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1. 发明授权

US5944747A Method for preferential outer retinal stimulation 失效
标题翻译：优良外视网膜刺激的方法
公开(公告)号：US5944747A
公开(公告)日：1999-08-31
申请号：US041932
申请日：1998-03-13
申请人： Robert J. Greenberg , Mark S. Humayun , Eugene de Juan, Jr.
发明人： Robert J. Greenberg , Mark S. Humayun , Eugene de Juan, Jr.
IPC分类号： A61F9/08 , A61N1/36 , A61N1/32
CPC分类号： A61N1/36046
摘要： A method of focused phosphene generation through deeper intermediate retinal cellular electrical stimulation to the exclusion of direct ganglion cellular electrical stimulation comprises the steps of: a) positioning a stimulating electrode in the vicinity of retinal tissue; and b) applying a long duration stimulation signal to the electrode such that deeper intermediate retinal cells are preferentially stimulated over the retinal ganglion cells and proximal overlying surface axons. The long duration stimulation signal is preferably a biphasic signal having a negative and a positive phase pulse which is applied in cathodic fashion. To preferentially stimulate the deeper intermediate retinal elements the duration of the long duration stimulation signal is greater than 0.5 millisecond per phase pulse, and preferably equal to or longer than 2 millisecond per phase pulse. The biphasic signal is preferably adjusted to simulate a monophasic signal by adjusting the magnitude of the negative pulse in relation to positive pulse, and by adjusting the duration of the positive pulse in relation to the negative pulse to maintain approximately net zero charge introduction. Preferably, the ratio of the negative pulse to the positive pulse is approximately 10:1 or greater.
摘要翻译：通过更深的中间视网膜细胞电刺激产生聚焦磷酸的方法排除直接神经节细胞电刺激包括以下步骤：a）将刺激电极定位在视网膜组织附近; 和b）对电极施加长时间刺激信号，使得较深的中间视网膜细胞优先在视网膜神经节细胞和近侧上表面轴突上被刺激。长持续时间刺激信号优选是具有以阴极方式施加的负相和正相脉冲的双相信号。为了优先地刺激较深的中间视网膜元件，长时间刺激信号的持续时间大于每相脉冲0.5毫秒，并且优选地等于或大于每相脉冲2毫秒。优选地调节双相信号以通过相对于正脉冲调整负脉冲的幅度，并通过相对于负脉冲调整正脉冲的持续时间来维持近似净零电荷引入来模拟单相信号。优选地，负脉冲与正脉冲的比率为大约10:1或更大。

2. 发明授权

US5935155A Visual prosthesis and method of using same 失效
标题翻译：视觉假体及其使用方法
公开(公告)号：US5935155A
公开(公告)日：1999-08-10
申请号：US41933
申请日：1998-03-13
申请人： Mark S. Humayun , Eugene de Juan, Jr. , Robert J. Greenberg
发明人： Mark S. Humayun , Eugene de Juan, Jr. , Robert J. Greenberg
IPC分类号： A61F2/14 , A61F9/08 , A61N1/05 , A61N1/36 , F16L19/02
CPC分类号： A61N1/36046 , A61M39/1011 , A61M5/3213 , A61M2039/1033 , A61M39/10 , A61N1/0543
摘要： A visual prosthesis comprises a camera for perceiving a visual image and generating a visual signal output, retinal tissue stimulation circuitry adapted to be operatively attached to the user's retina, and wireless communication circuitry for transmitting the visual signal output to the retinal tissue stimulation circuitry within the eye. To generate the visual signal output the camera converts a visual image to electrical impulses which are sampled to selecting an image at a given point in time. The sampled image signal is then encoded to allow a pixelized display of it. This signal then is used to modulate a radio frequency carrier signal. A tuned coil pair having a primary and a secondary coil are used to transmit and receive the RF modulated visual signal which is then demodulated within the eye. The retinal stimulation circuitry includes a decoder for decoding the visual signal output into a plurality of individual stimulation control signals which are used by current generation circuitry to generate stimulation current signals to be used by an electrode array having a plurality of electrodes forming a matrix. The intraocular components are powered from energy extracted from the transmitted visual signal. The electrode array is attached to the retina via tacks, magnets, or adhesive.
摘要翻译：视觉假体包括用于感知视觉图像并产生视觉信号输出的相机，适于可操作地附接到用户视网膜的视网膜组织刺激电路，以及用于将视觉信号输出传输到视网膜组织刺激电路内的视觉信号输出眼。为了产生视觉信号输出，相机将视觉图像转换成电脉冲，其被采样以在给定时间点选择图像。然后对采样的图像信号进行编码以允许其像素化显示。该信号然后被用于调制射频载波信号。使用具有初级线圈和次级线圈的调谐线圈对来发射和接收RF调制的视觉信号，然后在眼睛内对其进行解调。视网膜刺激电路包括解码器，用于将视觉信号输出解码为多个单独的刺激控制信号，所述多个个体刺激控制信号由当前生成电路用于产生刺激电流信号以由具有形成矩阵的多个电极的电极阵列使用。眼内组件由从传输的视觉信号中提取的能量供电。电极阵列通过钉，磁体或粘合剂附着到视网膜上。

