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1. 发明申请

US20160000989A1 CARBON DIOXIDE REMOVAL SYSTEM 审中-公开
标题翻译：二氧化碳去除系统
公开(公告)号：US20160000989A1
公开(公告)日：2016-01-07
申请号：US14854926
申请日：2015-09-15
申请人： MAQUET CARDIOPULMONARY GmbH
发明人： Ulrich HAAG , Oliver MÖLLENBERG , Ralf THÖLKE , Mathias NAKEL , Rudolf KOBER
IPC分类号： A61M1/36
CPC分类号： A61M1/3627 , A61M1/1698 , A61M1/3609 , A61M1/3666 , A61M2205/3334 , A61M2205/3368 , A61M2230/202 , A61M2230/205 , A61M2230/208 , B01D19/0031 , B01D63/026 , B01D2313/90
摘要： An extracorporeal blood treatment system including a gas exchange module operatively associated with a gas supply unit and optional pump for removing CO2 from blood. The gas exchange module includes a plurality of short conduits that are uniquely configured and arranged in a gas exchange mat to for efficient CO2 diffusion under conditions of low blood flow.
摘要翻译：一种体外血液处理系统，包括与气体供应单元可操作地相关联的气体交换模块和用于从血液中去除CO 2的可选泵。气体交换模块包括多个短导管，其被独特地构造和布置在气体交换垫中，以在低血流的条件下有效地进行CO 2扩散。

2. 发明授权

US09199023B2 Oxygenator 有权
标题翻译：氧气机
公开(公告)号：US09199023B2
公开(公告)日：2015-12-01
申请号：US14041434
申请日：2013-09-30
申请人： TERUMO KABUSHIKI KAISHA
发明人： Kazuhiko Takeuchi
IPC分类号： A61M1/16 , B01D63/02 , B01D71/26 , B01D69/08
CPC分类号： A61M1/1698 , B01D63/02 , B01D63/026 , B01D69/081 , B01D71/26
摘要： An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30≦ε60 and OD≦4.5×ε are met where ε [μm] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [μm] is the outer diameter of the hollow fiber membrane.
摘要翻译：氧合器包括壳体; 中空纤维膜层，其存储在壳体中并具有多个具有气体交换功能的集成中空纤维膜; 气体入口部分和气体出口部分分别设置在中空纤维膜流明的气体通道的上游和下游; 以及分别设置在中空纤维膜的外部的血液通道的上游和下游的血液入口部分和血液出口部分。中空纤维膜层中的中空纤维膜在一端部和另一端部彼此固定。条件30＆nlE;＆egr 60和OD＆nlE; 4.5×＆egr; 在哪里遇到 [μm]是中空纤维膜层的固定部分的相邻中空纤维膜之间的平均间隔距离，OD [μm]是中空纤维膜的外径。

3. 发明授权

US09156003B2 Methods of making a hollow fiber membrane element adapted for use in water treatment and osmotic processes 有权
标题翻译：制备适用于水处理和渗透过程的中空纤维膜元件的方法
公开(公告)号：US09156003B2
公开(公告)日：2015-10-13
申请号：US14593777
申请日：2015-01-09
申请人： Maher Isaac Kelada
发明人： Maher Isaac Kelada
IPC分类号： B01D63/02 , B01D63/04 , B01D67/00 , B01D69/08 , C02F1/44
CPC分类号： B01D63/022 , B01D63/021 , B01D63/026 , B01D63/043 , B01D2313/20 , B01D2313/21 , B01D2319/022 , C02F1/44 , Y02E10/36 , Y02E50/346 , Y02W10/37 , Y10T29/49787 , Y10T29/49826 , Y10T29/49895 , Y10T156/1062
摘要： A method of making a membrane element adapted for use in water treatment and osmotic pressures, the method comprises providing a plurality of spacer structures having given dimension, placing one or more spacer structures on a hollow fiber (“HF”) assembly platform, extending rows of HFs with spaces having given width therebetween over the one or more spacer structures aligned with the longitudinal axis of the HF assembly platform, forming a membrane element comprising a stack of alternating rows of HFs and intervening spacer structures wherein each HF comprises a hydrophilic semipermeable membrane being adapted to achieve salt rejection of 98.5% or more and exhibiting a surface tension of 35 dynes/cm or more and the given dimensions, a first width and a second width are effective to maintain a Reynolds Number of 3000 or more and the stack maintaining a mechanical integrity at feed pumping pressure of 30 bars or higher.
摘要翻译：一种制备适于用于水处理和渗透压的膜元件的方法，所述方法包括提供具有给定尺寸的多个间隔结构，将一个或多个间隔结构放置在中空纤维（“HF”）组装平台上，在与HF组件平台的纵向轴线对准的一个或多个间隔结构上具有给定宽度的空间的HF，形成包含交替排列的叠层的膜元件和中间隔层结构，其中每个HF包含亲水性半透膜适用于达到98.5％以上的盐析，表现出35达因/厘米或更大的表面张力，给定的尺寸，第一宽度和第二宽度对于保持雷诺数为3000以上，堆叠保持有效进料泵送压力为30巴或更高时的机械完整性。

