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1. 发明申请

US20180126119A1 INTRAVASCULAR DEVICE DELIVERY SHEATH 审中-公开
公开(公告)号：US20180126119A1
公开(公告)日：2018-05-10
申请号：US15662008
申请日：2017-07-27
申请人： Sean A. McNiven , Randolf von Oepen , Yongjin Xie , Francisco Valencia , Ken C. Salvador
发明人： Sean A. McNiven , Randolf von Oepen , Yongjin Xie , Francisco Valencia , Ken C. Salvador
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09
CPC分类号： A61M25/005 , A61F2/2436 , A61F2/966 , A61F2210/0076 , A61F2230/0091 , A61F2250/0018 , A61F2250/0065 , A61M25/0045 , A61M25/0051 , A61M25/0136 , A61M25/0147 , A61M25/0662 , A61M25/09 , A61M2025/0046 , A61M2025/0063 , A61M2025/0175 , A61M2025/0681
摘要： An intravascular delivery system includes a delivery sheath capable of transmitting a predetermined tension or compression force in a longitudinal direction while maintaining flexibility to navigate tortuous anatomy. A method of delivering a medical device includes inserting an intravascular device delivery system including a delivery sheath having a continuous spine into a bodily lumen. A distal longitudinal force is applied to the delivery sheath. The distal force is transmitted through the continuous spine and across one or more slit cuts of the delivery sheath. A proximal longitudinal force is applied to the delivery sheath. The proximal longitudinal force is transmitted through the continuous spine of the delivery sheath.

2. 发明授权

US08900286B2 Medical device shield and methods for delivering a medical device 有权
标题翻译：医疗设备屏蔽和用于递送医疗设备的方法
公开(公告)号：US08900286B2
公开(公告)日：2014-12-02
申请号：US13037008
申请日：2011-02-28
申请人： Randolf von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
发明人： Randolf von Oepen , Travis R. Yribarren , Alex D. Alviar , Barbara E. Stamberg
IPC分类号： A61F2/06 , A61F2/00 , A61F2/958 , A61F2/966 , A61F2/95
CPC分类号： A61F2/0095 , A61F2002/9505 , A61F2002/9583 , A61F2002/9665
摘要： Device shields for packaging and protecting medical devices during storage and deployment. A device shield includes a housing configured to maintain a medical device and at least a portion of a medical device delivery apparatus within the housing, and a limit element having a first constraining position and a second open position.
摘要翻译：在存储和部署期间用于包装和保护医疗设备的设备屏蔽。设备屏蔽包括被配置为将医疗设备和医疗设备传送设备的至少一部分保持在壳体内的壳体，以及具有第一约束位置和第二打开位置的限制元件。

3. 发明授权

US08663311B2 Device comprising biodegradable bistable or multistable cells and methods of use 有权
标题翻译：包含可生物降解的双稳态或多态细胞的装置和使用方法
公开(公告)号：US08663311B2
公开(公告)日：2014-03-04
申请号：US11317495
申请日：2005-12-22
申请人： Petrus Antonius Besselink , Travis Yribarren , Randolf Von Oepen
发明人： Petrus Antonius Besselink , Travis Yribarren , Randolf Von Oepen
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61F2/0009 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/30062 , A61F2002/828 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2230/0013 , B23K2103/42 , B23K2103/50 , B33Y80/00
摘要： Expandable biodegradable devices formed of bistable and multistable unit cells for use in devices, such as stents and graft systems, are provided, in which the device has two or more stable configurations, including a contracted configuration and an expanded configuration, the contracted stable configuration having a smaller diameter than the expanded configuration.
摘要翻译：提供了用于诸如支架和移植物系统的装置中的双稳态和多单元电池形成的可膨胀的可生物降解的装置，其中装置具有两个或多个稳定的构造，包括收缩构型和扩张构型，收缩的稳定构型具有直径比扩张结构小。

4. 发明授权

US08530783B2 Laser cutting system 有权
标题翻译：激光切割系统
公开(公告)号：US08530783B2
公开(公告)日：2013-09-10
申请号：US12699262
申请日：2010-02-03
申请人： Rodney C. Ow , William E. Webler , Randolf Von Oepen
发明人： Rodney C. Ow , William E. Webler , Randolf Von Oepen
IPC分类号： B23K26/14
CPC分类号： B23K26/38
摘要： A laser cutting system including a chamber configured to provide a controlled environment while the laser is being used to cut a pattern into a material to reduce or eliminate heat and oxygen related changes to the mechanical characteristics of the material. A system for providing a gas to the controlled environment within the chamber, as well as a means for exhausting gas and cutting debris from the chamber is also described. A cutting mandrel that provides for flow of a shielding gas and also provides a means for dispersing a laser beam before it can produce unwanted damage to a section of tubing is also described.
摘要翻译：一种激光切割系统，包括被配置为在激光被用于将图案切割成材料以便减少或消除与材料的机械特性相关的热和氧相关变化时提供受控环境的腔室。还描述了一种用于向室内的受控环境提供气体的系统，以及用于从气室排出气体和切割碎屑的装置。还描述了提供保护气体流动的切割心轴，并且还提供了用于在激光束可以对管道的一部分产生不希望的损坏之前分散激光束的装置。

