专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US08003934B2 Methods and apparatus for ion sources, ion control and ion measurement for macromolecules 失效
标题翻译：离子源的方法和装置，大分子的离子控制和离子测量
公开(公告)号：US08003934B2
公开(公告)日：2011-08-23
申请号：US11517622
申请日：2006-09-08
申请人： Andreas Hieke
发明人： Andreas Hieke
IPC分类号： H01J3/14
CPC分类号： H01J37/08 , G21K1/087 , G21K5/02 , H01J49/04 , H01J49/06 , H01J49/067 , H01J49/164
摘要： Disclosed are methods, apparatus, systems, processes and other inventions relating to: ion sources with controlled electro-pneumatic superposition, ion source synchronized to RF multipole, ion source with charge injection, optimized control in active feedback system, radiation supported charge-injection liquid spray, ion source with controlled liquid injection as well as various embodiments and combinations of each of the foregoing.
摘要翻译：公开的方法，装置，系统，方法和其他发明涉及：具有受控电气气动叠加的离子源，与RF多极同步的离子源，具有电荷注入的离子源，主动反馈系统中的优化控制，辐射支持的电荷注入液具有受控液体注入的喷雾离子源以及前述各项的各种实施方案和组合。

52. 发明申请

US20110084205A1 Collision Cell 有权
标题翻译：碰撞细胞
公开(公告)号：US20110084205A1
公开(公告)日：2011-04-14
申请号：US12996226
申请日：2009-06-03
申请人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
发明人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/00 , H01J49/26
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
摘要翻译：提供了在质谱仪中操作充气碰撞池的方法。碰撞单元具有纵向轴线。导致离子进入碰撞池。在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使经处理的离子离开碰撞细胞。沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

53. 发明申请

US20100276582A1 MOLECULAR ION ACCELERATOR 有权
标题翻译：分子加速器
公开(公告)号：US20100276582A1
公开(公告)日：2010-11-04
申请号：US12431896
申请日：2009-04-29
申请人： Chung Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
发明人： Chung Hsuan Chen , Jung-Lee Lin , Nien-Yeen Hsu , Yi-Sheng Wang
IPC分类号： B01D59/44 , H01J49/00 , H01T23/00 , H01J27/24
CPC分类号： H05H5/047 , H01J49/06 , H01J49/40 , H01J49/403
摘要： A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.
摘要翻译：提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

54. 发明申请

US20090206248A1 ION ENERGY SPREAD REDUCTION FOR MASS SPECTROMETER 有权
标题翻译：离子能量减少大量光谱仪
公开(公告)号：US20090206248A1
公开(公告)日：2009-08-20
申请号：US12296831
申请日：2007-04-13
申请人： Alexander Makarov , Mikhail Monastyrskiy , Dmitry E. Grinfield
发明人： Alexander Makarov , Mikhail Monastyrskiy , Dmitry E. Grinfield
IPC分类号： B01D59/44 , H01J49/40 , H01J27/00
CPC分类号： H01J49/06
摘要： A method for reducing the energy spread of ions over a specific and limited mass to charge ratio range is disclosed, along with an ion deceleration arrangement for implementing such a method. An electric field, having an electric field strength E is generated by a deceleration electrode arrangement (250). Ions of a specific and limited mass to charge ratio range, but having a spread of energies, are directed into the decelerating electric field generated by the deceleration electrode arrangement (250). The decelerating electric field is then removed, once substantially all of the ions of the specific mass to charge ratio range have entered the decelerating electric field. By matching the electric field strength E to the energy spread of the ions upon entry into the electric field, the energy spread of the said ions is reduced. Preferred embodiments of the invention employ energy dispersion upstream of the ion deceleration arrangement. For example, an ion mirror arrangement (200) may be used, the ions reflecting off an ion mirror (220) within that ion mirror arrangement (200) to promote energy defocusing.
摘要翻译：公开了一种用于在特定且有限的质荷比范围内减小离子的能量扩散的方法，以及用于实现这种方法的离子减速布置。具有电场强度E的电场由减速电极装置（250）产生。特定且有限的质荷比范围但具有能量扩散的离子被引导到由减速电极装置（250）产生的减速电场。然后，除去减速电场，一旦基本上所有特定质荷比的离子进入减速电场。通过将电场强度E与进入电场的离子的能量扩散相匹配，所述离子的能量扩散减小。本发明的优选实施例在离子减速装置的上游采用能量分散。例如，可以使用离子镜装置（200），离子反射离开反射镜装置（200）内的离子反射镜（220）以促进能量散焦。

55. 发明授权

US07465939B2 Aberration correction device and method for operating same 有权
标题翻译：畸变校正装置及其操作方法
公开(公告)号：US07465939B2
公开(公告)日：2008-12-16
申请号：US11568175
申请日：2005-06-20
申请人： Juergen Frosien
发明人： Juergen Frosien
IPC分类号： H01J37/153
CPC分类号： H01J37/153 , H01J49/06 , H01J49/288 , H01J2237/057 , H01J2237/1534
摘要： The present invention provides an aberration correction device. The aberration correction device comprises a Wien filter element, a quadrupole element for compensating a focusing property of the Wien filter element, and at least one multipole element for spherical aberration correction. The Wien filter element and said quadrupole element are adapted to generate, in combination, an astigmatic image. Furthermore, the at least one multipole element is adapted to act essentially in a plane of sagittal or meridional focus of the astigmatic image. Thereby, chromatic aberration is reduced as well as spherical aberration can be corrected.
摘要翻译：本发明提供一种像差校正装置。像差校正装置包括维恩滤波器元件，用于补偿维恩滤波器元件的聚焦特性的四极元件和用于球面像差校正的至少一个多极元件。维恩滤波器元件和所述四极杆元件适于组合地产生像散图像。此外，至少一个多极元件适于基本上在像散图像的矢状或子午焦点的平面中起作用。从而，可以减小色差，并且可以校正球面像差。

