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51. 发明授权

US08554325B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

52. 发明授权

US08285388B2 Passive charge of implantable medical device utilizing external power source and method 有权
标题翻译：使用外部电源的可植入医疗器械的被动电荷和方法
公开(公告)号：US08285388B2
公开(公告)日：2012-10-09
申请号：US12686044
申请日：2010-01-12
申请人： Carl D. Wahlstrand
发明人： Carl D. Wahlstrand
IPC分类号： A61N1/378
CPC分类号： A61M5/14276 , A61M1/12 , A61M1/127 , A61M2205/3523 , A61M2205/8206 , A61M2205/8243 , A61N1/3787 , H02J7/0042 , H02J7/025 , H02J50/12 , H02J50/40 , H02J50/80
摘要： External power source for an implantable medical device implanted in a patient, the implantable medical device having a secondary coil operatively coupled to therapeutic componentry and method therefore. A modulation circuit is operatively coupled to a power source. A plurality of primary coils are operatively coupled to the modulation circuitry and physically associated with an article into which the patient may come into proximity. The modulation circuit drives at least one of the plurality of primary coils. A sensor is coupled to modulation circuit and is adapted to sense proximity of a component related to the implantable medical device. The modulation circuit commences operation to drive at least one of the plurality of primary coils when the sensor senses proximity with the component related to the implantable medical device.
摘要翻译：用于植入患者体内的可植入医疗装置的外部电源，所述可植入医疗装置具有可操作地耦合到治疗组件的次级线圈和因此的方法。调制电路可操作地耦合到电源。多个初级线圈可操作地耦合到调制电路并且物理上与患者可能接近的物品相关联。调制电路驱动多个初级线圈中的至少一个。传感器耦合到调制电路并且适于感测与可植入医疗装置相关的部件的接近度。当传感器感测到与可植入医疗装置相关的部件接近时，调制电路开始操作以驱动多个初级线圈中的至少一个。

53. 发明授权

US08280478B2 Evaluation of implantation site for implantation of implantable medical device 有权
标题翻译：植入医疗器械植入部位评估
公开(公告)号：US08280478B2
公开(公告)日：2012-10-02
申请号：US12538605
申请日：2009-08-10
申请人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
发明人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
IPC分类号： A61B5/04 , A61B6/00
CPC分类号： A61B5/6864 , A61B5/107 , A61B5/686 , A61B5/6868
摘要： In general, the invention is directed to strategies pertaining to implantation of an implantable medical device between a scalp and a skull of the patient. The invention pertains to collection of data such as data pertaining to the skull of the patient, the scalp of the patient, the vascular structure or neurological structures in the head of the patient, and the like. The data may be in the form of images, such as images generated by X-ray, magnetic resonance imaging, CT-scan and fluoroscopy. A surgeon can use the collected data to determine, for example, whether the patient is a candidate for a cranial implantation, whether the patient's skull and scalp can support the implantation, what configuration of device should be implanted, where the device should be implanted, and how the surgical incisions should be made.
摘要翻译：通常，本发明涉及关于在头皮和患者头骨之间植入可植入医疗装置的策略。本发明涉及诸如患者头骨，患者头皮，患者头部的血管结构或神经结构等数据的收集等。数据可以是图像的形式，例如通过X射线产生的图像，磁共振成像，CT扫描和荧光透视。外科医生可以使用收集的数据来确定例如患者是颅骨植入的候选者，患者的颅骨和头皮是否能够支撑植入，应植入装置的哪些配置，植入装置的位置，以及如何做外科切口。

54. 发明申请

US20120108998A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

55. 发明授权

US07684860B2 Components for reducing image distortion 有权
标题翻译：用于减少图像失真的组件
公开(公告)号：US07684860B2
公开(公告)日：2010-03-23
申请号：US11728028
申请日：2007-03-23
申请人： Carl D. Wahlstrand , Mark J. Conroy , John Kast , Erik R. Scott
发明人： Carl D. Wahlstrand , Mark J. Conroy , John Kast , Erik R. Scott
IPC分类号： A61N1/16
CPC分类号： G01R33/56572 , A61B5/055 , A61B34/10 , A61N1/05 , A61N1/0529 , A61N1/0551 , A61N1/08 , A61N1/086 , A61N1/3605 , A61N1/36125 , A61N1/3718 , A61N1/375 , A61N1/3758 , A61N1/378 , G01R33/3875 , H01M2/0217 , H01M2/026 , H01M2/0275 , H01M2/0285 , H01M2/0404 , H01M2/1066 , H01M2/22 , H01M2/263 , H01M2/30 , H01M10/0431 , H01M10/052 , H01M10/0525 , H01M10/0587 , H01M2220/30 , Y10T29/49 , Y10T29/49002
摘要： An implantable medical device includes a housing and a circuit board provided within the housing. The circuit board includes a plurality of electronic components electrically coupled thereto. At least one non-functional component is provided on the circuit board and formed from a material that has an electromagnetic permeability configured to reduce the amount of image distortion caused by at least one of the plurality of electronic components when the device is subject to a magnetic field during an MRI scan.
摘要翻译：可植入医疗装置包括壳体和设置在壳体内的电路板。电路板包括与其电耦合的多个电子部件。至少一个非功能部件设置在电路板上，并且由具有电磁渗透率的材料形成，该材料被配置为当该器件经受磁性时减少由多个电子部件中的至少一个引起的图像失真量在MRI扫描期间。

