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41. 发明授权

US07082898B2 Internal combustion engine of compression ignition type 失效
标题翻译：压缩点火式内燃机
公开(公告)号：US07082898B2
公开(公告)日：2006-08-01
申请号：US10817956
申请日：2004-04-06
申请人： Tohru Kitamura , Tomio Kimura , Shohei Okazaki , Akira Kato , Toshihiro Yamaki , Katsura Okubo , Moriyoshi Awasaka , Junji Yasuda , Yasuhiro Urata , Takashi Kakinuma , Yoshimasa Kaneko
发明人： Tohru Kitamura , Tomio Kimura , Shohei Okazaki , Akira Kato , Toshihiro Yamaki , Katsura Okubo , Moriyoshi Awasaka , Junji Yasuda , Yasuhiro Urata , Takashi Kakinuma , Yoshimasa Kaneko
IPC分类号： F02B1/14
CPC分类号： F02D41/3058 , F02B1/12 , F02B3/06 , F02B69/06 , F02D41/3035
摘要： The present invention aims at expanding an operation range for allowing a compression ignition combustion operation. The present invention provides an internal combustion engine of a compression ignition type that is capable of operating with a compression ignition combustion scheme in a given operation range. The ECU of the internal combustion engine detects an operating condition of the internal combustion engine and determines, according to the detected operating condition, which mode is to be used operate the internal combustion engine, a 4-cycle compression ignition mode or a 2-cycle compression ignition mode. The ECU controls the internal compression engine to perform the compression ignition mode determined. According to the present invention, the compression ignition combustion operation is switched from 4-cycle to 2-cycle when the operating condition of the internal combustion engine is in such state that the 4-cycle compression ignition mode cannot be performed, fro example, when the exhaust temperature is low.
摘要翻译：本发明旨在扩大用于允许压缩点火燃烧操作的操作范围。本发明提供一种压缩点火式的内燃机，其能够在给定的操作范围内使用压缩点火燃烧方案。内燃机的ECU检测内燃机的运转状态，根据检测到的运转状况，判断要使用哪种运行方式的内燃机，4循环压缩点火模式或2循环压缩点火模式。 ECU控制内部压缩引擎执行压缩点火模式。根据本发明，当内燃机的运行状态处于不能进行4循环压缩点火模式的状态时，压缩点火燃烧运转从4循环切换到2循环，例如，当排气温度低。

42. 发明授权

US06611744B1 Steering assist apparatus for traveling in reverse 失效
标题翻译：转向辅助装置反向行驶
公开(公告)号：US06611744B1
公开(公告)日：2003-08-26
申请号：US09807348
申请日：2001-07-13
申请人： Kazunori Shimazaki , Koji Hika , Satoshi Yamada , Isao Suzuki , Masahiko Ando , Tomio Kimura , Kousuke Teramura , Hisashi Kuriya
发明人： Kazunori Shimazaki , Koji Hika , Satoshi Yamada , Isao Suzuki , Masahiko Ando , Tomio Kimura , Kousuke Teramura , Hisashi Kuriya
IPC分类号： G06F700
CPC分类号： B60R1/00 , B60R2300/207 , B60R2300/301 , B60R2300/302 , B60R2300/305 , B60R2300/404 , B60R2300/806 , B60R2300/8086 , B60T2201/10 , B62D15/028
摘要： A steering assist apparatus includes a camera for picking up the rear side of a vehicle, a monitor disposed in a driver's compartment of the vehicle, a steering angle sensor for detecting a steering angle of a steering wheel, and a display controlling unit for displaying on the monitor an image through said camera when the vehicle reverses and for superimposing and displaying on said monitor a guide display for assisting the drive of the vehicle when the vehicle is to be parked. The guide display includes a steering start guide line fixedly displayed in a predetermined position of an image field of the monitor for guiding a steering start position for parking, and a steering amount guide mark moved and displayed along the steering start guide line on the image field of the monitor in correspondence with a steering angle of the steering wheel detected by the steering angle sensor. The driver performs the steering operation of the vehicle while recognizing the position for the opposite turning of the steering wheel and the steering amount and the steering start position for parking on the basis of the image on the rear side of the vehicle and the steering amount guide mark and the steering start guide line.
摘要翻译：转向辅助装置包括用于拾取车辆后侧的照相机，设置在车辆的驾驶室中的监视器，用于检测方向盘的转向角的转向角传感器，以及用于显示方向盘的显示控制单元当车辆反转时，通过所述摄像机监视图像，并且在所述监视器上叠加和显示用于当车辆停放时辅助车辆的驱动的引导显示器。引导显示器包括固定地显示在监视器的图像场的预定位置的导向引导线，用于引导用于停车的转向开始位置，以及沿着转向启动引导线在图像场上移动和显示的转向量引导标记与转向角传感器检测到的方向盘的转向角对应的监视器。驾驶员在基于车辆后方的图像识别出方向盘的相对转动的位置和转向量以及用于停车的转向开始位置的位置时，执行车辆的转向操作，并且转向量引导件标记和转向启动指导线。

