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1. 发明申请

US20150129497A1 CARTRIDGE AND METHOD FOR INCREASING MYOCARDIAL FUNCTION 审中-公开
公开(公告)号：US20150129497A1
公开(公告)日：2015-05-14
申请号：US14327145
申请日：2014-07-09
申请人： H. David Humes , Deborah A. Buffington
发明人： H. David Humes , Deborah A. Buffington
IPC分类号： A61M1/16 , A61M1/36 , A61M1/34
CPC分类号： A61M1/3486 , A61K31/00 , A61K31/194 , A61M1/16 , A61M1/1625 , A61M1/34 , A61M1/3472 , A61M1/3666 , A61M1/3679 , A61M1/3687 , A61M2202/0427 , A61M2202/0439 , A61M2205/126 , A61M2210/125
摘要： The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.

2. 发明授权

US08251941B2 Selective cytopheresis devices and related methods thereof 有权
标题翻译：选择性细胞分离装置及其相关方法
公开(公告)号：US08251941B2
公开(公告)日：2012-08-28
申请号：US12201576
申请日：2008-08-29
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
摘要翻译：本发明涉及用于治疗和/或预防受试者内的炎性病症的系统和装置及相关方法。更具体地，本发明涉及隔离白细胞和/或血小板然后抑制其炎症作用的系统，装置和相关方法。

3. 发明申请

US20110190679A1 EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM 审中-公开
标题翻译：基于细胞的细胞治疗设备和递送系统
公开(公告)号：US20110190679A1
公开(公告)日：2011-08-04
申请号：US13027481
申请日：2011-02-15
申请人： H. David Humes , Deborah Buffington , Gretchen Hageman
发明人： H. David Humes , Deborah Buffington , Gretchen Hageman
IPC分类号： A61M1/36 , A61M1/28 , C12N5/00
CPC分类号： A61M1/3687 , A61K35/12 , A61K35/22 , A61M1/3689
摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
摘要翻译：公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。一个实施方案包括长的中空纤维，其中细胞层在腔内体积内生长或在双重中空填充的室内生长。另一个实施例包括晶片或一系列晶片，其提供生长细胞的基底。将晶片插入设备中。装置可以将预先选择的分子例如激素递送到哺乳动物的体循环中和/或可以递送不同细胞产物的成员。该装置适于将产生和分泌预先选择的分子的活细胞固定到血液或流体中。本发明还提供了一种用于经皮引入本发明的装置的预选血管或体腔的微创方法。

4. 外观设计

USD629893S1 Medical device connector 有权
标题翻译：医疗器械连接器
公开(公告)号：USD629893S1
公开(公告)日：2010-12-28
申请号：US29336096
申请日：2009-04-28
申请人： H. David Humes
设计人： H. David Humes

5. 发明申请

US20100266562A1 SELECTIVE CYTOPHERESIS DEVICES AND RELATED METHODS THEREOF 有权
公开(公告)号：US20100266562A1
公开(公告)日：2010-10-21
申请号：US12827601
申请日：2010-06-30
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61K35/14 , C12M1/00 , A61P29/00 , A61M1/14
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

6. 发明授权

US06716208B2 Implantable device and use therefor 失效
标题翻译：可植入设备及其用途
公开(公告)号：US06716208B2
公开(公告)日：2004-04-06
申请号：US09735209
申请日：2000-12-12
申请人： H. David Humes
发明人： H. David Humes
IPC分类号： A61K932
CPC分类号： A61K9/0024 , A61F2/01 , A61F2/022 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61K38/00 , A61M31/002
摘要： Disclosed is an implantable device for delivering a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation. The device comprises a blood permeable element that can be anchored to an inner wall of an intact blood vessel. The device also comprises a capsule that is held in place within the blood vessel by the anchored blood permeable element. The capsule encloses viable cells which produce and secrete the pre-selected molecule into blood passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel the device of the invention.
摘要翻译：公开了用于将预先选择的分子例如激素递送到哺乳动物的全身循环中的可植入装置。该装置包括可以锚固到完整血管的内壁的血液可渗透元件。该装置还包括通过锚固的血液可渗透元件在血管内保持就位的胶囊。胶囊包围活细胞，其产生并将预先选择的分子分泌到通过胶囊的血液中。本发明还提供了一种用于经皮引入本发明的装置的预选血管的微创方法。

7. 发明授权

US06410320B1 Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules 失效
标题翻译：用于肾小管干细胞分离和生长的方法和组合物，体外肾管形成和肾小管的离体构建
公开(公告)号：US06410320B1
公开(公告)日：2002-06-25
申请号：US09494044
申请日：2000-01-31
申请人： H. David Humes
发明人： H. David Humes
IPC分类号： C12N500
CPC分类号： C12N5/0687 , A61K35/12 , A61K48/00 , C12N2501/11 , C12N2501/148 , C12N2501/15 , C12N2501/385 , C12N2502/28 , C12N2510/00 , C12N2533/54
摘要： Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on culturing adult kidney cells in a culture media treated with combinations of transforming growth factor-&bgr;1, epidermal growth factor, and all-trans retinoic acid.
摘要翻译：公开了包括提供肾小管干细胞分离和纯化以及体外肾细胞发生的方法，包括培养基条件。该方法依赖于在转化生长因子-β1，表皮生长因子和全反式视黄酸组合处理的培养基中培养成年肾细胞。

8. 发明授权

US5704910A Implantable device and use therefor 失效
公开(公告)号：US5704910A
公开(公告)日：1998-01-06
申请号：US461042
申请日：1995-06-05
申请人： H. David Humes
发明人： H. David Humes
IPC分类号： A61M37/00 , A61F2/01 , A61F2/02 , A61K9/48 , A61K35/12 , A61K38/00 , A61K38/22 , A61K38/28 , A61M31/00
CPC分类号： A61K9/0024 , A61F2/01 , A61F2/022 , A61M31/002 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61K38/00
摘要： Disclosed is an implantable device for delivering a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation. The device comprises a blood permeable element that can be anchored to an inner wall of an intact blood vessel. The device also comprises a capsule that is held in place within the blood vessel by the anchored blood permeable element. The capsule encloses viable cells which produce and secrete the pre-selected molecule into blood passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel the device of the invention.

9. 发明授权

US09498566B2 Selective cytopheresis devices and related methods thereof 有权
公开(公告)号：US09498566B2
公开(公告)日：2016-11-22
申请号：US13531872
申请日：2012-06-25
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M37/00 , A61M1/36 , A61M1/34 , A61K31/34 , G01N33/569
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

10. 发明授权

US08425447B2 Selective cytopheresis devices and related methods thereof 有权
公开(公告)号：US08425447B2
公开(公告)日：2013-04-23
申请号：US13593169
申请日：2012-08-23
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M37/00
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.

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