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51. 发明申请

US20120130118A1 METHODS FOR PRODUCING AND USING A TETRAFLUOROTOLUENE COMPOUND 审中-公开
标题翻译：用于生产和使用四氢氟碳青霉烯化合物的方法
公开(公告)号：US20120130118A1
公开(公告)日：2012-05-24
申请号：US13359594
申请日：2012-01-27
申请人： Koji HAGIYA
发明人： Koji HAGIYA
IPC分类号： C07C67/24 , C07C29/10 , C07C17/093 , C07C41/18
CPC分类号： C07C41/18 , C07C17/093 , C07C25/13 , C07C29/10 , C07C43/1786 , C07C67/24 , C07C69/63 , C07C33/46
摘要： A tetrafluorotoluene compound represented by the formula (1): wherein R represents a C1-C6 alkyl group, and a method for producing a tetrafluorotoluene compound represented by the formula (1) which comprises hydrogenating a tetrafluorobenzyl alcohol compound represented by the formula (2): Wherein R represents a C1-C6 alkyl group.
摘要翻译：由式（1）表示的四氟甲苯化合物：其中R表示C1-C6烷基，以及由式（1）表示的四氟甲苯化合物的制备方法，其包括将式（2）表示的四氟苄醇化合物其中R表示C1-C6烷基。

52. 发明申请

US20120095261A1 Process for preparation of alpha-ketoglutaric acid 失效
标题翻译： α-酮戊二酸的制备方法
公开(公告)号：US20120095261A1
公开(公告)日：2012-04-19
申请号：US12925133
申请日：2010-10-13
申请人： Guoji Zhang
发明人： Guoji Zhang
IPC分类号： C07C277/00 , C07C59/185
CPC分类号： C07C277/08 , C07C51/02 , C07C51/41 , C07C51/412 , C07C51/43 , C07C51/47 , C07C67/347 , C07C279/02 , C07C69/63 , C07C59/347
摘要： A process for preparation of α-ketoglutaric acid, which is adapted for preparing L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crude α-ketoglutaratic acid aqueous solution; (c) purifying the crude α-ketoglutaratic acid aqueous solution to obtain purified α-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purified α-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purified α-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.
摘要翻译：一种制备α-酮戊二酸的方法，其适用于制备1 - 1和2：1的L-精氨酸α-酮戊二酸，包括以下步骤：（a）使二氯乙酸甲酯和丙烯酸甲酯与甲醇钠反应，得到 2,2-二氯戊二酸二甲酯; （b）使来自步骤（a）的2,2-二氯戊二酸二甲酯与氢氧化物溶液反应，得到粗α-酮戊二酸水溶液; （c）纯化粗α-酮戊二酸水溶液，得到纯化的α-酮戊二酸水溶液; 和（d）通过加水调节纯化的α-酮戊二酸水溶液的浓度，由此纯化的α-酮戊二酸水溶液的收率为约75％。在避免使用大量有机溶剂的同时，本发明的方法具有显着的高产率，可以实现批量生产，制造成本低，生产时间缩短。

53. 发明申请

US20120022285A1 Novel alkoxy enones and enamino ketones and a process for preparation thereof 有权
标题翻译：新型烷氧基烯酮和烯氨基酮及其制备方法
公开(公告)号：US20120022285A1
公开(公告)日：2012-01-26
申请号：US13010863
申请日：2011-01-21
申请人： Sergii Pazenok , Norbert Lui , Arnd Neeff
发明人： Sergii Pazenok , Norbert Lui , Arnd Neeff
IPC分类号： C07C67/10 , C07C69/12
CPC分类号： C07C67/11 , C07C69/007 , C07C69/63 , C07D401/04
摘要： The present invention relates to novel alkoxy enones and enamino ketones, and to a novel process for preparation thereof. Alkoxy enones and enamino ketones are valuable intermediates for preparation of pyrazoles and anthranilamides, which can be used as insecticides.
摘要翻译：本发明涉及新的烷氧基烯酮和烯氨基酮，以及其制备方法。烷氧基酮和烯氨基酮是用于制备可用作杀虫剂的吡唑和邻氨基苯甲酰胺的有价值的中间体。

