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1. 发明公开

US20240355610A1 DEVICE AND METHOD FOR THE SPECTROMETRIC ANALYSIS OF SAMPLE MATERIAL 审中-公开
公开(公告)号：US20240355610A1
公开(公告)日：2024-10-24
申请号：US18634324
申请日：2024-04-12
申请人： Bruker Daltonics GmbH & Co. KG
发明人： Sebastian BÖHM , Andreas HAASE
IPC分类号： H01J49/40 , H01J49/00 , H01J49/04 , H01J49/16
CPC分类号： H01J49/403 , H01J49/0004 , H01J49/0418 , H01J49/164 , H01J49/405
摘要： The disclosure relates to devices and methods for the spectrometric analysis of sample material located on a sample support, and in particular on a flat sample support plate, using axial time-of-flight analysis. One operating mode of the devices and methods comprises an adjustment of the pulse focal position for the abrupt ablation and/or abrupt desorption of sample material in a z-direction that is perpendicular to a tangential plane at the location of ablation and/or desorption at the sample support, and the selection of a suitable setting for an acceleration with time lag of the ablated and/or desorbed and ionized sample material onto a flight path. It can be particularly advantageous to use these devices and methods in mass spectrometry imaging (MSI). The devices and methods can, in particular, be used with laser desorption/ionization (LDI) and specifically matrix-assisted laser desorption/ionization (MALDI).

2. 发明申请

US20190103263A1 ION TRAP 审中-公开
公开(公告)号：US20190103263A1
公开(公告)日：2019-04-04
申请号：US16118736
申请日：2018-08-31
申请人： SHIMADZU CORPORATION
发明人： Roger GILES , Matthew Clive GILL
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/4225 , H01J49/067 , H01J49/24 , H01J49/403 , H01J49/4295
摘要： An ion trap having a segmented electrode structure having a plurality of segments consecutively positioned along an axis, wherein each segment of the segmented electrode structure includes a plurality of electrodes arranged around the axis. A first voltage supply is configured to operate in a radially confining mode in which at least some electrodes belonging to each segment are supplied with at least one AC voltage waveform so as to provide a confining electric field for radially confining ions within the segment. A second voltage supply is configured to operate in a trapping mode in which at least some of the electrodes belonging to the segments are supplied with different DC voltages so as to provide a trapping electric field that has an axially varying profile for urging ions towards and trapping ions in a target segment of the plurality of segments. A first chamber is configured to receive ions from an ion source, wherein a first subset of the segments are located within the first chamber. A second chamber is configured to receive ions from the first chamber, wherein a second subset of the segments are located within the second chamber, and wherein the target segment is one of the second subset of segments. A gas pump is configured to pump gas out from the second chamber so as to provide the second chamber with a lower gas pressure than the first chamber. A gas flow restricting section is located between the first chamber and second chamber, wherein the gas flow restricting section is configured to allow ions to pass from the first chamber to the second chamber whilst restricting gas flow from the first chamber to the second chamber.

3. 发明授权

US10037878B2 Blanking out of pulses in pulsed lasers for LDI mass spectrometers 有权
公开(公告)号：US10037878B2
公开(公告)日：2018-07-31
申请号：US15251138
申请日：2016-08-30
申请人： Bruker Daltonik GmbH
发明人： Andreas Haase
IPC分类号： H01J49/40 , H01J49/00 , H01S3/115 , H01S3/00 , G02F1/03 , H01J49/16 , H01S3/0941 , H01S3/10 , G02F1/35
CPC分类号： H01J49/403 , G02F1/0311 , G02F2001/3507 , G02F2001/354 , H01J49/0027 , H01J49/164 , H01J49/406 , H01S3/0057 , H01S3/09415 , H01S3/10061 , H01S3/115
摘要： The invention relates to optically pumped and pulsed solid-state lasers which are used in mass spectrometers in particular for ionization by matrix-assisted laser desorption (MALDI) and which operate at pulse frequencies of up to 10 kilohertz or even higher. The invention proposes that, instead of interrupting the clocked sequence of the laser operation, individual light pulses or groups of light pulses are blanked out so that subsequent light pulses do not have a higher energy density, in accordance with the requirements for LDI processes. Methods and devices for the blanking out of light pulses are provided which are, in particular, low cost and considerably less complex than other methods.

