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31. 发明申请

US20090279169A1 Relating to Scanning Confocal Microscopy 有权
标题翻译：关于扫描共焦显微镜
公开(公告)号：US20090279169A1
公开(公告)日：2009-11-12
申请号：US12440790
申请日：2007-09-14
申请人： Robert Alan Hoult , Steve Morris Bush , George Robert Sealy , Dionisis Korontzis
发明人： Robert Alan Hoult , Steve Morris Bush , George Robert Sealy , Dionisis Korontzis
IPC分类号： G02B21/06 , G02B26/08
CPC分类号： G02B21/0028 , G02B21/0032 , G02B21/0076 , G02B23/16 , G02B26/0816
摘要： An assembly (100) and a method are provided for inputting a light beam into a light path extending from the confocal scanning head (102) to the microscope (104) of a scanning confocal microscope system to illuminate a selected region of a sample mounted in the microscope. The assembly comprises a light input for receiving a light beam from a light source; beam directing means (8, 12) for controlling the path of the light beam with reference to the shape of the selected region of the sample; and a beam coupler (16) for selective coupling the light beam into the light path from the confocal scanning head (102) to the microscope (104), with the beam direction being controlled by the beam directing means so as to illuminate the selected region. A scanning confocal microscope system including such an assembly is also described, together with a method of calibrating the system. In addition, an optical switch for selectively switching a light beam between two paths is disclosed.
摘要翻译：提供了一种组件（100）和方法，用于将光束输入到从共焦扫描头（102）延伸到扫描共聚焦显微镜系统的显微镜（104）的光路中，以照亮安装在显微镜。组件包括用于接收来自光源的光束的光输入; 光束引导装置（8,12），用于参照样本的选定区域的形状来控制光束的路径; 以及用于将光束选择性地耦合到从共焦扫描头（102）到显微镜（104）的光路中的光束耦合器（16），其中光束方向由光束引导装置控制，以便照亮所选择的区域。还描述了包括这种组件的扫描共焦显微镜系统以及校准系统的方法。另外，公开了一种用于在两个路径之间选择性地切换光束的光学开关。

32. 发明授权

US07616986B2 Optical fiber scanner for performing multimodal optical imaging 有权
标题翻译：用于执行多模光学成像的光纤扫描器
公开(公告)号：US07616986B2
公开(公告)日：2009-11-10
申请号：US10880008
申请日：2004-06-28
申请人： Eric Seibel , Xingde Li , Xiumei Liu
发明人： Eric Seibel , Xingde Li , Xiumei Liu
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B3/102 , A61B5/0062 , A61B5/0066 , A61B5/0068 , B31B2105/001 , G02B6/262 , G02B6/32 , G02B6/3502 , G02B7/08 , G02B21/0028 , G02B21/0036 , G02B21/006 , G02B21/0076 , G02B23/2423 , G02B26/103
摘要： An optical fiber scanner is used for multiphoton excitation imaging, optical coherence tomography, or for confocal imaging in which transverse scans are carried out at a plurality of successively different depths within tissue. The optical fiber scanner is implemented as a scanning endoscope using a cantilevered optical fiber that is driven into resonance or near resonance by an actuator. The actuator is energized with drive signals that cause the optical fiber to scan in a desired pattern at successively different depths as the depth of the focal point is changed. Various techniques can be employed for depth focus tracking at a rate that is much slower than the transverse scanning carried out by the vibrating optical fiber. The optical fiber scanner can be used for confocal imaging, multiphoton fluorescence imaging, nonlinear harmonic generation imaging, or in an OCT system that includes a phase or frequency modulator and delay line.
摘要翻译：光纤扫描器用于多光子激发成像，光学相干断层扫描或用于共焦成像，其中横向扫描在组织内的多个连续不同的深度进行。光纤扫描器被实现为使用由致动器驱动到共振或接近谐振的悬臂光纤的扫描内窥镜。致动器通过驱动信号通电，当驱动信号使焦点的深度改变时，光纤以连续不同的深度以所需的图案扫描。可以采用比由振动光纤执行的横向扫描慢得多的速度进行深度聚焦跟踪的各种技术。光纤扫描器可用于共焦成像，多光子荧光成像，非线性谐波生成成像，或在包括相位或频率调制器和延迟线的OCT系统中。

