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51. 发明授权

US06073759A Pre-filled package containing unit dose of medical gas and method of making same 有权
公开(公告)号：US06073759A
公开(公告)日：2000-06-13
申请号：US252682
申请日：1999-02-22
申请人： Andrew N. Lamborne , Eugene de Juan, Jr.
发明人： Andrew N. Lamborne , Eugene de Juan, Jr.
IPC分类号： A61M5/178 , A61J1/00 , A61J1/20 , A61M5/00 , A61M13/00 , B65D81/20 , A61M31/00
CPC分类号： A61M5/002 , A61M13/003 , A61F9/0017 , A61J1/20 , A61J1/201 , A61J1/2082 , A61J1/2096 , A61M2209/06 , A61M2210/0612
摘要： A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.

52. 发明授权

US5935155A Visual prosthesis and method of using same 失效
标题翻译：视觉假体及其使用方法
公开(公告)号：US5935155A
公开(公告)日：1999-08-10
申请号：US41933
申请日：1998-03-13
申请人： Mark S. Humayun , Eugene de Juan, Jr. , Robert J. Greenberg
发明人： Mark S. Humayun , Eugene de Juan, Jr. , Robert J. Greenberg
IPC分类号： A61F2/14 , A61F9/08 , A61N1/05 , A61N1/36 , F16L19/02
CPC分类号： A61N1/36046 , A61M39/1011 , A61M5/3213 , A61M2039/1033 , A61M39/10 , A61N1/0543
摘要： A visual prosthesis comprises a camera for perceiving a visual image and generating a visual signal output, retinal tissue stimulation circuitry adapted to be operatively attached to the user's retina, and wireless communication circuitry for transmitting the visual signal output to the retinal tissue stimulation circuitry within the eye. To generate the visual signal output the camera converts a visual image to electrical impulses which are sampled to selecting an image at a given point in time. The sampled image signal is then encoded to allow a pixelized display of it. This signal then is used to modulate a radio frequency carrier signal. A tuned coil pair having a primary and a secondary coil are used to transmit and receive the RF modulated visual signal which is then demodulated within the eye. The retinal stimulation circuitry includes a decoder for decoding the visual signal output into a plurality of individual stimulation control signals which are used by current generation circuitry to generate stimulation current signals to be used by an electrode array having a plurality of electrodes forming a matrix. The intraocular components are powered from energy extracted from the transmitted visual signal. The electrode array is attached to the retina via tacks, magnets, or adhesive.
摘要翻译：视觉假体包括用于感知视觉图像并产生视觉信号输出的相机，适于可操作地附接到用户视网膜的视网膜组织刺激电路，以及用于将视觉信号输出传输到视网膜组织刺激电路内的视觉信号输出眼。为了产生视觉信号输出，相机将视觉图像转换成电脉冲，其被采样以在给定时间点选择图像。然后对采样的图像信号进行编码以允许其像素化显示。该信号然后被用于调制射频载波信号。使用具有初级线圈和次级线圈的调谐线圈对来发射和接收RF调制的视觉信号，然后在眼睛内对其进行解调。视网膜刺激电路包括解码器，用于将视觉信号输出解码为多个单独的刺激控制信号，所述多个个体刺激控制信号由当前生成电路用于产生刺激电流信号以由具有形成矩阵的多个电极的电极阵列使用。眼内组件由从传输的视觉信号中提取的能量供电。电极阵列通过钉，磁体或粘合剂附着到视网膜上。

