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1. 发明授权

US09943401B2 Therapeutic device for pain management and vision 有权
公开(公告)号：US09943401B2
公开(公告)日：2018-04-17
申请号：US12384659
申请日：2009-04-06
申请人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
发明人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
IPC分类号： A61F2/14 , A61F9/00 , G02C7/04
CPC分类号： A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.

2. 发明授权

US09125735B2 Method of correcting vision using corneal onlays 有权
标题翻译：使用角膜镶嵌矫正视力的方法
公开(公告)号：US09125735B2
公开(公告)日：2015-09-08
申请号：US12897131
申请日：2010-10-04
申请人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro
发明人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro
IPC分类号： A61F2/14 , A61F9/00
CPC分类号： A61F9/007 , A61F2/142 , A61F2/1451 , A61F2/1453 , A61F9/0017 , A61F2250/0019
摘要： A corneal onlay is configured to adhere to the cornea so as to inhibit epithelial growth under the onlay. Structures can be provided on the onlay to adhere the onlay to the eye. At least one of an epithelial layer or the water inhibiting layer can be provided on or over the onlay, for example a natural epithelial layer or water inhibiting layer that inhibits, for example minimizes, water penetration into the onlay, so as to adhere the onlay to the eye with pumping of the endothelium. The water inhibiting layer may comprise a therapeutic covering positioned over the onlay to inhibit swelling of the cornea. The posterior surface of the onlay may be shaped so as to fit the anterior exposed surface of the cornea.
摘要翻译：角膜镶嵌被配置成粘附在角膜上，以便抑制覆盖物下的上皮生长。可以在镶嵌上提供结构以将贴面粘附到眼睛上。上皮层或水分抑制层中的至少一个可以设置在覆盖物上或上方，例如天然上皮层或水分抑制层，其抑制例如使水渗入到镶嵌物中的最小程度，以便粘附该覆盖层通过泵送内皮到眼睛。防水层可以包括定位在覆层上的治疗覆盖物，以抑制角膜的肿胀。垫片的后表面可以被成形为适合角膜的前暴露表面。

3. 发明申请

US20150133878A1 Ocular Insert Apparatus and Methods 有权
标题翻译：眼插入装置和方法
公开(公告)号：US20150133878A1
公开(公告)日：2015-05-14
申请号：US14600505
申请日：2015-01-20
申请人： Eugene de Juan, JR. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
发明人： Eugene de Juan, JR. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
IPC分类号： A61F9/00 , A61L27/16 , A61L27/02 , A61K9/00
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

4. 发明授权

US08939948B2 Ocular insert apparatus and methods 有权
标题翻译：眼插装置和方法
公开(公告)号：US08939948B2
公开(公告)日：2015-01-27
申请号：US13618052
申请日：2012-09-14
申请人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
发明人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton , Alexander J. Gould
IPC分类号： A61M35/00 , A61B17/00 , A61F9/00 , A61K9/00 , A61K47/34
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

5. 发明授权

US08715712B2 Ocular insert apparatus and methods 有权
标题翻译：眼插装置和方法
公开(公告)号：US08715712B2
公开(公告)日：2014-05-06
申请号：US13688019
申请日：2012-11-28
申请人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Jose D. Alejandro
发明人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Jose D. Alejandro
IPC分类号： A61F2/00
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

6. 发明授权

US08715346B2 Intraocular, accommodating lens and methods of use 有权
标题翻译：眼内镜，适配镜片及使用方法
公开(公告)号：US08715346B2
公开(公告)日：2014-05-06
申请号：US13858647
申请日：2013-04-08
申请人： Eugene de Juan, Jr. , Stephen Boyd , Hanson Gifford , Cary Reich
发明人： Eugene de Juan, Jr. , Stephen Boyd , Hanson Gifford , Cary Reich
IPC分类号： A61F2/16
CPC分类号： A61F2/1694 , A61F2/1635 , A61F2/1648 , A61F2002/1682 , A61F2210/0019
摘要： An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.
摘要翻译：眼内透镜适于插入具有区域接触区域的囊袋中。所述眼内透镜包括形状改变光学元件和容纳元件，所述容纳元件包括至少一个力传递元件和多个间隔开的接触元件，每个接触元件适于接触所述区域接触区域的一部分，并以所述光学元件被配置为与哺乳动物眼睛的睫状肌，哺乳动物眼睛的小环和眼睛中的玻璃体压力中的至少一个配合，以实现对光学元件的适应形状和不适应的形状的变化。

