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    • 25. 发明授权
    • Method of assaying target substance in sample, aptamer molecule method of constructing the same
    • 测定样品中目标物质的方法,适体分子构建方法
    • US08143004B2
    • 2012-03-27
    • US12443053
    • 2007-09-27
    • Kazunori IkebukuroKoji Sode
    • Kazunori IkebukuroKoji Sode
    • C12Q1/68
    • G01N33/5308
    • A method for measuring a test substance whereby the test substance in a sample can be specifically measured without using an antibody against the test substance; an aptamer molecule used therefor; and a method for creating the aptamer are disclosed. An aptamer capable of hybridizing with an oligonucleotide when it is bound to a test substance, but is incapable of hybridizing with the oligonucleotide when it is not bound to the test substance, is utilized. The aptamer is brought into contact with a sample, and the aptamer bound to the test substance is brought into contact with an immobilized oligonucleotide which hybridizes with the aptamer, to bind the aptamer to a solid phase, followed by measurement of the aptamer immobilized on the solid phase.
    • 一种测试物质的方法,其中可以特异性地测量样品中的测试物质,而不使用针对测试物质的抗体; 用于其的适体分子; 并且公开了用于产生适配体的方法。 当与被检物质结合时能够与寡核苷酸杂交,但是当不与被检物质结合时,不能与寡核苷酸杂交的适体。 使适体与样品接触,使与测试物质结合的适配体与与适体杂交的固定化寡核苷酸接触,将适体结合固相,随后测定固定在 固相。
    • 26. 发明申请
    • MICROFLUIDIC DEVICE FOR TRAPPING SINGLE CELL
    • 用于捕获单细胞的微流体装置
    • US20100240041A1
    • 2010-09-23
    • US12670990
    • 2008-07-31
    • Tadashi MatsunagaAtsushi ArakakiTomoyuki TaguchiMasahito Hosokawa
    • Tadashi MatsunagaAtsushi ArakakiTomoyuki TaguchiMasahito Hosokawa
    • C12Q1/68C12M1/00C12N5/00
    • G01N15/1484B01L3/502761B01L2200/0668B01L2300/0681B01L2300/0819B01L2300/0877B01L2300/0887B01L2400/049C12Q1/6841G01N15/1475C12Q2565/629
    • It is to provide a microfluidic device which separates and captures with high efficiency a large amount of cells in a sample at one-cell level without damaging the cells by utilizing a microfabrication technology. The device sequentially comprises: an upper substrate consisting of a plastic plate provided with a groove for forming a microchannel communicating a sample-supply opening and a sample-discharge opening; a plastic upper flat plate forming the microchannel by cooperating with the upper substrate, the plate being provided with an aperture for a micromesh; a holding plate holding a plastic micromesh having a plurality of micro through-pores for capturing cells; a plastic lower flat plate provided with an aperture for suctioning; and a lower substrate consisting of a plastic flat plate provided with a groove for forming a suction channel, wherein the micro through-pores for capturing cells of the micromesh have an inverted mortar-like shape or a cylindrical shape, and wherein the upper flat plate is constituted by a softer plastic as compared to the upper substrate.
    • 它提供了一种微流体装置,其以单细胞水平高效地分离和捕获样品中的大量细胞,而不通过利用微细加工技术损伤细胞。 所述装置依次包括:上基板,由具有沟槽的塑料板构成,所述槽用于形成连通供样开口的微通道和采样排出口; 通过与上基板配合形成微通道的塑料上平板,该板设置有微孔的孔; 保持板,其保持具有用于捕获细胞的多个微通孔的塑料微镜; 一个塑料下平板设有一个用于抽吸的孔; 以及由设置有用于形成吸引通道的槽的塑料平板构成的下基板,其中,用于捕获微胶粒的细胞的微通孔具有倒立的砂浆状或圆筒形状,并且其中上平板 由与上基板相比较软的塑料构成。
    • 27. 发明授权
    • Measuring apparatus, measuring method, and characteristic measurement unit
    • 测量装置,测量方法和特征测量单元
    • US07796257B2
    • 2010-09-14
    • US12087663
    • 2006-12-27
    • Yukitoshi OtaniKazuhiko OkaToshitaka WakayamaAtsushi Taniguchi
    • Yukitoshi OtaniKazuhiko OkaToshitaka WakayamaAtsushi Taniguchi
    • G01J4/00
    • G01N21/21G01J4/04
    • A measuring apparatus includes a light intensity information acquisition section 40 that acquires light intensity information relating to a measurement light containing a given band component, the measurement light having been modulated by optical elements included in an optical system 10 and a measurement target (or a sample 100), and a calculation section 50 that calculates at least one matrix element of a Mueller matrix that indicates the optical characteristics of the measurement target based on the light intensity information relating to the measurement light and a theoretical expression for the light intensity of the measurement light. The light intensity information acquisition section 40 acquires the light intensity information relating to a plurality of the measurement lights obtained from the optical system 10 by changing setting of a principal axis direction of at least one of the optical elements. The calculation section 50 performs a carrier amplitude coefficient calculation process, and a matrix element calculation process that calculates the at least one matrix element based on a carrier amplitude coefficient and the theoretical expression for the carrier amplitude coefficient including the at least one matrix element.