33. 发明授权

US07447539B2 Method and equipment for fiber optic high-resolution, in particular confocal, fluorescence imaging 有权
标题翻译：光纤高分辨率的方法和设备，特别是共聚焦，荧光成像
公开(公告)号：US07447539B2
公开(公告)日：2008-11-04
申请号：US10521607
申请日：2003-07-11
申请人： Magalie Genet , Bertrand Viellerobe , Frederic Berier , Sophie Clade
发明人： Magalie Genet , Bertrand Viellerobe , Frederic Berier , Sophie Clade
IPC分类号： A61B1/06
CPC分类号： H04N1/0281 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0084 , G02B21/0028 , G02B21/0032 , G02B21/0048 , G02B21/0072 , G02B21/0076 , G02B21/0084 , G02B23/26 , G02B26/101
摘要： A method using an image guide having several thousands of optical fibers, an excitation signal emitted by a source, deflected and injected by turns into the optical fibers, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method focuses the beam in the fiber output to excite a subsurface plane to produce a confocal image. The production of a divergent beam in the fiber output can excite a micro-volume of the tissue from the surface. The method deflects the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one-by-one.
摘要翻译：使用具有数千光纤的图像引导器的方法，由源发射的激发信号，被偏转并被轮流注入光纤中，光纤输出中的组织的每个激发点发射，以返回由光纤，然后检测并数字化以形成图像元素。该方法将光束聚焦在光纤输出中以激发地下平面以产生共焦图像。纤维输出中的发散光束的产生可以从表面激发组织的微量。该方法使得激励信号以对应于每秒钟拍摄的图像的速度相应的速度偏转，足以实时使用，并且检测在对应于最小频率的检测频率处的荧光信号，以对纤维进行逐一采样。

34. 发明申请

US20080137363A1 Fibre Bundle Confocal Endomicroscope 有权
标题翻译：纤维束共聚焦显微镜
公开(公告)号：US20080137363A1
公开(公告)日：2008-06-12
申请号：US11795421
申请日：2006-01-20
申请人： Martin Russell Harris
发明人： Martin Russell Harris
IPC分类号： A61B1/07 , G02B21/06
CPC分类号： G02B6/06 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B1/042 , A61B5/0068 , A61B5/0084 , G02B21/0028 , G02B23/243 , G02B23/2453 , G02B23/2469
摘要： A fibre bundle confocal microscope or endoscope (200), comprising a light source (142) for providing a beam of light (160), a coherent fibre bundle of optical fibres (152), a scanner (202) for receiving the beam and scanning the beam over a proximal end of the bundle (162), so that the beam is launched into a plurality of the fibres sequentially, a plurality of the fibres thereby acting sequentially as an at least one delivery fibre (204), a spatial filter (172), and a photodetector (174) operatively associated with the spatial filter to receive return light from one or more of the fibres. The return light from the delivery fibre is excluded from the photodetector by the spatial filter.
摘要翻译：一种纤维束共聚焦显微镜或内窥镜（200），包括用于提供光束（160）的光源（142），光纤的相干光纤束（152），用于接收光束的扫描器（202）所述光束在束（162）的近端上，使得光束被顺序地发射到多个光纤中，因此多个光纤依次作为至少一个传送光纤（204），空间滤波器（204） 172）和与空间滤波器可操作地相关联以接收来自一个或多个光纤的返回光的光电检测器（174）。来自传送光纤的返回光被空间滤光器从光电检测器排除。

35. 发明申请

US20070233396A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20070233396A1
公开(公告)日：2007-10-04
申请号：US11537170
申请日：2006-09-29
申请人： Guillermo Tearney , Dvir Yelin , Brett Bourna
发明人： Guillermo Tearney , Dvir Yelin , Brett Bourna
IPC分类号： G01N33/48
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和布置，用于获得与诸如解剖结构的一部分的样本相关联的信息。可以使用可以基于从样本上的位置获得的信号的第一数据和第二数据来生成信息，其中可以通过将从样本接收的第二信号与第三参考信号组合来获得第二数据。也可以基于该信息生成样本的一部分的图像。例如，第一数据可以与光谱编码显微镜数据相关联，并且第二数据可以与光学相干断层扫描数据相关联。

