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1. 发明授权

US08501213B2 Multiple drug delivery from a balloon and a prosthesis 有权
标题翻译：来自气球和假体的多次药物递送
公开(公告)号：US08501213B2
公开(公告)日：2013-08-06
申请号：US13617628
申请日：2012-09-14
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

2. 发明授权

US08431145B2 Multiple drug delivery from a balloon and a prosthesis 有权
公开(公告)号：US08431145B2
公开(公告)日：2013-04-30
申请号：US12371422
申请日：2009-02-13
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

3. 发明申请

US20110230515A1 COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF DISEASES 有权
标题翻译：化合物和治疗和预防疾病的方法
公开(公告)号：US20110230515A1
公开(公告)日：2011-09-22
申请号：US13118342
申请日：2011-05-27
申请人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha , Yen-Chih J. Chen , John L. Toner
发明人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha , Yen-Chih J. Chen , John L. Toner
IPC分类号： A61K31/436 , C07D491/052 , A61P31/00 , A61P35/00 , A61P37/06
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/254 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/606 , C07D498/14 , C07D498/18
摘要： A prodrug compound of a rapamycin analog and methods for inhibiting, treating, and preventing mammalian diseases.
摘要翻译：雷帕霉素类似物的前药化合物和用于抑制，治疗和预防哺乳动物疾病的方法。

4. 发明申请

US20090060970A1 Compositions and methods of administering paclitaxel with other drugs using medical devices 有权
标题翻译：使用医疗器械给予紫杉醇与其他药物的组合物和方法
公开(公告)号：US20090060970A1
公开(公告)日：2009-03-05
申请号：US11548974
申请日：2006-10-12
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Matthew Mack
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Matthew Mack
IPC分类号： A61K31/337 , A61K31/436 , A61K31/573 , A61K31/565 , A61K39/395 , A61K31/704 , A61K31/727 , A61K38/49 , A61K38/48 , A61F2/02
CPC分类号： A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

5. 发明授权

US07399480B2 Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices 有权
标题翻译：使用医疗器械向其他治疗物质施用含四唑的雷帕霉素类似物的方法
公开(公告)号：US07399480B2
公开(公告)日：2008-07-15
申请号：US10977288
申请日：2004-10-29
申请人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha
发明人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha
IPC分类号： A61F2/00
CPC分类号： A61K31/7048 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , C07D498/18
摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
摘要翻译：一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。适用于本发明的药物包括但不限于：该药物可与另一药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

6. 发明授权

US06890546B2 Medical devices containing rapamycin analogs 有权
标题翻译：含有雷帕霉素类似物的医疗器械
公开(公告)号：US06890546B2
公开(公告)日：2005-05-10
申请号：US09950307
申请日：2001-09-10
申请人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha
发明人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha
IPC分类号： A61L27/00 , A61K31/436 , A61L27/34 , A61L27/54 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , A61P9/10 , A61P31/10 , A61P35/00 , A61P37/02 , A61P37/06 , C07D498/18 , A61F6/06
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/148 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/604 , A61L2300/606 , C07D498/18
摘要： A medical device comprising a supporting structure having a coating on the surface thereof, the coating containing a therapeutic substance, such as, for example, a drug. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to,
摘要翻译：一种医疗装置，包括在其表面具有涂层的支撑结构，所述涂层含有治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。适用于本发明的药物包括但不限于，

7. 发明授权

US08569333B2 Compounds and methods for treatment and prevention of diseases 有权
标题翻译：用于治疗和预防疾病的化合物和方法
公开(公告)号：US08569333B2
公开(公告)日：2013-10-29
申请号：US13118342
申请日：2011-05-27
申请人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha , Yen-Chih J. Chen , John L. Toner
发明人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha , Yen-Chih J. Chen , John L. Toner
IPC分类号： C07D498/18 , A61K31/445 , A61P41/00
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/254 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/606 , C07D498/14 , C07D498/18
摘要： A prodrug compound of a rapamycin analog and methods for inhibiting, treating, and preventing mammalian diseases.
摘要翻译：雷帕霉素类似物的前药化合物和用于抑制，治疗和预防哺乳动物疾病的方法。

8. 发明授权

US08057816B2 Compositions and methods of administering paclitaxel with other drugs using medical devices 有权
标题翻译：使用医疗器械给予紫杉醇与其他药物的组合物和方法
公开(公告)号：US08057816B2
公开(公告)日：2011-11-15
申请号：US11548974
申请日：2006-10-12
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Matthew Mack
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Matthew Mack
IPC分类号： A61F2/00 , A01N63/00 , A01N43/42 , A01N43/04 , A61K39/395 , A61K31/44 , A61K31/56 , A61K31/727 , A61K31/355
CPC分类号： A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包含治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

9. 发明申请

US20100023108A1 Multiple Drug Delivery From A Balloon And A Prosthesis 有权
标题翻译：从气球和假体的多个药物递送
公开(公告)号：US20100023108A1
公开(公告)日：2010-01-28
申请号：US12371422
申请日：2009-02-13
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

10. 发明申请

US20090047323A1 Medical Devices Containing Rapamycin Analogs 审中-公开
标题翻译：含雷帕霉素类似物的医疗器械
公开(公告)号：US20090047323A1
公开(公告)日：2009-02-19
申请号：US12255603
申请日：2008-10-21
申请人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha , Yen-Chih J. Chen , John L. Toner
发明人： Karl W. Mollison , Angela M. LeCaptain , Sandra E. Burke , Keith R. Cromack , Peter J. Tarcha , Yen-Chih J. Chen , John L. Toner
IPC分类号： A61F2/04 , A61K31/436 , A61K31/565
CPC分类号： C07D498/18 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/254 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/606
摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
摘要翻译：一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。适用于本发明的药物包括但不限于式（I）。该药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

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