血液出口从壳体突出，并且在靠近壳体的血液出口端部附近设置通道扩大部，并具有增大的通道横截面积。通过过滤器构件的血液通过在通过扩大中减速而到达血液出口。

63. 发明授权

US08647569B1 Paracorporeal respiratory assist lung 有权
标题翻译：体外呼吸辅助肺
公开(公告)号：US08647569B1
公开(公告)日：2014-02-11
申请号：US13084100
申请日：2011-04-11
申请人： William J. Federspiel , Brian J. Frankowski , Brendan C. Mack , Scott W. Morley , Meir Rosenberg , Robert G. Svitek
发明人： William J. Federspiel , Brian J. Frankowski , Brendan C. Mack , Scott W. Morley , Meir Rosenberg , Robert G. Svitek
IPC分类号： A61M1/00 , A61M37/00 , B01D63/00 , C02F1/44
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/1086 , A61M1/265 , A61M1/267 , A61M2205/3334 , B01D63/02 , B01D63/16 , B01D2313/10
摘要： A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.
摘要翻译：体外呼吸辅助肺配置有以快速变化的速度旋转的环形圆柱形中空纤维膜（纤维束）。流体（例如血液）被引入装置的中心并且径向通过纤维束。使用旋转致动器（例如，电动机或磁耦合）以快速变化的速度旋转束。纤维束的旋转为流体提供离心动能，给予装置泵送能力，并且可以产生泰勒涡流以增加传质。纤维束的旋转增加了流体和中空纤维之间的相对速度，并增加了传质。可以改变纤维束的孔隙率以增强与血液的气体交换。或者，旋转芯可以与固定纤维束一起使用。

64. 发明申请

US20140030146A1 OXYGENATOR 有权
标题翻译：氧化剂
公开(公告)号：US20140030146A1
公开(公告)日：2014-01-30
申请号：US14041434
申请日：2013-09-30
申请人： TERUMO KABUSHIKI KAISHA
发明人： Kazuhiko TAKEUCHI
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , B01D63/02 , B01D63/026 , B01D69/081 , B01D71/26
摘要： An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30≦ε60 and OD≦4.5×ε are met where ε [μm] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [μm] is the outer diameter of the hollow fiber membrane.
摘要翻译：氧合器包括壳体; 中空纤维膜层，其存储在壳体中并具有多个具有气体交换功能的集成中空纤维膜; 气体入口部分和气体出口部分分别设置在中空纤维膜流明的气体通道的上游和下游; 以及分别设置在中空纤维膜的外部的血液通道的上游和下游的血液入口部分和血液出口部分。中空纤维膜层中的中空纤维膜在一端部和另一端部彼此固定。满足条件30 @ epsilon60和OD@4.5×epsilon，其中epsilon [mum]是在中空纤维膜层的固定部分处的相邻中空纤维膜之间的平均间隔距离，OD [mum]是中空纤维膜层的外径纤维膜。

65. 发明申请

US20130343954A1 COMPACT INTEGRATED BLOOD PUMP OXYGENATOR OR GAS TRANSFER DEVICE WITH HYDROGEL IMPELLER PACKING MATERIAL AND ROLLOVER IMPELLER OUTLET 有权
标题翻译：紧凑型集成血液泵氧化剂或气体传输装置，带有水压叶轮包装材料和滚筒式叶轮出口
公开(公告)号：US20130343954A1
公开(公告)日：2013-12-26
申请号：US13916739
申请日：2013-06-13
申请人： Ension, Inc.
发明人： Mark J. Gartner , Brian J. Fill , Patrick Cahalan , Linda Cahalan
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/1029 , A61M1/122 , A61M1/262 , A61M1/267
摘要： An integrated blood pump oxygenator comprises an an impeller housing supporting an impeller; with an annular hydrogel impeller packing material adjacent the bearings and around the shaft of the impeller. The oxygenator including a rollover outlet in the form of an annular chamber extending around a center pump housing member; and further including an annular chamber within an annular array of hollow fiber membranes in fluid communication with the annular chamber extending from the impeller around the center pump housing; wherein the annular chamber provides substantially perpendicular radial outward cross flow across the membranes.
摘要翻译：集成的血液泵充氧器包括支撑叶轮的叶轮壳体; 与环形水凝胶叶轮包装材料相邻的轴承和叶轮的轴周围。所述充氧器包括围绕中心泵壳体构件延伸的环形室形式的翻转出口; 并且还包括在环形阵列的中空纤维膜内的环形室，其与从中心泵壳体周围的叶轮延伸的环形室流体连通; 其中所述环形室提供穿过所述膜的基本上垂直的径向向外横向流。

