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    • 5. 发明授权
    • Bioactive polymers
    • 生物活性聚合物
    • US09567294B2
    • 2017-02-14
    • US14763356
    • 2014-01-22
    • Sealife Pharma GmbH
    • Alexander PretschMichael NaglChristoph WiesnerHeinz Burgmann
    • C07C279/00C08G73/02A01N47/40C07C277/08C07C279/08
    • C07C279/00A01N47/40C07C277/08C07C279/08C08G73/02
    • Polycondensation products of aminoguanidine and/or 1,3-diaminoguanidine with one or more diamines are provided including polyguanidine derivatives of the following formula (I) or a salt thereof: wherein X is selected from —NH2, aminoguanidino and 1,3-diaminoguanidino; Y is selected from —H and —R1—NH2; or X and Y together represent a chemical bond to give a cyclic structure; R1 is selected from divalent organic radicals having 2 to 20 carbon atoms, in which optionally one or more carbon atoms are replaced by O or N; a and b are each 0 or 1, wherein a+b≠2 if no 1,3-diaminoguanidine units are included; R2 is selected from —H and —NH2, wherein R2 is —NH2 if a+b=0, R2 is —H or —NH2 if a+b=1, and R2 is —H if a+b=2; and n≧2. Production methods and uses of the polyguanidine derivatives are also provided.
    • 提供氨基胍和/或1,3-二氨基胍与一种或多种二胺的缩聚产物,包括下式(I)的聚胍衍生物或其盐:其中X选自-NH 2,氨基胍基和1,3-二氨基鸟嘌呤; Y选自-H和-R1-NH2; 或X和Y一起表示化学键以产生环状结构; R1选自具有2至20个碳原子的二价有机基团,其中任选地一个或多个碳原子被O或N替代; a和b各自为0或1,其中a + b≠2,如果不包括1,3-二氨基胍单元; 如果a + b = 0,则R 2选自-H和-NH 2,其中如果a + b = 0,R 2为-NH 2,如果a + b = 1,则R 2为-H 2或如果a + b = 2,则R 2为-H。 n≥2。 还提供了聚胍衍生物的生产方法和用途。
    • 9. 发明授权
    • Methods for production of high concentration of arginine bicarbonate solution at high pressure
    • 在高压下生产高浓度精氨酸碳酸氢盐溶液的方法
    • US09035093B2
    • 2015-05-19
    • US13515829
    • 2010-12-13
    • Donghui Wu
    • Donghui Wu
    • C07C277/08
    • C07C277/08C07C279/14
    • Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution.
    • 以非常高的浓度生产精氨酸碳酸氢盐溶液的方法,包括在升高的压力和温度下使包含精氨酸的第一部分的精氨酸浆料与二氧化碳源一起在升高的压力和温度下反应,将后续部分精氨酸加入到所得溶液中,并与压缩的二氧化碳反应 提供包含超过50重量%的最终溶液,其包括通过使精氨酸水浆料升高压力和温度来制备精氨酸溶液,并使精氨酸溶液与二氧化碳气体源反应以形成包含精氨酸和 碳酸氢根阴离子并从溶液中回收精氨酸碳酸氢盐。