7. 发明授权

US08628792B2 Drug cores for sustained release of therapeutic agents 有权
标题翻译：用于持续释放治疗剂的药物核心
公开(公告)号：US08628792B2
公开(公告)日：2014-01-14
申请号：US13367823
申请日：2012-02-07
申请人： Deepank Utkhede , Robert W. Shimizu , Rachna Jain , Stephen Boyd , Hanson S. Gifford , Eugene De Juan, Jr. , Cary J. Reich
发明人： Deepank Utkhede , Robert W. Shimizu , Rachna Jain , Stephen Boyd , Hanson S. Gifford , Eugene De Juan, Jr. , Cary J. Reich
IPC分类号： A61F2/00 , B28B11/12
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/00772 , A61F2230/0069 , A61F2250/0067 , A61K31/5575 , A61K47/34 , A61L27/54 , A61L2300/41 , A61L2300/602 , A61L2300/802 , Y02A50/395
摘要： A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.
摘要翻译：可以通过将包含治疗剂和基质前体的液体混合物注入鞘体来制造固体药物核心插入物。注射可以在低于环境温度下进行。将混合物固化以形成固体药物基质核心。治疗剂可以是在约室温下的液体，其形成液滴在基质材料中的分散体。固体药物核心的表面例如通过切割管而暴露，并且固体药物核心的暴露表面在植入患者体内释放治疗剂量。在一些实施方案中，插入体抑制治疗剂的释放，例如具有对治疗剂基本上不可渗透的材料，使得治疗量通过暴露表面释放，从而避免将治疗剂释放到非靶组织。

8. 发明授权

US08574294B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
标题翻译：具有刚度质量的眼植入物，植入方法和系统
公开(公告)号：US08574294B2
公开(公告)日：2013-11-05
申请号：US12970567
申请日：2010-12-16
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译：本文描述了用于治疗眼睛状况的装置和方法。描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长成员植入眼睛。细长构件具有赋予细长构件刚性的壁材料。选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

9. 发明申请

US20130274692A1 SUBCONJUCTIVAL IMPLANT FOR POSTERIOR SEGMENT DRUG DELIVERY 审中-公开
标题翻译：用于分支部门药物递送的分支植入物
公开(公告)号：US20130274692A1
公开(公告)日：2013-10-17
申请号：US13814470
申请日：2011-08-04
申请人： Yair Alster , Eugene De Juan, JR. , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人： Yair Alster , Eugene De Juan, JR. , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61K31/00 , A61K31/573 , A61K31/58
摘要： A therapeutic device can be configured to place the reservoir substantially between the conjunctiva and the scleral such that the size of the reservoir can be increased and the size of the scleral penetration decreased so as to decrease invasiveness. The device may comprise a substantially constant reservoir volume and drug release mechanism, in which the volume of the reservoir and mechanism are tuned to receive a quantity of therapeutic agent with a volume of injected formulation and release the therapeutic agent for an extended time with a release rate profile. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent, and a plurality of interconnecting channels can extend from the first side to the second side.
摘要翻译：治疗装置可以被配置为将储存器基本上放置在结膜和巩膜之间，使得储存器的尺寸可以增加并且巩膜穿透的尺寸减小以降低侵入性。该装置可以包括基本上恒定的储存器体积和药物释放机构，其中储存器和机构的体积被调谐以接收一定量的具有注射制剂体积的治疗剂，并释放治疗剂延长的时间费率简介。多孔结构可以包括联接到储存器的第一侧和耦合到患者以释放治疗剂的第二侧，并且多个互连通道可以从第一侧延伸到第二侧。

10. 发明申请

US20130144128A1 OCULAR INSERT APPARATUS AND METHODS 有权
标题翻译： OCULAR插入装置和方法
公开(公告)号：US20130144128A1
公开(公告)日：2013-06-06
申请号：US13618052
申请日：2012-09-14
申请人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton
发明人： Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , K. Angela MacFarlane , Janelle Chang , Stephen Boyd , David Sierra , Jose D. Alejandro , Douglas Sutton
IPC分类号： A61B17/00
CPC分类号： A61F9/0017 , A61B17/00234 , A61K9/0051 , A61K47/34 , A61L27/025 , A61L27/16
摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.
摘要翻译：舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

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