54. 发明授权

US08039665B2 Method for producing fluorine-containing carboxylic acid ester 失效
标题翻译：含氟羧酸酯的制造方法
公开(公告)号：US08039665B2
公开(公告)日：2011-10-18
申请号：US12665269
申请日：2008-06-18
申请人： Takeshi Kondo
发明人： Takeshi Kondo
IPC分类号： C07C69/63
CPC分类号： C07C67/00 , C07C69/63
摘要： A method for producing a fluorine-containing carboxylic acid ester represented by the general formula R1HCFCOOR2 involves reacting a fluorine-containing ether represented by the general formula R1HCFCF2OR2 with water in the presence of a solid catalyst. The solid catalyst is at least one selected from the group consisting of alumina, titania, zirconia, sulfated zirconia, an activated carbon on which sulfuric acid is supported, a resin having acid sites, and aluminum phosphate. In the general formulas R1HCFCOOR2 and R1HCFCF2OR2, R1 represents a fluorine atom or a C1-4 perfluoroalkyl group, and R2 represents a monovalent organic group.
摘要翻译：由通式R1HCFCOOR2表示的含氟羧酸酯的制造方法包括在固体催化剂存在下使由通式R 1 HCFCF 2 OR 2表示的含氟醚与水反应。固体催化剂是选自氧化铝，二氧化钛，氧化锆，硫酸化氧化锆，负载硫酸的活性炭，具有酸性位置的树脂和磷酸铝的至少一种。在通式R1HCFCOOR2和R1HCFCF2OR2中，R1表示氟原子或C1-4全氟烷基，R2表示一价有机基团。

