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1. 发明授权

US07488953B2 Multimode ionization source 有权
标题翻译：多模电离源
公开(公告)号：US07488953B2
公开(公告)日：2009-02-10
申请号：US11444095
申请日：2006-05-31
申请人： Steven M. Fischer , Darrell L. Gourley , James L. Bertsch
发明人： Steven M. Fischer , Darrell L. Gourley , James L. Bertsch
IPC分类号： H01J27/02
CPC分类号： H01J49/107 , H01J49/0445 , H01J49/162 , H01J49/165 , H01J49/168
摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.
摘要翻译：本发明提供了一种与质谱仪一起使用的装置和方法。本发明的多模电离源提供用于电离分子的一个或多个大气压电离源（例如电喷雾，大气压化学电离和/或大气压光电离）。还公开了使用多模电离源产生离子的方法。该装置和方法提供了组合离子源的优点，而没有各个源的固有缺点。在一个实施例中，多模式电离源包括封闭在内室中用于干燥带电气溶胶的红外发射器。 ESI / APCI多模式源可以包括电晕针护罩和/或辅助电极。

2. 发明申请

US20080042056A1 Photoactivated collision induced dissociation (PACID) (apparatus and method) 有权
标题翻译：光活化碰撞诱导解离（PACID）（仪器和方法）
公开(公告)号：US20080042056A1
公开(公告)日：2008-02-21
申请号：US11506933
申请日：2006-08-18
申请人： Steven M. Fischer , Harry F. Prest , Robert Lee
发明人： Steven M. Fischer , Harry F. Prest , Robert Lee
IPC分类号： H01J49/10
CPC分类号： H01J49/0059 , G01N33/6848 , G01N33/6851 , H01J49/0068
摘要： The invention provides a system apparatus and methods for fragmenting various molecules. In particular, the invention may be employed for fragmenting biomolecules like peptides to determine sequence information. The invention provides a mass spectrometry system for photo-activated collision induced dissociation. The mass spectrometry system or device includes an ion source for producing ions, a photon source adjacent to the ion source for photo-activating ions produced by the ion source, an electrical element adjacent to the photon source for creating an electric field for accelerating ions produced by the ion source and photo-activated by the photon source; wherein ions are produced by the ion source, photo-activated by the photon source and accelerated into a surface to cause dissociation of the activated ions; and a detector downstream from the ion source for detecting the collision induced and dissociated ions.Methods for molecule and/or peptide fragmentation are also disclosed.
摘要翻译：本发明提供了一种分散各种分子的系统装置和方法。特别地，本发明可用于片段生物分子如肽以确定序列信息。本发明提供了一种用于光激活碰撞诱导解离的质谱系统。质谱系统或装置包括用于产生离子的离子源，邻近于离子源的光子源，用于由离子源产生的光激活离子;邻近光子源的电元件，用于产生用于加速产生的离子的电场由离子源和光子源激活; 其中离子由离子源产生，由光子源光激活并加速到表面以引起活化离子的解离; 以及用于检测碰撞诱导和离解离子的离子源下游的检测器。还公开了分子和/或肽断裂的方法。

3. 发明授权

US07259368B2 Apparatus for delivering ions from a grounded electrospray assembly to a vacuum chamber 有权
标题翻译：用于将离子从接地电喷雾组件输送到真空室的装置
公开(公告)号：US07259368B2
公开(公告)日：2007-08-21
申请号：US11361125
申请日：2006-02-24
申请人： William D. Frazer , Steven M. Fischer , Robert K. Crawford
发明人： William D. Frazer , Steven M. Fischer , Robert K. Crawford
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/165 , H01J49/045
摘要： The present invention relates to an apparatus for delivering ions to a vacuum chamber. The apparatus comprises an ionization chamber, an ionization region within the ionization chamber, a vacuum interface at a vacuum interface voltage and a vacuum chamber, wherein the ionization chamber communicates with the vacuum chamber through the vacuum interface. Sample is introduced into the ionization chamber from an electrospray assembly at approximately ground potential. Two electrodes are provided within the chamber such that three electric fields are generated, a first field extending from the electrospray assembly to the first electrode, a second field extending from the second electrode to the first electrode, and a third field extending from the second electrode to the vacuum interface. Ions are forced to travel through the fields in order before entering the vacuum chamber. In addition, the invention provides a method of delivering ions to a vacuum chamber.
摘要翻译：本发明涉及一种用于将离子输送到真空室的装置。该装置包括电离室，电离室内的电离区域，真空界面电压下的真空界面和真空室，其中电离室通过真空界面与真空室连通。将样品从大约接地电位的电喷雾组件引入电离室。在室内提供两个电极，使得产生三个电场，从电喷雾组件延伸到第一电极的第一场，从第二电极延伸到第一电极的第二场和从第二电极延伸的第三场到真空界面。在进入真空室之前，离子被迫穿过田野。此外，本发明提供了将离子输送到真空室的方法。