53. 发明授权

US4991567A Micro-iris retractor 失效
标题翻译：微虹膜牵开器
公开(公告)号：US4991567A
公开(公告)日：1991-02-12
申请号：US465334
申请日：1990-01-16
申请人： Brooks W. McCuen, II , Dyson Hickingbotham , Eugene de Juan, Jr.
发明人： Brooks W. McCuen, II , Dyson Hickingbotham , Eugene de Juan, Jr.
IPC分类号： A61B17/00 , A61B17/02 , A61F9/007
CPC分类号： A61F9/007 , A61B17/0231 , A61B2017/00349 , A61B2017/00473
摘要： This invention concerns the use of stainless steel, disposable tacks to be employed in the mechanical dilation of the iris during opthalmic surgery. Intended for temporary iris fixation, the tack is provided with a hook built onto its proximal end, and with a sharp anterior blade at its distal end. The anterior blade allows easy insertion of the tack through the peripheral cornea of the eye, at the limbal area, and an applicator is provided with a forked holder to firmly grasp the hook in securely placing and removing the tack in the surgical procedure.
摘要翻译：本发明涉及在眼科手术期间使用不锈钢，一次性钉头用于虹膜的机械扩张。为了临时虹膜固定，粘性钉设置有在其近端上构建的钩，并且在其远端具有尖锐的前刀片。前刀片允许粘性剂容易地插入眼睛周边角膜，在边缘区域，并且施用器设置有叉形保持器，以在手术过程中牢固地抓住钩子以牢固地放置和移除粘性。

54. 发明授权

US10166142B2 Small molecule delivery with implantable therapeutic device 有权
公开(公告)号：US10166142B2
公开(公告)日：2019-01-01
申请号：US14236863
申请日：2012-08-03
申请人： Eugene De Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人： Eugene De Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号： A61F9/00 , A61K9/00 , A61K31/382 , A61K31/407 , A61K31/519
摘要： A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

55. 发明授权

US09585789B2 Ocular implant with hydrogel expansion capabilities 有权
标题翻译：眼部植入物具有水凝胶扩张能力
公开(公告)号：US09585789B2
公开(公告)日：2017-03-07
申请号：US13365175
申请日：2012-02-02
申请人： Tom Silvestrini , Eugene De Juan, Jr. , Dan Rosenman
发明人： Tom Silvestrini , Eugene De Juan, Jr. , Dan Rosenman
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0061 , A61F2250/0087
摘要： An ocular implant includes an elongate member having an internal lumen forming a flow pathway that provides a fluid pathway between the anterior chamber and the suprachoroidal space of the eye. The implant includes a hydrogel member attached to the elongate member, wherein the hydrogel member is adapted to expand upon implantation of the elongate member in the eye. An attachment attaches the hydrogel member to the elongate member.
摘要翻译：眼部植入物包括细长构件，其具有形成流动路径的内部内腔，所述流动路径在眼睛的前房和脉管外空间之间提供流体通路。所述植入物包括连接到所述细长构件的水凝胶构件，其中所述水凝胶构件适于在细长构件植入眼中时扩张。附件将水凝胶构件附接到细长构件。

56. 发明申请

US20140358125A1 SMALL MOLECULE DELIVERY WITH IMPLANTABLE THERAPEUTIC DEVICE 审中-公开
标题翻译：小分子递送与可植入治疗设备
公开(公告)号：US20140358125A1
公开(公告)日：2014-12-04
申请号：US14236863
申请日：2012-08-03
申请人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号： A61F9/00 , A61K31/382
CPC分类号： A61F9/0017 , A61F2250/0031 , A61F2250/0068 , A61K9/0051 , A61K31/382 , A61K31/407 , A61K31/519 , F04C2270/041
摘要： A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译：一种能够释放治疗剂的治疗装置，所述治疗剂包括与包含储存器的容器相连的多孔结构。贮存器可以包含一定量的体积，当耦合到多孔结构并且植入患者体内时，释放处理量的治疗剂延长时间。所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。

57. 发明申请

US20140066831A1 OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权
标题翻译：具有坚固质量的OCULAR植入物，植入和系统的方法
公开(公告)号：US20140066831A1
公开(公告)日：2014-03-06
申请号：US14071500
申请日：2013-11-04
申请人： Thomas A. Silvestrini , Eugene de Juan, JR.
发明人： Thomas A. Silvestrini , Eugene de Juan, JR.
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译：本文描述了用于治疗眼睛状况的装置和方法。描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长成员植入眼睛。细长构件具有赋予细长构件刚性的壁材料。选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