66. 发明授权

US08602090B2 Heat exchanger, method for manufacturing the heat exchanger, and method for manufacturing heart-lung machine 有权
标题翻译：热交换器，热交换器的制造方法以及制造心肺机的方法
公开(公告)号：US08602090B2
公开(公告)日：2013-12-10
申请号：US12087360
申请日：2006-12-26
申请人： Tomokazu Niitsuma , Minoru Tanaka
发明人： Tomokazu Niitsuma , Minoru Tanaka
IPC分类号： F28F9/02
CPC分类号： A61M1/1698 , A61M1/3666 , A61M2205/3606 , A61M2205/366 , B29C41/045 , B29C41/20 , B29C65/70 , B29C66/1142 , B29C66/53465 , B29C66/54 , F28D7/0091 , F28D7/16 , F28D2021/005 , F28F9/02 , F28F21/067 , Y10T29/4935 , Y10T29/49357 , Y10T29/49359
摘要： A heat exchange module 12 is formed by stacking pipe groups obtained by fixing a plurality of pipes 1 with use of pipe array holding members 9a to 9d. Flow path forming members 50 are arranged on pipe groups in the uppermost and lowermost layers, and walls 51 and 52 are provided so as to protrude from the outer-side pipe array holding members and the inner-side pipe array holding members. Flow path members 63 are provided between the walls 51 and 52 adjacent to each other so as to allow through holes 53 and 54 to communicate with each other. The heat exchange module 12 is housed in the housing 2, and while rotating the housing 2, a resin material 24 is filled into a space enclosed by the two inner-side pipe array holding members of each pipe group in the housing 2, interstices around the pipes present between an opening 15a of the housing and the outer-side pipe array holding members, and interstices around the pipes present between an opening 15b of the housing and the outer-side pipe array holding members.
摘要翻译：热交换模块12通过使用管阵列保持构件9a至9d固定多个管1而获得的管组而形成。流路形成构件50布置在最上层和最下层的管组上，壁51和52设置成从外侧管阵列保持构件和内侧管阵列保持构件突出。流路构件63设置在彼此相邻的壁51和52之间，以允许通孔53和54彼此连通。热交换模块12容纳在壳体2中，同时在壳体2旋转的同时，将树脂材料24填充到由壳体2中的每个管组的两个内侧管阵列保持构件包围的空间中，存在于壳体的开口15a和外侧管阵列保持构件之间的管以及存在于壳体的开口15b和外侧管阵列保持构件之间的管周围的间隙。

67. 发明申请

US20130288370A1 CYTOPHERESIS CARTRIDGES AND USE THEREOF 审中-公开
标题翻译： CYTOPHERESIS CARTRIDGES及其用途
公开(公告)号：US20130288370A1
公开(公告)日：2013-10-31
申请号：US13878954
申请日：2011-10-14
申请人： H. David Humes , Deborah Buffington , Christopher J. Pino
发明人： H. David Humes , Deborah Buffington , Christopher J. Pino
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61M1/1698 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M2202/0427 , A61M2202/0439 , B01D63/02 , B01D2313/44
摘要： The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions within a subject and to related methods. More particularly, the invention relates to a cytopheretic cartridge that includes a housing and, disposed within the housing, a solid support capable of sequestering activated leukocytes and/or platelets.
摘要翻译：本发明涉及用于治疗和/或预防受试者内的炎性病症的细胞底物盒和相关方法。更具体地说，本发明涉及一种包括壳体和在外壳内设置能够隔离活化的白细胞和/或血小板的固体支持物的细胞底物盒。

68. 发明授权

US08545754B2 Radial design oxygenator with heat exchanger 有权
标题翻译：径向设计加氧器与换热器
公开(公告)号：US08545754B2
公开(公告)日：2013-10-01
申请号：US12428674
申请日：2009-04-23
申请人： Walt L. Carpenter , Robert W. Olsen , Michael J. Hobday , Alford L. McLevish , Christopher J. Plott , Roderick E. Briscoe , Patrick J. Cloutier , Anil Thapa , Ming Li , Kevin McIntosh , Ken Merte
发明人： Walt L. Carpenter , Robert W. Olsen , Michael J. Hobday , Alford L. McLevish , Christopher J. Plott , Roderick E. Briscoe , Patrick J. Cloutier , Anil Thapa , Ming Li , Kevin McIntosh , Ken Merte
IPC分类号： A61M1/00 , A61M1/16
CPC分类号： A61M1/1698
摘要： Disclosed is an apparatus for oxygenating and controlling the temperature of blood in an extracorporeal circuit. The apparatus has an inlet and an outlet that is located radially outward from the inlet in order to define a flowpath through the apparatus. The apparatus comprises: a core that is substantially centrally located in the apparatus and to which blood from a patient can be supplied through the inlet; a heat exchanger comprising a plurality of heat transfer elements that are arranged around the core and between which blood from the core can move radially outward; and an oxygenator comprising a plurality of gas exchange elements that are arranged around the heat exchanger and between which blood from the heat exchanger can move radially outward before exiting the apparatus through the outlet.
摘要翻译：公开了一种用于对体外循环中的血液进行氧化和控制的装置。该装置具有从入口径向向外定位的入口和出口，以便限定穿过该装置的流路。所述装置包括：基本中心地位于所述装置中的芯，并且来自患者的血液可以通过所述入口供应到所述芯; 一种热交换器，包括多个传热元件，所述多个传热元件布置在所述芯部周围，并且来自所述芯体的血液可径向向外移动; 以及包括多个气体交换元件的氧合器，所述多个气体交换元件布置在所述热交换器周围，并且在通过所述出口离开所述设备之前，来自所述热交换器的血液可径向向外移动。