4. 发明授权

US09984863B2 Multi-reflecting time-of-flight mass spectrometer with axial pulsed converter 有权
公开(公告)号：US09984863B2
公开(公告)日：2018-05-29
申请号：US15300998
申请日：2015-03-31
申请人： LECO Corporation
发明人： Anatoly N. Verenchikov
IPC分类号： H01J49/40 , G01N30/72 , H01J49/00 , H01J49/44
CPC分类号： H01J49/403 , G01N30/72 , H01J49/0031 , H01J49/406 , H01J49/44
摘要： Apparatuses and methods for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter. The bunching method is particularly suitable for ion sources with relatively large spatial emittance, otherwise unable to fir the acceptance of orthogonal accelerators. The method is particularly suitable for multi-reflecting TOF MS, which accommodates small size ion packets and where the duty cycle advantage of orthogonal accelerators is minor.

5. 发明申请

US20180053641A1 SHOT-TO-SHOT SAMPLING USING A MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
公开(公告)号：US20180053641A1
公开(公告)日：2018-02-22
申请号：US15682112
申请日：2017-08-21
申请人： Eung Joon Jo , Yohahn Jo
发明人： Eung Joon Jo , Yohahn Jo
IPC分类号： H01J49/00 , H01J49/16 , H01J49/40
CPC分类号： H01J49/0036 , G06N20/00 , H01J49/0009 , H01J49/164 , H01J49/40 , H01J49/403
摘要： Embodiments relate to an apparatus, method, or computer program. A laser may be configured to irradiate a plurality of laser pulses on a target area to ionize a sample placed in the target area into at least one ionized particle. Electrodes at a first end of a flight tube may be configured to accelerate ionized particles into the flight tube. A detector at a second opposite end of the flight tube may independently measure a time of flight of the ionized particles through the flight tube and an intensity of the ionized particles.

6. 发明授权

US09728392B2 Mass spectrometer electrode 有权
公开(公告)号：US09728392B2
公开(公告)日：2017-08-08
申请号：US14599968
申请日：2015-01-19
申请人： Hamilton Sundstrand Corporation
发明人： Ben D. Gardner
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/4255 , H01J49/403
摘要： A monolithic electrode includes a first portion devoid of apertures and a second portion surrounded by the first portion, the second portion having a web defining a plurality of apertures. A method for forming an electrode includes forming a first electrode portion devoid of apertures and forming a second electrode portion having a web defining a plurality of apertures. The web of the second electrode portion connects to the first electrode portion.

7. 发明授权

US09595432B2 Time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪和飞行时间质谱仪分析离子的方法
公开(公告)号：US09595432B2
公开(公告)日：2017-03-14
申请号：US12518236
申请日：2007-12-07
申请人： Roger Giles , Michael Sudakov , Hermann Wollnik
发明人： Roger Giles , Michael Sudakov , Hermann Wollnik
IPC分类号： H01J49/00 , H01J49/40 , H01J49/42
CPC分类号： H01J49/403 , H01J49/4295
摘要： A time-of-flight mass spectrometer (1) comprises an ion source a segmented linear ion device (10) for receiving sample ions supplied by the ion source and a time-of-flight mass analyzer for analyzing ions ejected from the segmented device. A trapping voltage is applied to the segmented device to trap ions initially into a group of two or more adjacent segments and subsequently to trap them in a region of the segmented device shorter than the group of segments. The trapping voltage may also be effective to provide a uniform trapping field along the length of the device (10).
摘要翻译：飞行时间质谱仪（1）包括离子源，用于接收由离子源提供的样品离子的分段线性离子装置（10）和用于分析从分段装置喷射的离子的飞行时间质量分析器。捕获电压被施加到分段器件，以将离子初始化为两个或更多个相邻段的一组，并且随后将它们捕获在分段器件的比段组短的区域中。捕获电压也可以有效地沿着装置（10）的长度提供均匀的捕获场。