3. 发明授权

US5109844A Retinal microstimulation 失效
标题翻译：视网膜微刺激
公开(公告)号：US5109844A
公开(公告)日：1992-05-05
申请号：US595442
申请日：1990-10-11
申请人： Eugene de Juan, Jr. , Mark S. Humayun , D. Howard Phillips
发明人： Eugene de Juan, Jr. , Mark S. Humayun , D. Howard Phillips
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37205
摘要： A method for stimulating a retinal ganglion cell in a retina without penetrating the retinal basement membrane at the surface of the retina comprises: (a) positioning a ganglion cell stimulating electrode on or above the retinal basement membrane; (b) providing a ground electrode in operative association with the ganglion cell stimulating electrode, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by the stimulating electrode; and (c) applying a voltage to said stimulating electrode sufficient to produce an electric current which penetrates the retina and produces an action potential in a retinal ganglion cell. Apparatus for practicing the foregoing method is also disclosed.
摘要翻译：用于刺激视网膜中视网膜神经节细胞而不穿透视网膜表面的视网膜基底膜的方法包括：（a）将神经节细胞刺激电极定位在视网膜基底膜上或上方; （b）提供与神经节细胞刺激电极可操作关联的接地电极，其中接地电极位于视网膜基底膜上或上方，并定位成用于捕获由刺激电极产生的电流; 和（c）向所述刺激电极施加足以产生穿透视网膜并在视网膜神经节细胞中产生动作电位的电流的电压。还公开了用于实施上述方法的装置。

4. 发明授权

US06866142B2 Pre-filled package containing unit dose of medical gas and method of making the same 有权
标题翻译：预装包装单位剂量的医用气体及其制造方法
公开(公告)号：US06866142B2
公开(公告)日：2005-03-15
申请号：US10290093
申请日：2002-11-07
申请人： Andrew N. Lamborne , Eugene de Juan, Jr.
发明人： Andrew N. Lamborne , Eugene de Juan, Jr.
IPC分类号： A61M5/178 , A61J1/00 , A61J1/20 , A61M5/00 , A61M13/00 , A61M31/00 , B65D81/20
CPC分类号： A61M5/002 , A61F9/0017 , A61J1/20 , A61J1/201 , A61J1/2082 , A61J1/2096 , A61M13/003 , A61M2209/06 , A61M2210/0612
摘要： A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.
摘要翻译：提供了单位剂量的充气注射器，其在使用之前填充有气体并封装在阻气材料中以增加保质期，即使气体泄漏和注射器内容物的稀释最小化。注射器填充有选定的气体并密封在由高阻气材料制成的容器内。容器还装有选定的气体。容器材料被选择为具有足以防止选定气体从容器扩散进入大气中的气体透过率。容器中的气体体积大于大气压，以防止大气污染物进入容器和注射器。

5. 发明授权

US06309419B1 Tympanic membrane prosthesis with mechanical fixation 有权
标题翻译：鼓膜假体与机械固定
公开(公告)号：US06309419B1
公开(公告)日：2001-10-30
申请号：US09276710
申请日：1999-03-26
申请人： Eugene de Juan, Jr. , R. Scott Rader , Terry H. Shelley , Andrew N. Lamborne , Alexander C. Walsh , John K. Niparko
发明人： Eugene de Juan, Jr. , R. Scott Rader , Terry H. Shelley , Andrew N. Lamborne , Alexander C. Walsh , John K. Niparko
IPC分类号： A61F218
CPC分类号： A61F2/18 , A61F2002/183
摘要： A tympanic membrane prosthesis is provided that includes, in combination, a generally flat, planar membrane sized to overlay a tear or perforation in the tympanic membrane and having at least one preformed perforation, and at least one mechanical fixation device for fixing the membrane to the tympanic membrane of a patient. Each mechanical fixation device is a tack component including a sharp, piercing distal end, an enlarged proximal end and a shaft extending therebetween. A tack insertion device is provided to guide the tack to and through the tear covering membrane.
摘要翻译：提供了一种鼓膜假体，其组合包括大致平坦的平面膜，其大小适于覆盖鼓膜中的泪液或穿孔并且具有至少一个预成形穿孔，以及至少一个机械固定装置，用于将膜固定到患者的鼓膜。每个机械固定装置是一种粘性部件，包括尖锐的，穿刺的远端，扩大的近端和在它们之间延伸的轴。提供一种定位插入装置，用于将粘性物引导并穿过泪膜覆盖膜。

