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1. 发明授权

US06974435B2 Method for enriching a bodily fluid with a gas 有权
标题翻译：用气体浓缩体液的方法
公开(公告)号：US06974435B2
公开(公告)日：2005-12-13
申请号：US10279507
申请日：2002-10-24
申请人： Derek J. Daw , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
发明人： Derek J. Daw , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
IPC分类号： A61M1/14 , A61M1/10 , A61M1/32 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3663 , A61M1/32 , A61M1/3626
摘要： A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.
摘要翻译：系统利用氧合装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。氧合装置可以采取放置在外壳内的一次性药筒的形式。电子控制器管理系统的各个方面，例如生产富含气体的流体，流速，气泡检测和自动操作和关闭。

2. 发明授权

US06582387B2 System for enriching a bodily fluid with a gas 有权
公开(公告)号：US06582387B2
公开(公告)日：2003-06-24
申请号：US09813068
申请日：2001-03-20
申请人： Daw J. Derek , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
发明人： Daw J. Derek , William R. Patterson , Stephen E. Myrick , Jeffrey L. Creech , Vincent Divino, Jr. , Gregory P. Watson , Paul J. Zalesky
IPC分类号： A61M3700
CPC分类号： A61M1/3663 , A61M1/32 , A61M1/3626
摘要： A system utilizes an oxygenation device to generate a gas-enriched physiologic fluid and to combine it with a bodily fluid to create a gas-enriched bodily fluid. The oxygenation device may take the form of a disposable cartridge, which is placed within an enclosure. An electronic controller manages various aspects of the system, such as the production of gas-enriched fluids, flow rates, bubble detection, and automatic operation and shut down.

3. 发明授权

US06936221B1 Method of forming gas-enriched fluid 失效
标题翻译：形成富集气体的方法
公开(公告)号：US06936221B1
公开(公告)日：2005-08-30
申请号：US09468471
申请日：1999-12-21
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M1/16 , A61M1/36 , A61M25/00 , A61M1/34 , A61M37/00
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： A method for forming a gas-enriched fluid is provided. The method includes a step of providing a mixing chamber having a first inlet, a second inlet, and an outlet. A first fluid is delivered into the mixing chamber via the first inlet and flows vertically. A second fluid having a liquid phase supersaturated with a gas is delivered to the mixing chamber via the second inlet to mix with the first fluid and from the gas-enriched fluid.
摘要翻译：提供了一种形成富含气体的流体的方法。该方法包括提供具有第一入口，第二入口和出口的混合室的步骤。第一流体经由第一入口输送到混合室中并垂直流动。具有用气体过饱和的液相的第二流体经由第二入口输送到混合室，以与第一流体和富含气体的流体混合。

4. 发明授权

US06855291B2 Method of blood oxygenation 失效
标题翻译：血氧合法
公开(公告)号：US06855291B2
公开(公告)日：2005-02-15
申请号：US10384301
申请日：2003-03-07
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/16 , A61M1/36 , A61M1/14 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成含氧血液，再次输送到患者或其他部位。

5. 发明授权

US06602467B1 Apparatus and method for blood oxygenation 失效
标题翻译：用于血氧的设备和方法
公开(公告)号：US06602467B1
公开(公告)日：2003-08-05
申请号：US09410344
申请日：1999-09-30
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M114
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The mixed fluid exits the chamber via an outlet for delivery to a patient.
摘要翻译：提供了一种用于血氧的装置和方法。该装置有利地包括液体 - 液体氧合装置。液体 - 液体氧合组件包括具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地位于混合室中，使得第一流体和第二流体通常彼此进入混合室，以促进混合和液体 - 液体气体的转移。混合流体通过出口离开室以输送给患者。

6. 发明授权

US06387324B1 Apparatus and method for blood oxygenation 有权
公开(公告)号：US06387324B1
公开(公告)日：2002-05-14
申请号：US09409952
申请日：1999-09-30
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M114
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

7. 发明授权

US07172727B2 Apparatus for blood oxygenation 失效
标题翻译：血氧合仪
公开(公告)号：US07172727B2
公开(公告)日：2007-02-06
申请号：US10953747
申请日：2004-09-29
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。耦合到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到该液体中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次输送到患者或其他部位。

8. 发明授权

US06565807B1 Method of blood oxygenation 失效
标题翻译：血氧合法
公开(公告)号：US06565807B1
公开(公告)日：2003-05-20
申请号：US09467670
申请日：1999-12-21
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其它类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次用于输送到患者或其他部位。

9. 发明授权

US06890482B2 Apparatus for blood oxygenation 有权
标题翻译：血氧合仪
公开(公告)号：US06890482B2
公开(公告)日：2005-05-10
申请号：US10424031
申请日：2003-04-25
申请人： Vincent Divino, Jr. , Jeffrey L. Creech , William R. Patterson , Stephen E. Myrick
发明人： Vincent Divino, Jr. , Jeffrey L. Creech , William R. Patterson , Stephen E. Myrick
IPC分类号： A61M1/16 , A61M1/36 , A61M25/00 , A61M1/14 , A61M37/00
CPC分类号： A61M1/3621 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/325 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3626 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , C01B13/02 , Y10S128/03 , Y10S261/28 , A61M2202/0007
摘要： An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The mixed fluid exits the chamber via an outlet for delivery to a patient.
摘要翻译：提供了一种用于血氧的装置和方法。该装置有利地包括液体 - 液体氧合装置。液体 - 液体氧合组件包括具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地定位在混合室中，使得第一流体和第二流体通常彼此进入混合室以促进混合和液体 - 液体气体转移。混合流体通过出口离开室以输送给患者。

10. 发明授权

US06811750B2 Apparatus for blood oxygenation 有权
标题翻译：血氧合仪
公开(公告)号：US06811750B2
公开(公告)日：2004-11-02
申请号：US10071702
申请日：2002-02-08
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： Apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了用于血氧合的装置和方法。该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。耦合到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到该液体中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其它类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次输送到患者或其他部位。

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