55. 发明申请

US20110217654A1 Latent acids and their use 有权
标题翻译：潜在酸及其用途
公开(公告)号：US20110217654A1
公开(公告)日：2011-09-08
申请号：US13028323
申请日：2011-02-16
申请人： Hitoshi Yamato , Toshikage Asakura , Akira Matsumoto , Keita Tanaka , Yuichi Nishimae
发明人： Hitoshi Yamato , Toshikage Asakura , Akira Matsumoto , Keita Tanaka , Yuichi Nishimae
IPC分类号： G03F7/004 , C07C69/753 , C07D311/74 , C07C69/63 , C07D307/77 , C07D207/277 , C07C309/82 , C07C69/96 , C07C271/24 , C07D265/30 , C07D233/38 , C08F28/02 , G03F7/20
CPC分类号： C07C69/63 , B33Y70/00 , B33Y80/00 , C07C69/753 , C07C69/96 , C07C271/24 , C07C309/82 , C07D207/277 , C07D233/38 , C07D265/30 , C07D307/77 , C07D311/74 , C08F28/02 , G03F7/004 , G03F7/20
摘要： The invention pertains to a compound generating an acid of the formula I or II, for instance corresponding sulfonium and iodonium salts, as well as corresponding sulfonyloximes wherein X is CH2 or CO; Y is O, NR4, S, O(CO), O(CO)O, O(CO)NR4, OSO2, O(CS), or O(CS)NR4; R1 is for example C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl, C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, interrupted C2-C18alkyl, interrupted C3-C30cycloalkyl, interrupted C3-C30cycloalkyl-C1-C18alkyl, interrupted C4-C30cycloalkenyl, phenyl, naphthyl, anthracyl, phenanthryl, biphenylyl, fluorenyl or heteroaryl, all unsubstituted or are substituted; or R1 is NR12R13; R2 and R3 are for example C3-C30cycloalkylene, C3-C30cycloalkyl-C1-C18alkylene, C1-C18alkylene, C1-C10haloalkylene, C2-C12alkenylene, C4-C30cycloalkenylene, phenylene, naphthylene, anthracylene, phenanthrylene, biphenylene or heteroarylene; all unsubstituted or substituted; R4 is for example C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl; R12 and R13 are for example C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl, Ar, (CO)R15, (CO)OR15 or SO2R15; and Ar is phenyl, biphenylyl, fluorenyl, naphthyl, anthracyl, phenanthryl or heteroaryl, all unsubstituted or substituted.
摘要翻译：本发明涉及产生式I或II的酸的化合物，例如相应的锍盐和碘鎓盐，以及其中X是CH 2或CO的相应的磺酰肟; Y是O，NR4，S，O（CO），O（CO）O，O（CO）NR4，OSO2，O（CS）或O（CS）NR4; R 1是例如C 1 -C 18烷基，C 1 -C 10卤代烷基，C 2 -C 12烯基，C 4 -C 30环烯基，苯基-C 1 -C 3烷基，C 3 -C 30环烷基，C 3 -C 30环烷基-C 1 -C 18烷基，间断的C 2 -C 18烷基，间断的C 3 -C 30环烷基，间断的C 3 -C 30环烷基-C 1 -C 18烷基，间断的C 4 -C 30环烯基，苯基，萘基，蒽基，菲基，联苯基，芴基或杂芳基，全部未取代或被取代; 或R1是NR12R13; R2和R3是例如C 3 -C 30亚环烷基，C 3 -C 30环烷基-C 1 -C 18亚烷基，C 1 -C 18亚烷基，C 1 -C 10卤代亚烷基，C 2 -C 12亚烯基，C 4 -C 30亚环烯基，亚苯基，亚萘基，亚蒽基，亚菲基，亚联苯基或亚杂芳基。全部未取代或取代; R4是例如C 3 -C 30环烷基，C 3 -C 30环烷基-C 1 -C 18烷基，C 1 -C 18烷基，C 1 -C 10卤代烷基，C 2 -C 12链烯基，C 4 -C 30环烯基，苯基-C 1 -C 3烷基; R 12和R 13例如为C 3 -C 30环烷基，C 3 -C 30环烷基-C 1 -C 18烷基，C 1 -C 18烷基，C 1 -C 10卤代烷基，C 2 -C 12烯基，C 4 -C 30环烯基，苯基-C 1 -C 3烷基，Ar，（CO）R 15 CO）OR15或SO2R15; 并且Ar是苯基，联苯基，芴基，萘基，蒽基，菲基或杂芳基，全部是未取代或取代的。

56. 发明申请

US20110178315A1 PROCESS FOR THE CONVERSION OF A CRUDE GLYCEROL, CRUDE MIXTURES OF NATURALLY DERIVED MULTICOMPONENT ALIPHATIC HYDROCARBONS OR ESTERS THEREOF TO A CHLOROHYDRIN 有权
标题翻译：转化果糖的转化方法，天然衍生的多元醇二烃或其衍生物与氯仿的混合物
公开(公告)号：US20110178315A1
公开(公告)日：2011-07-21
申请号：US13023783
申请日：2011-02-09
申请人： Bruce D. Hook , John Briggs , Robert M. Campbell , William J. Kruper, JR. , David J. Schreck , Richard D. Varjian , Jeffrey G. Hippler
发明人： Bruce D. Hook , John Briggs , Robert M. Campbell , William J. Kruper, JR. , David J. Schreck , Richard D. Varjian , Jeffrey G. Hippler
IPC分类号： C07D301/02 , C07C31/36
CPC分类号： C07D301/27 , C07C29/62 , C07C67/287 , C07C69/003 , C07C69/63 , C07C31/36 , C07C31/42
摘要： A process for converting a crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof to a chlorohydrin, by contacting the crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; wherein said crude glycerol, said ester of crude glycerol, or mixture thereof is derived from a renewable raw material. Chlorohydrins made by the process of the present invention are useful in preparing epoxides such as epichlorohydrins.
摘要翻译：通过将粗甘油，天然衍生的多羟基化脂肪族烃或其酯的起始原料的粗混合物与超大气压源的原料甘油，天然衍生的多羟基化脂肪族烃或其酯的粗混合物与氯代醇反应，氯化氢的分压足够的时间和足够的温度，并且其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 其中所述粗甘油，所述粗甘油酯或其混合物衍生自可再生原料。通过本发明方法制备的氯代醇可用于制备环氧化物如表氯醇。

