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    • 5. 发明授权
    • Apparatus for blood oxygenation
    • 血氧合仪
    • US06811750B2
    • 2004-11-02
    • US10071702
    • 2002-02-08
    • William R. PattersonStephen E. MyrickVincent Divino, Jr.Jeffrey L. CreechMark S. Buhr
    • William R. PattersonStephen E. MyrickVincent Divino, Jr.Jeffrey L. CreechMark S. Buhr
    • A61M136
    • A61M1/1698A61M1/3613A61M2202/0476B01F3/04758Y10S128/03Y10S261/28
    • Apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
    • 提供了用于血氧合的装置和方法。 该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。 耦合到第一入口的雾化喷嘴在室内形成细小的液体,气体扩散到该液体中,以产生气体过饱和流体,其通过出口被去除。 去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。 或者,血液可以由泵提供给高压中空纤维或其它类型的膜氧合器,其中氧气扩散通过膜并进入血液以形成氧合血液,再次输送到患者或其他部位。
    • 6. 发明授权
    • Method of blood oxygenation
    • 血氧合法
    • US06602468B2
    • 2003-08-05
    • US09469261
    • 1999-12-21
    • William R. PattersonJeffrey L. Creech
    • William R. PattersonJeffrey L. Creech
    • A61M134
    • A61M1/1698A61M1/3613A61M2202/0476B01F3/04758Y10S261/27
    • A method for a bubble-free oxygenated blood delivery is provided. The method includes a step of selecting a delivery system having a tubular elongated member with a lumen. The selecting step comprises determining an effective diameter of the lumen needed to achieve a bubble-free delivery of the oxygenated blood based on a specified oxygenated blood flow rate and a desired target oxygen partial pressure in the oxygenated blood. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.
    • 提供了一种无气泡氧合血液输送的方法。 该方法包括选择具有管腔的细长构件的输送系统的步骤。 选择步骤包括基于指定的氧化血流速度和氧合血液中期望的目标氧分压来确定实现氧合血液的无气泡递送所需的内腔的有效直径。 输送系统包括具有近端部分,远端部分和位于近端部分和远端部分之间的过渡部分的大致管状细长部件。 过渡部分与近端部分相比是相对柔性的,并且与远端部分相比是相对较硬的。 在另一个实施例中,输送系统包括大致管状的细长构件,其具有近端部分和具有多个孔的远端部分。
    • 7. 发明授权
    • Method for blood oxygenation
    • US06596235B2
    • 2003-07-22
    • US09778433
    • 2001-02-07
    • Vincent Divino, Jr.Paul J. ZaleskyWilliam R. Patterson
    • Vincent Divino, Jr.Paul J. ZaleskyWilliam R. Patterson
    • A61M136
    • A61M1/1698A61M1/3613A61M2202/0476B01F3/04758
    • An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.
    • 9. 发明授权
    • Variable shroud for a turbomachine
    • 涡轮机可变护罩
    • US4127357A
    • 1978-11-28
    • US809582
    • 1977-06-24
    • William R. Patterson
    • William R. Patterson
    • F01D11/08F01D11/10F01D11/22F04D29/08
    • F01D11/22
    • A turbine shroud segment is supported by a pair of eccentric shafts which are rotated in response to the engine operating temperatures to selectively vary the radial position of the shroud segment so as to minimize the radial clearance between the shroud segment and the rotatable blades circumscribed therein during variable operating conditions. The bimetal actuator moves in response to changes in the temperature of the cooling air to rotate a ring gear which in turn rotates the eccentric shafts to modulate the radial position of the shroud segment. By proper selection of component design specification and operating parameters, the radial clearance can be minimized during steady-state operating conditions without attendant rubbing during transient operating conditions.
    • 涡轮机护罩段由一对偏心轴支撑,所述一对偏心轴响应于发动机工作温度而旋转,以选择性地改变护罩段的径向位置,以便最小化护罩区段与其间限制的可旋转叶片之间的径向间隙 可变运行条件。 双金属致动器响应于冷却空气的温度变化而移动,以旋转环形齿轮,该环形齿轮又旋转偏心轴以调节护罩段的径向位置。 通过适当选择部件设计规范和操作参数,在稳态运行条件下可以使径向间隙最小化,而不需要在瞬态运行条件下进行摩擦。