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51. 发明授权

US08214035B2 System and method for utilizing brain state information to modulate cardiac therapy 有权
公开(公告)号：US08214035B2
公开(公告)日：2012-07-03
申请号：US11796575
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/00 , A61B5/00
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/0476 , A61B5/4094 , A61N1/365 , A61N1/37288
摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

52. 发明申请

US20120116179A1 TECHNIQUES FOR DATA RETENTION UPON DETECTION OF AN EVENT IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：在可移植医疗设备中检测事件的数据保留技术
公开(公告)号：US20120116179A1
公开(公告)日：2012-05-10
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/00 , G06F12/02
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

53. 发明申请

US20120108998A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

54. 发明申请

US20120022340A1 DETECTING SLEEP TO EVALUATE THERAPY 有权
标题翻译：检测睡眠以评估治疗
公开(公告)号：US20120022340A1
公开(公告)日：2012-01-26
申请号：US13249862
申请日：2011-09-30
申请人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/0476 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。此外，可以使用脑波信号来识别患者的睡眠状态。

55. 发明申请

US20100292753A1 Method and Apparatus for Detection of Nervous System Disorders 审中-公开
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US20100292753A1
公开(公告)日：2010-11-18
申请号：US12816055
申请日：2010-06-15
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61N1/36
CPC分类号： A61B5/0478 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , G16H20/30 , G16H40/63 , G16H40/67 , G16H50/20
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

56. 发明申请

US20100274115A1 LEAD EXTENSION WITH PHYSIOLOGICAL DATA RECORDER 审中-公开
标题翻译：引导延伸与生理数据记录器
公开(公告)号：US20100274115A1
公开(公告)日：2010-10-28
申请号：US12429921
申请日：2009-04-24
申请人： Jonathan C. Werder , Randy M. Jensen , Donald L. Deyo
发明人： Jonathan C. Werder , Randy M. Jensen , Donald L. Deyo
IPC分类号： A61B5/0476
CPC分类号： A61N1/0551 , A61B5/0031 , A61N1/0531 , A61N1/0534
摘要： A lead extension is provided that includes a physiological data recorder configured to store physiological data from the patient. A first extension segment may electrically and physically couple an implantable medical lead to the physiological data recorder, and a second extension segment may electrically and physically couple an implantable medical device (IMD) or a secondary lead extension to the physiological data recorder. The physiological data recorder may include a processor that collects the physiological data derived from sensed electrical signals from the medical lead and a memory to store the physiological data. The physiological data recorder may also wirelessly transmit the physiological data to an external programmer, or be explanted for data retrieval. In some examples, the physiological data recorder may be powered by electrical signals generated by the IMD, which may be either signals intended solely for charging, or signals intended for stimulation therapy.
摘要翻译：提供引线扩展，其包括被配置为存储来自患者的生理数据的生理数据记录器。第一延伸段可以电和物理地将可植入医疗引线耦合到生理数据记录器，并且第二延伸段可以将可植入医疗设备（IMD）或次级引线延伸部分电气和物理耦合到生理数据记录器。生理数据记录器可以包括收集来自医疗引线的感测电信号的生理数据的处理器和用于存储生理数据的存储器。生理数据记录器也可以将生理数据无线地传输到外部编程器，或者被移植用于数据检索。在一些示例中，生理数据记录器可以由IMD产生的电信号供电，IMD可以是仅用于充电的信号或用于刺激治疗的信号。

57. 发明申请

US20100042187A1 CONNECTING ELECTRICAL SOURCES TO ELECTRODE NODES IN A MEDICAL DEVICE 有权
标题翻译：将电源连接到医疗设备中的电极点
公开(公告)号：US20100042187A1
公开(公告)日：2010-02-18
申请号：US12541611
申请日：2009-08-14
申请人： Jonathan C. Werder , Todd D. Heathershaw
发明人： Jonathan C. Werder , Todd D. Heathershaw
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/0551 , A61N1/36185
摘要： This disclosure describes electrical stimulators that include some electrical sources (e.g., current sources, voltage sources) that are directly connected to a plurality of electrode nodes, and other electrical sources that may be selectively connected to selected ones of the plurality of electrode nodes via a switching unit, such as a multiplexer. One example stimulator comprises a processor, a plurality of electrode nodes, and a stimulation generator that is coupled to the processor and to the plurality of electrode nodes. The stimulation generator comprises a plurality of negative electrical sources, a switching unit, and at least one positive electrical source. The negative electrical sources are each directly connected to a different one of the plurality of electrode nodes. The switching unit is connected to each of the plurality of electrode nodes. The at least one positive electrical source is connected to the switching unit. The switching unit is configured to connect the at least one positive electrical source to a selected one or more of the plurality of electrode nodes.
摘要翻译：本公开描述了电刺激器，其包括直接连接到多个电极节点的一些电源（例如，电流源，电压源），以及可以经由一个或多个电极节点选择性地连接到多个电极节点中的选定电极节点的其他电源开关单元，例如多路复用器。一个示例性刺激器包括处理器，多个电极节点和耦合到处理器和多个电极节点的刺激发生器。刺激发生器包括多个负电源，开关单元和至少一个正电源。负电源各自直接连接到多个电极节点中的不同的一个。开关单元连接到多个电极节点中的每一个。至少一个正电源连接到开关单元。开关单元被配置为将至少一个正电源连接到多个电极节点中选定的一个或多个电极节点。

58. 发明授权

US07624293B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07624293B2
公开(公告)日：2009-11-24
申请号：US11355489
申请日：2006-02-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G06F1/12 , G06F1/14 , G06F1/04
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

59. 发明申请

US20090099627A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20090099627A1
公开(公告)日：2009-04-16
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/36 , A61B5/0476 , A61M37/00
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

60. 发明授权

US07421297B2 Monopolar stimulation assembly including at least one remote electrode 有权
标题翻译：单极刺激组件包括至少一个远程电极
公开(公告)号：US07421297B2
公开(公告)日：2008-09-02
申请号：US11095306
申请日：2005-03-31
申请人： Jonathon E. Giftakis , Jonathan C. Werder , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Jonathan C. Werder , Paul H. Stypulkowski
IPC分类号： A61N1/372
CPC分类号： A61N1/0539 , A61B5/4094 , A61B5/6864 , A61B2018/00434 , A61N1/0534 , A61N1/3605 , A61N1/36082 , A61N1/3752
摘要： An assembly for sensing physiologic signals and delivering monopolar stimulation therapy includes a pulse generator, a lead body that is coupled to the pulse generator and includes a first lead, at least one stimulating electrode coupled to the first lead and adapted to receive stimulating pulses from the pulse generator, and a remote electrode that is coupled to the pulse generator and positioned away from the pulse generator.
摘要翻译：用于感测生理信号和递送单极刺激治疗的组件包括脉冲发生器，引线体，其连接到所述脉冲发生器并且包括第一引线，耦合到所述第一引线的至少一个刺激电极，并适于接收来自所述第一引线的刺激脉冲脉冲发生器以及耦合到脉冲发生器并远离脉冲发生器定位的远程电极。

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