43. 发明授权

US5591752A Quinoline derivative 失效
标题翻译：喹啉衍生物
公开(公告)号：US5591752A
公开(公告)日：1997-01-07
申请号：US505172
申请日：1995-08-16
申请人： Tomio Kimura , Yoshio Kaku , Takashi Ikuta , Hiroshi Fujiwara , Hitoshi Ueno , Eiji Okanari
发明人： Tomio Kimura , Yoshio Kaku , Takashi Ikuta , Hiroshi Fujiwara , Hitoshi Ueno , Eiji Okanari
IPC分类号： C07D405/12 , C07D405/14 , C07D403/10 , A61K31/47 , C07D407/10
CPC分类号： C07D405/12 , C07D405/14
摘要： This invention relates to a compound (a quinoline derivative) represented by the formula (I): ##STR1## The quinoline derivative of this invention has a strong leukotriene antagonistic action and is extremely useful as an antiallergic medicine and an anti-inflammatory medicine.
摘要翻译： PCT No.PCT / JP94 / 00234 Sec。 371日期：1995年8月16日 102（e）日期1995年8月16日PCT 1994年2月16日PCT PCT。 WO94 / 19345 PCT公开号 1994年9月1日本发明涉及由式（I）表示的化合物（喹啉衍生物）：本发明具有强烈的白三烯拮抗作用，作为抗过敏药和抗炎药非常有用。

44. 发明授权

US5436242A Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof for inhibiting blood platelet aggregation 失效
标题翻译：四氢噻吩并吡啶衍生物，呋喃和吡咯类似物用于抑制血小板聚集
公开(公告)号：US5436242A
公开(公告)日：1995-07-25
申请号：US161046
申请日：1993-12-01
申请人： Hiroyuki Koike , Fumitoshi Asai , Atsuhiro Sugidachi , Tomio Kimura , Teruhiko Inoue , Shigeyoshi Nishino , Yasunori Tsuzaki
发明人： Hiroyuki Koike , Fumitoshi Asai , Atsuhiro Sugidachi , Tomio Kimura , Teruhiko Inoue , Shigeyoshi Nishino , Yasunori Tsuzaki
IPC分类号： A61K31/435 , A61K31/135 , A61K31/365 , A61K31/4365 , A61P7/02 , C07D221/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/535 , C07D273/01
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.
摘要翻译：式（I）化合物：其中R1是氢，烷基，卤素，卤代烷基，羟基，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基，氨基，烷酰基，卤代烷酰基，羧基，烷氧基羰基，氨基甲酰基，氰基，硝基，烷磺酰基，卤代烷磺酰基或氨磺酰基; R 2是5,6-二氢-1,4,2-二恶嗪-3-基; R3是氢，羟基，任选取代的烷氧基，芳烷氧基，烷酰氧基，烯酰基氧基，环烷基羰基氧基，芳基羰基氧基，烷氧基羰基氧基，芳烷氧基羰基氧基，邻苯二甲酰氧基，（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲氧基，（5- 苯基-2-氧代-1,3-二氧杂环戊烯-4-基）甲氧基，任选取代的氨基或硝基; Y是-NH-或氧或硫; n为1至5; 和所述式（I）化合物的互变异构体和盐具有抑制血小板聚集的能力，因此可用于治疗和预防血栓形成和栓塞。

45. 发明授权

US5288726A Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation 失效
标题翻译：四氢噻吩并吡啶衍生物，呋喃和吡咯类似物及其制备和用途，用于抑制血小板聚集
公开(公告)号：US5288726A
公开(公告)日：1994-02-22
申请号：US941676
申请日：1992-09-08
申请人： Hiroyuki Koike , Fumitoshi Asai , Atsuhiro Sugidachi , Tomio Kimura , Teruhiko Inoue , Shigeyoshi Nishino , Yasunori Tsuzaki
发明人： Hiroyuki Koike , Fumitoshi Asai , Atsuhiro Sugidachi , Tomio Kimura , Teruhiko Inoue , Shigeyoshi Nishino , Yasunori Tsuzaki
IPC分类号： A61K31/435 , A61K31/135 , A61K31/365 , A61K31/4365 , A61P7/02 , C07D221/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , A01K3/14 , C07D513/04
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.
摘要翻译：式（I）化合物：（*化学结构*）（I）其中：R1是氢，烷基，卤素，卤代烷基，羟基，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基，氨基，烷酰基，卤代烷酰基，羧基，烷氧基羰基，氨基甲酰基，氰基，硝基，烷磺酰基，卤代烷磺酰基或氨磺酰基; R 2是任选取代的烷酰基，任选取代的烯酰基，任选取代的环烷基羰基，取代的苯甲酰基或5,6-二氢-1,4,2-二恶嗪-3-基; R3是氢，羟基，任选取代的烷氧基，芳烷氧基，烷酰氧基，烯酰氧基，环烷基羰基氧基，芳基羰基氧基，烷氧基羰基氧基，芳烷氧基羰基氧基，邻苯二甲酰氧基，（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲氧基，（5- 苯基-2-氧代-1,3-二氧杂环戊烯-4-基）甲氧基，任选取代的氨基或硝基; Y是-NH-或氧或硫; n为1至5; 和所述式（I）化合物的互变异构体和盐具有抑制血小板聚集的能力，因此可用于治疗和预防血栓形成和栓塞。

