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61. 发明授权

US08057813B2 Multiple drug delivery from a balloon and a prosthesis 有权
标题翻译：来自气球和假体的多次药物递送
公开(公告)号：US08057813B2
公开(公告)日：2011-11-15
申请号：US11084172
申请日：2005-03-18
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F13/00
CPC分类号： A61F2/91 , A61F2/86 , A61F2/915 , A61F2/958 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2002/91591 , A61F2250/0067 , A61F2310/0097 , A61K47/6957 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

62. 发明申请

US20110213451A1 MEDICAL DEVICE SHIELD AND METHODS FOR DELIVERING A MEDICAL DEVICE 有权
标题翻译：医疗装置护罩及用于输送医疗装置的方法
公开(公告)号：US20110213451A1
公开(公告)日：2011-09-01
申请号：US13037008
申请日：2011-02-28
申请人： Randolf Von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
发明人： Randolf Von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
IPC分类号： A61F2/06 , A61M25/00
CPC分类号： A61F2/0095 , A61F2002/9505 , A61F2002/9583 , A61F2002/9665
摘要： Device shields for packaging and protecting medical devices during storage and deployment. A device shield includes a housing configured to maintain a medical device and at least a portion of a medical device delivery apparatus within the housing, and a limit element having a first constraining position and a second open position.
摘要翻译：在存储和部署期间用于包装和保护医疗设备的设备屏蔽。设备屏蔽包括被配置为将医疗设备和医疗设备传送设备的至少一部分保持在壳体内的壳体，以及具有第一约束位置和第二打开位置的限制元件。

63. 发明申请

US20110160847A1 APPARATUS FOR DELIVERY AND DEPLOYMENT OF AN EXPANDABLE STENT WITHIN A BLOOD VESSEL 有权
标题翻译：用于在血管中输送和释放可膨胀的血栓的装置
公开(公告)号：US20110160847A1
公开(公告)日：2011-06-30
申请号：US13012587
申请日：2011-01-24
申请人： Randolf Von Oepen , Volker Trösken , Volker Marx , Armin Stopper , Louise Balfe , Lorcan James Coffey
发明人： Randolf Von Oepen , Volker Trösken , Volker Marx , Armin Stopper , Louise Balfe , Lorcan James Coffey
IPC分类号： A61F2/82
CPC分类号： A61F2/958
摘要： An improved apparatus for delivering and deployment of an expandable stent with a protection sheath within a blood vessel is provided. The system comprises a fluid pressure device which is coupled with a retraction device for the protection sheath such that after retraction of the protection sheath the stent is automatically deployed by the fluid pressure device. The advantage of the invention is an easy and simple operation of the apparatus.
摘要翻译：提供了一种用于在血管内输送和展开具有保护护套的可扩张支架的改进装置。该系统包括流体压力装置，该流体压力装置与用于保护护套的收回装置相耦合，使得在保护护套收回之后，支架由流体压力装置自动展开。本发明的优点是装置的简单和简单的操作。

64. 发明授权

US07942854B1 Agent delivery catheter including an anchor and injection needle 有权
标题翻译：代理输送导管，包括锚和注射针
公开(公告)号：US07942854B1
公开(公告)日：2011-05-17
申请号：US12022047
申请日：2008-01-29
申请人： Randolf Von Oepen , Greg Chan
发明人： Randolf Von Oepen , Greg Chan
IPC分类号： A61M5/178
CPC分类号： A61M39/0208 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00349 , A61B2018/00392 , A61M25/0084 , A61M25/0136 , A61M25/0147 , A61M25/04 , A61M25/0662 , A61M39/0247 , A61M2025/0092 , A61M2025/0681 , A61M2039/0223 , A61M2039/0261
摘要： An agent delivery catheter that uses an anchoring needle and injection needle for treating tissue, such as infarcted heart tissue, includes a first needle, a second needle extendable through the first needle and a control unit for displacing and adjusting the position of both the first and second needles relative to a distal end of the delivery catheter.
摘要翻译：使用锚定针和注射针来治疗组织的药剂递送导管，例如梗死心脏组织，包括第一针，可穿过第一针的第二针和用于移位和调节第一和第二针的位置的控制单元第二针相对于输送导管的远端。

65. 发明授权

US07887577B2 Apparatus for a stent having an expandable web structure 有权
标题翻译：用于具有可扩张腹板结构的支架的装置
公开(公告)号：US07887577B2
公开(公告)日：2011-02-15
申请号：US10903080
申请日：2004-07-30
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by connection elements. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations.
摘要翻译：本发明提供了一种支架，其包括管状柔性体，其具有壁，所述壁具有可从收缩输送构型扩展到展开构造的腹板结构。网状结构包括多个相邻的网状图案，其中每个网状图案由邻接的网构成，并且网状图案通过连接元件互连。每个邻接的腹板包括插入在两个横向部分之间以形成凹形或凸形构造的中心部分。

