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1. 发明申请

US20190194691A1 Vector-Free Delivery of Gene Editing Proteins and Compositions to Cells and Tissues 审中-公开
公开(公告)号：US20190194691A1
公开(公告)日：2019-06-27
申请号：US16067431
申请日：2016-12-22
申请人： Avectas Limited
发明人： Michael Maguire , Shirley O'Dea
IPC分类号： C12N15/87 , C12N9/22 , C12N15/11 , B01L3/00 , B01L5/00
CPC分类号： C12N15/87 , B01L3/527 , B01L3/567 , B01L5/00 , B01L2400/0487 , B01L2400/06 , C12N9/22 , C12N15/11 , C12N15/113 , C12N2310/20 , C12N2320/32 , C12N2800/80
摘要： The present subject matter provides a method for delivering a gene editing composition across a plasma membrane of a cell. Related apparatus, system, techniques, compositions, and articles are also described.

2. 发明申请

US20140295546A1 FLUID DISTRIBUTION IN A SAMPLE EXPOSURE DEVICE 有权
标题翻译：样品曝光装置中的流体分布
公开(公告)号：US20140295546A1
公开(公告)日：2014-10-02
申请号：US14355393
申请日：2012-10-29
申请人： British American Tobacco (Investments) Limited
发明人： Jason Adamson , Marianna Gaca
IPC分类号： C12M1/00
CPC分类号： C12M23/40 , B01L1/025 , B01L3/50853 , B01L5/00 , B01L2200/023 , B01L2200/025 , B01L2200/026 , B01L2300/041 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/0829 , B01L2300/0864 , B01L2400/086 , C12M29/00
摘要： The invention relates to fluid distribution in an exposure device. The exposure device, in some examples, is a device for exposing living cell cultures or cellular tissues to a fluid such as cigarette smoke, air and/or other gases or gas mixtures, for use in studies of the effects on the cell cultures or tissues of their exposure to the fluid. A fluid distribution member is described for distributing the fluid in the exposure device, the member including a plurality of apertures in a surface arranged such that, when the distribution member is fitted to the fluid exposure device, the distribution member receives fluid applied to the surface of the member and distributes the fluid, via the apertures, to samples to be exposed to the fluid in the exposure device.
摘要翻译：本发明涉及曝光装置中的流体分布。暴露装置在一些实例中是用于将活细胞培养物或细胞组织暴露于诸如香烟烟雾，空气和/或其它气体或气体混合物的流体的装置，用于研究对细胞培养物或组织的影响他们暴露于流体。流体分配构件被描述为用于在暴露装置中分配流体，该构件包括在表面中布置的多个孔，使得当分配构件安装到流体暴露装置时，分配构件接收施加到表面的流体并将流体经由孔分配到样品以暴露于曝光装置中的流体。

3. 发明申请

US20140170673A1 UNITARY CARTRIDGE FOR PARTICLE PROCESSING 有权
标题翻译：颗粒加工单位盒
公开(公告)号：US20140170673A1
公开(公告)日：2014-06-19
申请号：US14179760
申请日：2014-02-13
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译：用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。墨盒与操作系统接口，用于进行颗粒处理。流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。墨盒可以采用任何合适的处理颗粒的技术。

4. 发明申请

US20060269446A1 Unitary cartridge for particle processing 有权
标题翻译：用于颗粒处理的单一墨盒
公开(公告)号：US20060269446A1
公开(公告)日：2006-11-30
申请号：US11295183
申请日：2005-12-05
申请人： John Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
发明人： John Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： B01L9/00
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译：用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。墨盒与操作系统接口，用于进行颗粒处理。流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。墨盒可以采用任何合适的处理颗粒的技术。