46. 发明授权

US4443548A Process for preparing L-.alpha.-methylphenyl alanines 失效
标题翻译：制备L-α-甲基苯基丙氨酸的方法
公开(公告)号：US4443548A
公开(公告)日：1984-04-17
申请号：US376236
申请日：1982-05-07
申请人： Tokio Oshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
发明人： Tokio Oshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
IPC分类号： C12P13/02 , C12N9/80 , C12P13/04 , C12P41/00 , C12R1/01 , C12R1/06 , C12R1/07 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/465 , C12R1/645 , C12R1/72 , C12R1/78 , C12R1/845 , C12R1/88 , C12R1/885 , C07B19/02 , C12P13/22
CPC分类号： C12P13/04 , C12N9/80
摘要： Biochemical optical resolution of DL-.alpha.-methylphenyl alanines in which DL-.alpha.-methylphenyl alanine amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-.alpha.-methylphenyl alanines having the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be independently a hydrogen atom or lower alkyl groups, or R.sub.1 and R.sub.2 may be alkylene groups combined together to form 5 through 8-membered rings is produced by the steps of:(a) making a DL-.alpha.-methylphenyl alanine amide having the general formula (II): ##STR2## wherein R.sub.1 and R.sub.2 are the same as defined above, interact with the culture product of a microorganism capable of producing enzyme catalyzing the hydrolysis of L-isomer of DL-.alpha.-methylphenyl alanine amides or the treated product thereof, whereby asymmetric hydrolysis of an L-.alpha.-methylphenyl alanine amide is effected; and(b) separating the resultant L-.alpha.-methylphenyl alanines from the hydrolysis mixture.
摘要翻译：描述了DL-α-甲基苯丙氨酰胺与能够产生酰胺酶的微生物或其处理产物相互作用的DL-α-甲基苯基丙氨酸的生物化学光学拆分。具有通式（I）的L-α-甲基苯基丙氨酸：其中R 1和R 2可以独立地为氢原子或低级烷基，或者R 1和R 2可以是亚烷基结合在一起形成5至8个通过以下步骤制备环状环：（a）制备具有通式（II）的DL-α-甲基苯基丙氨酸酰胺：其中R 1和R 2与上述定义相同，与能够产生催化DL-α-甲基苯丙氨酸酰胺的L-异构体或其处理产物的水解的酶的微生物的培养产物，从而实现了L-α-甲基苯丙氨酸酰胺的不对称水解; 和（b）从水解混合物中分离所得的L-α-甲基苯基丙氨酸。

47. 发明申请

US20120220593A1 Substituted Acrylamide Derivative and Pharmaceutical Composition Comprising the Same 失效
标题翻译：取代的丙烯酰胺衍生物和药物组合物
公开(公告)号：US20120220593A1
公开(公告)日：2012-08-30
申请号：US13404647
申请日：2012-02-24
申请人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
发明人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
IPC分类号： A61K31/166 , C07D207/327 , A61K31/402 , A61P19/10 , A61K31/5375 , A61P19/00 , A61P3/00 , C07C233/87 , C07D295/15
CPC分类号： A61K31/166 , C07C237/22 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2602/08 , C07D207/327 , C07D277/30 , C07D295/13 , C07D307/54 , C07D317/54 , C07D333/16 , C07D407/04 , C07D409/04 , Y02P20/55
摘要： A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; R2 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; and X is, for example, a hydroxyl group or a C1-C6 alkoxy group].
摘要翻译：一种药物组合物，其包含具有式（I）的化合物或其药理学上可接受的盐作为活性成分：[其中，R 1为例如可以被一个或多于一个基团取代的C 6 -C 10芳基来自取代基组α; R2是例如可以被一个或多个选自取代基组α的一个基团取代的C 6 -C 10芳基; X是例如羟基或C1-C6烷氧基]。

