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21. 发明授权

US4023919A Thermal actuated valve for clearance control 失效
标题翻译：用于间隙控制的热致动阀
公开(公告)号：US4023919A
公开(公告)日：1977-05-17
申请号：US626863
申请日：1975-10-29
申请人： William R. Patterson
发明人： William R. Patterson
IPC分类号： F01D11/18 , F01D11/24 , F01D25/24
CPC分类号： F01D11/24 , F01D11/18
摘要： A shroud closely surrounding a high thermal inertia rotor is provided with a support structure having low thermal inertia characteristics. The support structure is selectively exposed to different temperature mediums during transient operation by way of a thermal actuated valve so as to cause a rapid growth thereof during periods of engine acceleration and a slow shrinkage thereof during periods of deceleration of the engine. In this manner the clearance relationship between the shroud and enclosed rotor is maintained at a minimum during periods of steady-state and transitional operation to thereby increase the efficiency of the combination.
摘要翻译：紧密围绕高热惯性转子的护罩设置有具有低热惯性特性的支撑结构。在通过热致动阀的瞬态操作期间，支撑结构选择性地暴露于不同的温度介质，以便在发动机加速期间及其在发动机减速期间的缓慢收缩期间使其快速增长。以这种方式，在稳态和过渡操作期间，护罩和封闭转子之间的间隙关系保持最小，从而提高组合的效率。

22. 发明申请

US20110118777A1 METALLIC COILS ENLACED WITH FIBERS FOR EMBOLIZATION OF A BODY CAVITY 有权
标题翻译：金属线圈与纤维嵌入，用于塑造身体
公开(公告)号：US20110118777A1
公开(公告)日：2011-05-19
申请号：US13010671
申请日：2011-01-20
申请人： William R. Patterson , Earl Slee , Tom Wilder , Thomas McCarthy , Brian Strauss , Herman Monstadt , Hans Henkes
发明人： William R. Patterson , Earl Slee , Tom Wilder , Thomas McCarthy , Brian Strauss , Herman Monstadt , Hans Henkes
IPC分类号： A61M29/00
CPC分类号： A61L31/18 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00004 , A61B2017/00526 , A61L31/022 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/606 , A61L2430/36
摘要： The invention provides for vaso-occlusive coils comprising fibers.
摘要翻译：本发明提供了包含纤维的血管闭塞线圈。

23. 发明申请

US20100271012A1 ELECTROMAGNETIC POSITION AND ORIENTATION SENSING SYSTEM 有权
标题翻译：电磁位置和方位感应系统
公开(公告)号：US20100271012A1
公开(公告)日：2010-10-28
申请号：US12768102
申请日：2010-04-27
申请人： William R. Patterson , Harvey F. Silverman , Kenneth J. Silverman
发明人： William R. Patterson , Harvey F. Silverman , Kenneth J. Silverman
IPC分类号： G01B7/14
CPC分类号： G01D5/204 , G01B7/003 , G01B7/004 , G01B7/14 , G01D5/2086 , G01R35/005 , G01V3/081 , G01V13/00
摘要： Magnetic tracking systems and methods for determining the position and orientation of a remote object. A magnetic tracking system includes a stationary transmitter for establishing a reference coordinate system, and at least one receiver. The remote object is attached to, mounted on, or otherwise coupled to the receiver. The transmitter can include a set of three mutually perpendicular coils having a common center point, or a set of three coplanar coils with separate centers. The receiver can include a set of three orthogonal coils. The position and orientation of the receiver and the remote object coupled thereto is determined by measuring the nine mutual inductances between the three transmitter coils and the three receiver coils. The magnetic tracking system provides reduced power consumption, increased efficiency, digital compensation for component variation, automatic self-calibration, automatic synchronization with no connections between transmitter and receiver, and rapid low-cost implementation.
摘要翻译：用于确定远程物体的位置和方向的磁跟踪系统和方法。磁跟踪系统包括用于建立参考坐标系的固定发射器和至少一个接收器。远程物体附接到，安装在或以其他方式耦合到接收器。发射机可以包括一组具有公共中心点的三个相互垂直的线圈，或者具有单独中心的一组三个共面线圈。接收机可以包括一组三个正交线圈。通过测量三个发射器线圈和三个接收器线圈之间的九个互感来确定接收器和耦合到其的远程对象的位置和方向。磁跟踪系统提供降低的功耗，提高效率，组件变化的数字补偿，自动自校准，无发送器和接收器之间的连接的自动同步以及快速的低成本实施。

24. 发明申请

US20100094113A1 HEMODYNAMIC MONITORING DURING AUTOMATED MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
标题翻译：血液自动测量期间的血液动力学监测
公开(公告)号：US20100094113A1
公开(公告)日：2010-04-15
申请号：US12576121
申请日：2009-10-08
申请人： Mark Ries Robinson , Mike Borrello , William R. Patterson
发明人： Mark Ries Robinson , Mike Borrello , William R. Patterson
IPC分类号： A61B5/1473 , A61B5/02 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/14532 , A61B5/14546
摘要： The present invention provides methods and apparatuses that can provide measurement of analytes such as glucose with a variety of sensors in connection with hemodynamic monitoring. Some embodiments of the present invention enable the use of a single arterial access site for automated blood glucose measurement as well as hemodynamic monitoring. Some embodiments of the present invention can reduce or eliminate nuisance hemodynamic alarms. Some embodiments of the present invention can provide hemodynamic monitoring during an automated analyte measurement process. An example apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with or integrated into the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system.
摘要翻译：本发明提供了可以提供诸如葡萄糖等分析物与血液动力学监测相结合的各种传感器的测量方法和装置。本发明的一些实施例使得能够使用单个动脉进入部位进行自动血糖测量以及血液动力学监测。本发明的一些实施例可以减少或消除麻烦的血液动力学警报。本发明的一些实施方案可以在自动分析物测量过程中提供血液动力学监测。根据本发明的示例性装置包括血液存取系统，其适于从身体去除血液并将至少一部分血液注入体内。这样的装置还包括安装有或集成到血液存取系统中的分析物传感器，使得分析物传感器测量血液中已被血液存取系统从体内除去的分析物。

