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1. 发明申请

US20110207180A1 TEMPERATURE CONTROL DEVICE WITH A FLEXIBLE TEMPERATURE CONTROL SURFACE 有权
标题翻译：具有柔性温度控制表面的温度控制装置
公开(公告)号：US20110207180A1
公开(公告)日：2011-08-25
申请号：US13098299
申请日：2011-04-29
申请人： Phil BELGRADER , Christopher G. COONEY , Robert DOEBLER , Anna HICKERSON , Bruce IRVINE , Ali NADIM , James STERLING , Reza MIRAGHAIE
发明人： Phil BELGRADER , Christopher G. COONEY , Robert DOEBLER , Anna HICKERSON , Bruce IRVINE , Ali NADIM , James STERLING , Reza MIRAGHAIE
IPC分类号： C12P19/34
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译：公开了一种用于控制反应室中的温度的装置。该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触反应室接收温度控制液后。还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。

2. 发明授权

US07955840B2 Thermal cycler for PCR including temperature control bladder 有权
标题翻译：热循环仪用于PCR，包括温度控制膀胱
公开(公告)号：US07955840B2
公开(公告)日：2011-06-07
申请号：US11843843
申请日：2007-08-23
申请人： Phil Belgrader
发明人： Phil Belgrader
IPC分类号： C12M1/38
CPC分类号： C12M41/22 , B01L7/02 , B01L7/525 , B01L2300/0832 , B01L2300/0838 , B01L2300/123 , B01L2300/1805 , B01L2300/185 , C12Q1/686 , G05D23/185
摘要： Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one thermally conductive temperature-control bladder disposed therein, which bladder is configured to receive a temperature-control substance at a second temperature into said bladder and expel said temperature-control substance from said bladder. The bladder is further configured such that upon receiving the temperature-control substance, the bladder expands to abut substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.
摘要翻译：描述了在受控温度下进行化学反应的方法和装置。在一个实施例中，由本发明提供的装置包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体。反应室具有导热的内部和外部表面，在第一温度下限定内部体积。该装置还包括设置在其中的至少一个导热温度控制囊，该囊被构造成在第二温度下将温度控制物质接纳到所述膀胱中并从所述膀胱排出所述温度控制物质。气囊被进一步构造成使得在接收到温度控制物质时，气囊膨胀以基本上邻接所述反应室的所述外表面的至少一部分，以使所述温度控制物质与所述内部体积的反应室。

3. 发明授权

US09127312B2 Analysis of nucleic acids 有权
标题翻译：核酸分析
公开(公告)号：US09127312B2
公开(公告)日：2015-09-08
申请号：US13385277
申请日：2012-02-09
申请人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
发明人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
摘要： Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
摘要翻译：本文提供了用于分析核酸的改进的方法，组合物和试剂盒。改进的方法，组合物和试剂盒可以使得样品中核酸的拷贝数估计可以进行。本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如，两个或多个拷贝是位于同一染色体或不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。

4. 发明申请

US20090126514A1 Devices for collection and preparation of biological agents 审中-公开
标题翻译：用于收集和制备生物制剂的装置
公开(公告)号：US20090126514A1
公开(公告)日：2009-05-21
申请号：US11896701
申请日：2007-09-05
申请人： Eric Gregory Burroughs , Kenneth Scott Damer , Phil Belgrader , Benjamin Raab
发明人： Eric Gregory Burroughs , Kenneth Scott Damer , Phil Belgrader , Benjamin Raab
IPC分类号： G01N1/04 , B01J19/00
CPC分类号： G01N1/2208 , G01N1/2211 , G01N2001/022 , G01N2001/2223 , G01N2015/0069 , G01N2015/0088
摘要： A sample collection system and method for airborne biological agents is disclosed. The sample collection system comprises a sample collection module that collects particles in an air flow and transfer the collected particles into a sampling fluid, and a sample preparation module that is responsible for accepting the sampling fluid from the sample collection module, continuously aggregating or concentrating the collected particles in the sampling fluid during the sampling process and recycling a particle-lean sampling fluid back to the collection module.
摘要翻译：公开了一种用于空气传播生物制剂的样品收集系统和方法。样品收集系统包括样品收集模块，其收集空气流中的颗粒并将收集的颗粒转移到采样流体中;以及样品制备模块，其负责接收来自样品采集模块的取样流体，连续聚集或浓缩在采样过程中采样液中收集的颗粒，并将稀薄的样品回流回收集模块。

5. 发明申请

US20090111193A1 Sample preparation device 审中-公开
标题翻译：样品制备装置
公开(公告)号：US20090111193A1
公开(公告)日：2009-04-30
申请号：US12213942
申请日：2008-06-26
申请人： Christopher G. Cooney , Phil Belgrader
发明人： Christopher G. Cooney , Phil Belgrader
IPC分类号： G01N1/34 , B01L11/00 , B01L3/02 , C12M1/33
CPC分类号： G01N1/34 , B01L3/5025 , B01L2200/0631 , B01L2300/0681 , B01L2300/0832 , G01N1/405 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also disclosed are sample filters containing glass frit is coated with an capture agent that binds specifically to an analyte of interest, sample filters containing a hydrophilic matrix with impregnated chemicals that lyses cell membranes, a cartridge base and an integrated sample preparation cartridge.
摘要翻译：公开了一种样品制备装置。样品制备装置包括限定第一开口和第二开口之间的通道的壳体; 以及占据所述通道的一部分的样品过滤器。样品过滤器包含与核酸特异性结合的整料吸附剂。还公开了包含玻璃料的样品过滤器，其涂覆有特异性结合目的分析物的捕获剂，包含亲水基质的样品过滤器，其中浸渍的化学物质裂解细胞膜，滤筒基底和集成样品制备盒。