8. 发明授权

US09576782B2 Orthogonal acceleration system for time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪的正交加速系统
公开(公告)号：US09576782B2
公开(公告)日：2017-02-21
申请号：US14928793
申请日：2015-10-30
申请人： PerkinElmer Health Sciences, Inc.
发明人： David G. Welkie
IPC分类号： H01J49/40 , H05H5/02 , H05H5/04 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/40 , H01J49/403 , H05H5/02 , H05H5/047
摘要： An orthogonal pulse accelerator for a Time-of-Flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension. The first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates, and the orthogonal pulse accelerator directs ions in the ion beam through the apertures.
摘要翻译：用于飞行时间质量分析器的正交脉冲加速器包括在第一平面中延伸的导电第一板和与第一板间隔开的第二板。第二板包括限定多个孔的栅格，每个孔具有在第一方向上延伸的第一尺寸和与第一尺寸正交的第二尺寸，第一和第二尺寸位于第二平面中，而第二尺寸开始大于第一维度。第一和第二板位于飞行时间质量分析器中，以在质量分析仪的操作期间接收在第一和第二板之间的区域中沿第一方向传播的离子束，并且正交脉冲加速器指示离子束中的离子通过孔。

9. 发明授权

US09400261B2 Sensor apparatus and method for use with gas ionization systems 有权
标题翻译：用于气体电离系统的传感器装置和方法
公开(公告)号：US09400261B2
公开(公告)日：2016-07-26
申请号：US14355475
申请日：2012-11-15
申请人： Owlstone Limited
发明人： Mike Black , Matthew Hart , John Somerville , Alastair Taylor , Iva Manasi , Max Allsworth
IPC分类号： G01N27/68 , G01N27/62 , H01J49/04 , H01J49/40
CPC分类号： H01J49/0422 , G01N27/622 , G01N27/624 , G01N27/68 , H01J49/40 , H01J49/403
摘要： An ion mobility gas detector apparatus including a detector core, an inlet gas path, an exhaust gas path, a source of diluent gas, and at least one or more sensors for measuring temperature, pressure and humidity of gas streams. Further included is a mixing mechanism adapted to mix at least first and second gas streams in response to one or more sensor measurements. A controller is provided for applying drive signals to the detector core.
摘要翻译：包括检测器芯，入口气体路径，排气路径，稀释气体源以及用于测量气流的温度，压力和湿度的至少一个或多个传感器的离子迁移率气体检测器装置。还包括一种混合机构，其适于响应于一个或多个传感器测量值混合至少第一和第二气流。提供了一种用于将驱动信号施加到检测器芯的控制器。

10. 发明授权

US09048075B1 Time-of-flight type mass spectrometer 有权
标题翻译：飞行时间型质谱仪
公开(公告)号：US09048075B1
公开(公告)日：2015-06-02
申请号：US14154722
申请日：2014-01-14
申请人： SHIMADZU CORPORATION
发明人： Kei Kodera
IPC分类号： H01J49/40 , H01J49/04 , H01J49/02 , H01J49/16
CPC分类号： H01J49/403 , H01J49/164
摘要： A time-of-flight type mass spectrometer in which, at the time when ions are generated by irradiating a sample with a laser beam, an extraction electric field having a potential gradient that decreases gradually from a sample plate toward an extraction electrode is formed. Ions are roughly separated in accordance with the m/z in the extraction region due to the effect of this electric field, and ions with a large m/z remain near the sample. The voltages applied to the sample plate and an auxiliary electrode are increased after a delay time has passed so as to form an acceleration electric field having a potential gradient with a polygonal line pattern. Since this electric field is similar to an ideal potential gradient curve, it is possible to provide the ions with appropriate potential energy changes for each m/z, improving resolution by appropriately realizing energy convergence over a wide m/z range.
摘要翻译：飞行时间型质谱仪，其中，当通过用激光束照射样品产生离子时，形成具有从样品板朝向提取电极逐渐减小的电位梯度的提取电场。由于这种电场的影响，离子根据提取区域中的m / z大致分离，并且具有大m / z的离子保留在样品附近。施加到样品板和辅助电极的电压在延迟时间过去之后增加，以形成具有多边形线图案的电位梯度的加速电场。由于该电场类似于理想的电位梯度曲线，所以可以为每个m / z提供适当的势能变化的离子，通过在宽的m / z范围内适当地实现能量收敛来提高分辨率。

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