6. 发明授权

US5993072A Adapter assembly for connecting multiple optic fiber illuminated microsurgical instruments to a single light source 失效
标题翻译：用于将多个光纤照明的显微外科器械连接到单个光源的适配器组件
公开(公告)号：US5993072A
公开(公告)日：1999-11-30
申请号：US633428
申请日：1996-04-17
申请人： Eugene de Juan, Jr. , Gregg D. Scheller , Michael D. Auld , Dyson Hickingbotham
发明人： Eugene de Juan, Jr. , Gregg D. Scheller , Michael D. Auld , Dyson Hickingbotham
IPC分类号： A61B5/00 , G02B6/24 , G02B6/38 , G02B6/36
CPC分类号： A61B5/0084 , G02B6/241 , G02B6/3833 , A61B2562/228 , G02B6/3834 , Y10S385/902
摘要： An assembly of connectors adapt multiple optic fiber illuminators of microsurgical instruments for use with a variety of different available light sources.
摘要翻译：连接器的组件适应于用于各种不同可用光源的显微外科器械的多个光纤照明器。

7. 发明授权

US09883968B2 Fluid exchange apparatus and methods 有权
公开(公告)号：US09883968B2
公开(公告)日：2018-02-06
申请号：US13615229
申请日：2012-09-13
申请人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, Jr. , Douglas Sutton , Kathleen Cogan Farinas
发明人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, Jr. , Douglas Sutton , Kathleen Cogan Farinas
IPC分类号： A61F9/00 , A61M25/00 , A61M39/02 , A61M5/14 , A61M5/32 , A61M5/46 , A61M39/00 , A61M5/142
CPC分类号： A61F9/0008 , A61F9/0017 , A61M5/141 , A61M5/14276 , A61M5/3202 , A61M5/3291 , A61M5/46 , A61M25/007 , A61M39/0247 , A61M2025/0031 , A61M2025/0039 , A61M2039/0081 , A61M2039/009 , A61M2039/027 , A61M2039/0276 , A61M2039/0294 , A61M2205/6045 , A61M2205/6054 , A61M2209/045 , A61M2210/0612
摘要： An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

8. 发明授权

US09498385B2 Conformable therapeutic shield for vision and pain 有权
公开(公告)号：US09498385B2
公开(公告)日：2016-11-22
申请号：US13503842
申请日：2010-10-25
申请人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人： Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC分类号： A61F13/00 , A61F13/12 , A61F9/00 , A61F9/013 , A61F9/04 , A61L27/18 , G02C7/04 , A61F9/008
CPC分类号： G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

9. 发明授权

US09492315B2 Implantable therapeutic device 有权
公开(公告)号：US09492315B2
公开(公告)日：2016-11-15
申请号：US13814464
申请日：2011-08-05
申请人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
发明人： Eugene de Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

10. 发明授权

US09421126B2 Anterior segment drug delivery 有权
标题翻译：前段药物递送
公开(公告)号：US09421126B2
公开(公告)日：2016-08-23
申请号：US13151001
申请日：2011-06-01
申请人： Yair Alster , Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
发明人： Yair Alster , Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
IPC分类号： A61F9/00 , A61M35/00 , A61K9/00 , A61K31/19 , A61K31/407 , A61K31/4178 , A61K31/5377 , A61K31/5415 , A61K31/43 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61K9/0051 , A61K31/19 , A61K31/335 , A61K31/407 , A61K31/4178 , A61K31/43 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/002
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.
摘要翻译：治疗系统包括放置在眼睛的光学区域外的区域上的眼部插入物。眼睛插入件包括两个结构：第一骨架结构和第二缓冲结构。第一结构用作骨架框架，其保持沿着眼睛前部的植入物的定位，并向第二缓冲结构提供支撑。该第一结构将治疗系统的附着维持在眼前部至少三十天。在一些实施例中，第一结构保持恒定的尺寸和形状，例如。环形，具有触觉的环或曲线环，其限制并限制性地接合下部和上部结膜孔，以将植入物保持在泪液和/或针对眼睛的组织。

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