58. 发明申请

US20140031769A1 THERAPEUTIC AGENT FORMULATIONS FOR IMPLANTED DEVICES 审中-公开
标题翻译：用于植入装置的治疗剂制剂
公开(公告)号：US20140031769A1
公开(公告)日：2014-01-30
申请号：US13988298
申请日：2011-11-18
申请人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson , Blaine Bueche
发明人： Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson , Blaine Bueche
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1652 , A61K31/573
摘要： An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.
摘要翻译：治疗剂的可注射制剂可以包含治疗剂和稳定剂，使得当治疗剂从治疗装置释放时，大部分稳定剂保留在治疗装置中以稳定治疗剂。可注射制剂可以包含一种或多种粘合剂颗粒或可侵蚀材料颗粒，使得可以将制剂注射到治疗装置中。结合剂颗粒可以可逆地结合治疗剂以调节治疗剂的释放，并且可侵蚀的材料颗粒可以产生酸的质子，以增加治疗剂的稳定性并且可以调节治疗剂的释放。治疗剂可以与稳定剂，结合剂颗粒或可侵蚀颗粒中的一种或多种组合以增加治疗剂的稳定性并且可以调节释放。

59. 发明申请

US20140028979A1 METHODS AND APPARATUS TO IDENTIFY EYE COVERINGS FOR VISION 有权
标题翻译：识别眼睛覆盖面的方法和设备
公开(公告)号：US20140028979A1
公开(公告)日：2014-01-30
申请号：US13885135
申请日：2011-10-25
申请人： Eugene De Juan ,Jr. , Yair Alster , Cary J. Reich , Ashley Tuan , Angela K. MacFarlane , Matt Clarke , Brian Levy
发明人： Eugene De Juan ,Jr. , Yair Alster , Cary J. Reich , Ashley Tuan , Angela K. MacFarlane , Matt Clarke , Brian Levy
IPC分类号： G02C7/04 , G02C7/02
CPC分类号： G02C7/047 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/1015 , A61B3/107 , A61B3/18 , A61F9/00804 , A61F9/00806 , A61F9/04 , A61F2009/00859 , A61F2009/00872 , G02C7/027 , G02C7/04 , G02C7/048 , G02C7/049 , G02C2202/16
摘要： Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering. The covering can be identified based on an inner corneal curvature and an outer corneal curvature and one or more of a limbus sag height or a conjunctival sag height. The covering may form a chamber when placed on the eye to pump tear liquid under at least a portion of the covering. The covering may comprise an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The covering may comprise a material having high oxygen permeability, for example silicone, with a wettable coating disposed on at least an upper surface of the coating.
摘要翻译：方法和装置可以配合护理眼睛。可以识别覆盖物，以便在覆盖物下方提供改善的泪液流动。可以基于内部角膜曲率和外部角膜曲率以及角膜缘下垂高度或结膜下垂高度中的一个或多个来识别覆盖物。当覆盖物放置在眼睛上时，该覆盖物可以形成一个室，以在至少一部分覆盖物之下泵送泪液。覆盖物可以包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分，并提供用于上皮再生的环境。覆盖物可以包括具有高氧渗透性的材料，例如硅树脂，其中可湿性涂层设置在涂层的至少上表面上。

60. 发明申请

US20130324942A1 IMPLANTABLE THERAPEUTIC DEVICE 有权
标题翻译：可植入治疗装置
公开(公告)号：US20130324942A1
公开(公告)日：2013-12-05
申请号：US13814464
申请日：2011-08-05
申请人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
发明人： Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the 188 second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译：用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第188侧的距离的有效长度。治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。

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