69. 发明申请

US20130226064A1 Portable medical apparatus for cardiopulmonary aid to patients 审中-公开
标题翻译：便携式医疗器械用于患者的心肺辅助
公开(公告)号：US20130226064A1
公开(公告)日：2013-08-29
申请号：US13881224
申请日：2011-11-04
申请人： Daniele Galavotti , Corrado Bellini
发明人： Daniele Galavotti , Corrado Bellini
IPC分类号： A61M1/36
CPC分类号： A61M1/3666 , A61M1/1698 , A61M2209/08
摘要： A portable medical apparatus (1) for cardiopulmonary aid to patients (P) comprises: an extracorporeal circuit (500) for circulating the blood of a patient (P), which in turn comprises a line (200) for drawing venous blood from a patient (P) and a line (300) for returning arterial blood to said patient (P); at least one filtering arrangement (5, 6) placed on said extracorporeal circuit (500); a pumping unit (10) for pumping blood along the extracorporeal circuit (500); a heat exchanger (100) having an exchange body (101) for thermoregulating blood in said extracorporeal circuit (500); an oxygenator unit (111) for blood oxygenation; said medical apparatus comprising a transportable machine body (2) in which at least one seat (21) is formed for removable coupling with said exchange body (101).
摘要翻译：用于对患者（P）进行心肺辅助的便携式医疗设备（1）包括：用于循环患者（P）的血液的体外循环（500），所述体外回路（500）又包括用于从患者抽取静脉血的管线（200）（P）和用于将动脉血返回到所述患者（P）的管线（300）; 放置在所述体外回路（500）上的至少一个过滤装置（5,6）; 用于沿着体外循环（500）泵送血液的泵送单元（10）; 具有用于使所述体外回路（500）中的血液温度调节的交换体（101）的热交换器（100）。用于血氧合的氧合器单元（111）所述医疗设备包括可移动机体（2），其中至少一个座（21）形成为用于与所述交换体（101）可拆卸联接。

70. 发明申请

US20130197420A1 NANOPOROUS MEMBRANES, DEVICES, AND METHODS FOR RESPIRATORY GAS EXCHANGE 审中-公开
标题翻译：用于呼吸气体交换的纳米膜，装置和方法
公开(公告)号：US20130197420A1
公开(公告)日：2013-08-01
申请号：US13522991
申请日：2011-01-19
申请人： William H. Fissell, IV , Harihara Baskaran , Shuvo Roy , Ken Goldman
发明人： William H. Fissell, IV , Harihara Baskaran , Shuvo Roy , Ken Goldman
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , B01D61/00 , B01D63/08 , B01D67/0062 , B01D67/0093 , B01D71/02 , B01D2323/38 , B01D2325/02 , B01D2325/021 , B01D2325/028
摘要： One aspect of the present invention relates to a silicon nanoporous membrane for oxygenating blood. The nanoporous membrane includes a first major surface, a second major surface, and a plurality of pores extending between the first and second major surfaces. The first major surface is for contacting a gas. The second major surface is for contacting blood and is oppositely disposed from said first major surface. The first and second major surfaces define a membrane thickness. Each of the pores is defined by a length, a width, and a height. Each of the pores is separated by a uniform interpore distance.
摘要翻译：本发明的一个方面涉及用于使血液充氧的硅纳米多孔膜。纳米多孔膜包括第一主表面，第二主表面和在第一和第二主表面之间延伸的多个孔。第一个主要表面是用于接触气体。第二主表面用于接触血液并且与所述第一主表面相对地设置。第一和第二主表面限定膜厚度。每个孔由长度，宽度和高度限定。每个孔由均匀的间隙距离分开。

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