57. 发明申请

US20100267828A1 DHA DERIVATIVES AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译： DHA衍生物及其作为药物使用
公开(公告)号：US20100267828A1
公开(公告)日：2010-10-21
申请号：US12740377
申请日：2008-10-30
申请人： Anne Kristin Holmeide , Ragnar Hovland
发明人： Anne Kristin Holmeide , Ragnar Hovland
IPC分类号： A61K31/232 , C07C69/587 , C07C67/00 , C12P7/64 , A61P3/10 , A61P3/04 , A61P29/00
CPC分类号： C07C69/587 , C07C67/26 , C07C67/28 , C07C69/63
摘要： The present disclosure relates to compounds of the general formula (I): wherein R1 and R2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; or any pharmaceutically acceptable salt, solvate, complex, or pro-drug thereof; and their use as medicaments for the treatment of various diseases and conditions, for example, reduction of elevated triglyceride levels, i.e., hypertriglyceridemia, reduction of non-HDL cholesterol, reduction of glucose and HbA1c, and improvement of insulin resistance. The present disclosure also relates to a pharmaceutical composition comprising compounds of formula (I), as well as to processes for preparing compounds according to formula (I).
摘要翻译：本公开内容涉及通式（I）的化合物：其中R 1和R 2相同或不同，并且选自氢原子，羟基，烷基，卤素原子，烷氧基，酰氧基酰基，烯基，炔基，芳基，烷硫基，烷氧基羰基，烷基亚磺酰基，烷基磺酰基，氨基和烷基氨基; 或其药学上可接受的盐，溶剂化物，复合物或前体药物; 以及它们作为用于治疗各种疾病和病症的药物的用途，例如降低甘油三酯水平升高，即高甘油三酯血症，降低非HDL胆固醇，降低葡萄糖和HbA1c以及改善胰岛素抵抗。本公开还涉及包含式（I）化合物的药物组合物，以及用于制备根据式（I）的化合物的方法。

58. 发明申请

US20100210524A1 NOVEL ESTROGEN RECEPTOR LIGANDS 审中-公开
标题翻译：新颖的雌激素受体配体
公开(公告)号：US20100210524A1
公开(公告)日：2010-08-19
申请号：US12452678
申请日：2008-07-21
申请人： Theresa Apelqvist , Joakim Löfstedt , Thomas Norin , Mattias Wennerstål , Xiongyu Wu , Lars Hagberg
发明人： Theresa Apelqvist , Joakim Löfstedt , Thomas Norin , Mattias Wennerstål , Xiongyu Wu , Lars Hagberg
IPC分类号： A61K31/122 , C07C49/747 , C07C255/47 , A61K31/277 , C07C251/44 , A61K31/15 , C07C233/33 , A61K31/167 , C07D333/38 , A61K31/381 , C07D307/46 , A61K31/341 , C07D277/34 , A61K31/426 , C07D207/333 , A61K31/40 , C07C69/78 , A61K31/235 , C07D261/08 , A61K31/42 , C07C211/45 , A61K31/136 , C07D231/56 , A61K31/416 , C07D407/10 , C07D209/52 , A61K31/403 , C07C311/08 , A61K31/18 , C07C311/21 , A61K31/663 , A61K31/565 , A61K38/23 , A61K31/59 , A61P35/00 , A61P37/06 , A61P25/00 , A61P19/00 , A61P19/10 , A61P3/04 , A61P3/06 , A61P9/00 , A61P15/00
CPC分类号： C07C49/747 , C07C45/513 , C07C45/62 , C07C45/63 , C07C45/65 , C07C45/66 , C07C45/673 , C07C45/676 , C07C45/68 , C07C45/69 , C07C45/71 , C07C45/72 , C07C45/78 , C07C49/753 , C07C49/84 , C07C69/63 , C07C225/22 , C07C233/33 , C07C251/44 , C07C255/47 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2602/22 , C07C2602/30 , C07D207/333 , C07D209/44 , C07D209/94 , C07D231/56 , C07D261/08 , C07D277/24 , C07D277/34 , C07D307/46 , C07D307/52 , C07D333/16 , C07D333/22 , C07D333/38 , C07C49/633
摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are as defined in the specification. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的酯，酰胺，溶剂合物或其盐，包括这种酯或酰胺的盐，以及这种酯，酰胺或盐的溶剂合物，其中W，X， Y，Z，R 1，R 2，R 7，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15和R 16如说明书中所定义。本发明还提供了这样的化合物在治疗或预防与雌激素受体活性相关的疾病或病症相关的病症中的用途。