36. 发明授权

US07154111B2 Cornea characteristics measuring device 失效
公开(公告)号：US07154111B2
公开(公告)日：2006-12-26
申请号：US10685886
申请日：2003-10-15
申请人： Jesse H. Shaver
发明人： Jesse H. Shaver
IPC分类号： G01N21/86 , G01B9/00
CPC分类号： G02B21/0056 , A61B3/1005 , G01B11/028 , G02B21/0028 , G02B27/16
摘要： An apparatus for measuring characteristics of a substance is provided. The apparatus includes a light source to generate light to form an image. A splitter transmits the light from the light source to a first lens, which collimates the light. A second lens receives the collimated light and is adapted to oscillate with respect to the substance and adapted to transmit and focus the light to a focal region within the substance, such that the oscillation will cause the focal region to pass back and forth through the substance and its surfaces/interfaces. A sensor receives light reflected from the focal region and provides a signal indicative of characteristics of the substance at the focal region.

37. 发明申请

US20060274407A1 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US20060274407A1
公开(公告)日：2006-12-07
申请号：US10557461
申请日：2004-05-20
申请人： William Fox , Christopher DiStasio , Scott Grodevant
发明人： William Fox , Christopher DiStasio , Scott Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. An imaging head (28) is gimble mounted on a multi-axis compound arm (34) to allow for precise placement of a confocal objective (116) extending from the head at selected locations against the skin of the patient while providing for patient comfort. The arm (34) attaches the head to an upright station (10) which may be movable along the floor on which the station is disposed. The station (10) has a platform (16) on which a keyboard (24) and a display (22) for monitoring the images is supported. The station (10) also supports a personal computer (PC) (26) for processing signals providing the images on the display and controlling the microscope. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. Controls (50) for the fine positioning and focusing are on the head (28) for ease of use. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。成像头（28）被安装在多轴复合臂（34）上，以允许在选定位置处从选定位置延伸的聚焦物镜（116）精确地放置在患者皮肤上，同时提供患者舒适度。臂（34）将头部附接到直立站（10），其可以沿着设置站的地板移动。站（10）具有平台（16），支撑用于监视图像的键盘（24）和显示器（22）。站（10）还支持个人计算机（PC）（26），用于处理在显示器上提供图像并控制显微镜的信号。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底板（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。用于精细定位和聚焦的控制器（50）位于头部（28）上以便于使用。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

38. 发明申请

US20050228229A1 Compact confocal endoscope and endomicroscope method and apparatus 有权
标题翻译：紧凑型共焦内窥镜和内窥镜的方法和装置
公开(公告)号：US20050228229A1
公开(公告)日：2005-10-13
申请号：US11142449
申请日：2005-06-02
申请人： Martin Harris
发明人： Martin Harris
IPC分类号： G02B21/00 , G02B23/24 , A61B1/04 , A61B1/06
CPC分类号： G02B21/0076 , G02B21/0028 , G02B21/0068 , G02B23/2407
摘要： The present invention provides a confocal endoscope, microscope or endomicroscope including a light source of coherent light for illuminating a sample, a beam splitter and light receiving means, wherein an incident beam of light from the light source is directed onto the beam splitter and hence onto the sample, and light returning from the sample and incident on the beam splitter is deviated or displaced by the beam splitter by a small angle or distance relative to the incident beam, and received by the light receiving means located to receive the returning light and near the light source. The invention also a method for performing confocal endoscopy or microscopy including illuminating a sample by means of an incident or excitatory beam of coherent light, and deviating or displacing light returning from the sample by a small angle or distance relative to the incident beam.
摘要翻译：本发明提供一种共焦内窥镜，显微镜或内窥镜，其包括用于照射样品的相干光的光源，分束器和光接收装置，其中来自光源的入射光束被引导到分束器上，并因此被引导到样品和从样品返回并入射到分束器上的光由分束器相对于入射光束偏移或移位一小角度或距离，并被位于接收返回光并靠近的光接收装置接收光源。本发明还涉及一种用于进行共焦内窥镜检查或显微镜检查的方法，包括通过入射或兴奋性相干光束照射样品，以及使从样品返回的光相对于入射光束偏移小的角度或距离。