4. 发明授权

US07166836B1 Ion beam focusing device 有权
标题翻译：离子束聚焦装置
公开(公告)号：US07166836B1
公开(公告)日：2007-01-23
申请号：US11221491
申请日：2005-09-07
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J49/42 , H01J37/26
CPC分类号： H01J49/42 , H01J49/04
摘要： The invention provides an apparatus for focusing ions exiting a multipole mass filter. In general terms, the ion focusing apparatus comprises: a housing having an ion entrance and an ion exit, and, contained within the housing: a) a multipole ion guide having an open ion entrance end, and b) a neutral gas. The ion focusing apparatus is configured so that an ion beam enters the housing via the ion entrance and is collisionally focused by the multipole ion guide and neutral gas prior to exiting the housing. The apparatus is readily employed to collisionally focus an ion beam exiting a quadrupole mass filter. Also provided is a mass spectrometry system containing the ion focusing apparatus, and methods employing the same.
摘要翻译：本发明提供一种用于聚焦离开多极质量过滤器的离子的装置。一般来说，离子聚焦装置包括：具有离子入口和离子出口的壳体，并且容纳在壳体内：a）具有开放离子入口端的多极离子导向器，以及b）中性气体。离子聚焦装置被配置为使得离子束经由离子入口进入壳体并且在离开壳体之前被多极离子导向器和中性气体碰撞聚焦。该装置容易地用于将离开四极质量过滤器的离子束碰撞地聚焦。还提供了含有离子聚焦装置的质谱系统及其应用方法。

5. 发明授权

US07034291B1 Multimode ionization mode separator 有权
公开(公告)号：US07034291B1
公开(公告)日：2006-04-25
申请号：US10971658
申请日：2004-10-22
申请人： Steven M. Fischer , Darrell L. Gourley , Patricia H. Cormia
发明人： Steven M. Fischer , Darrell L. Gourley , Patricia H. Cormia
IPC分类号： H01J49/04
CPC分类号： H01J49/107 , H01J49/06 , H01J49/165
摘要： A multimode ionization source includes an electrospray ionization source for providing a charged aerosol, an atmospheric pressure ionization source downstream from the electrospray ionization source for further ionizing said charged aerosol, and a mode separator, or mask, situated so as to separate a portion of the charged aerosol and prevent the portion from being exposed to the atmospheric pressure ionization source.

6. 发明授权

US06998605B1 Apparatus for delivering ions from a grounded electrospray assembly to a vacuum chamber 有权
公开(公告)号：US06998605B1
公开(公告)日：2006-02-14
申请号：US09579276
申请日：2000-05-25
申请人： William D. Frazer , Steven M. Fischer , Robert K. Crawford
发明人： William D. Frazer , Steven M. Fischer , Robert K. Crawford
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/165 , H01J49/045
摘要： The present invention relates to an apparatus for delivering ions to a vacuum chamber. The apparatus comprises an ionization chamber, an ionization region within the ionization chamber, a vacuum interface at a vacuum interface voltage and a vacuum chamber, wherein the ionization chamber communicates with the vacuum chamber through the vacuum interface. Sample is introduced into the ionization chamber from an electrospray assembly at approximately ground potential. Two electrodes are provided within the chamber such that three electric fields are generated, a first field extending from the electrospray assembly to the first electrode, a second field extending from the second electrode to the first electrode, and a third field extending from the second electrode to the vacuum interface. Ions are forced to travel through the fields in order before entering the vacuum chamber. In addition, the invention provides a method of delivering ions to a vacuum chamber.

