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21. 发明授权

US08007733B2 Non-contact radiant heating and temperature sensing device for a chemical reaction chamber 有权
标题翻译：用于化学反应室的非接触辐射加热和温度感测装置
公开(公告)号：US08007733B2
公开(公告)日：2011-08-30
申请号：US11925002
申请日：2007-10-26
申请人： John Shigeura , Janice G. Shigeura, legal representative
发明人： John Shigeura
IPC分类号： B01J19/00 , F27D11/00
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/00822 , B01J2219/00862 , B01J2219/00873 , B01J2219/00934 , B01J2219/00943 , B01J2219/00961 , B01L3/50851 , B01L2200/147 , B01L2300/0803 , B01L2300/1838 , B01L2300/185 , B01L2300/1861 , B01L2300/1872 , B01L2400/0409 , G01N2035/00366 , G01N2035/00415
摘要： An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber without direct physical contact between a heating device and the reaction chamber, or between a temperature sensor and the reaction chamber. A plurality of chemical reaction chambers can simultaneously or sequentially be heated independently and monitored separately.
摘要翻译：提供了一种用于加热和感测化学反应室的温度并且在加热装置与反应室之间或温度传感器与反应室之间没有直接物理接触的装置和方法。多个化学反应室可以独立地同时或顺序地加热并单独监测。

22. 发明申请

US20110207180A1 TEMPERATURE CONTROL DEVICE WITH A FLEXIBLE TEMPERATURE CONTROL SURFACE 有权
标题翻译：具有柔性温度控制表面的温度控制装置
公开(公告)号：US20110207180A1
公开(公告)日：2011-08-25
申请号：US13098299
申请日：2011-04-29
申请人： Phil BELGRADER , Christopher G. COONEY , Robert DOEBLER , Anna HICKERSON , Bruce IRVINE , Ali NADIM , James STERLING , Reza MIRAGHAIE
发明人： Phil BELGRADER , Christopher G. COONEY , Robert DOEBLER , Anna HICKERSON , Bruce IRVINE , Ali NADIM , James STERLING , Reza MIRAGHAIE
IPC分类号： C12P19/34
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译：公开了一种用于控制反应室中的温度的装置。该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触反应室接收温度控制液后。还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。

23. 发明申请

US20110172128A1 MULTI-WELL DEVICE 审中-公开
标题翻译：多设备
公开(公告)号：US20110172128A1
公开(公告)日：2011-07-14
申请号：US13063828
申请日：2009-09-14
申请人： Anthony Davies , Dermot Kelleher , Yuri Volkov , Siobhan Mitchell
发明人： Anthony Davies , Dermot Kelleher , Yuri Volkov , Siobhan Mitchell
IPC分类号： C40B60/00
CPC分类号： B01L3/50851 , B01L3/5085 , B01L2300/0829 , B01L2300/185
摘要： A device comprising a plurality of sample wells wherein the device has a plurality of compartments, each compartment surrounding at least one well. The compartments are defined by compartment wall means. The compartment wall means may be associated with at least one well or the compartment wall means may be associated with a group of wells. The compartment may house an environmental buffering system.
摘要翻译：一种包括多个样品阱的装置，其中所述装置具有多个隔室，每个隔室围绕至少一个孔。隔间由隔间壁装置限定。隔室壁装置可以与至少一个井相关联，或者隔室壁装置可以与一组井相关联。隔间可容纳环境缓冲系统。

24. 发明授权

US07955840B2 Thermal cycler for PCR including temperature control bladder 有权
标题翻译：热循环仪用于PCR，包括温度控制膀胱
公开(公告)号：US07955840B2
公开(公告)日：2011-06-07
申请号：US11843843
申请日：2007-08-23
申请人： Phil Belgrader
发明人： Phil Belgrader
IPC分类号： C12M1/38
CPC分类号： C12M41/22 , B01L7/02 , B01L7/525 , B01L2300/0832 , B01L2300/0838 , B01L2300/123 , B01L2300/1805 , B01L2300/185 , C12Q1/686 , G05D23/185
摘要： Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one thermally conductive temperature-control bladder disposed therein, which bladder is configured to receive a temperature-control substance at a second temperature into said bladder and expel said temperature-control substance from said bladder. The bladder is further configured such that upon receiving the temperature-control substance, the bladder expands to abut substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.
摘要翻译：描述了在受控温度下进行化学反应的方法和装置。在一个实施例中，由本发明提供的装置包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体。反应室具有导热的内部和外部表面，在第一温度下限定内部体积。该装置还包括设置在其中的至少一个导热温度控制囊，该囊被构造成在第二温度下将温度控制物质接纳到所述膀胱中并从所述膀胱排出所述温度控制物质。气囊被进一步构造成使得在接收到温度控制物质时，气囊膨胀以基本上邻接所述反应室的所述外表面的至少一部分，以使所述温度控制物质与所述内部体积的反应室。