25. 发明授权

US07172727B2 Apparatus for blood oxygenation 失效
标题翻译：血氧合仪
公开(公告)号：US07172727B2
公开(公告)日：2007-02-06
申请号：US10953747
申请日：2004-09-29
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。耦合到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到该液体中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次输送到患者或其他部位。

26. 发明授权

US07013703B2 System and method of evaluating or calibrating a bubble detector 有权
标题翻译：评估或校准气泡检测器的系统和方法
公开(公告)号：US07013703B2
公开(公告)日：2006-03-21
申请号：US10750428
申请日：2003-12-31
申请人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
发明人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
IPC分类号： G06K9/00
CPC分类号： G01N35/08 , A61M1/32 , A61M1/3626 , A61M2202/0476 , A61M2209/02 , G01N2291/015 , G01N2291/02433 , G01N2291/02466
摘要： A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, the bubble detector may initiate a system shut down. A bubble detector can be evaluated or calibrated by introducing bubbles into a conduit, detecting the bubbles introduced into the conduit using visual inspection or a bubble detector of known resolution and comparing the results with the examination of a bubble detector under evaluation.
摘要翻译：气泡检测器利用超声波换能器在气泡通过传感器时进行取样。分析返回信号的包络线以确定每个采样气泡的体积。如果在一定时间内采样的气泡的总体积超过所需的最大体积，则气泡检测器可能会启动系统关闭。气泡检测器可以通过将气泡引入管道中进行评估或校准，使用目视检查或者已知分辨率的气泡检测器检测导入导管的气泡，并将结果与正在评估的气泡检测器进行比较。

27. 发明授权

US06974435B2 Method for enriching a bodily fluid with a gas 有权
标题翻译：用气体浓缩体液的方法
公开(公告)号：US06974435B2
公开(公告)日：2005-12-13
申请号：US10279507
申请日：2002-10-24
申请人： Derek J. Daw , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
发明人： Derek J. Daw , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
IPC分类号： A61M1/14 , A61M1/10 , A61M1/32 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3663 , A61M1/32 , A61M1/3626
摘要： A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.
摘要翻译：系统利用氧合装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。氧合装置可以采取放置在外壳内的一次性药筒的形式。电子控制器管理系统的各个方面，例如生产富含气体的流体，流速，气泡检测和自动操作和关闭。

28. 发明授权

US06843099B2 Bubble detector and method of evaluation or calibration thereof 有权
标题翻译：气泡检测器及其评估或校准方法
公开(公告)号：US06843099B2
公开(公告)日：2005-01-18
申请号：US10610084
申请日：2003-06-30
申请人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
发明人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
IPC分类号： G01N29/02 , A61H33/02 , A61M1/36 , G01N35/08
CPC分类号： G01N35/08 , A61M1/32 , A61M1/3626 , A61M2202/0476 , A61M2209/02 , G01N2291/015 , G01N2291/02433 , G01N2291/02466
摘要： A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, the bubble detector may initiate a system shut down. A bubble detector can be evaluated or calibrated by introducing bubbles into a conduit, detecting the bubbles introduced into the conduit using visual inspection or a bubble detector of known resolution and comparing the results with the examination of a bubble detector under evaluation.
摘要翻译：气泡检测器利用超声波换能器在气泡通过传感器时进行取样。分析返回信号的包络线以确定每个采样气泡的体积。如果在一定时间内采样的气泡的总体积超过所需的最大体积，则气泡检测器可能会启动系统关闭。气泡检测器可以通过将气泡引入管道中进行评估或校准，使用目视检查或者已知分辨率的气泡检测器检测导入导管的气泡，并将结果与正在评估的气泡检测器进行比较。

29. 发明授权

US06759008B1 Apparatus and method for blood oxygenation 有权
标题翻译：用于血氧的设备和方法
公开(公告)号：US06759008B1
公开(公告)日：2004-07-06
申请号：US09410179
申请日：1999-09-30
申请人： William R. Patterson , Jeffrey L. Creech
发明人： William R. Patterson , Jeffrey L. Creech
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S261/27
摘要： An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The apparatus also includes a delivery system coupled to the blood oxygenation assembly. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.
摘要翻译：提供了用于血氧和输送的装置。该装置有利地包括液体至液体氧合组件，其具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地位于混合室中，使得第一流体和第二流体通常彼此进入混合室，以促进混合和液体 - 液体气体的转移。该装置还包括耦合到血液氧合组件的递送系统。输送系统包括具有近端部分，远端部分和位于近端部分和远端部分之间的过渡部分的大致管状细长部件。过渡部分与近端部分相比是相对柔性的，并且与远端部分相比是相对较硬的。在另一个实施例中，输送系统包括大致管状的细长构件，其具有近端部分和具有多个孔的远端部分。

30. 发明授权

US06582387B2 System for enriching a bodily fluid with a gas 有权
公开(公告)号：US06582387B2
公开(公告)日：2003-06-24
申请号：US09813068
申请日：2001-03-20
申请人： Daw J. Derek , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
发明人： Daw J. Derek , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
IPC分类号： A61M3700
CPC分类号： A61M1/3663 , A61M1/32 , A61M1/3626
摘要： A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.

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