7. 发明授权

US06661003B2 Dielectric capillary high pass ion filter 失效
公开(公告)号：US06661003B2
公开(公告)日：2003-12-09
申请号：US10224637
申请日：2002-08-20
申请人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
发明人： Steven M. Fischer , Robert K. Crawford , Charles W. Russ, IV
IPC分类号： B01D5944
CPC分类号： H01J49/04
摘要： For delivery of ions from a higher pressure ion source to a mass analyzer operating at high vacuum, high pass ion filtration is effected within a dielectric capillary interface between the higher pressure ionization chamber and the lower pressure environment of a mass analyzer, by application of electrical potentials to end electrodes and to at least one electrode associated with the dielectric capillary between the ends, to create an end-to-end electric field generally opposing gas flow-assisted movement of ions from the upstream end to the downstream end, and to create a steeper voltage gradient along an upstream portion than along a downstream portion of the capillary. The voltage gradient along the steeper upstream portion of the capillary is sufficiently steep to cause ions having drift velocities below a lower limit to stall within the capillary. The respective potentials may be adjusted to increase the steepness of the upstream voltage gradient to increase the drift velocity lower limit.

8. 发明授权

US06653626B2 Ion sampling for APPI mass spectrometry 有权
公开(公告)号：US06653626B2
公开(公告)日：2003-11-25
申请号：US10155364
申请日：2002-05-23
申请人： Steven M. Fischer , Darrell L. Gourley , Patricia H. Cormia , James L. Bertsch
发明人： Steven M. Fischer , Darrell L. Gourley , Patricia H. Cormia , James L. Bertsch
IPC分类号： H01J4926
CPC分类号： G01N30/7253 , H01J27/24 , H01J49/0431 , H01J49/145 , H01J49/162
摘要： An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.

9. 发明授权

US06649909B2 Internal introduction of lock masses in mass spectrometer systems 有权
标题翻译：在质谱仪系统内部引入锁定质量
公开(公告)号：US06649909B2
公开(公告)日：2003-11-18
申请号：US10081780
申请日：2002-02-20
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4910
CPC分类号： H01J49/0009 , H01J49/004
摘要： An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions adjacent the ion optics creates lock mass ions within the ion optics. Lock mass ions mix with the analyte ions in the ion optics prior to mass analysis. The source of lock mass ions may include various means for ionizing lock mass molecules including but not limited to photoionization, field desorption-ionization, electron ionization, and thermal ionization means. An apparatus and method of mass calibrating a tandem mass spectrometer is also provided. The mass calibration apparatus includes a collision cell for fragmenting analyte ions and a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.
摘要翻译：提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。与离子光学器件相邻的锁定质量离子源产生离子光学器件内的锁定质子离子。在质量分析之前，将质子离子与离子光学中的分析物离子混合。锁定质量离子的来源可以包括用于电离锁定质量分子的各种装置，包括但不限于光电离，场解吸电离，电子离子化和热电离装置。还提供了质量校准串联质谱仪的装置和方法。质量校准装置包括用于碎裂分析物离子的碰撞单元和邻近所述碰撞室的锁定质量离子源，用于在碰撞室中产生锁定质量离子。

10. 发明授权

US06417511B1 Ring pole ion guide apparatus, systems and method 有权
标题翻译：环形极离子导向装置，系统及方法
公开(公告)号：US06417511B1
公开(公告)日：2002-07-09
申请号：US09617877
申请日：2000-07-17
申请人： Charles W. Russ, IV , Steven M. Fischer
发明人： Charles W. Russ, IV , Steven M. Fischer
IPC分类号： H01J4900
CPC分类号： H01J49/065 , H01J49/063
摘要： A ring pole ion guide apparatus and method provide the focusing and confinement advantages of conventional multipoles and the axial field of a conventional DC ring guide all in one device. The ring pole apparatus comprises a ring stack portion and a multipole portion, wherein the ring stack portion essentially overlaps the multipole portion inside and outside along a central axis. The ring pole apparatus can be used in a mass spectrometer system to guide ions from the ion source to the mass spectrometer or between mass spectrometer stages, or to dissociate ions into daughter ions in an ion dissociation system. A single ring pole ion guide can span a plurality of pressure transition stages with several of the rings acting as pressure partitions.
摘要翻译：环形离子引导装置和方法提供常规的多极的聚焦和约束优点以及传统的直流环导轨的轴向场。环形杆装置包括环形堆叠部分和多极部分，其中环形堆叠部分沿着中心轴线基本上与多极部分内部和外部重叠。环状电极装置可用于质谱仪系统中以将离子从离子源引导到质谱仪或质谱仪级之间，或者将离子离解成离子离解系统中的子离子。单个环形极离子引导件可以跨越多个压力过渡级，其中几个环用作压力分隔件。

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