25. 发明授权

US07841247B2 Temperature controller for small fluid samples with different heat capacities 有权
标题翻译：具有不同热容的小型流体样品的温度控制器
公开(公告)号：US07841247B2
公开(公告)日：2010-11-30
申请号：US11814620
申请日：2006-01-20
申请人： James E. Baumgardner
发明人： James E. Baumgardner
IPC分类号： G01N1/22
CPC分类号： B01L3/502715 , B01L3/5027 , B01L5/00 , B01L7/54 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2300/185
摘要： A system for controlling the temperature of fluidic samples includes a device having a first outer surface and a second outer surface which are parallel to one another. The interior of the device contains two or more channels suitable for accommodating samples. The channels lay on a common plane that is also parallel to the first and second outer surfaces. A temperature sensor is positioned between the channels along the common plane. A heater is thermally coupled to one of the two outer surfaces while a heat sink is coupled to the other of the two outer surfaces, thereby establishing a temperature gradient between the first and second outer surfaces. A temperature controller receives sensed temperature input from the temperature sensor and adjusts the heater in response thereto.
摘要翻译：用于控制流体样品的温度的系统包括具有彼此平行的第一外表面和第二外表面的装置。设备的内部包含两个或更多个适用于容纳样品的通道。通道位于平行于第一和第二外表面的公共平面上。温度传感器位于沿共同平面的通道之间。加热器热耦合到两个外表面中的一个，同时散热器耦合到两个外表面中的另一个，从而在第一和第二外表面之间建立温度梯度。温度控制器接收来自温度传感器的感测温度输入并响应于此调节加热器。

26. 发明申请

US20100247380A1 Module for a Modular Microfluidic System 审中-公开
标题翻译：模块化微流体系统模块
公开(公告)号：US20100247380A1
公开(公告)日：2010-09-30
申请号：US12225838
申请日：2007-03-28
申请人： Astrid Lohf , Reinhold Schneeberger , Robert Sendner , Johann Sippl
发明人： Astrid Lohf , Reinhold Schneeberger , Robert Sendner , Johann Sippl
IPC分类号： G01N33/00
CPC分类号： B01J19/0093 , B01J2219/00804 , B01J2219/0081 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00867 , B01J2219/00871 , B01J2219/00873 , B01J2219/00961 , B01J2219/00986 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2300/185 , B01L2300/1883 , F28D2021/0077 , F28F2260/02
摘要： In order to be able to introduce fluid components extraneous to the system into a modular microfluidic system comprising modules arranged alongside one another which can be connected to one another with fluid connection by connecting parts comprising connecting channels with short connecting paths and good temperature controllability, a module with the following features is provided: the module has a plate-shaped microfluidic part which comprises a fluid channel system and on whose top side, in edge regions to the potentially adjacent modules of the microfluidic system has fluid connections, the fluidic connection to adjacent modules being establishable by means of the connecting parts adjacent in edge regions on the upper side, below the microfluidic part is arranged an insulation vessel which can be filled and flowed through by a temperature control fluid and is concluded at the to by the microfluidic part which serves as a lid.
摘要翻译：为了将能够将系统外部的流体成分引入到模块化微流体系统中，该模块化微流体系统包括彼此并排配置的模块，该模块可以通过连接具有短连接路径的连接通道的部件和良好的温度可控性通过流体连接彼此连接，提供了具有以下特征的模块：模块具有板状微流体部件，其包括流体通道系统，并且其顶侧在与微流体系统的潜在相邻模块的边缘区域具有流体连接，流体连接到相邻模块可通过在上侧边缘区域，微流体部分下面相邻的连接部件来建立，该绝缘容器可以由温度控制流体填充和流过，并且由微流体部分结束，作为盖子。

27. 发明申请

US20100005867A1 TEMPERATURE ADJUSTMENT OF A FLUIDIC SAMPLE WITHIN A FLUIDIC DEVICE 审中-公开
标题翻译：流体设备中流体样品的温度调节
公开(公告)号：US20100005867A1
公开(公告)日：2010-01-14
申请号：US12374043
申请日：2006-07-17
申请人： Thomas Doerr
发明人： Thomas Doerr
IPC分类号： G01N1/44 , G01N30/30 , G01N30/02
CPC分类号： B01L3/5027 , B01L7/54 , B01L2300/0816 , B01L2300/1816 , B01L2300/185 , B01L2300/1861 , G01N30/30 , G01N30/603 , G01N30/6095 , G01N2030/027 , G01N2030/3015
摘要： A temperature control unit (216) for a column (201) of a fluidic device (200) for analyzing a fluidic sample, wherein the fluidic device (200) is adapted to conduct the fluidic sample through the column (201), the temperature control unit (216) being arranged to adjust a temperature of the fluidic sample in a flow path between an inlet 5 (207) of the column (201) and an outlet (208) of the column (201) so that a temperature adjustment effect occurs selectively in an interior of the column (201).
摘要翻译：一种用于分析流体样品的流体装置（200）的柱（201）的温度控制单元（216），其中流体装置（200）适于将流体样品通过柱（201），温度控制单元（216）布置成在柱（201）的入口5（207）和塔（201）的出口（208）之间的流动路径中调节流体样品的温度，使得发生温度调节效应选择性地在柱（201）的内部。

