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    • 3. 发明申请
    • BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
    • 基于硼酸盐的基因发生器和包含这种基因发生器的基础反应性组合物
    • US20160340374A1
    • 2016-11-24
    • US15114048
    • 2015-01-22
    • WAKO PURE CHEMICAL INDUSTRIES, LTD.
    • Nobuhiko SAKAIKosuke YANABA
    • C07F9/22G03F7/004C07F5/02C07D487/04C07C279/26C07D233/50
    • C07F9/22C07C229/26C07C279/02C07C279/04C07C279/16C07C279/18C07C279/26C07C2601/14C07D233/50C07D487/04C07F5/027C07F9/065C07F9/5337C07F9/572C07F9/6584C07F9/65848G03F7/0045
    • An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound.The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R2 to R4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z+ represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)
    • (其中R1表示烷基;可被卤素原子,烷基,烷氧基或烷硫基取代的芳基炔基;烯基; 2-糠基乙炔基; 2-噻吩基乙炔基;或 2,6-二噻吩基; R 2〜R 4各自独立地表示烷基;可被卤素原子,烷基,烷氧基或烷硫基取代的芳基炔基;可被取代的芳基 具有卤素原子,烷基,烷氧基或烷硫基;呋喃基;噻吩基或N-烷基取代的吡咯基; Z +表示具有胍基的铵阳离子,双胍基或 磷腈鎓基或磷鎓阳离子)
    • 4. 发明授权
    • Process for preparation of α-ketoglutaric acid
    • α-酮戊二酸的制备方法
    • US08680329B2
    • 2014-03-25
    • US12925133
    • 2010-10-13
    • Guoji Zhang
    • Guoji Zhang
    • C07C229/26
    • C07C277/08C07C51/02C07C51/41C07C51/412C07C51/43C07C51/47C07C67/347C07C279/02C07C69/63C07C59/347
    • A process of preparation of α-ketoglutaric acid for mass production of L-arginine α-ketoglutarate 1:1 and 2:1 includes the steps of: reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain Dimethyl 2,2 -dichloroglutarate; reacting the dimethyl 2,2-dichloroglutarate with hydroxide solution to obtain crude α-ketoglutaric acid aqueous solution; purifying the crude α-ketoglutaric acid aqueous solution to obtain purified α-ketoglutaric acid aqueous solution; and adjusting the concentration of the purified α-ketoglutaric acid aqueous solution by adding water. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.
    • 制备α-酮戊二酸的方法,用于大量生产α-酮戊二酸1:1和2:1的L-精氨酸包括以下步骤:使二氯乙酸甲酯和丙烯酸甲酯与甲醇钠反应,得到2,2-二氯戊二酸二甲酯 ; 使2,2-二氯戊二酸二甲酯与氢氧化物溶液反应,得到粗α-酮戊二酸水溶液; 纯化粗α-酮戊二酸水溶液,得到纯化的α-酮戊二酸水溶液; 并通过加水调节纯化的α-酮戊二酸水溶液的浓度。 在避免使用大量有机溶剂的同时,本发明的方法具有显着的高产率,可以实现批量生产,制造成本低,生产时间缩短。