5. 发明申请

US20030188587A1 Sampling system for a separation channel 审中-公开
标题翻译：分离通道采样系统
公开(公告)号：US20030188587A1
公开(公告)日：2003-10-09
申请号：US10296587
申请日：2003-03-25
发明人： Andreas Manz
IPC分类号： G01N001/44 , G01N001/22 , G01N021/73
CPC分类号： G01N35/1097 , B01L5/00 , G01N30/16 , G01N30/6095 , G01N35/08
摘要： A sampling system for providing a sample plug 70 from a fluid sample, comprising: a flow channel through which a flow of a fluid sample is passed; plasma generators 12 and 14; and a control unit configured to drive the plasma generator 12 at a power level at which the fluid sample is modified by the plasma P1 and interrupt busy the plasma P1 for a period of time such as to allow a plug of the fluid sample to pass downstream thereof. The volume of the plug 70 is determined by the time period during which the plasma P1 is interrupted. With the plasma P1 being maintained, the components of the plug 70 separate on transit through a separation channel 10. These components pass through the second plasma P2, and the emissions generated are detected by an optical detector 16.
摘要翻译：一种用于从流体样品提供样品塞70的采样系统，包括：流动通道，流体样品流过该流动通道; 等离子体发生器12和14; 以及控制单元，其被配置为以等离子体P1改变流体样品的功率水平驱动等离子体发生器12，并且中断等离子体P1一段时间，以允许流体样品的塞子通过下游其中。插头70的体积由等离子体P1中断的时间段确定。在保持等离子体P1的情况下，塞70的部件在通过分离通道10运送时分离。这些部件通过第二等离子体P2，并且所产生的发射由光学检测器16检测。

6. 发明授权

US5122341A Device for gas contaminant tester training 失效
标题翻译：气体污染物测试仪培训装置
公开(公告)号：US5122341A
公开(公告)日：1992-06-16
申请号：US599165
申请日：1990-10-17
申请人： Harry F. Klodowski , Philip A. Hider , Patricia A. Morin
发明人： Harry F. Klodowski , Philip A. Hider , Patricia A. Morin
IPC分类号： B01L5/00 , G01N31/22 , G01N33/00
CPC分类号： G01N31/224 , B01L5/00
摘要： A device for demonstrating the operation of gas contaminant testing apparatus and for training persons to use such apparatus. The device can be portable and allows demonstration of and training on testing apparatus in a location removed from the environment in which the gaseous medium and its gaseous and vaporous contaminants are normally found. The device uses very small contaminant samples for demonstration in order to minimize personnel exposure and inadvertent or deliberate releases to the environment. The device allows the substitutions of, for training and demonstration purposes, a harmless gaseous medium for the actual gaseous medium of interest. In a preferred embodiment, designed for demonstrating the operation of a refrigerant contaminant testing apparatus, air is susbstituted for refrigerant as the gaseous medium in which contaminants are entrained when using the device. In that embodiment, air is caused to flow through a container holding a contaminant sample of interest. Vapors of the contaminant mix with the air and the mixture is caused to flow through a refrigerant contaminant testing tube connected to the device, resulting in testing tube indications that emulate the indications to be expected when testing a refrigerant sample containing the contaminant. More than one sample container can be fitted into the device and there can be one or more tester connections. The sample containers are interchangeable so that demonstrating a variety of contaminants is possible. The device may be used as an adjunct to gas testing apparatus for testing a gas sample collected at a remote location.
摘要翻译：一种用于演示气体污染物测试装置的操作和培训人员使用这种装置的装置。该装置可以是便携式的，并且允许在从气体介质及其气态和气态污染物通常发现的环境中移除的位置上的测试装置上的演示和训练。该设备使用非常小的污染物样品进行示范，以尽量减少人员暴露和无意或故意向环境释放。该装置允许用于训练和演示目的的替代用于感兴趣的实际气体介质的无害气体介质。在优选的实施方案中，为了证明制冷剂污染物测试装置的操作，空气被用作制冷剂，作为在使用该装置时夹带污染物的气态介质。在该实施例中，使空气流过容纳感兴趣的污染物样品的容器。使污染物与空气和混合物的混合物的蒸气流过连接到设备的制冷剂污染物测试管，导致试验管迹，其模拟在测试含有污染物的制冷剂样品时的预期指示。可以在设备中安装多个样品容器，并且可以有一个或多个测试仪连接。样品容器是可互换的，以便能够证明各种污染物。该装置可以用作用于测试在远程位置收集的气体样品的气体检测装置的附件。