6. 发明授权

US08759085B2 Temperature control device with a flexible temperature control surface 有权
标题翻译：温控装置具有灵活的温度控制面
公开(公告)号：US08759085B2
公开(公告)日：2014-06-24
申请号：US13098195
申请日：2011-04-29
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
IPC分类号： C12M1/38 , B01L7/00 , C12M1/34 , C12M3/00
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译：公开了一种用于控制反应室中的温度的装置。该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触反应室接收温度控制液后。还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。

7. 发明授权

US08334117B2 Temperature control device with a flexible temperature control surface 有权
标题翻译：温控装置具有灵活的温度控制面
公开(公告)号：US08334117B2
公开(公告)日：2012-12-18
申请号：US13098299
申请日：2011-04-29
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
IPC分类号： C12P19/34
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译：公开了一种用于控制反应室中的温度的装置。该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触反应室接收温度控制液后。还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。

8. 发明申请

US20090053772A1 Thermal Cycler for PCR Including Temperature Control Bladder 有权
标题翻译：用于PCR的热循环仪包括温度控制膀胱
公开(公告)号：US20090053772A1
公开(公告)日：2009-02-26
申请号：US11843843
申请日：2007-08-23
申请人： Phil Belgrader
发明人： Phil Belgrader
IPC分类号： C12P19/34 , C12M1/00 , B01L7/00 , B01J19/18 , F28D15/00
CPC分类号： C12M41/22 , B01L7/02 , B01L7/525 , B01L2300/0832 , B01L2300/0838 , B01L2300/123 , B01L2300/1805 , B01L2300/185 , C12Q1/686 , G05D23/185
摘要： Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one thermally conductive temperature-control bladder disposed therein, which bladder is configured to receive a temperature-control substance at a second temperature into said bladder and expel said temperature-control substance from said bladder. The bladder is further configured such that upon receiving the temperature-control substance, the bladder expands to abut substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.
摘要翻译：描述了在受控温度下进行化学反应的方法和装置。在一个实施例中，由本发明提供的装置包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体。反应室具有导热的内部和外部表面，在第一温度下限定内部体积。该装置还包括设置在其中的至少一个导热温度控制囊，该囊被构造成在第二温度下将温度控制物质接纳到所述膀胱中并从所述膀胱排出所述温度控制物质。气囊被进一步构造成使得在接收到温度控制物质时，气囊膨胀以基本上邻接所述反应室的所述外表面的至少一部分，以使所述温度控制物质与所述内部体积的反应室。

9. 发明申请

US20120322058A1 Analysis of nucleic acids 有权
标题翻译：核酸分析
公开(公告)号：US20120322058A1
公开(公告)日：2012-12-20
申请号：US13385277
申请日：2012-02-09
申请人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
发明人： John Frederick Regan , Serge Saxonov , Mike Lucero , Ben Hindson , Phil Belgrader , Simant Dube , Austin So , Jeffrey Clark Mellen , Nicholas Jack Heredia , Kevin Ness , Bill Colston
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
摘要： Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
摘要翻译：本文提供了用于分析核酸的改进的方法，组合物和试剂盒。改进的方法，组合物和试剂盒可以使得样品中核酸的拷贝数估计可以进行。本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如，两个或多个拷贝是位于同一染色体或不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。

10. 发明申请

US20110269191A1 THERMAL CYCLER FOR PCR INCLUDING TEMPERATURE CONTROL BLADDER 有权
标题翻译：用于PCR的热循环器，包括温度控制刮板
公开(公告)号：US20110269191A1
公开(公告)日：2011-11-03
申请号：US13098336
申请日：2011-04-29
申请人： Phil BELGRADER
发明人： Phil BELGRADER
IPC分类号： C12P19/34
CPC分类号： C12M41/22 , B01L7/02 , B01L7/525 , B01L2300/0832 , B01L2300/0838 , B01L2300/123 , B01L2300/1805 , B01L2300/185 , C12Q1/686 , G05D23/185
摘要： Methods and devices for performing chemical reactions under controlled temperature are described. In one embodiment, the devices provided by the invention comprise a housing diminished hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal volume therein at a first temperature. The device also includes at least one temperature-control substance at a second temperature into said bladder and expel said temperature-control substance, the bladder expands to about substantially at least a portion of said exterior surfaces of said reaction chamber to enable thermal exchange between said temperature-control substance the said internal volume of reaction chamber.
摘要翻译：描述了在受控温度下进行化学反应的方法和装置。在一个实施例中，由本发明提供的装置包括减小的壳体，其保持设置在壳体的内部容积内的反应室。反应室具有导热的内部和外部表面，在第一温度下限定内部体积。该装置还包括在第二温度下的至少一个温度控制物质进入所述气囊并排出所述温度控制物质，所述气囊膨胀至所述反应室的所述外表面的基本上至少一部分，以使所述温度控制物质反应室的所述内部体积。

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