59. 发明授权

US07683222B2 Method of producing a fluorine-containing compound 有权
标题翻译：含氟化合物的制造方法
公开(公告)号：US07683222B2
公开(公告)日：2010-03-23
申请号：US11242776
申请日：2005-10-05
申请人： Yushi Kaneko , Takayuki Ito , Taizo Ono
发明人： Yushi Kaneko , Takayuki Ito , Taizo Ono
IPC分类号： C07C17/00
CPC分类号： C07B39/00 , C07C67/307 , C07C69/63
摘要： A method of producing a fluorine-containing compound, which contains the step of: fluorinating a substrate in a solvent with fluorine gas, wherein as said substrate, a substrate that cannot substantially undergo fluorinating reaction independently, is allowed to react, in the presence of a substrate that rapidly undergoes fluorinating reaction independently.
摘要翻译：一种制备含氟化合物的方法，其包括以下步骤：用氟气氟化溶剂中的基材，其中作为所述基材，独立地基本上不能进行氟化反应的基材在存在下进行反应快速独立地进行氟化反应的底物。

60. 发明申请

US20100055609A1 COMPOUND, METHOD FOR PREPARING THE COMPOUND AND RESIST COMPOSITION CONTAINING THE COMPOUND 有权
标题翻译：化合物，用于制备化合物的方法和含有该化合物的抗蚀剂组合物
公开(公告)号：US20100055609A1
公开(公告)日：2010-03-04
申请号：US12552085
申请日：2009-09-01
申请人： Ichiki TAKEMOTO , Nobuo Ando , Mitsuhiro Hata
发明人： Ichiki TAKEMOTO , Nobuo Ando , Mitsuhiro Hata
IPC分类号： G03F7/004 , C07C69/63
CPC分类号： C07C67/08 , C07C67/11 , C07C69/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , G03F7/0045 , G03F7/0392
摘要： A compounds represented by the Formula (I) or the Formula (I′). wherein Z1 and Z2 independently represent a hydrogen atom, a C1 to C12 alkyl group or a C3 to C12 cyclic saturated hydrocarbon group, provided that at least one of Z1 and Z2 represent a C1 to C12 alkyl group or a C3 to C12 cyclic saturated hydrocarbon group; rings Y1 and Y2 independently represents an optionally substituted C3 to C20 alicyclic hydrocarbon group; Q1 to Q4 and Q′1 to Q′4 independently represent a fluorine atom or a C1 to C6 perfluoroalkyl group; and m and n independently represent an integer of 0 to 5.
摘要翻译：由式（I）或式（I'）表示的化合物。其中Z 1和Z 2独立地表示氢原子，C 1至C 12烷基或C 3至C 12环状饱和烃基，条件是Z 1和Z 2中的至少一个表示C 1至C 12烷基或C 3至C 12环状饱和烃组; 环Y1和Y2独立地表示任选取代的C 3至C 20脂环族烃基; Q1至Q4和Q'1至Q'4独立地表示氟原子或C1至C6全氟烷基; m和n独立地表示0〜5的整数。

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