56. 发明授权

US07657319B2 Programming interface with an unwrapped 2D view of a stimulation lead with complex electrode array geometry 有权
标题翻译：具有复杂电极阵列几何形状的刺激引线的展开2D视图的编程界面
公开(公告)号：US07657319B2
公开(公告)日：2010-02-02
申请号：US11591170
申请日：2006-10-31
申请人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
发明人： Steven M. Goetz , Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand
IPC分类号： A61N1/18
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： A method of programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. The method further includes guided programming to select electrode combinations and parameter values to support efficacy. The techniques may be applied to a programming interface associated with a clinician programmer, a patient programmer, or both. A user interface permits a user to view electrodes from different perspectives relative to the lead. For example, the user interface provides an unwrapped two-dimensional array view of a lead and a concentric axial view of the lead. The user interface may include an axial control medium to select and/or view electrodes at different axial positions along the length of a lead, and a rotational control medium to select and/or view electrodes at different angular positions around a circumference of the lead.
摘要翻译：一种编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量的方法。该方法还包括引导编程以选择电极组合和参数值以支持功效。这些技术可以应用于与临床医生程序员，患者程序员或两者相关联的编程接口。用户界面允许用户从相对于铅的不同角度来观察电极。例如，用户界面提供引线的未展开的二维阵列视图和引线的同心轴向视图。用户界面可以包括轴向控制介质，用于选择和/或查看沿引线长度的不同轴向位置处的电极;以及旋转控制介质，用于选择和/或查看围绕引线圆周的不同角位置处的电极。

57. 发明申请

US20090292327A1 IMPLANTABLE MEDICAL DEVICE WITH ANTI-INFECTION AGENT 有权
标题翻译：具有抗感染剂的可植入医疗器械
公开(公告)号：US20090292327A1
公开(公告)日：2009-11-26
申请号：US12536258
申请日：2009-08-05
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device comprises an anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：可植入医疗装置包括抗感染剂。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

58. 发明申请

US20090099627A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20090099627A1
公开(公告)日：2009-04-16
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/36 , A61B5/0476 , A61M37/00
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

59. 发明授权

US07317947B2 Headset recharger for cranially implantable medical devices 有权
标题翻译：用于头部可植入医疗器械的耳机充电器
公开(公告)号：US07317947B2
公开(公告)日：2008-01-08
申请号：US10835548
申请日：2004-04-29
申请人： Carl D. Wahlstrand , William C. Phillips , Robert M. Skime
发明人： Carl D. Wahlstrand , William C. Phillips , Robert M. Skime
IPC分类号： A61N1/378
CPC分类号： A61N1/3787
摘要： The invention is directed to a recharging system and associated techniques to recharge an implantable medical device (IMD). In particular, a recharging system according to the invention comprises a headset having an energy delivery module that delivers energy to a power source of an IMD implanted on or within the cranium of a patient. The energy delivery module may comprise a coil for inductive transfer of energy to the power source. The headset may be configured for placement over the head of the patient, and may further only partially cover the top of the head. The energy delivery module may be adjustably coupled to the headset. In some embodiments, the position of the energy delivery module may be adjusted along three or four axes, including a rotational axis, allowing the coil to be placed over an IMD located at any of a variety of locations on or within the cranium.
摘要翻译：本发明涉及一种再充电系统和相关技术以对可植入医疗装置（IMD）进行再充电。特别地，根据本发明的再充电系统包括具有能量递送模块的头戴式耳机，所述能量递送模块将能量传递到植入在患者的颅骨上或内部的IMD的动力源。能量传递模块可以包括用于将能量感应地传递到电源的线圈。耳机可以被配置为放置在患者的头部上，并且还可以仅部分地覆盖头部的顶部。能量传递模块可以可调整地耦合到耳机。在一些实施例中，能量输送模块的位置可以沿着三个或四个轴线（包括旋转轴线）进行调整，允许线圈放置在位于颅骨上或颅内的各种位置中的任何位置上的IMD上。

60. 发明申请

US20070203546A1 Electrical and activation field models for configuring stimulation therapy 有权
标题翻译：用于配置刺激治疗的电和激活场模型
公开(公告)号：US20070203546A1
公开(公告)日：2007-08-30
申请号：US11591299
申请日：2006-10-31
申请人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
发明人： Richard T. Stone , Warren W. Ball , Carl D. Wahlstrand , Steven M. Goetz , Lynn M. Otten
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36082
摘要： The disclosure describes a method and system that generates an electrical field model of defined stimulation therapy and displays the electrical field model to a user via a user interface. The electrical field model is generated based upon a patient anatomy and stimulation parameters to illustrate which areas of a patient anatomical region will be covered by the electrical field during therapy. In addition, a neuron model may be applied to the electrical field model to generate an activation field model. The activation field model indicates which neurons will be activated by the electrical field in the anatomical region. These field models may be used by a clinician to determine effective therapy prior to stimulation delivery. In particular, the field models may be beneficial when programming non axi-symmetric, or three-dimensional (3D), leads which allow greater flexibility in creating stimulation fields.
摘要翻译：本公开描述了一种产生定义的刺激疗法的电场模型并通过用户界面向用户显示电场模型的方法和系统。基于患者解剖学和刺激参数产生电场模型，以说明在治疗期间患者解剖区域的哪些区域将被电场覆盖。此外，神经元模型可以应用于电场模型以产生激活场模型。激活场模型指示哪个神经元将被解剖区域中的电场激活。临床医生可以使用这些现场模型来确定在刺激递送之前的有效治疗。特别地，当编程非轴对称或三维（3D））引线时，场模型可能是有益的，这些引导允许在创建刺激场方面具有更大的灵活性。

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