7. 发明授权

US5077016A Apparatus for producing gas-air concentrations 失效
标题翻译：用于产生气体 - 空气浓度的装置
公开(公告)号：US5077016A
公开(公告)日：1991-12-31
申请号：US245685
申请日：1988-09-16
申请人： Richard E. Layng , Linda Deschere , Gunther J. Evanina , Purnachandra G. Pai
发明人： Richard E. Layng , Linda Deschere , Gunther J. Evanina , Purnachandra G. Pai
IPC分类号： B01F3/02 , B01L5/00 , G01N1/22 , G01N1/28 , G01N1/38 , G01N33/00
CPC分类号： B01F3/02 , B01L5/00 , G01N1/38 , G01N33/0011 , G01N2001/2264 , G01N2001/2893 , Y10T137/87652 , Y10T137/8766
摘要： Accordingly, the present invention is an apparatus for mixing gas and air to obtain a plurality of predetermined gas-air concentrations including means for supplying gas from a constant pressure gas source. A conduit has a first end connected to the supplying means and a second end connected to a means for diffusing air with the gas to obtain a predetermined gas-air concentration.
摘要翻译：因此，本发明是一种用于混合气体和空气以获得多个预定气体 - 空气浓度的装置，包括用于从恒压气体源供应气体的装置。导管具有连接到供应装置的第一端和连接到用于使空气与气体扩散以获得预定气体 - 空气浓度的装置的第二端。

8. 发明申请

US20190195876A1 UNITARY CARTRIDGE FOR PARTICLE PROCESSING 审中-公开
公开(公告)号：US20190195876A1
公开(公告)日：2019-06-27
申请号：US16291869
申请日：2019-03-04
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： G01N33/577 , B01L3/00 , C12M1/00 , B01L9/00 , G01N15/10 , G01N15/14
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.

9. 发明申请

US20150224500A1 CARTRIDGE FOR DISPENSING A FLUID COMPRISING A REAGENT 有权
标题翻译：用于分配包含试剂的流体的盒
公开(公告)号：US20150224500A1
公开(公告)日：2015-08-13
申请号：US14530857
申请日：2014-11-03
申请人： Roche Diagnostics Operations, Inc.
发明人： Thorsten Brueckner , Peter Koltay , Norbert Oranth , Juergen Spinke , Laurent Tanguy
IPC分类号： B01L3/00 , B01L5/00 , G01N35/10 , B01L1/00
CPC分类号： B01L3/52 , B01L1/00 , B01L3/523 , B01L5/00 , B01L2200/0684 , B01L2200/141 , B01L2300/048 , B01L2300/0681 , B01L2400/086 , G01N35/1002 , Y10T436/11
摘要： A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.
摘要翻译：呈现用于分配流体的盒。墨盒包括用于接收流体并用于接收通气气体的储存室。储存室包括用于接收通气气体的入口和用于分配流体的出口。当处于操作位置时，储存室的至少一部分填充有通气气体。入口位于填充有通气气体的部分中。流体包含试剂。墨盒还包括用于限制通过入口的气体扩散的挡板。储存室通过挡板接收通气气体。入口在储存室的被填充有通风气体的部分内保持恒定的气体压力。

10. 发明申请

US20120164743A1 MICROCHANNEL CHIP AND METHOD FOR GAS-LIQUID PHASE SEPARATION USING SAME 有权
标题翻译：使用相同的气相液相分离的微通道芯片和方法
公开(公告)号：US20120164743A1
公开(公告)日：2012-06-28
申请号：US13262103
申请日：2010-03-31
申请人： Arata Aota , Yuko Kihira , Mari Sasaki , Takehiko Kitamori , Kazuma Mawatari
发明人： Arata Aota , Yuko Kihira , Mari Sasaki , Takehiko Kitamori , Kazuma Mawatari
IPC分类号： G01N21/78 , G01N1/18 , B01D53/00
CPC分类号： B01D19/0031 , B01D53/22 , B01D69/02 , B01D71/36 , B01D2325/02 , B01D2325/04 , B01D2325/38 , B01L3/502753 , B01L5/00 , B01L2300/0816 , B01L2400/0478 , G01N35/08 , Y10T436/17 , Y10T436/173845 , Y10T436/175383 , Y10T436/25375
摘要： A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 μm to 100 μm. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.
摘要翻译：一种具有在基板上形成的微通道的微通道芯片和其上部被多孔膜覆盖的气液相分离微通道，该气液相分离微通道与微通道的下游端连接，深度为10 μm至100μm。另外，气相分离方法是通过除去气相从流过微通道的两相流中分离液相流的方法，由气相和液相组成的两相流该液相在上述微通道的周围流动，气相在液相流的内部流动。

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