66. 发明授权

US07875067B2 Apparatus for delivery and deployment of an expandable stent within a blood vessel 有权
标题翻译：用于在血管内递送和展开可扩张支架的装置
公开(公告)号：US07875067B2
公开(公告)日：2011-01-25
申请号：US10523596
申请日：2003-08-07
申请人： Randolf Von Oepen , Volker Trösken , Volker Marx , Armin Stopper , Louise Balfe , Lorcan Coffey
发明人： Randolf Von Oepen , Volker Trösken , Volker Marx , Armin Stopper , Louise Balfe , Lorcan Coffey
IPC分类号： A61F2/06
CPC分类号： A61F2/958
摘要： Apparatus for delivering and deploying an expandable stent having a protection sheath within a blood vessel is provided. The apparatus comprises a fluid pressure device that is coupled with a retraction device for the protection sheath, wherein the stent is automatically deployed by the fluid pressure device after retraction of the protection sheath.
摘要翻译：提供了用于在血管内递送和展开具有保护护套的可扩张支架的装置。该装置包括与用于保护护套的回缩装置联接的流体压力装置，其中在退回保护套之后，支架由流体压力装置自动展开。

67. 发明授权

US07794491B2 Apparatus for a stent having an expandable web structure and delivery system 有权
公开(公告)号：US07794491B2
公开(公告)日：2010-09-14
申请号：US10903014
申请日：2004-07-30
申请人： Randolf Von Oepen , Gerd Seibold
发明人： Randolf Von Oepen , Gerd Seibold
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558
摘要： The present invention provides a stent comprising a tubular flexible body having a wall with a web structure that is expandable from a contracted delivery configuration to deployed configuration. The web structure comprises a plurality of neighboring web patterns, where each web patterns is composed of adjoining webs, and the web patterns are interconnected by transition sections. Each adjoining web comprises a central section interposed between two lateral sections to form concave or convex configurations. A delivery system for the stent is also provided.

68. 发明申请

US20100222866A1 METAL ALLOY FOR MEDICAL DEVICES AND IMPLANTS 有权
标题翻译：金属合金用于医疗器械和植入物
公开(公告)号：US20100222866A1
公开(公告)日：2010-09-02
申请号：US12717425
申请日：2010-03-04
申请人： Jurgen Wachter , Jens Trötzschel , Randolf Von Oepen
发明人： Jurgen Wachter , Jens Trötzschel , Randolf Von Oepen
IPC分类号： A61F2/82
CPC分类号： C22C27/02 , A61L27/047 , A61L31/022 , A61L31/18 , C22C27/00 , C22C30/00
摘要： The present invention relates to a medical device or implant made at least in part of a high strength, low modulus metal alloy comprising Niobium, Tantalum, and at least one element selected from the group consisting of Zirconium, Tungsten, and Molybdenum. The medical devices according to the present invention provide superior characteristics with regard to bio-compatibility, radio-opacity and MRI compatibility.
摘要翻译：本发明涉及至少部分由包含铌，钽以及选自锆，钨和钼的至少一种元素的高强度低模量金属合金制成的医疗器械或植入物。根据本发明的医疗装置在生物相容性，无线电透明性和MRI兼容性方面提供优异的特性。

69. 发明授权

US07771459B2 Fastener having torque optimized head 失效
标题翻译：紧固件具有扭矩优化头
公开(公告)号：US07771459B2
公开(公告)日：2010-08-10
申请号：US11145692
申请日：2005-06-06
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/86 , A61B17/58
CPC分类号： A61B17/888 , A61B17/8615 , A61B17/864 , A61B2017/00004
摘要： Disclosed is a medical fastener that can be mounted to a bone of a patient. The medical fastener can include a head portion comprising a recess having a first portion, a second tapered portion extending from the first portion, and a third cylindrical portion extending from the second tapered portion. A threaded body portion can extend from the head portion. The first portion and the second portion can have a Torx geometry or star-shaped configuration. Also disclosed is a driver usable to mount the medical fastener to the bone. The driver can include a tip that is complementary to the recess and an end that enables the driver to mount to a drill or other device that can rotate the driver.
摘要翻译：公开了可以安装到患者的骨骼上的医疗紧固件。医疗紧固件可以包括头部，头部包括具有第一部分的凹部，从第一部分延伸的第二锥形部分和从第二锥形部分延伸的第三圆柱形部分。螺纹体部分可以从头部延伸。第一部分和第二部分可以具有Torx几何形状或星形配置。还公开了可用于将医疗紧固件安装到骨头的驱动器。驱动器可以包括与凹部互补的尖端和使得驱动器能够安装到能够旋转驱动器的钻孔或其他装置的端部。

70. 发明申请

US20100076377A1 Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权
标题翻译：具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件
公开(公告)号：US20100076377A1
公开(公告)日：2010-03-25
申请号：US12238026
申请日：2008-09-25
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/606 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。水凝胶聚合物可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到所需治疗部位。一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。

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