48. 发明授权

US08143446B2 Substituted acrylamide derivative and pharmaceutical composition comprising the same 有权
标题翻译：取代的丙烯酰胺衍生物和包含它们的药物组合物
公开(公告)号：US08143446B2
公开(公告)日：2012-03-27
申请号：US11914209
申请日：2006-05-11
申请人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
发明人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
IPC分类号： C07C235/30 , C07C235/42 , A61K31/16
CPC分类号： A61K31/166 , C07C237/22 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2602/08 , C07D207/327 , C07D277/30 , C07D295/13 , C07D307/54 , C07D317/54 , C07D333/16 , C07D407/04 , C07D409/04 , Y02P20/55
摘要： A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; R2 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; and X is, for example, a hydroxyl group or a C1-C6 alkoxy group].
摘要翻译：一种药物组合物，其包含具有式（I）的化合物或其药理学上可接受的盐作为活性成分：[其中，R 1为例如可以被一个或多于一个基团取代的C 6 -C 10芳基来自取代基组α; R2是例如可以被一个或多个选自取代基组α的一个基团取代的C 6 -C 10芳基; X是例如羟基或C1-C6烷氧基]。

49. 发明授权

US07935835B2 Substituted cycloalkene derivative 有权
标题翻译：取代的环烯烃衍生物
公开(公告)号：US07935835B2
公开(公告)日：2011-05-03
申请号：US12066813
申请日：2006-09-13
申请人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
发明人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
IPC分类号： C07D319/00 , C07D315/00 , C07D327/00
CPC分类号： C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
摘要： A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.
摘要翻译：式（I）化合物其中X，Y，环A，环B，l，m，R 1，R 2，R 4和R 5如本文所定义，以抑制由内毒素诱导的细胞内信号转导或细胞活化并抑制细胞反应由于细胞内信号转导和细胞活化，例如过量产生炎症介质如TNF-α，其药理学上可接受的盐，其制备方法，以及含有上述取代的环烯烃衍生物作为活性成分的药物，其优于与细胞内信号转导或由内毒素诱导的细胞活化以及对细胞内信号转导和细胞的细胞反应相关的诸如败血症（败血症休克，弥散性血管内凝血，多器官功能衰竭等）的疾病的预防和/或治疗激活。

50. 发明申请

US20100211267A1 PARKING ASSISTANCE APPARATUS, VEHICLE-SIDE APPARATUS OF PARKING ASSISTANCE APPARATUS, PARKING ASSIST METHOD, AND PARKING ASSIST PROGRAM 失效
标题翻译：停车辅助装置，停车辅助装置的车辆装置，停车辅助方法和停车辅助程序
公开(公告)号：US20100211267A1
公开(公告)日：2010-08-19
申请号：US12670713
申请日：2008-07-04
申请人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka , Hideo Yanagisawa
发明人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka , Hideo Yanagisawa
IPC分类号： B62D6/00 , B62D15/02 , B60Q1/48
CPC分类号： G08G1/168 , B60R1/00 , B60R2300/108 , B60R2300/302 , B60R2300/50 , B60R2300/70 , B60R2300/8026 , B60R2300/806 , B60W30/095 , B60W40/02 , B60W2420/403 , B62D15/028
摘要： A parking assistance apparatus makes it easy for a driver to grasp a relative positional relation between a vehicle and a target parking position and makes it possible to park the vehicle at the target parking position in a parking space with accuracy.An image of a mark M in a parking space S is taken by a vehicle-side camera 7. A relative position calculation portion 8 calculates a relative positional relation between the vehicle and a target parking position T based on the taken image of the mark M. A backward locus calculation portion 9 calculates an expected locus when the vehicle moves based on the relative positional relation and based on a steering angle detected by a steering angle sensor 15. An image of the parking space S is taken by a parking-space-side camera 3 and transmitted to a vehicle-side apparatus 1. An image composition portion 12 composes the image of the parking space S from the parking-space-side camera 3 and the expected locus calculated by the backward locus calculation portion 9. The composed image is displayed on the monitor 14 located in the vicinity of a drivers seat of the vehicle.
摘要翻译：停车辅助装置使驾驶员容易掌握车辆与目标停车位置之间的相对位置关系，并且能够准确地将车辆停放在停车位置的目标停车位置。停车空间S中的标记M的图像由车辆侧照相机7拍摄。相对位置计算部8基于拍摄到的标记M的图像计算车辆与目标停车位置T之间的相对位置关系反向轨迹计算部9基于相对位置关系，基于由转向角传感器15检测到的转向角来计算车辆移动时的预期轨迹。停车位S的图像由停车位 - 图像合成部12从停车位侧摄像机3构成停车空间S的图像，由向后轨迹计算部9计算出的预期轨迹构成。图像显示在位于车辆驾驶员座位附近的监视器14上。

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