28. 发明授权

US07632470B2 Microstructure, microreactor, micro heat exchanger and method for fabricating microstructure 有权
标题翻译：微结构，微反应器，微型热交换器和微结构制造方法
公开(公告)号：US07632470B2
公开(公告)日：2009-12-15
申请号：US11206111
申请日：2005-08-18
申请人： Kazuaki Tabata , Takayuki Yamada , Mutsuya Takahashi , Yoshihisa Yamazaki
发明人： Kazuaki Tabata , Takayuki Yamada , Mutsuya Takahashi , Yoshihisa Yamazaki
IPC分类号： B01J19/00 , B01J10/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00873 , B01J2219/00889 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/185 , F28F2260/02
摘要： A microstructure includes first and second plates. The first plate defines a recess. The second plate is bonded to the first plate to block an opening of the recess to thereby form a closed vacuum space or a closed space filled with inert gas.
摘要翻译：微结构包括第一和第二板。第一板限定凹槽。第二板结合到第一板以阻挡凹部的开口，从而形成封闭的真空空间或填充有惰性气体的封闭空间。

29. 发明授权

US07623289B2 Observation apparatus having thermoregulation mechanism 有权
标题翻译：观察装置具有温度调节机制
公开(公告)号：US07623289B2
公开(公告)日：2009-11-24
申请号：US11658132
申请日：2005-07-21
申请人： Mitsuo Harada
发明人： Mitsuo Harada
IPC分类号： G02B21/26
CPC分类号： B01L7/00 , B01L2300/0654 , B01L2300/0829 , B01L2300/185 , G01N21/0332 , G02B21/30 , G02B21/33
摘要： An observation apparatus comprises a thermoregulation mechanism including a liquid receiving frame (28) that has a heater (43) for heating the outer frame of an immersion objective lens (13) and adapted to heat and maintain the temperature of the immersion liquid (30) contained in the frame (28) by means of the heater (43) and via the outer frame of the immersion objective lens (13) so as to maintain the temperature of the specimen (34) in the container at a constant level by utilizing heat conduction. The thermoregulation mechanism of the observation apparatus is so adapted that, when the temperature of the immersion liquid (30) decreases during a measurement/observation operation due to discharge of heat, the liquid (30) is heated again by the heater (43) to prevent the temperature of the specimen (34) from changing and maintain the temperature at a constant level.
摘要翻译：观察装置包括温度调节机构，其包括具有用于加热浸没物镜（13）的外框的加热器（43）的液体接收框架（28），并且适于加热和保持浸没液体（30）的温度，通过加热器（43）和通过浸没物镜（13）的外框架包含在框架（28）中，以通过利用热量将样品（34）在容器中的温度保持在恒定水平传导。观察装置的温度调节机构使得当由于放热而在测量/观察操作期间浸液（30）的温度降低时，液体（30）再次被加热器（43）加热至防止样品（34）的温度变化并将温度保持在恒定水平。

30. 发明申请

US20090162265A1 Microreactor Assembly Incorporating Interconnect Backbone 有权
标题翻译：微反应器装配连接骨干
公开(公告)号：US20090162265A1
公开(公告)日：2009-06-25
申请号：US12340878
申请日：2008-12-22
申请人： Stephane Poissy , Ronan Tanguy
发明人： Stephane Poissy , Ronan Tanguy
IPC分类号： B01J19/18 , B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00804 , B01J2219/0081 , B01J2219/00824 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01L3/502707 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2300/0816 , B01L2300/0874 , B01L2300/185 , C04B37/005 , C04B37/045 , C04B2237/10 , C04B2237/32
摘要： A microreactor assembly comprising a fluidic interconnect backbone and plurality of fluidic microstructures is provided. The fluidic microstructures are supported by respective portions of the fluidic interconnect backbone, The microreactor assembly comprises a plurality of non-polymeric interconnect seals associated with the interconnect input and output ports. The interconnect input port of the fluidic interconnect backbone is interfaced with the microchannel output port of a first fluidic microstructure at one of the non-polymeric interconnect seals. The interconnect output port of the fluidic interconnect backbone is interfaced with the microchannel input port of a second fluidic microstructure at another of the non-polymeric interconnect seals. The interconnect microchannel is defined entirely by the fluidic interconnect backbone and is configured such that it extends from the non-polymeric interconnect seal at the microchannel output port of the first fluidic microstructure to the non-polymeric interconnect seal at the microchannel input port of the second fluidic microstructure without interruption by additional sealed interfaces.
摘要翻译：提供了一种包括流体互连主链和多个流体微结构的微反应器组件。流体微结构由流体互连骨架的相应部分支撑。微反应器组件包括与互连输入和输出端口相关联的多个非聚合物互连密封件。流体互连主干的互连输入端口与非聚合物互连密封件之一处的第一流体微结构的微通道输出端口相接。流体互连主干的互连输出端口与另一个非聚合互连密封件处的第二流体显微组织的微通道输入端口相接合。互连微通道完全由流体互连骨架限定，并且被配置为使得其从第一流体微结构的微通道输出端口处的非聚合物互连密封件延伸到第二流体微通道的微通道输入端口处的非聚合物互连密封件通过额外的密封界面不中断流体显微组织。

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