    • 测量装置包括光强度信息获取部分40,其获取与包含给定频带分量的测量光有关的光强度信息,测量光已被包括在光学系统10中的光学元件和测量对象(或样品 100),以及计算部50,其基于与测量光有关的光强度信息和测量光强度的理论表达式,计算指示测量对象的光学特性的Mueller矩阵的至少一个矩阵元素 光。 光强度信息获取部40通过改变至少一个光学元件的主轴方向的设定来获取与从光学系统10获得的多个测量光有关的光强度信息。 计算部分50执行载波幅度系数计算处理和基于载波幅度系数和包括至少一个矩阵元素的载波幅度系数的理论表达式来计算至少一个矩阵元素的矩阵元素计算处理。
    • 28. 发明授权
    • Distance measuring system
    • 距离测量系统
    • US07679728B2
    • 2010-03-16
    • US12224559
    • 2007-03-02
    • Takashi Kurokawa
    • Takashi Kurokawa
    • G01C3/08G01B11/14
    • G01S17/08G01C3/06G01S7/4818G01S7/497G01S17/87
    • The distance detector 12b returns part of the light received from the distance detector 12a located at the starting point side by reflection, or reflection and refraction, sends the remaining part of the light to the distance detectors 12b, 12c, 12d and 12e located at the forefront end side by transmission, refraction, reflection or a combination thereof, and returns the returned light from the distance detectors 12b-12e to the distance detector 11a located at the starting point by transmission, refraction, reflection or a combination thereof. By using laser light sources, it is possible to measure the distance from the laser light sources to multiple points or the distance between two points with a high degree of accuracy.
    • 距离检测器12b通过反射或反射和折射来返回从位于起始点侧的距离检测器12a接收的部分光,将剩余部分的光发送到位于该位置处的距离检测器12b,12c,12d和12e 通过透射,折射,反射或其组合的前端侧,并且通过透射,折射,反射或其组合将来自距离检测器12b-12e的返回光返回到位于起点的距离检测器11a。 通过使用激光光源,可以以高精度测量从激光光源到多个点的距离或两点之间的距离。
    • 29. 发明授权
    • Front wheel steering control device
    • 前轮转向控制装置
    • US07668635B2
    • 2010-02-23
    • US11659204
    • 2005-05-18
    • Pongsathorn RaksincharoensakMasao Nagai
    • Pongsathorn RaksincharoensakMasao Nagai
    • B62D12/00A01B69/00B63G8/20G05D1/00B62D6/00B62D11/00B62D11/02B62D3/00B62D7/00B60S9/00
    • B62D6/003
    • A front wheel steering control device improves the handling and stability of a vehicle with respect to the steering wheel angles. The front wheel steering control device includes an input device for obtaining the steering wheel angle and the vehicle velocity, a first computing device for computing a yaw-rate for the vehicle which maintains the vehicle gravity center point sideslip angle at zero based on the steering wheel angle and the vehicle velocity that are obtained by the input device, a second computing device for computing a target front wheel actual steering angle for realizing the yaw-rate calculated by the first computing device, a control device for performing a steering control of the vehicle based on the target front wheel actual steering angle calculated by the second computing device. The ideal determination of the vehicle steering gear ratio and the derivative steering gain are relatively easy.
    • 前轮转向控制装置改善车辆相对于方向盘角度的操纵和稳定性。 前轮转向控制装置包括用于获得方向盘角度和车辆速度的输入装置,用于计算车辆的偏航率的第一计算装置,其基于方向盘将车辆重心中心点侧滑角维持在零 角度和车辆速度,用于计算用于实现由第一计算装置计算的偏航率的目标前轮实际转向角的第二计算装置,用于执行车辆的转向控制的控制装置 基于由第二计算装置计算出的目标前轮实际转向角。 车辆转向传动比和导向转向增益的理想判定比较容易。
    • 30. 发明申请
    • Distance Measuring System
    • 距离测量系统
    • US20090180099A1
    • 2009-07-16
    • US12224559
    • 2007-03-02
    • Takashi Kurokawa
    • Takashi Kurokawa
    • G01C3/06G01S17/32G01C15/00
    • G01S17/08G01C3/06G01S7/4818G01S7/497G01S17/87
    • The distance detector 12b returns part of the light received from the distance detector 12a located at the starting point side by reflection, or reflection and refraction, sends the remaining part of the light to the distance detectors 12b, 12c, 12d and 12e located at the forefront end side by transmission, refraction, reflection or a combination thereof, and returns the returned light from the distance detectors 12b-12e to the distance detector 11a located at the starting point by transmission, refraction, reflection or a combination thereof. By using laser light sources, it is possible to measure the distance from the laser light sources to multiple points or the distance between two points with a high degree of accuracy.
    • 距离检测器12b通过反射或反射和折射来返回从位于起始点侧的距离检测器12a接收的部分光,将剩余部分的光发送到位于该位置处的距离检测器12b,12c,12d和12e 通过透射,折射,反射或其组合的前端侧,并且通过透射,折射,反射或其组合将来自距离检测器12b-12e的返回光返回到位于起点的距离检测器11a。 通过使用激光光源,可以以高精度测量从激光光源到多个点的距离或两点之间的距离。