39. 发明申请

US20050161329A1 Multiplexed capillary electrophoresis systems 审中-公开
标题翻译：多重毛细管电泳系统
公开(公告)号：US20050161329A1
公开(公告)日：2005-07-28
申请号：US10511282
申请日：2003-04-14
申请人： Katariina Hutterer , Nels Olson , Stevan Jovanovich , Thomas Armstrong , Dean Burgi , Vladislav Dolnik
发明人： Katariina Hutterer , Nels Olson , Stevan Jovanovich , Thomas Armstrong , Dean Burgi , Vladislav Dolnik
IPC分类号： G01N21/64 , G01N27/447 , G01N27/453 , G01N30/46 , G02B21/00
CPC分类号： G01N27/44782 , G01N21/6486 , G01N27/44721 , G01N27/44743 , G01N27/44773 , G01N30/463 , G01N2021/6439 , G02B21/0028 , G02B21/004 , G02B21/0076
摘要： Multi-capillary systems for high-throughput electrophoretic separation and detection of biomolecules are disclosed. One embodiment of the invention uses galactomannans as a size-sieving matrix for multi-channel electrophoretic separations of biomolecules. Multi-color detection for the simultaneous analysis of controls and standards in the same channels as the samples, and endogenous fluorescence detection are also disclosed. Another embodiment of the invention is a two dimensional system for separation of complex samples, using multiplexed capillary electrophoresis system as the second dimension, with a fraction collection step connecting the two separation steps. The systems allow for separations to be accomplished with a highly parallel manner, or in a two-dimensional format.
摘要翻译：公开了用于高通量电泳分离和生物分子检测的多毛细管系统。本发明的一个实施方案使用半乳甘露聚糖作为尺寸筛选基质用于生物分子的多通道电泳分离。还公开了用于同时分析与样品相同通道中的对照和标准物以及内源性荧光检测的多色检测。本发明的另一个实施方案是使用多重毛细管电泳系统作为第二维度分离复杂样品的二维系统，连接两个分离步骤的级分收集步骤。这些系统允许以高度平行的方式或以二维格式来实现分离。

40. 发明申请

US20050157386A1 Tissue specimen holder 有权
公开(公告)号：US20050157386A1
公开(公告)日：2005-07-21
申请号：US11020387
申请日：2004-12-22
申请人： Roger Greenwald , James Zavislan
发明人： Roger Greenwald , James Zavislan
IPC分类号： B01L3/00 , G01N1/36 , G01N21/03 , G02B21/00 , G02B21/34 , A61D1/02 , A61B17/22
CPC分类号： G01N21/0303 , B01L3/508 , B01L2300/043 , B01L2300/0609 , B01L2300/0654 , B01L2300/0672 , B01L2300/0822 , B01L2400/0683 , G01N1/36 , G01N2021/0339 , G01N2021/0342 , G01N2021/0364 , G02B21/0028 , G02B21/34
摘要： A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. An objective lens of the confocal imaging system receives and supports the plate, preferably by a magnetic coupling ring around the plate which is magnetically attached to the barrel of the objective lens. The lens may be fixed and a mechanism for positioning the tray with respect to the lens in a direction along the optical axis of the lens and in orthogonal directions perpendicular to that axis shares a common support with the lens. Wavefront distortion which may result from an effectively corrugated surface of the specimen is minimized by selecting an immersion liquid which equals the refractive index of the near surface tissues. The tissue determines the index of the immersion fluid. The thicknesses and refractive indices of the window and plate are then determined to correct the residual aberration of the optical system. Different trays having different window and plate thicknesses and indices may be provided for different specimen species such as kidney, liver, cervix, et cetera. Thus, a generic confocal imaging system with a generic objective lens is corrected for image aberration and wavefront distortion due to the surface corrugations of the tissue. The correction is simplified since the bag is compliant and compresses so that the optical thickness along the axis between the objective lens and the focal plane in or at the specimen is substantially invariant whether the beam is focused at the interface between the specimen and the window or within the specimen over a focusing range which can extend over several millimeters.

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