56. 发明申请

US20080290266A1 METHOD AND SYSTEM FOR EXTRACTING ION BEAMS COMPOSED OF MOLECULAR IONS (CLUSTER ION BEAM EXTRACTION SYSTEM) 有权
标题翻译：用于提取分子离子的离子束（聚束离子束提取系统）的方法和系统
公开(公告)号：US20080290266A1
公开(公告)日：2008-11-27
申请号：US12125176
申请日：2008-05-22
申请人： Thomas N. Horsky , Sami K. Hahto
发明人： Thomas N. Horsky , Sami K. Hahto
IPC分类号： H01J49/00
CPC分类号： H01J49/06
摘要： A new type of triode extraction system, a Cluster Ion Beam Extraction System, is disclosed for broad energy range cluster ion beam extraction applications while still being applicable to atomic and molecular ion species as well. The extraction aperture plate contours are set to minimize the beam cross over and at the same time shield the source from excess extraction electric fields thus allowing smaller values of the extraction gap. In addition, a novel focusing feature is integrated into these new optics which allows the beam to be either focused or de-focused in the non-dispersive plane by using a bipolar bias voltage of only a few kV over a broad range of beam energy. This is a superior solution to a stand-alone electrostatic lens solution, for example an einzel lens, which would require tens of kV of bias voltage in order to be able to focus an energetic beam.
摘要翻译：公开了一种新型的三极管提取系统，即群离子束提取系统，用于宽能量范围的簇离子束提取应用，同时仍适用于原子和分子离子物种。提取孔径板轮廓被设置为最小化束交叉并且同时将源遮蔽于过量的提取电场，从而允许较小的提取间隙值。此外，将新颖的聚焦特征集成到这些新的光学器件中，其允许光束在非分散平面中被聚焦或去聚焦，通过在宽范围的光束能量上使用仅几kV的双极偏置电压。这是独立静电透镜解决方案的优越解决方案，例如双面透镜，其将需要几十kV的偏置电压，以便能够聚焦能量束。

57. 发明申请

US20080258052A1 MASS SPECTROMETER INTERFACE 有权
标题翻译：质谱仪界面
公开(公告)号：US20080258052A1
公开(公告)日：2008-10-23
申请号：US12163030
申请日：2008-06-27
申请人： Charles Jolliffe , Gholamreza Javahery , Lisa Cousins
发明人： Charles Jolliffe , Gholamreza Javahery , Lisa Cousins
IPC分类号： H01J49/28
CPC分类号： H01J49/0422 , H01J49/04 , H01J49/044 , H01J49/0468 , H01J49/06 , H01J49/26 , Y10T436/24
摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
摘要翻译：公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。质谱仪界面提供改进的去溶剂化学选择性和离子迁移。部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

58. 发明授权

US07223968B2 Multimode ionization mode separator 有权
标题翻译：多模电离模式分离器
公开(公告)号：US07223968B2
公开(公告)日：2007-05-29
申请号：US11349469
申请日：2006-02-06
申请人： Steven M. Fischer , Darrell L. Gourley , Patricia H. Cormia
发明人： Steven M. Fischer , Darrell L. Gourley , Patricia H. Cormia
IPC分类号： H01J49/04
CPC分类号： H01J49/107 , H01J49/06 , H01J49/165
摘要： A multimode ionization source includes an electrospray ionization source for providing a charged aerosol, an atmospheric pressure ionization source downstream from the electrospray ionization source for further ionizing said charged aerosol, and a mode separator, or mask, situated so as to separate a portion of the charged aerosol and prevent the portion from being exposed to the atmospheric pressure ionization source.
摘要翻译：多模电离源包括用于提供带电气溶胶的电喷雾离子化源，用于电喷雾离子化源的下游的大气压电离源，用于进一步电离所述带电气体，以及模式分离器或掩模，并且防止该部分暴露于大气压电离源。

59. 发明授权

US07098452B2 Atmospheric pressure charged particle discriminator for mass spectrometry 有权
公开(公告)号：US07098452B2
公开(公告)日：2006-08-29
申请号：US10778424
申请日：2004-02-13
申请人： Bradley Schneider , Thomas R. Covey
发明人： Bradley Schneider , Thomas R. Covey
IPC分类号： H01J49/04
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

60. 发明申请

US20060124859A1 Multimode ionization mode separator 有权
标题翻译：多模电离模式分离器
公开(公告)号：US20060124859A1
公开(公告)日：2006-06-15
申请号：US11349469
申请日：2006-02-06
申请人： Steven Fischer , Darrell Gourley , Patricia Cormia
发明人： Steven Fischer , Darrell Gourley , Patricia Cormia
IPC分类号： H01J27/24
CPC分类号： H01J49/107 , H01J49/06 , H01J49/165
摘要： A multimode ionization source includes an electrospray ionization source for providing a charged aerosol, an atmospheric pressure ionization source downstream from the electrospray ionization source for further ionizing said charged aerosol, and a mode separator, or mask, situated so as to separate a portion of the charged aerosol and prevent the portion from being exposed to the atmospheric pressure ionization source.
摘要翻译：多模电离源包括用于提供带电气溶胶的电喷雾离子化源，用于电喷雾离子化源的下游的大气压电离源，用于进一步电离所述带电气体，以及模式分离器或掩模，并且防止该部分暴露于大气压电离源。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式