4. 发明授权

US09138521B2 Device for removing fluid from blood in a patient 有权
公开(公告)号：US09138521B2
公开(公告)日：2015-09-22
申请号：US13532506
申请日：2012-06-25
申请人： Barry A. Solomon , Gregory S. Erman , Frank A. Fazio
发明人： Barry A. Solomon , Gregory S. Erman , Frank A. Fazio
IPC分类号： A61M37/00 , A61M1/16 , A61M1/34 , B01D61/14 , B01D63/02 , B01D65/08
CPC分类号： A61M1/1678 , A61M1/1627 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2205/3331 , A61M2209/088 , B01D61/145 , B01D63/026 , B01D65/08 , B01D2313/10 , B01D2313/12 , B01D2313/21
摘要： An ultrafiltration device and method for the removal of excess fluid in hypervolemic patients and/or removal of toxins in the blood including for patients suffering from either renal or cardiovascular disease is disclosed. An embodiment of the device includes a housing containing multiple large bore hollow fiber membranes which are connected to the patient's vascular system via a connecting element comprising bifurcated fluid pathway elements to physiologically channel the blood flow either to or from each hollow fiber membrane of the device, a channel to direct the fluid removed by the device to a suitable collection container or the patient's bladder, and controls that control excessive removal of the water from the patient. Devices can be either worn extracorporeally or surgically implanted in order to allow for continuous fluid removal with ambulatory freedom.

5. 发明申请

US20150174533A1 WOVEN MEMBRANE MODULE WITH CONTROLLED TUBESHEET EPOXY WICKING 有权
标题翻译：带有管状环氧蜡的WOVEN膜组件
公开(公告)号：US20150174533A1
公开(公告)日：2015-06-25
申请号：US14136505
申请日：2013-12-20
申请人： L'Air Liquide, Societe Anonyme pour l'Etude et Exploitation des Procedes Georges Claude
发明人： Tao LI , Edgar S. SANDERS, JR. , Michael D. BENNETT
IPC分类号： B01D63/02 , B01D53/22
CPC分类号： B01D63/02 , B01D53/22 , B01D63/021 , B01D63/022 , B01D63/026 , B01D2053/224
摘要： A gas separation membrane module is formed from a woven fabric of weft membrane hollow fibers and warp yarns. The membrane module includes an active hollow fiber region spanning the inner edges of the two tubesheets. The membrane module also includes two tubesheets formed by encapsulating membrane fiber on one or both ends. The tubesheet on the end includes a first sub-region adjacent the active fiber and a second sub-region extending from first sub-region to the outer face of the tubesheet. The spacing of the warp threads is relatively denser in the first sub-region than in the active region or the second sub-region.
摘要翻译：气体分离膜组件由纬纱中空纤维和经纱的机织织物形成。膜组件包括横跨两个管板的内边缘的活性中空纤维区域。膜组件还包括通过在一端或两端封装膜纤维而形成的两个管板。端板上的管板包括邻近有源光纤的第一子区域和从第一子区域延伸到管板的外表面的第二子区域。经线的间距在第一子区域比在有源区域或第二子区域中相对更密集。