5. 发明授权

US08501213B2 Multiple drug delivery from a balloon and a prosthesis 有权
标题翻译：来自气球和假体的多次药物递送
公开(公告)号：US08501213B2
公开(公告)日：2013-08-06
申请号：US13617628
申请日：2012-09-14
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

6. 发明授权

US08431145B2 Multiple drug delivery from a balloon and a prosthesis 有权
公开(公告)号：US08431145B2
公开(公告)日：2013-04-30
申请号：US12371422
申请日：2009-02-13
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

7. 发明申请

US20130006220A1 DRUG COATED BALLOON CATHETER 有权
标题翻译：药物涂层气囊导管
公开(公告)号：US20130006220A1
公开(公告)日：2013-01-03
申请号：US13616305
申请日：2012-09-14
申请人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, JR. , Richard R. Newhauser
发明人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, JR. , Richard R. Newhauser
IPC分类号： A61M25/10
CPC分类号： A61M25/1006 , A61F2/958 , A61M25/0119 , A61M2025/1015 , A61M2025/105 , A61M2025/1059 , A61M2025/1065 , A61M2025/1068
摘要： The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.
摘要翻译：本发明涉及用于治疗患者的管腔系统的气囊导管。具体地，本发明涉及具有位于导管的远端部分的柔性膜的导管，柔性膜在展开之前保持基本上未曝光的构象。优选地，当部署到暴露的构象时，柔性膜能够将治疗剂递送至局部环境。

8. 发明申请

US20120239139A1 MEDICAL IMPLANTS CONTAINING FK506 (TACROLIMUS) METHODS OF MAKING AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含FK506（TACROLIMUS）制造方法的医用植绒及其使用方法
公开(公告)号：US20120239139A1
公开(公告)日：2012-09-20
申请号：US13481129
申请日：2012-05-25
申请人： Stephan Wnendt , Randolf Von Oepen , Bernd Kuttler , Gerhard Lang , Guenter Lorenz , Axel Grandt
发明人： Stephan Wnendt , Randolf Von Oepen , Bernd Kuttler , Gerhard Lang , Guenter Lorenz , Axel Grandt
IPC分类号： A61F2/82 , B05D3/10
CPC分类号： A61L31/16 , A61L2300/416 , A61L2300/606
摘要： Implants and methods of making same are provided for treatment or prophylaxis of coronary or peripheral vascular constrictions or vascular occlusions, and particularly, stenoses or restenoses, that comprise FK506 in chemically covalently bound, non-covalently bound or physically immobilized form.
摘要翻译：提供了植入物及其制备方法，用于治疗或预防化学共价结合，非共价结合或物理固定化形式的冠状或外周血管收缩或血管闭塞，特别是狭窄或再狭窄，其包含FK506。

9. 发明申请

US20120209317A1 VESSEL CLOSURE SYSTEM 有权
标题翻译：船舶关闭系统
公开(公告)号：US20120209317A1
公开(公告)日：2012-08-16
申请号：US13028041
申请日：2011-02-15
申请人： Randolf Von Oepen
发明人： Randolf Von Oepen
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/0644 , A61B17/068 , A61B46/10 , A61B2017/00398 , A61B2017/00668
摘要： A power driven vessel closure device is configured for closing a hole in a wall of a body lumen. The vessel closure device can include a power operated drive system and a closure element delivery system. The closure element delivery system can be removably, operably, couplable with the power operated drive system. That is, the closure element system can be directly or indirectly attached to and removed from the power operated drive system, or components thereof. The operation of the power operated drive system can operate the closure element delivery system so as to move the closure element within the vessel closure device and deploy the closure element to close the hole.
摘要翻译：动力驱动的容器封闭装置构造成用于封闭体腔的壁中的孔。容器封闭装置可以包括动力驱动的驱动系统和闭合元件输送系统。闭合元件输送系统可以与动力驱动的驱动系统可拆卸地，可操作地连接。也就是说，闭合元件系统可以直接或间接附接到动力驱动系统或其部件上并从其移除。动力驱动驱动系统的操作可以操作闭合元件输送系统，以便将封闭元件移动到容器封闭装置内并展开封闭元件以封闭孔。

10. 发明授权

US08226603B2 Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery 有权
标题翻译：具有由用于管腔内药物递送的纤维基质形成的覆盖物的可膨胀构件
公开(公告)号：US08226603B2
公开(公告)日：2012-07-24
申请号：US12237998
申请日：2008-09-25
申请人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
发明人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61L29/085 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , Y10T29/49826
摘要： The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same.
摘要翻译：本发明一般涉及用于血管成形术和治疗剂递送的管腔内导管装置。特别地，本发明涉及具有设置在其上的治疗剂的可膨胀构件的导管和用于递送治疗剂的纤维基质覆盖物及其使用方法。

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