6. 发明授权

US08974668B2 Hollow fiber membrane element and methods of making same 有权
标题翻译：中空纤维膜元件及其制造方法
公开(公告)号：US08974668B2
公开(公告)日：2015-03-10
申请号：US14175073
申请日：2014-02-07
申请人： Maher Isaac Kelada
发明人： Maher Isaac Kelada
IPC分类号： B01D63/04 , B01D63/02 , C02F1/44
CPC分类号： B01D63/022 , B01D63/021 , B01D63/026 , B01D63/043 , B01D2313/20 , B01D2313/21 , B01D2319/022 , C02F1/44 , Y02E10/36 , Y02E50/346 , Y02W10/37 , Y10T29/49787 , Y10T29/49826 , Y10T29/49895 , Y10T156/1062
摘要： A membrane element consisting of a hollow fiber stack (HF stack) comprising a plurality of substantially equally spaced hollow fibers (HFs) comprising multiple alternate rows of HFs comprising first ends extending through and between contact structures comprising solid thermoset material, each HF consisting of a hydrophilic semipermeable membrane defining an elongated lumen, each HF comprising a portion that extends from one contact structure to an opposed contact structure, wherein the HFs in alternate rows are aligned with the spaces in adjacent rows, forming a hexagonal pattern comprising repeating adjacent and/overlapping hexagons, wherein each hexagon comprises a central hollow fiber (central HF) surrounded by six immediately adjacent HFs defining a hexagonal perimeter comprising six sides, the six immediately adjacent HFs being substantially equally spaced from one another and substantially equally spaced from the central hollow fiber, wherein the spacing is adapted to maintain a Reynolds' number of about 3000 or more, and wherein the hydrophilic semipermeable membrane is adapted to achieve salt rejection of 98.5% or more and exhibits a surface tension of 35 dynes/cm or more.
摘要翻译：由中空纤维堆叠（HF堆叠）组成的膜元件包括多个基本等间隔的中空纤维（HF），其包括多个交替的HF排，所述HF排列包括延伸穿过包含固体热固性材料的接触结构之间的第一端，每个HF由亲水半透膜限定细长的内腔，每个HF包括从一个接触结构延伸到相对的接触结构的部分，其中交替行中的HF与相邻行中的空间对准，形成包括重复相邻和/重叠的六边形图案六边形，其中每个六边形包括由六个直接相邻的HF围绕的中心中空纤维（中心HF），其限定包括六个边的六边形周边，六个紧邻的HF彼此基本上等间隔并且与中心中空纤维基本等间隔开，其中所述间隔适于维持a 约3000以上的雷诺数，其中亲水性半透膜适于达到98.5％以上的盐析，表现出35达因/厘米或更高的表面张力。

7. 发明授权

US08956537B2 Hollow fiber membrane module, filtration apparatus using the same, and method for manufacturing the filtration apparatus 有权
标题翻译：中空纤维膜组件，使用其的过滤装置以及过滤装置的制造方法
公开(公告)号：US08956537B2
公开(公告)日：2015-02-17
申请号：US13258610
申请日：2010-03-23
申请人： Kwang-Jin Lee , Moo-Seok Lee
发明人： Kwang-Jin Lee , Moo-Seok Lee
IPC分类号： B01D69/08 , B01D63/04 , B01D63/02 , B01D65/00
CPC分类号： B01D63/02 , B01D63/026 , B01D65/00 , B01D2313/02 , B01D2313/06 , B01D2313/12 , B01D2313/21 , B01D2315/06 , Y10T29/49826
摘要： Disclosed are a hollow fiber membrane module, a filtration apparatus based on the same, and a method for manufacturing the filtration apparatus. The hollow fiber membrane module includes two headers respectively provided with a permeate collecting unit therein, wherein each of the headers has grooves on its two sides, the grooves being extended in a length direction of the hollow fiber membrane. Since one slide rod can simultaneously be inserted into grooves of two adjacent hollow fiber membrane modules, the hollow fiber membrane modules can mutually serve as guides for insertion/ejection thereof. Also, since the grooves formed on the header can serve as insertion holes into which a clamp is inserted, the clamp can be used for coupling between the hollow fiber membrane module and another element and reinforcement of the coupling.
摘要翻译：公开了一种中空纤维膜组件，基于该过滤装置的过滤装置及其制造方法。中空纤维膜组件包括两个头部，其中分别设置有渗透物收集单元，其中每个集管在其两侧具有凹槽，所述凹槽沿中空纤维膜的长度方向延伸。由于一个滑杆可以同时插入两个相邻的中空纤维膜组件的槽中，所以中空纤维膜组件可以作为其插入/弹出的引导件。此外，由于形成在集管上的槽可以用作插入夹具的插入孔，所以夹具可用于中空纤维膜组件和另一元件之间的联接以及联接器的加固。

8. 发明申请

US20140231333A1 HOLLOW FIBER MEMBRANE ELEMENT AND METHODS OF MAKING SAME 审中-公开
标题翻译：中空纤维膜元件及其制造方法
公开(公告)号：US20140231333A1
公开(公告)日：2014-08-21
申请号：US14175073
申请日：2014-02-07
申请人： MAHER ISAAC KELADA
发明人： MAHER ISAAC KELADA
IPC分类号： B01D63/04 , B01D63/02
CPC分类号： B01D63/022 , B01D63/021 , B01D63/026 , B01D63/043 , B01D2313/20 , B01D2313/21 , B01D2319/022 , C02F1/44 , Y02E10/36 , Y02E50/346 , Y02W10/37 , Y10T29/49787 , Y10T29/49826 , Y10T29/49895 , Y10T156/1062
摘要： A membrane element comprising: a hollow fiber (HF) stack comprising a plurality of loosely packed hollow fibers (HFs) comprising first ends extending through one contact structure and opposed ends extending through an opposed contact structure, each HF comprising an elongated lumen extending between the one contact structure and the opposed contact structure and comprising a hydrophilic semipermeable membrane adapted to achieve salt rejection of 98.5% or more and exhibiting a surface tension of 35 dynes/cm or more; the membrane element being adapted to be encased in a frame and submersed in a first fluid and for induced osmosis between lumens of the plurality of loosely packed HFs and the first fluid, the membrane element having sufficient mechanical integrity when encased in the frame and submersed in the first fluid to sustain turbulence flow across and along surfaces of the plurality of loosely packed HFs at a Reynolds' Number of about 3,000 or more and to maintain said mechanical integrity at feed pumping pressures of 30 bars or higher.
摘要翻译：一种膜元件，包括：包含多个松散包装的中空纤维（HF）的中空纤维（HF）堆叠，其包括延伸穿过一个接触结构的第一端和延伸穿过相对接触结构的相对端，每个HF包括在一个接触结构和相对的接触结构，并且包括适于实现98.5％或更高的盐排斥并且表现出35达因/厘米或更大的表面张力的亲水半透膜; 膜元件适于包封在框架中并浸没在第一流体中，并且用于多个松散包装的HF和第一流体的流体之间的诱导渗透，当包装在框架中并浸没在膜元件中时，膜元件具有足够的机械完整性维持湍流的第一流体以大约3,000或更大的雷诺数来流过和沿着多个松散包装的HF的表面流动并且在30巴或更高的进料泵送压力下保持所述机械完整性。

9. 发明授权

US08728316B2 Membrane filter unit 有权
标题翻译：膜过滤器单元
公开(公告)号：US08728316B2
公开(公告)日：2014-05-20
申请号：US12600249
申请日：2007-05-14
申请人： Yoshihito Nakahara , Tetsuya Torichigai , Hiroyuki Okazaki
发明人： Yoshihito Nakahara , Tetsuya Torichigai , Hiroyuki Okazaki
IPC分类号： B01D65/02 , B01D63/02
CPC分类号： B01D63/043 , B01D61/18 , B01D63/026 , B01D2313/06 , B01D2313/21 , B01D2315/06 , C02F3/1273 , C02F3/30 , C02F3/308 , C02F3/34 , C02F2101/105 , C02F2101/16 , C02F2203/006 , C02F2303/20 , C02F2303/24 , C05F17/0018 , C05F17/0027 , Y02P20/145 , Y02W10/15 , Y02W30/43 , Y02W30/47
摘要： A membrane filter unit includes a hollow fiber membrane module with a plurality of sheet-like hollow fiber membrane elements arrayed in parallel at predetermined intervals, each of the hollow fiber membrane elements obtained by arranging a great number of porous hollow fiber membranes in parallel, and an air diffuser arranged below the hollow fiber membrane module for releasing minute bubbles toward a lower end of the hollow fiber membrane module and generating a gas-liquid mixed flow vertically swirling between an inner space and an outer space of the hollow fiber membrane module. The membrane filter unit has a residue eliminating mechanism for forming a forced flow in part of the mixed flow between the porous hollow fiber membranes and between the sheet-like hollow fiber membrane elements of the fiber membrane module.
摘要翻译：膜过滤器单元包括具有以预定间隔平行排列的多个片状中空纤维膜元件的中空纤维膜组件，每个中空纤维膜元件通过平行布置多个多孔中空纤维膜而获得，空气扩散器，布置在中空纤维膜组件的下方，用于向中空纤维膜组件的下端释放微小气泡，并产生在中空纤维膜组件的内部空间和外部空间之间垂直旋转的气液混合流。膜过滤器单元具有用于在多孔中空纤维膜之间和纤维膜组件的片状中空纤维膜元件之间的部分混合流中形成强制流动的残渣消除机构。

10. 发明申请

US20140030146A1 OXYGENATOR 有权
标题翻译：氧化剂
公开(公告)号：US20140030146A1
公开(公告)日：2014-01-30
申请号：US14041434
申请日：2013-09-30
申请人： TERUMO KABUSHIKI KAISHA
发明人： Kazuhiko TAKEUCHI
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , B01D63/02 , B01D63/026 , B01D69/081 , B01D71/26
摘要： An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30≦ε60 and OD≦4.5×ε are met where ε [μm] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [μm] is the outer diameter of the hollow fiber membrane.
摘要翻译：氧合器包括壳体; 中空纤维膜层，其存储在壳体中并具有多个具有气体交换功能的集成中空纤维膜; 气体入口部分和气体出口部分分别设置在中空纤维膜流明的气体通道的上游和下游; 以及分别设置在中空纤维膜的外部的血液通道的上游和下游的血液入口部分和血液出口部分。中空纤维膜层中的中空纤维膜在一端部和另一端部彼此固定。满足条件30 @ epsilon60和OD@4.5×epsilon，其中epsilon [mum]是在中空纤维膜层的固定部分处的相邻中空纤维膜之间的平均间隔距离，OD [mum]是中空纤维膜层的外径纤维膜。

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